Protein kinase C

Adams, 1991, TPA-induced activation of MAP kinease, FEBS Lett., 10.1016/0014-5793(91)81230-6 Ahmed, 1990, Human n-chimaerin cDNA encodes a novel phorbol ester receptor, Biochem. J., 272, 767, 10.1042/bj2720767 Akers, 1987, Calcium promoted translocation of protein kinase C to synaptic membranes: relation to the phosphorylation of an endogenous substrate (protein fl) involved in synaptic plasticity, J. Neurosci., 7, 3976, 10.1523/JNEUROSCI.07-12-03976.1987 Akita, 1990, Possible role of Ca2+-independent protein kinase C isozyme, nPKCϵ in thryotropin-releasing hormone-stimulated signal transduction: differential down-regulation of nPKCϵ in GH4C1 cells, Biochem. biophys. Res. Commun., 172, 184, 10.1016/S0006-291X(05)80191-3 Albert, 1986, Widespread occurrence of ‘87 kDa’, a major specific substrate for protein kinase C, 83, 2822 Albert, 1987, The 87-kDa protein, a major specific substrate for protein kinase C: purification from bovine brain and characterization, 84, 7046 Alexander, 1989, A protein kinase C pseudosubstrate peptide inhibits phosphorylation of the CD3 antigen in streptolysin-O-permeabilized human T lymphocytes, Biochem. J., 260, 893, 10.1042/bj2600893 Angel, 1987, Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor, Cell, 49, 729, 10.1016/0092-8674(87)90611-8 Ashendel, 1985, The phorbol ester receptor: a phospholipid-regulated kinase, Biochim. biophys. Acta, 822, 219, 10.1016/0304-4157(85)90009-7 Ashendel, 1983, Protein kinase activity associated with a phorbol ester receptor purified from mouse brain, Cancer Res., 43, 4333 Atchison, 1987, The role of the k enhancer and its binding factor NF-kB in the developmental regulation of k gene transcription, Cell, 48, 121, 10.1016/0092-8674(87)90362-X Bacher, 1991, Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin and heart, Molec. cell Biol., 11, 126, 10.1128/MCB.11.1.126 Baeuerle, 1988, IkB: A specific inhibitor of the NF-kB transcription factor, Science, 242, 540, 10.1126/science.3140380 Baeuerle, 1988, Phorbol-ester-induced activation of the NF-kB transcription factor involves dissociation of an apparently cytoplasmic NF-kB/inhibitor complex, LIII, 789 Baichwal, 1990, Control of c-Jun activity by interaction of a cell-specific inhibitor with regulatory domain δ: Differences between v- and c-Jun, Cell, 63, 815, 10.1016/0092-8674(90)90147-7 Baker, 1989, Similarity between phospholipase C and the regulatory domain of protein kinase C, Molec. cell. Endocr., 61, 139, 10.1016/0303-7207(89)90197-4 Ballester, 1985, Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate, J. biol. Chem., 260, 15194, 10.1016/S0021-9258(18)95721-2 Ballou, 1988, S6 kinase in quiescent Swiss mouse 3T3 cells is activated by phosphorylation in response to serum treatment, 85, 7154 Bazzi, 1988, Association of protein kinase C with phospholipid monolayers: two-stage irreversible binding, Biochemistry, 27, 6776, 10.1021/bi00418a020 Bazzi, 1990, Protein kinase C interaction with calcium: A phospholipid-dependent process, Biochemistry, 29, 7624, 10.1021/bi00485a012 Benowitz, 1987, Molecular properties of the growth-associated protein GAP-43 (B-50), J. Neurochem., 48, 1640, 10.1111/j.1471-4159.1987.tb05713.x Berg, 1990, Zinc fingers and other metal-binding domains, J. biol. Chem., 265, 6513, 10.1016/S0021-9258(19)39172-0 Berridge, 1987, Inositol trisphosphate and diacylglycerol: two interacting second messengers, A. Rev. Biochem., 56, 159, 10.1146/annurev.bi.56.070187.001111 Berry, 1990, Protein kinase C and T cell activation, Eur. J. Biochem., 189, 205, 10.1111/j.1432-1033.1990.tb15478.x Billah, 