Protein kinase inhibitors that inhibit induction of lytic program and replication of Epstein–Barr virus

Antiviral Research - Tập 96 - Trang 296-304 - 2012
R. Goswami1, S. Gershburg1, A. Satorius1, E. Gershburg1
1Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794-9626, USA

Tài liệu tham khảo

Adamson, 1998, Rescue of the Epstein–Barr virus BZLF1 mutant, Z(S186A), early gene activation defect by the BRLF1 gene product, Virology, 251, 187, 10.1006/viro.1998.9396 Arcaro, 1993, Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses, Biochem. J., 296, 297, 10.1042/bj2960297 Asai, 2006, Epstein–Barr virus protein kinase BGLF4 is a virion tegument protein that dissociates from virions in a phosphorylation-dependent process and phosphorylates the viral immediate–early protein BZLF1, J. Virol., 80, 5125, 10.1128/JVI.02674-05 Bahlis, 2005, N-Benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells, Leuk. Lymphoma, 46, 899, 10.1080/10428190500080595 Bertrand, 1994, Induction of a common pathway of apoptosis by staurosporine, Exp. Cell Res., 211, 314, 10.1006/excr.1994.1093 Bilder, 1991, Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells, Am. J. Physiol., 260, C721, 10.1152/ajpcell.1991.260.4.C721 Biron, 2002, Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole l-riboside with a unique mode of action, Antimicrob. Agents Chemother., 46, 2365, 10.1128/AAC.46.8.2365-2372.2002 Brown, 2003, NF-kappaB inhibits gammaherpesvirus lytic replication, J. Virol., 77, 8532, 10.1128/JVI.77.15.8532-8540.2003 Chen, 2000, A protein kinase activity associated with Epstein–Barr virus BGLF4 phosphorylates the viral early antigen EA-D in vitro, J. Virol., 74, 3093, 10.1128/JVI.74.7.3093-3104.2000 Chin, 1999, K252a induces cell cycle arrest and apoptosis by inhibiting Cdc2 and Cdc25c, Cancer Invest., 17, 391, 10.3109/07357909909021430 Daibata, 1990, Activation of latent EBV via anti-IgG-triggered, second messenger pathways in the Burkitt’s lymphoma cell line Akata, J. Immunol., 144, 4788, 10.4049/jimmunol.144.12.4788 Daikoku, 1997, Purification and characterization of the protein kinase encoded by the UL13 gene of herpes simplex virus type 2, Virology, 235, 82, 10.1006/viro.1997.8653 Dal Porto, 2004, B cell antigen receptor signaling 101, Mol. Immunol., 41, 599, 10.1016/j.molimm.2004.04.008 Darr, 2001, Epstein–Barr virus immediate-early protein BRLF1 induces the lytic form of viral replication through a mechanism involving phosphatidylinositol-3 kinase activation, J. Virol., 75, 6135, 10.1128/JVI.75.13.6135-6142.2001 Davies, 1991, Induction of Epstein–Barr virus lytic cycle by tumor-promoting and non-tumor-promoting phorbol esters requires active protein kinase C, J. Virol., 65, 6838, 10.1128/JVI.65.12.6838-6844.1991 Davies, 2000, Specificity and mechanism of action of some commonly used protein kinase inhibitors, Biochem. J., 351, 95, 10.1042/0264-6021:3510095 Fabbro, 2000, PKC412 – a protein kinase inhibitor with a broad therapeutic potential, Anticancer Drug Des., 15, 17 Fan, 2001, Epstein–Barr viral load measurement as a marker of EBV-related disease, Mol. Diagn., 6, 279, 10.2165/00066982-200106040-00009 Favata, 1998, Identification of a novel inhibitor of mitogen-activated protein kinase kinase, J. Biol. Chem., 273, 18623, 10.1074/jbc.273.29.18623 Feederle, 2000, The Epstein–Barr virus lytic program is controlled by the co-operative functions of two transactivators, EMBO J., 19, 3080, 10.1093/emboj/19.12.3080 Fox, 