Protocatechuic acid induces cell death in HepG2 hepatocellular carcinoma cells through a c-Jun N-terminal kinase-dependent mechanism

Ansorena E, Garcia-Trevijano ER, Martinez-Chantar ML, et al. S-Adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells. Hepatology. 2002;35:274–80.

Babich H, Visioli F. In vitro cytotoxicity to human cells in culture of some phenolics from olive oil. Farmaco. 2003;58(5):403–7.

Chan AS, Yip EC, Yung LY, et al. Immuno-regulatory effects of CKBM on the activities of mitogen-activated protein kinases and the release of cytokines in THP-1 monocytic cells. Biol Pharm Bull. 2005a; 28:1645–50.

Chan AS, Pang H, Yip EC, Tam YK, Wong YH. Carvacrol and eugenol differentially stimulate intracellular Ca2+ mobilization and mitogen-activated protein kinases in Jurkat T-cells and monocytic THP-1 cells. Planta Med. 2005b;71:634–39.

Chang WC, Hsu FL. Inhibition of platelet activation and endothelial cell injury by polyphenolic compounds isolated from Lonicera japonica Thunb. Prostaglandins Leukot Essent Fatty Acids. 1992;45:307–12.

Chen JC, Chung JG, Lin KM. Effects of luteolin on arylamine N-acetyltransferase activity in human liver tumour cells. Cytobios. 2000;102:95–106.

Harper SJ, LoGrasso P. Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38. Cell Signal. 2001;13:299–310.

Horinaka M, Yoshida T, Shiraishi T, et al. Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells. Oncogene. 2005;24:7180–9.

Huang X. A review on the survey and prospect of Jinyinhua. China Journal of Chinese Materia Medica. 1997;22:247–9.

Ichijo H. From receptors to stress-activated MAP kinases. Oncogene. 1999;18:6087–93.

Jiang Y, Satoh K, Kusama K, Watanabe S, Sakagami H. Interaction between chlorogenic acid and antioxidants. Anticancer Res. 2000;20(4): 2473–6.

Jin Z, El-Deiry WS. Overview of cell death signaling pathways. Cancer Biol Ther. 2005;4(2):139–63.

Lee JH, Ko WS, Kim YH, Kang HS, Kim HD, Choi BT. Anti-inflammatory effect of the aqueous extract from Lonicera japonica flower is related to inhibition of NFκB activation through reducing IκBα degradation in rat liver. Int J Mol Med. 2001;7:79–83.

Li XP, Yu J, Luo JY, et al. Determination and pharmacokinetic study of chlorogenic acid in rat dosed with Yin-Huang granules by RP-HPLC. Biomed Chromatogr. 2006;20(2):206–10.

Lin WL, Hsieh YJ, Chou FP, Wang CJ, Cheng MT, Tseng TH. Hibiscus protocatechuic acid inhibits lipopolysaccharide-induced rat hepatic damage. Arch Toxicol. 2003;77:42–7.

Liu AM, Wong YH. μ-Opioid receptor-mediated phosphorylation of IκB kinase in human neuroblastoma SH-SY5Y cells. Neurosignals. 2005;14:136–42.

Liu CL, Wang JM, Chu CY, Cheng MT, Tseng TH. In vivo protective effect of protocatechuic acid on tert-butyl hydroperoxide-induced rat hepatotoxicity. Food Chem Toxicol. 2002;40(5):635–41.

Lou HX, Lang WJ, Lu MJ. Water soluble constituents from Lonicera japonica. Chinese Traditional and Herbal Drugs. 1996;27:195–9.

Matsuo M, Sasaki N, Saga K, Kaneko T. Cytotoxicity of flavonoids toward cultured normal human cells. Biol Pharm Bull. 2005;28(2):253–9.

Nanba T. (ed.) “Wakanyaku Hyaka Zukan II,” Hoiku-sya, Osaka; 1994:162–73.

Nishina H, Wada T, Katada T. Physiological roles of SAPK/JNK signaling pathway. J Biochem (Tokyo). 2004;136:123–6.

Ohta S, Sato N, Tu SH, Shinoda M. Protective effects of Taiwan crude drugs on experimental liver injuries. Yakugaku Zasshi. 1993;113:870–80.

Panoutsopoulos GI, Beedham C. Enzymatic oxidation of vanillin, isovanillin and protocatechuic aldehyde with freshly prepared guinea pig liver slices. Cell Physiol Biochem. 2005;15(1–4):89–98.

Shi JZ, Wan L, Cheng XF. Protective effect of fulvotomentosides on chemical toxin-induced liver damage in mice. Pharmacology and Clinical Application of Chinese Medicine. 1990;6:33.

Shi Y, Shi RB, Lu YR. Advance in research of botanical resources, chemical ingredients, and pharmacological effects for Lonicera japonica. J Chin Pharm. 1999;34:724–8.

Sun D, Gong Y, Kojima H, et al. Increasing cell membrane potential and GABAergic activity inhibits malignant hepatocyte growth. Am J Physiol Gastrointest Liver Physiol. 2003;285: G129.

Tanaka T, Nishikawa A, Shima H, et al. Inhibitory effects of chlorogenic acid, reserpine, polyprenoic acid (E-5166), or coffee on hepatocarcinogenesis in rats and hamsters. Basic Life Sci. 1990;52:429–40.

Tanaka T, Kojima T, Kawamori T, Mori H. Chemoprevention of digestive organs carcinogenesis by natural product protocatechuic acid. Cancer. 1995;75:1433–9.

Tseng TH, Wang CJ, Kao ES, Chu HY. Hibiscus protocatechuic acid protects against oxidative damage induced by tert-butylhydroperoxide in rat primary hepatocytes. Chem Biol Interact. 1996;101:137–48.

Tseng TH, Kao TW, Chu CY, Chou FP, Lin WL, Wang CJ. Induction of apoptosis by hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression. Biochem Pharmacol. 2000;60(3):307–15.

Tsuda T, Horio F, Osawa T. Absorption and metabolism of cyanidin 3-O-β-d-glucoside in rats. FEBS Lett. 1999;449(2–3):179–82.

Wu GS. The functional interactions between the p53 and MAPK signaling pathways. Cancer Biol Ther. 2004;3:156–61.

Yu JC, Min ZD, Ip NY. Melia toosendan regulates PC12 cell differentiation via the activation of protein kinase A and extracellular signal-regulated kinases. Neurosignals. 2004;13:248–57.

Zhang Q. Study on the protective function of ganyaoling on liver damage in animals. Chinese Traditional and Herbal Drugs. 1993;24:535–7.