1990, The regulation and cellular functions of phosphatidylcholine hydrolysis, Biochem. J., 269, 281, 10.1042/bj2690281 Blackshear, 1986, Protein kinase C-stimulated phosphorylation in vitro of a Mr 80,000 protein phosphorylated in response to phorbol esters and growth factors in intact fibroblasts, J. biol. Chem., 261, 1459, 10.1016/S0021-9258(17)36115-X Bloomquist, 1988, Isolation of a putative phospholipase C gene of Drosophila, norpA, and its role in phototransduction, Cell, 54, 723, 10.1016/S0092-8674(88)80017-5 Bonser, 1988, Evidence that a second stereochemical centre in diacylglycerols defines interaction at the recognition site of protein kinase C, FEBS Lett., 234, 341, 10.1016/0014-5793(88)80112-1 Borner, 1990, Transformation by a ras oncogene causes increased expression of protein kinase C-α and decreased expression of protein kinase C-ϵ, Cell Growth Diff., 1, 653 Boyle, 1991, Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity, Cell, 64, 573, 10.1016/0092-8674(91)90241-P Brindley, 1984, Intracellular translocation of phosphatidate phosphohydrolase and its possible role in the control of glycerolipid synthesis, Prog. Lipid. Res., 23, 115, 10.1016/0163-7827(84)90001-8 Burgoyne, 1989, A role for membrane inserved protein kinase C in cellular memory?, TIBS, 14, 87 Burns, 1990, Expression of the α, β2 and γ protein kinase C isozymes in the baculovirus-insect cell expression system, J. biol. Chem., 265, 12044, 10.1016/S0021-9258(19)38505-9 Carpenter, 1987, Coping with a growing family, Nature, 325, 107, 10.1038/325107a0 Castagna, 1982, Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters, J. biol. Chem., 257, 7847, 10.1016/S0021-9258(18)34459-4 Cazaubon, 1990, Effector dependent conformational changes in protein kinase Cγ through epitope mapping with inhibitory monoclonal antibodies, Eur. J. Biochem., 194, 799, 10.1111/j.1432-1033.1990.tb19472.x Chan, 1986, Phosphoprotein F1: purification and characterization of a brain kinase C substrate related to plasticity, J. Neurosci., 6, 3618, 10.1523/JNEUROSCI.06-12-03618.1986 Chatterjee, 1988, DNA-binding properties of an adenovirus 289R E1A protein, EMBO J., 7, 835, 10.1002/j.1460-2075.1988.tb02882.x Chen, 1989, Molecular cloning and sequence analysis of two distinct types of Xenopus laevis protein kinase C, Sec. Mess. Phosphoprot., 12, 251 Chen, 1990, Characterization of the 5′-flanking region of the rat protein kinase C γ gene, J. biol. Chem., 265, 19961, 10.1016/S0021-9258(17)45468-8 Cochet, 1986, Altered catalytic properties of protein kinase C in phorbol ester treated cells, Biochem. biophys. Res. Commun., 134, 1031, 10.1016/0006-291X(86)90355-4 Connolly, 1986, Protein kinase C phosphorylates human platelet inositol triphosphate 5′-phosphomonoesterase, increasing the phosphatase activity, Cell, 46, 951, 10.1016/0092-8674(86)90077-2 Contente, 1990, Expression of gene rrg is associated with reversion of NIH 3T3 transformed by LTR-c-H-las, Science, 249, 796, 10.1126/science.1697103 Coussens, 1986, Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signalling pathways, Science, 233, 859, 10.1126/science.3755548 Coussens, 1987, Alternative splicing increases the diversity of the human protein kinase C family, DNA, 6, 389, 10.1089/dna.1987.6.389 Csermely, 1988, Zinc increases the affinity of phorbol ester receptor in T lymphocytes, Biochem. biophys. Res. Commun., 154, 578, 10.1016/0006-291X(88)90179-9 Cuadrado, 1990, Expression of protein kinase C I in NIH 3T3 cells increased its growth response to specific activators, FEBS Lett., 260, 281, 10.1016/0014-5793(90)80123-Z Downward, 