1998, A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase, Protein Sci., 7, 2249, 10.1002/pro.5560071102 Gao, 2001, 12-O-tetradecanoylphorbol-13-acetate induces Epstein–Barr virus reactivation via NF-kappaB and AP-1 as regulated by protein kinase C and mitogen-activated protein kinase, Virology, 286, 91, 10.1006/viro.2001.0965 Gershburg, 2004, Effects of maribavir and selected indolocarbazoles on Epstein–Barr virus protein kinase BGLF4 and on viral lytic replication, Antimicrob. Agents Chemother., 48, 1900, 10.1128/AAC.48.5.1900-1903.2004 Gershburg, 2002, Phosphorylation of the Epstein–Barr virus (EBV) DNA polymerase processivity factor EA-D by the EBV-encoded protein kinase and effects of the l-riboside benzimidazole 1263W94, J. Virol., 76, 998, 10.1128/JVI.76.3.998-1003.2002 Gershburg, 2008, Conserved herpesvirus protein kinases, Biochim. Biophys. Acta, 1784, 203, 10.1016/j.bbapap.2007.08.009 Gershburg, 2007, Epstein–Barr virus-encoded protein kinase (BGLF4) is involved in production of infectious virus, J. Virol., 81, 5407, 10.1128/JVI.02398-06 Gershburg, 2010, Key motifs in EBV (Epstein–Barr virus)-encoded protein kinase for phosphorylation activity and nuclear localization, Biochem. J., 431, 227, 10.1042/BJ20100558 Gschwendt, 1994, Rottlerin, a novel protein kinase inhibitor, Biochem. Biophys. Res. Commun., 199, 93, 10.1006/bbrc.1994.1199 Hamirally, 2009, Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress, PLoS Pathog., 5, e1000275, 10.1371/journal.ppat.1000275 Han, 2000, The staurosporine analog, Ro-31-8220, induces apoptosis independently of its ability to inhibit protein kinase C, Cell Death Differ., 7, 521, 10.1038/sj.cdd.4400681 He, 1997, The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines, J. Virol., 71, 405, 10.1128/JVI.71.1.405-411.1997 Hers, 1999, The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity, FEBS Lett., 460, 433, 10.1016/S0014-5793(99)01389-7 Iwakiri, 2004, Phosphatidylinositol 3-kinase is a determinant of responsiveness to B cell antigen receptor-mediated Epstein–Barr virus activation, J. Immunol., 172, 1561, 10.4049/jimmunol.172.3.1561 Jacob, 2011, Viral serine/threonine protein kinases, J. Virol., 85, 1158, 10.1128/JVI.01369-10 Johnson, 2002, Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases, Science, 298, 1911, 10.1126/science.1072682 Kawaguchi, 2003, Protein kinases conserved in herpesviruses potentially share a function mimicking the cellular protein kinase cdc2, Rev. Med. Virol., 13, 331, 10.1002/rmv.402 Kieff, 2007, Epstein–Barr virus and its replication, 2603 Kurosaki, 2010, B cell signaling and fate decision, Annu. Rev. Immunol., 28, 21, 10.1146/annurev.immunol.021908.132541 Lazdins, 1987, TPA induction of Epstein–Barr virus early antigens in Raji cells is blocked by selective protein kinase-C inhibitors, Int. J. Cancer, 40, 846, 10.1002/ijc.2910400624 Liu, 2008, NF-kappaB inhibitors induce lytic cytotoxicity in Epstein–Barr virus-positive nasopharyngeal carcinoma cells, Cell Biol. Int., 32, 1006, 10.1016/j.cellbi.2008.03.022 Marschall, 2002, Direct targeting of human cytomegalovirus protein kinase pUL97 by kinase inhibitors is a novel principle for antiviral therapy, J. Gen. Virol., 83, 1013, 10.1099/0022-1317-83-5-1013 Massillon, 1994, Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor, Biochem. J., 299, 123, 10.1042/bj2990123 McKenna, 1993, Inhibition by Ro 31-8220 of acid secretory activity induced by carbachol indicates a stimulatory role for protein kinase C in the action of muscarinic agonists on