Psychotropic dose equivalence in Japan

Psychiatry and Clinical Neurosciences - Tập 69 Số 8 - Trang 440-447 - 2015
Toshiya Inada1, Ataru Inagaki2
1Seiwa Hospital, Institute of Neuropsychiatry, Tokyo, Japan
2School of International Politics, Economics and Communication Health Administration Center Aoyama Gakuin University Tokyo Japan

Tóm tắt

Psychotropic dose equivalence is an important concept when estimating the approximate psychotropic doses patients receive, and deciding on the approximate titration dose when switching from one psychotropic agent to another. It is also useful from a research viewpoint when defining and extracting specific subgroups of subjects. Unification of various agents into a single standard agent facilitates easier analytical comparisons. On the basis of differences in psychopharmacological prescription features, those of available psychotropic agents and their approved doses, and racial differences between Japan and other countries, psychotropic dose equivalency tables designed specifically for Japanese patients have been widely used in Japan since 1998. Here we introduce dose equivalency tables for: (i) antipsychotics; (ii) antiparkinsonian agents; (iii) antidepressants; and (iv) anxiolytics, sedatives and hypnotics available in Japan. Equivalent doses for the therapeutic effects of individual psychotropic compounds were determined principally on the basis of randomized controlled trials conducted in Japan and consensus among dose equivalency tables reported previously by psychopharmacological experts. As these tables are intended to merely suggest approximate standard values, physicians should use them with discretion. Updated information of psychotropic dose equivalence in Japan is available at http://www.jsprs.org/en/equivalence.tables/. [Correction added on 8 July 2015, after first online publication: A link to the updated information has been added.]

Từ khóa


Tài liệu tham khảo

Inagaki A, 1999, Dose Equivalence of Psychotropic Drugs

10.1176/ajp.144.11.1494

Kubota T, 2001, Frequency distribution of CYP2C19, CYP2D6, and CYP2C19 mutant‐alleles in several different populations, Yakubutsu dotai (Xenobio Metabol and Dispos), 16, 69

10.1186/1471-2288-2-6

Inagaki A, 1998, Dose equivalence of psychotropic drugs. [1] Dose equivalence of orally administered neuroleptics (1), Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 1, 101

Inagaki A, 1998, Dose equivalence of psychotropic drugs. [2] Dose equivalence of orally administered neuroleptics (2), Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 1, 215

Inagaki A, 1998, Dose equivalence of psychotropic drugs. [3] Dose equivalence of orally administered neuroleptics (3), Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 1, 335

Inagaki A, 1998, Dose equivalence of psychotropic drugs. [4] Dose equivalence of orally administered neuroleptics (4), Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 1, 443

Inagaki A, 2001, Dose equivalence of psychotropic drugs. [14] Dose equivalence of novel antipsychotics (1): Quetiapine, Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 4, 681

Inagaki A, 2001, Dose equivalence of psychotropic drugs. [15] Dose equivalence of novel antipsychotics (2): Perospirone, Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 4, 869

Inagaki A, 2001, Dose equivalence of psychotropic drugs. [16] Dose equivalence of novel antipsychotics (3): Olanzapine, Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 4, 997

Inagaki A, 2006, Dose equivalence of psychotropic drugs. [17] Dose equivalence of novel antipsychotics (4): Aripiprazole, Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 9, 249

Inagaki A, 2006, Dose equivalence of psychotropic drugs. [18] Dose equivalence of psychotropic drugs: 2006 version, Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 9, 1443

Inagaki A, 2008, Dose equivalence of psychotropic drugs. [21] Dose equivalence of novel antipsychotics (5): Blonanserin, Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 11, 887

Inagaki A, 2012, Dose equivalence of psychotropic drugs. [23] Dose equivalence of novel antipsychotics: Paliperidone extended release, Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 15, 397

10.1016/0022-3956(74)90071-5

10.1093/oxfordjournals.schbul.a033302

Gelder MG, 2000, New Oxford Textbook of Psychiatry

Meltzer HY, 2000, Current Diagnosis & Treatment in Psychiatry, 260

Sadock BJ, 2001, Kaplan & Sadock's Pocket Handbook of Psychiatric Drug Treatment

10.1176/appi.ajp.159.11.1932

10.1080/j.1440-1614.2004.01340.x

10.4088/JCP.v64n0607

10.1093/oxfordjournals.schbul.a007071

Marangell LB, 2004, Essentials of Clinical Psychiatry, 783

Kamijima K, 2004, Dose equivalency and adequate dose of atypical antipsychotic, quetiapine, Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 7, 1385

Akimoto T, 2005, Dosing strategy for Quetiapine: Its determination and adjustment in schizophrenia, Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 8, 1199

Inagaki A, 2007, Dose equivalence of psychotropic drugs. [20] Dose equivalence of injectable antipsychotics, Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 10, 2373

Inagaki A, 1998, Dose equivalence of psychotropic drugs. [5] Dose equivalence of depot neuroleptics (1), Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 1, 557

Inagaki A, 1998, Dose equivalence of psychotropic drugs. [6] Dose equivalence of depot neuroleptics (2), Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 1, 663

Inagaki A, 2010, Dose equivalence of psychotropic drugs. [22] Dose equivalence of depot antipsychotics: Risperidone long‐acing injection, Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 13, 1349

Inagaki A, 1998, Dose equivalence of psychotropic drugs. [8] Dose equivalence of antiparkinsonian drugs (1), Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 1, 887

Inagaki A, 1998, Dose equivalence of psychotropic drugs. [9] Dose equivalence of antiparkinsonian drugs (2), Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 1, 969

10.1177/070674379403900203

Leon J, 1994, A pilot effort to determine benztropine equivalents of anticholinergic medications, Hosp. Community Psychiatry, 45, 606

10.1001/archpsyc.1972.01750220084016

10.4088/JCP.v58n0505

Inagaki A, 1998, Dose equivalence of psychotropic drugs. [10] Dose equivalence of antidepressants (1), Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 1, 1087

Inagaki A, 1998, Dose equivalence of psychotropic drugs. [11] Dose equivalence of antidepressants (2), Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 1, 1209

Inagaki A, 2006, Dose equivalence of psychotropic drugs. [19] Dose equivalence of novel antidepressants (1): Sertraline, Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 9, 1859

10.1192/pb.22.1.15

10.1016/S0193-953X(05)70283-5

Inagaki A, 1999, Dose equivalence of psychotropic drugs. [12] Dose equivalence of anxiolytic drugs, sedatives and hypnotics (1), Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 2, 297

Inagaki A, 1999, Dose equivalence of psychotropic drugs. [13] Dose equivalence of anxiolytic drugs, sedatives and hypnotics (2), Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 2, 411

Inagaki A, 2012, Dose equivalence of psychotropic drugs. [24] Dose equivalence of anti‐anxiolytics/hypnotics (3): Eszopiclone, Rinsyo Seishin Yakuri (Jpn. J. Clin. Psychopharmacol.), 15, 1403

10.1002/hup.510

Thông tin
Thông tin xuất bản

Psychiatry and Clinical Neurosciences

Tập 69 Số 8

440-447

Thông tin tác giả