1990, Stimulation of p21ras upon T-cell activation, Nature, 346, 719, 10.1038/346719a0 Eicholtz, 1990, A pseudosubstrate peptide inhibits protein kinase C-mediated pholsphorylation in permeabilised Rat-1 cells, FEBS Lett., 261, 147, 10.1016/0014-5793(90)80657-5 Eldar, 1990, Overexpression of protein kinase C α-subtype in Swiss/3T3 fibroblasts causes loss of both high and low affinity receptor numbers of EGF receptor, J. biol. Chem., 265, 13290, 10.1016/S0021-9258(19)38297-3 Epand, 1990, The role of membrane biophysical properties in the regulation of protein kinase C activity, TIPS, 11, 317 Erusalimsky, 1989, Internal amino acid sequence analysis of the 80 kDa protein kinase C substrate from rat brain: relationship to the 87 kDa substrate from bovine brain, FEBS Lett., 255, 149, 10.1016/0014-5793(89)81079-8 Europe-Finner, 1987, GTP analogues stimulate inositol trisphosphate formation transiently in Dictyostelium, J. Cell. Sci., 87, 221, 10.1242/jcs.87.2.221 Evans, 1990, TPA and resiniferatoxin-mediated activation of NADPH-oxidase. A possible role for Rx-kinase augmentation of PKC, FEBS Lett., 267, 253, 10.1016/0014-5793(90)80938-F Evans, 1991, Phorbol ester activation of the isotypes of protein kinase C from bovine and rat brain, Biochem. Soc. Trans., 10.1042/bst0190397 Evans, 1988, Zinc fingers: gilt by association, Cell, 52, 1, 10.1016/0092-8674(88)90522-3 Finkenzeller, 1990, Sequence of human protein kinase C α, Nucl. Acids Res., 18, 2183, 10.1093/nar/18.8.2183 Fleischman, 1986, Ras-transformed cells: altered levels of phosphatidylinositol 4,5 bisphosphate and catabolites, Science, 231, 407, 10.1126/science.3001936 Flint, 1990, Autophosphorylation of protein kinase C at three separated regions of its primary sequence, Science, 249, 408, 10.1126/science.2377895 Ford, 1989, Activation of protein kinase C by naturally occurring ether-linked diglycerides, J. biol. Chem., 264, 13818, 10.1016/S0021-9258(18)80074-6 Freisewinkel, 1991, Down-regulation of protein kinase C-γ is independent of a functional kinase domain, FEBS Lett., 280, 262, 10.1016/0014-5793(91)80307-O Ganong, 1986, Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols, 83, 1184 Geisow, 1986, Common domain structure of Ca2+ and lipid-binding proteins, FEBS Lett., 203, 99, 10.1016/0014-5793(86)81445-4 Ghosh, 1990, Activation in vitro of NF-k-B by phosphorylation of its inhibitor I-k-B, Nature, 344, 678, 10.1038/344678a0 Ghosh, 1990, Cloning of the p50 DNA binding subunit of NF-kB: homology to rel and dorsal, Cell, 62, 1019, 10.1016/0092-8674(90)90276-K Graff, 1989, Characterisation of the phosphorylation sites in the chicken and bovine myristoylated alanine-rich c-kinase substrate protein, a prominent cellular substrate for protein kinase-C, J. biol. Chem., 264, 1912, 10.1016/S0021-9258(18)80153-3 Hall, 1990, Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene, J. molec. Biol., 211, 11, 10.1016/0022-2836(90)90006-8 Hanks, 1988, The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains, Science, 241, 42, 10.1126/science.3291115 Hannun, 1985, Activation of protein kinase-C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidyl serine, J. biol. Chem., 260, 10039, 10.1016/S0021-9258(17)39208-6 Hardie, 1988, Pseudosubstrates turn off protein kinases, Nature, 335, 592, 10.1038/335592a0 Heymans, 1987, Alkyl analogs of diacylglycerol as activator of protein kinase C, FEBS Lett., 218, 35, 10.1016/0014-5793(87)81013-X Hosoda, 1989, Immunocytochemical localization of the β1 subspecies of protein kinase C in rat brain, 86, 1393 House, 1987, The influence of basic residues on the