isolated rat parietal cells, Biochem. Pharmacol., 46, 583, 10.1016/0006-2952(93)90541-4 Mori, 2006, Functional role of phosphatidylinositol 3-kinase/Akt pathway on cell growth and lytic cycle of Epstein–Barr virus in the Burkitt’s lymphoma cell line, P3HR-1, Virus Genes, 32, 327, 10.1007/s11262-005-6918-9 Murata, 2009, Efficient production of infectious viruses requires enzymatic activity of Epstein–Barr virus protein kinase, Virology, 389, 75, 10.1016/j.virol.2009.04.007 Oussaief, 2011, NF-kappaB-mediated modulation of inducible nitric oxide synthase activity controls induction of the Epstein–Barr virus productive cycle by transforming growth factor beta 1, J. Virol., 85, 6502, 10.1128/JVI.02560-10 Overton, 1992, Herpes simplex virus type 1 gene UL13 encodes a phosphoprotein that is a component of the virion, Virology, 190, 184, 10.1016/0042-6822(92)91204-8 Palumbo, 1997, The tyrphostin AG17 induces apoptosis and inhibition of cdk2 activity in a lymphoma cell line that overexpresses bcl-2, Cancer Res., 57, 2434 Peng, 2010, Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency, J. Gen. Virol., 91, 463, 10.1099/vir.0.015073-0 Pierce, 1997, Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo, J. Biol. Chem., 272, 21096, 10.1074/jbc.272.34.21096 Prichard, 1999, A recombinant human cytomegalovirus with a large deletion in UL97 has a severe replication deficiency, J. Virol., 73, 5663, 10.1128/JVI.73.7.5663-5670.1999 Rickinson, 2007, Epstein–Barr virus, 2655 Ringshausen, 2006, Mechanisms of apoptosis-induction by rottlerin: therapeutic implications for B-CLL, Leukemia, 20, 514, 10.1038/sj.leu.2404113 Satoh, 1999, The interaction of mitogen-activated protein kinases to Epstein–Barr virus activation in Akata cells, Virus Genes, 18, 57, 10.1023/A:1008021402908 Schultz, 1999, Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity, J. Med. Chem., 42, 2909, 10.1021/jm9900570 Takada, 1984, Cross-linking of cell surface immunoglobulins induces Epstein–Barr virus in Burkitt lymphoma lines, Int. J. Cancer, 33, 27, 10.1002/ijc.2910330106 Takada, 1991, An Epstein–Barr virus-producer line Akata: establishment of the cell line and analysis of viral DNA, Virus Genes, 5, 147, 10.1007/BF00571929 Tovey, 1978, Activation of latent Epstein–Barr virus by antibody to human IgM, Nature, 276, 270, 10.1038/276270a0 Umezawa, 1990, Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors, FEBS Lett., 260, 198, 10.1016/0014-5793(90)80102-O van Zeijl, 1997, The human cytomegalovirus UL97 protein is phosphorylated and a component of virions, Virology, 231, 72, 10.1006/viro.1997.8523 Vlahos, 1994, A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), J. Biol. Chem., 269, 5241, 10.1016/S0021-9258(17)37680-9 Wang, 2009, Maribavir inhibits Epstein-Barr viral transcription in addition to viral DNA replication, J Virol., 83, 12108, 10.1128/JVI.01575-09 Williams, 2003, In vitro activities of benzimidazole d- and l-ribonucleosides against herpesviruses, Antimicrob. Agents Chemother., 47, 2186, 10.1128/AAC.47.7.2186-2192.2003 Wymann, 1996, Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction, Mol. Cell. Biol., 16, 1722, 10.1128/MCB.16.4.1722 Zacny, 1999, Inhibition of Epstein–Barr virus replication by a benzimidazole l-riboside: novel antiviral mechanism of 5,6-dichloro-2-(isopropylamino)-1-beta-l-ribofuranosyl-1H-benzimidazole, J. Virol., 73, 7271, 10.1128/JVI.73.9.7271-7277.1999 Zaharevitz, 1999, Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases, Cancer Res., 59, 2566