Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis

Journal of Magnetic Resonance Imaging - Tập 5 Số 3 - Trang 281-285 - 1995
Renata Longo1, Piero Pollesello2,3, Claudio Ricci1, Flora Masutti4, Bjarne J. Kvam2, Luisa Bercich5, Lory Saveria Crocè6,4, Piergiovanni Grigolato7, Sergio Paoletti2,3, B. de Bernard3, Claudio Tiribelli6,3, L. Dalla Palma1
1Institutes of Radiology, University of Trieste, Trieste, Italy
2Centre Ricerche POLY-bios, Trieste, Italy
3Department of BBCM, University of Trieste, Trieste, Italy
4Medical Pathology, University of Trieste, Trieste, Italy
5Pathologic Anatomy, University of Trieste, Trieste, Italy
6Centro Studi Fegato, Unlversltà degli Studl di Trieste, Trieste Italy
7Institute of Anatomy, University of Brescia, Brescia, Italy

Tóm tắt

AbstractTo demonstrate that the lipid volume fraction In liver steatosis can be accurately estimated with in vivo hydrogen‐1 magnetic resonance (MR) spectroscopy, the authors developed a calibration procedure based on in vitro MR spectroscopy of lipid extracts from steatotlc liver specimens. The lipid volume fractions determined with the calibration procedure were compared with the results of histomorphometry and with calibrated computed tomographic (CT) data. The volume fraction of fat determined with MR spectroscopy was in good agreement with the CT results, whereas histomorphometry underestimated the amount of hepatic fat. The results indicate that determination of the fat volume fraction in steatotic liver can be achieved noninvasively with MR spectroscopy.

Từ khóa


Tài liệu tham khảo

10.1002/mrm.1910100206

10.1002/mrm.1910290203

10.1002/mrm.1910190108

10.1002/mrm.1910260203

10.1097/00004424-199304000-00006

den Hollander JA, 1992, Book of abstracts: Society of Magnetic Resonance in Medicine 1992, 849

10.2214/ajr.160.3.8430555

10.1097/00004424-199403000-00019

10.1148/radiology.153.1.6089263

10.1002/mrm.1910030609

10.1016/0730-725X(93)90217-2

10.1148/radiology.157.3.2997837

Ordidge RJ, 1985, Magnetic resonance in biology and medicine, 387

10.1111/j.1749-6632.1987.tb32915.x

10.1002/nbm.1940040206

10.1088/0031-9155/39/1/013

10.1016/0730-725X(94)92543-7

10.1006/bbrc.1993.1546

10.1016/S0021-9258(18)64849-5

Aferzon J, 1988, A micro‐computer based algorithm for digitized image simplification and information extraction, Anal Quant Cytol Histol, 10, 229

Sanchez L, 1990, Performance of a TV image analysis system as a microdensitometer, Anal Quant Cytol Histol, 12, 279

1975, ICRP publication 23. Reference man: anatomical physiological and metabolic characteristics

Overmoyer BA, 1987, Uniformity of liver density and nonheme (storage) iron distribution, Arch Pathol Lab Med, 111, 549

Thông tin
Thông tin xuất bản

Journal of Magnetic Resonance Imaging

Tập 5 Số 3

281-285

Thông tin tác giả