substrates specificity of protein kinase C, J. biol. Chem., 262, 772, 10.1016/S0021-9258(19)75853-0 Housey, 1987, Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family, 84, 1065 Housey, 1988, Overproduction of protein kinase C causes disordered growth control in rat fibroblasts, Cell, 52, 343, 10.1016/S0092-8674(88)80027-8 Hsiao, 1984, Oncogene-induced transformation of C3H10T1/2 cells is enhanced by tumor promoters, Science, 226, 552, 10.1126/science.6436974 Hsiao, 1989, Cells that overproduce protein kinase C are more susceptible to transformation by an activated H-ras oncogene, Molec. cell. Biol., 9, 2641, 10.1128/MCB.9.6.2641 Huang, 1987, Immunochemical identification of protein kinase C isozymes as products of discrete genes, Biochem. biophys. Res. Commun., 149, 946, 10.1016/0006-291X(87)90500-6 Huang, 1986, Autophosphorylation of rat brain Ca2+-activated and phospholipid-dependent protein kinase, J. biol. Chem., 261, 12134, 10.1016/S0021-9258(18)67213-8 Huang, 1986, Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase, 83, 8535 Huang, 1988, Biochemical characterisation of rat brain protein kinase C isozymes, J. biol. Chem., 263, 14839, 10.1016/S0021-9258(18)68115-3 Ido, 1987, Phosphorylation of the EGF receptor from A431 epidermoid carcinoma cells by three distinct types of protein kinase C, FEBS Lett., 219, 215, 10.1016/0014-5793(87)81219-X Imaoka, 1983, Purification and characterization of the 47,000-dalton protein phosphorylated during degranulation of human platelets, J. biol. Chem., 258, 11404, 10.1016/S0021-9258(17)44432-2 Inoue, 1977, Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues II, J. biol. Chem., 252, 7610, 10.1016/S0021-9258(17)41010-6 Isacke, 1986, Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and GRP, EMBO J., 5, 2889, 10.1002/j.1460-2075.1986.tb04584.x Ishikawa, 1986, Cysteine-rich regions conserved in amino-terminal halves of raf gene family products and protein kinase C, Jap. J. Cancer Res. (Gann), 77, 1183 Jaken, 1987, Purification and characterisation of three types of protein kinase C from rabbit brain cytosol, 84, 4418 Jamal, 1990, Transactivation of c-fos and β-actin genes by raf as a step in early response to transmembrane signals, Nature, 344, 463, 10.1038/344463a0 James, 1989, Myristoylation, phosphorylation and subcellular distribution of the 80-kDa protein kinase C substrate in BC3H1 myocytes, J. biol. Chem., 264, 20928, 10.1016/S0021-9258(19)30025-0 Janssens, 1987, Did vertebrate signal transduction mechanisms originate in eukaryotic microbes?, TIBS, 12, 456 Jimenez, 1989, A phospholipid-stimulated protein kinase from Dictyostelium discoideum, Biochem. J., 260, 557, 10.1042/bj2600557 Kaibuchi, 1986, Possible involvement of RAS-encoded proteins in glucose-induced inositol phospholipid turnover in Sacharomyces cerevisiae, 83, 8172 Kaibuchi, 1989, Molecular genetic analysis of the regulatory and catalytic domain of protein kinase, J. biol. Chem., 264, 13489, 10.1016/S0021-9258(18)80023-0 Katan, 1988, Determination of the primary structure of PLC-154 demonstrates diversity of phosphoinositide-specific phospholipase C activities, Cell, 54, 171, 10.1016/0092-8674(88)90549-1 Kemp, 1989, Regulation of protein kinases by pseudosubstrate prototopes, Cell Signal, 1, 303, 10.1016/0898-6568(89)90049-1 Kennelly, 1987, Rabbit skeletal muscle myosin light chain kinase, J. biol. Chem., 262, 11958, 10.1016/S0021-9258(18)45302-1 Kieran, 1990, The DNA binding subunit of NF-kB is identical to factor KBF1 and homologous to the rel oncogene product, Cell, 62, 1007, 10.1016/0092-8674(90)90275-J Kikkawa, 