Proteomic analyses of plasma-derived exosomes in immunoglobulin (Ig) G4-related disease and their potential roles in B cell differentiation and tissue damage

Wallace, 2019, Clinical phenotypes of IgG4-related disease: an analysis of two international cross-sectional cohorts, Ann. Rheumat. Dis., 78, 406, 10.1136/annrheumdis-2018-214603 Peng, 2019, Clinical outcomes and predictive relapse factors of IgG4-related disease following treatment: a long-term cohort study, J. Intern. Med., 286, 542, 10.1111/joim.12942 Perugino, 2020, IgG4-related disease: an update on pathophysiology and implications for clinical care, Nat. Rev. Rheumatol., 16, 702, 10.1038/s41584-020-0500-7 Lanzillotta, 2020, Advances in the diagnosis and management of IgG4 related disease, BMJ, 369, m1067, 10.1136/bmj.m1067 Carruthers, 2015, The diagnostic utility of serum IgG4 concentrations in IgG4-related disease, Ann. Rheumat. Dis., 74, 14, 10.1136/annrheumdis-2013-204907 Genschmer, 2019, Activated PMN exosomes: pathogenic entities causing matrix destruction and disease in the lung, Cell, 176, 113, 10.1016/j.cell.2018.12.002 Mathieu, 2019, Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication, Nat. Cell Biol., 21, 9, 10.1038/s41556-018-0250-9 Gao, 2018, Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy, Sci. Transl. Med., 10, 10.1126/scitranslmed.aat0195 Gao, 2018, Tumor-derived exosomes antagonize innate antiviral immunity, Nat. Immunol., 19, 233, 10.1038/s41590-017-0043-5 Valadi, 2007, Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells, Nat. Cell Biol., 9, 654, 10.1038/ncb1596 Li, 2013, Exosomes mediate the cell-to-cell transmission of IFN-alpha-induced antiviral activity, Nat. Immunol., 14, 793, 10.1038/ni.2647 Chatila, 2014, Regulatory T cells: exosomes deliver tolerance, Immunity, 41, 3, 10.1016/j.immuni.2014.07.001 Takahashi, 2017, Exosomes maintain cellular homeostasis by excreting harmful DNA from cells, Nat. Commun., 8, 15287, 10.1038/ncomms15287 Kalluri, 2020, 367 Robbins, 2016, Regulation of chronic inflammatory and immune processes by extracellular vesicles, J. Clin. Investig., 126, 1173, 10.1172/JCI81131 Whiteside, 2016, Exosomes and tumor-mediated immune suppression, J. Clin. Investig., 126, 1216, 10.1172/JCI81136 Li, 2014, Blockade of macrophage autophagy ameliorates activated lymphocytes-derived DNA induced murine lupus possibly via inhibition of proinflammatory cytokine production, Clin. Exp. Rheumatol., 32, 705 Lee, 2016, Circulating exosomes from patients with systemic lupus erythematosus induce an proinflammatory immune response, Arthritis Res. Ther., 18, 264, 10.1186/s13075-016-1159-y Yeh, 2015, Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling, Blood, 125, 3297, 10.1182/blood-2014-12-618470 Umehara, 2012, Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011, Mod. Rheumatol., 22, 21, 10.3109/s10165-011-0571-z Muraro, 2014, Anaphylaxis: guidelines from the European Academy of Allergy and clinical Immunology, Allergy, 69, 1026, 10.1111/all.12437 Gokce, 2011, Increasing proteome coverage with offline RP HPLC coupled to online RP nanoLC-MS, J. Chromatogr. B, Anal. Technol. Biomed. Life Sci., 879, 610, 10.1016/j.jchromb.2011.01.032 Mechtcheriakova, 2012, Activation-induced cytidine deaminase (AID) linking immunity, chronic inflammation, and cancer, Canc. Immunol. Immunother. : CII, 61, 1591, 10.1007/s00262-012-1255-z Lin, 2017, Circulating plasmablasts/plasma cells: a potential biomarker for IgG4-related disease, Arthritis Res. Ther., 19, 25, 10.1186/s13075-017-1231-2 Della-Torre, 2020, B lymphocytes directly contribute to tissue fibrosis in patients with IgG(4)-related disease, J. Allergy Clin. Immunol., 145, 968, 10.1016/j.jaci.2019.07.004 Wallace, 2015, Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4 concentrations, Ann. Rheumat. Dis., 74, 190, 10.1136/annrheumdis-2014-205233 Defendi, 2020, The immunopathology of complement proteins and innate immunity in autoimmune disease, Clin. Rev. Allergy Immunol., 58, 229, 10.1007/s12016-019-08774-5 Dijkstra, 2019, Complement activation and regulation in rheumatic disease, Semin. Immunol., 45, 101339, 10.1016/j.smim.2019.101339 Reis, 2019, New insights into the immune functions of complement, Nat. Rev. Immunol., 19, 503, 10.1038/s41577-019-0168-x Dunkelberger, 2010, Complement and its role in innate and adaptive immune responses, Cell Res., 20, 34, 10.1038/cr.2009.139 Khandelwal, 2016, The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21), Blood, 128, 1789, 10.1182/blood-2016-04-709634 Kremlitzka, 2016, Regulation of B cell functions by Toll-like receptors and complement, Immunol. Lett., 178, 37, 10.1016/j.imlet.2016.07.015 Wu, 2019 Conigliaro, 2019, Complement, infection, and autoimmunity, Curr. Opin. Rheumatol., 31, 532, 10.1097/BOR.0000000000000633 Wang, 2018 Liu, 2020 Fujisawa, 2021, Hypocomplementemia is related to elevated serum levels of IgG subclasses other than IgG4 in IgG4-related kidney disease, Mod. Rheumatol., 31, 241, 10.1080/14397595.2019.1709942 Yang, 2019, Follicular helper T cell derived exosomes promote B cell proliferation and differentiation in antibody-mediated rejection after renal transplantation, BioMed Res. Int., 2019, 6387924 Capello, 2019, Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity, Nat. Commun., 10, 254, 10.1038/s41467-018-08109-6 Gutzeit, 1950, Exosomes derived from Burkitt's lymphoma cell lines induce proliferation, differentiation, and class-switch recombination in B cells, J. Immunol. (Baltimore, Md, 2014, 5852 Onnis, 2018, The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II, Autophagy, 14, 2117, 10.1080/15548627.2018.1505153 Gilljam, 1950, Differential effects of reactive oxygen species on IgG versus IgM levels in TLR-stimulated B cells, J. Immunol. (Baltimore, Md, 2020, 2133 Wang, 2018, Role of complement system in patients with biopsy-proven immunoglobulin G4-related kidney disease, Hum. Pathol., 81, 220, 10.1016/j.humpath.2018.07.008 Tabeya, 2014, The role of cytotoxic T cells in IgG4-related dacryoadenitis and sialadenitis, the so-called Mikulicz's disease, Mod. Rheumatol., 24, 953, 10.3109/14397595.2014.882045 Chen, 2018, vol. 70, 1853 Ishiguro, 2020, vol. 72, 166