Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review

European Respiratory Journal - Tập 34 Số 4 - Trang 888-894 - 2009
Gábor Kovács1, Andrea Berghold2,3, Stefan Scheidl4, Horst Olschewski4
1Department of Pulmonology, Medical University Graz, Graz, Austria.
2Institute for Medical Informatics,
3Statistics and Documentation, Medical University of Graz, Graz, Austria.
4Dept of Pulmonology, and

Tóm tắt

According to current guidelines, pulmonary arterial hypertension (PAH) is diagnosed when mean pulmonary arterial pressure (P̄pa) exceeds 25 mmHg at rest or 30 mmHg during exercise. Issues that remain unclear are the classification ofP̄pavalues <25mmHg and whetherP̄pa>30 mmHg during exercise is always pathological.

We performed a comprehensive literature review and analysed all accessible data obtained by right heart catheter studies from healthy individuals to determine normalP̄paat rest and during exercise. Data on 1,187 individuals from 47 studies in 13 countries were included. Data were stratified for sex, age, geographical origin, body position and exercise level.

P̄paat rest was 14.0±3.3 mmHg and this value was independent of sex and ethnicity. RestingP̄pawas slightly influenced by posture (supine 14.0±3.3 mmHg, upright 13.6±3.1 mmHg) and age (<30 yrs: 12.8± 3.1mmHg; 30–50 yrs: 12.9±3.0 mmHg; ≥50 yrs: 14.7±4.0 mmHg).P̄paduring exercise was dependent on exercise level and age. During mild exercise,P̄pawas 19.4±4.8 mmHg in subjects aged <50 yrs compared with 29.4±8.4 mmHg in subjects ≥50 yrs (p<0.001).

In conclusion, whileP̄paat rest is virtually independent of age and rarely exceeds 20 mmHg, exerciseP̄pais age-related and frequently exceeds 30 mmHg, especially in elderly individuals, which makes it difficult to define normalP̄pavalues during exercise.

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European Respiratory Journal

Tập 34 Số 4

888-894

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