1982, Calcium-activated phospholipid-dependent protein kinase from rat brain, J. biol. Chem., 257, 13341, 10.1016/S0021-9258(18)33453-7 Kikkawa, 1983, Protein kinase C as a possible receptor protein of tumor promoting phorbol esters, J. biol. Chem., 258, 11442, 10.1016/S0021-9258(17)44245-1 Kikkawa, 1987, Identification of the structures of multiple subspecies of protein kinase C expressed in rat brain, FEBS Lett., 217, 227, 10.1016/0014-5793(87)80668-3 Kiley, 1990, Activation of α-protein kinase C leads to association with detergent-insoluble components of GH4C1 cells, Molec. Endocr., 4, 59, 10.1210/mend-4-1-59 Kiley, 1990, Protein kinase C heterogeneity in GH4C1 rat pituitary cells, J. biol. Chem., 265, 15704, 10.1016/S0021-9258(18)55455-7 Kishimoto, 1980, Activation of calcium- and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover, J. biol. Chem., 255, 2273, 10.1016/S0021-9258(19)85886-6 Kishimoto, 1989, Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain), J. biol. Chem., 264, 4088, 10.1016/S0021-9258(19)84966-9 Knopf, 1986, Cloning and expression of multiple protein kinase C cDNAs, Cell, 46, 491, 10.1016/0092-8674(86)90874-3 Kolch, 1991, Raf-1 protein kinase is required for growth of induced NIH/3T3 cells, Nature, 349, 426, 10.1038/349426a0 Kraft, 1990, Over-expression of protein kinase C beta 1 is not sufficient to induce factor independence in the interleukin-3-dependent myeloid cell line FDC-P1, Oncogene, 5, 1243 Krauss, 1989, Disturbances in growth control and gene expression in C3H/10T12 cell line that stably overproduces protein kinase C, Oncogene, 4, 991 Kubo, 1987, Primary structures of human protein kinase C β1 and β2 differ only in their C-terminal sequences, FEBS Lett., 223, 138, 10.1016/0014-5793(87)80524-0 Kubo, 1987, Nucleotide sequence of the 3′ portion of a human gene for protein kinase C βI/βII, Nucl. Acids Res., 15, 7179, 10.1093/nar/15.17.7179 Kuo, 1980, Calcium-dependent protein kinase: Widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin and trifluoperazine, 77, 7039 Lacal, 1987, Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product, Molec. cell. Biol., 7, 4146, 10.1128/MCB.7.11.4146 Leach, 1983, Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol, 80, 4208 Lee, 1986, The lipid-binding, regulatory domain of protein kinase C, J. biol. Chem., 261, 14867, 10.1016/S0021-9258(18)66795-X Leibersperger, 1990, Purification and characterization of a calcium-unresponsive, phorbol ester/phospholipid-activated protein kinase from porcine spleen, J. biol. Chem., 265, 16108, 10.1016/S0021-9258(17)46195-3 Lenardo, 1989, NF-kB: A pleitropic mediator of inducible and tissue-specific gene control, Cell, 58, 227, 10.1016/0092-8674(89)90833-7 Levin, 1990, A candidate protein kinase C gene, PKC1, is required for the S. cereviae cell cycle, Cell, 62, 213, 10.1016/0092-8674(90)90360-Q Li, 1991, Raf-1: a kinase currently without a cause but not lacking in effects, Cell, 64, 479, 10.1016/0092-8674(91)90228-Q Luderus, 1989, A protein kinase C-related enzyme activity in Dictyostelium discoideum, FEBS Lett., 253, 71, 10.1016/0014-5793(89)80932-9 Makowske, 1989, Complete activation of protein kinase C by an antipeptide antibody directed against the pseudosubstrate prototope, J. biol. Chem., 264, 16155, 10.1016/S0021-9258(18)71600-1 Makowske, 1986, A cDNA encoding protein kinase C identifies two species of mRNA in brain and GH3 cells, J. biol. Chem., 261, 13389, 10.1016/S0021-9258(18)67027-9 Maraganore, 1987, Structural elements for protein-phospholipid interactions may be shared in protein kinase C and phospholipases A2, TIBS, 12, 176 Maraganore, 1986, The lysine-49 phospholipase A2 from the venom of Agkistrodon piscivorus, J. biol. Chem., 261, 4797, 10.1016/S0021-9258(19)89175-5 Marais, 1989, Purification and characterisation of bovine brain protein kinase C isotypes α, β and γ, Eur. J. Biochem., 182, 129, 10.1111/j.1432-1033.1989.tb14809.x Marais, 1990, Studies on the primary sequence requirements for PKC-α,-β1 and -γ peptide substrates, FEBS Lett., 277, 151, 10.1016/0014-5793(90)80831-3 Masmoudi, 1989, Protein kinase C located in rat liver nuclei, J. biol. Chem., 264, 1172, 10.1016/S0021-9258(19)85068-8 Megidish, 1989, A mutant protein kinase C that can transform fibroblasts, Nature, 342, 807, 10.1038/342807a0 Meldrum, 1991, The PtdIns-PLC superfamily and signal transduction, Biochim. biophys. Acta, 1092, 49, 10.1016/0167-4889(91)90177-Y Meyer, 1991, Cloning of the DNA-binding subunit of human nuclear factor kB: The level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor α, 88, 966 Minakuchi, 1981, Widespread occurrence of calcium-activated phospholipid-dependent protein kinase in mammalian tissues, J. biol. Chem., 89, 1651 Mitchell, 1989, The phosphorylation of protein kinase C as a potential measure of activation, Biochem. J., 261, 131, 10.1042/bj2610131 Mochly-Rosen, 1990, A protein kinase C isozyme is translocated to cytoskeletal elements on activation, Cell Regul., 1, 693, 10.1091/mbc.1.9.693 Morris, 1988, Purification of a phosphoprotein from rat brain related to the 80 kDa substrate of protein kinase C identified in Swiss 3T3 fibroblasts, FEBS Lett., 231, 311, 10.1016/0014-5793(88)80840-8 Moses, 1981, Transforming growth factor production by chemically transformed cells, Cancer Res., 41, 2842 Muramatsu, 1989, A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester, Molec. cell. Biol., 9, 831, 10.1128/MCB.9.2.831 Niedel, 1983, Phorbol diester receptor copurifies with protein kinase C, 80, 36 Nishizuka, 1984, The role of protein kinase C in cell surface signal transduction and tumor promotion, Nature, 308, 693, 10.1038/308693a0 Nishizuka, 1988, The molecular heterogeneity of protein kinase-C and its implications for cellular regulation, Nature, 334, 661, 10.1038/334661a0 Nishizuka, 1989, Studies and prospectives of the protein kinase C family for cellular regulation, Cancer, 63, 1892, 10.1002/1097-0142(19890515)63:10<1892::AID-CNCR2820631005>3.0.CO;2-Z Nolan, 1991, DNA binding and I-kB inhibition of cloned p65 subunit of NF-kB, a rel-related polypeptide, Cell, 64, 961, 10.1016/0092-8674(91)90320-X Ogita, 1990, Protein kinase C in Saccharomyces cerevisiae: comparison with the mammalian enzyme, 87, 5011 Ohno, 1987, Tissue-specific expression of three distinct types of rabbit protein kinase, Nature, 325, 161, 10.1038/325161a0 Ohno, 1988, A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family, Cell, 53, 731, 10.1016/0092-8674(88)90091-8 Ohno, 1988, A fourth type of rabbit protein kinase C, Biochemistry, 27, 2083, 10.1021/bi00406a040 Ohno, 1980, A point mutation at the putative ATP-binding site of protein kinase Cα abolishes the kinase activity and renders it down-regulation-insensitive, J. biol. Chem., 265, 6296, 10.1016/S0021-9258(19)39325-1 Olivier, 1991, Expression and characterization of PKC-δ, Eur. J. Biochem., 10.1111/j.1432-1033.1991.tb16248.x Ono, 1986, Two types of complementary DNAs of rat brain protein kinase C, FEBS Lett., 206, 347, 10.1016/0014-5793(86)81010-9 Ono, 1986, Cloning of rat brain protein kinase C complementary DNA, FEBS Lett., 203, 111, 10.1016/0014-5793(86)80724-4 Ono, 1987, Identification of three additional members of rat protein kinase C family; δ-, ϵ and ζ- subspecies, FEBS Lett., 226, 125, 10.1016/0014-5793(87)80564-1 Ono, 1987, Expression and properties of two types of protein kinase C: Altenative splicing from single gene, Science, 236, 1116, 10.1126/science.3576226 Ono, 1988, The structure, expression and properties of additional members of the protein kinase C family, J. biol. Chem., 263, 6927, 10.1016/S0021-9258(18)68732-0 Ono, 1988, Nucleotide sequences of cDNAs for α and γ subspecies of rat brain protein kinase C, Nucl. Acids Res., 16, 5199, 10.1093/nar/16.11.5199 Ono, 1989, Protein kinase C χ subspecies from rat brain: Its structure, expression, and properties, 86, 3099 Ono, 1989, Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence, 86, 4868 Osada, 1990, A phorbol ester receptor/protein kinase, nPKCη, a new member of the protein kinase C family predominantly expressed in lung and skin, J. biol. Chem., 265, 22434, 10.1016/S0021-9258(18)45723-7 Otsu, 1991, Characterisation of two related 85 kd proteins containing SH2 and SH3 domains that bind to receptor tyrosine kinases and polyoma virus middle T antigen/pp60c-src complexes, and associate with phosphatidylinositol 3-kinase, Cell, 65, 91, 10.1016/0092-8674(91)90411-Q Pan, 1989, 1NMR studies of T4 gene 32 protein: effects of zinc removal and reconstitution, Biochemistry, 28, 8828, 10.1021/bi00448a022 Parker, 1984, Purification to homogeneity of protein kinase C from bovine brain—identity with the phorbol ester receptor, EMBO J., 3, 953, 10.1002/j.1460-2075.1984.tb01913.x Parker, 1986, The complete primary structure of protein kinase C—the major phorbol ester receptor, Science, 233, 853, 10.1126/science.3755547 Parker, 1989, Protein kinase C—a family affair, Molec. cell. Endocr., 65, 1, 10.1016/0303-7207(89)90159-7 Patel, 1989, Expression of a functional protein kinase C-γ using a baculovirus vector: Purification and characterisation of a single protein kinase C iso-enzyme, Cell. Signal, 1, 227, 10.1016/0898-6568(89)90040-5 Patel, 1987, Purification and characterization of an Mr 87,000 protein kinase C substrate from rat brain, J. biol. Chem., 262, 16686, 10.1016/S0021-9258(18)49309-X Pears, 1991, Down-regulation of a kinase-defective PKC-α, FEBS Lett., 284, 120, 10.1016/0014-5793(91)80776-Y Pears, 1990, Mutagenesis of the pseudosubstrate site of protein kinase C leads to activation, Eur. J. Biochem., 194, 89, 10.1111/j.1432-1033.1990.tb19431.x Pears, 1991, The regulatory domain of protein kinase C-ϵ restricts the catalytic-domain-specificity, Biochem. J., 276, 257, 10.1042/bj2760257 Perin, 1990, Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C, Nature, 345, 250, 10.1038/345260a0 Persons, 1988, Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I DNA, Cell, 52, 447, 10.1016/S0092-8674(88)80037-0 Pessin, 1990, Molecular species analysis of mitogen-stimulated 1,2-diglycerides in fibroblasts, J. biol. Chem., 265, 7959, 10.1016/S0021-9258(19)39024-6 Preiss, 1986, Quantitative measurement of sn-1,2-diacylglycerol present in platelets, hepatocytes and ras- and sis-transformed normal rat kidney cells, J. biol. Chem., 261, 8597, 10.1016/S0021-9258(19)84420-4 Rando, 1984, The stereospecific activation of protein kinase C, Biochem. biophys. Res. Commun., 122, 818, 10.1016/S0006-291X(84)80107-2 Rapp, 1988, Raf family serine/threonine protein kinase in mitogen signal transduction, LIII, 789 Ray, 1987, Rapid stimulation by insulin of a serine threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein-2 in vitro, 84, 1502 Rodriguez-Pena, 1986, Phosphorylation of an acidic mol. wt. 80,000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity, EMBO J., 5, 77, 10.1002/j.1460-2075.1986.tb04180.x Rose-John, 1988, Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblasts, Gene, 74, 465, 10.1016/0378-1119(88)90179-5 Rosenthal, 1987, Primary structure and mRNA localization of protein F1, a growth-related protein kinase C substrate associated with synaptic plasticity, EMBO J., 6, 3641, 10.1002/j.1460-2075.1987.tb02696.x Rosenthal, 1987, Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene, EMBO J., 6, 433, 10.1002/j.1460-2075.1987.tb04773.x Routtenberg, 1986 Rozengurt, 1983, Phorbol ester, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiscent 3T3 cells, 80, 7244 Saito, 1989, Immunocytochemical localisation of β2 subspecies of protein kinase C in the rat brain, 86, 3409 Sakane, 1990, Porcine diacylglycerol kinase sequence has zinc finger and E-F hand motifs, Nature, 344, 345, 10.1038/344345a0 Schaap, 1990, Expression, purification and characterization of protein kinase C-ϵ, J. biol. Chem., 265, 7301, 10.1016/S0021-9258(19)39114-8 Schaap, 1989, Unique substrate specificity and regulatory properties of PKC-ϵ: a rationale for diversity, FEBS Lett., 243, 351, 10.1016/0014-5793(89)80160-7 Schaap, 1990, Purification, cDNA-cloning and expression of human diacylglycerol kinase, FEBS Lett., 275, 151, 10.1016/0014-5793(90)81461-V Schaeffer, 1989, Isolation and characterization of two new Drosophila protein kinase C genes, including one speicifically expressed in photoreceptor cells, Cell, 57, 403, 10.1016/0092-8674(89)90915-X Seilhamer, 1986, Pancreatic phospholipase A2: Isolation of the human gene and cDNAs from porcine pancreas and human lung, DNA, 5, 519, 10.1089/dna.1.1986.5.519 Sekiguchi, 1988, Mode of activation and kinetic properties of three distinct forms of protein kinase C from rat brain, J. Biochem., 103, 759, 10.1093/oxfordjournals.jbchem.a122343 Sen, 1986, Multiple nuclear factors interact with the immunoglobulin enhances sequences, Cell, 46, 705, 10.1016/0092-8674(86)90346-6 Shen, 1990, A synthetic peptide of the pseudosubstrate domain of protein kinase C blocks cytoplasmic alkalinization during activation of the sea urchim egg, Devl Biol., 140, 272, 10.1016/0012-1606(90)90077-V Sheu, 1990, Neuron-specific protein f1/GAP-43 shows substrate specificity for the beta subtype of protein kinase C, Biochem. biophys. Res. Commun., 171, 1235, 10.1016/0006-291X(90)90818-8 Siegel, 1990, T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf-associated kinase activity via a protein kinase C-dependent pathway, J. biol. Chem., 265, 18472, 10.1016/S0021-9258(17)44776-4 Smith, 1990, Specificities of autoinhibitory domain peptides for four protein kinases, J. biol. Chem., 265, 1837, 10.1016/S0021-9258(19)39904-1 Soderling, 1990, Protein kinases. Regulation by autoinhibitory domains, J. Biol. Chem., 265, 1823, 10.1016/S0021-9258(19)39900-4 Speizer, 1989, Inhibition of phorbol ester binding and protein kinase C activity by heavy metals, J. biol. Chem., 264, 5581, 10.1016/S0021-9258(18)83586-4 Stabel, 1990, The Protein Kinase C Family, 414 Stahl, 1988, Sequence similarity of phospholipase C with the non-catalytic region of src, Nature, 332, 269, 10.1038/332269a0 Streb, 1983, Release of Ca2+ from a non-mitochondrial intra-cellular store in pancreatic acinar cells by inositol-1,4,5-triphosphate, Nature, 306, 67, 10.1038/306067a0 Stumpo, 1989, Molecular cloning, characterization and expression of a cDNA encoding the ‘80- to 87-kDa’ myristoylated alanine-rich C kinase substrate: A major cellular substrate for protein kinase C, 86, 4012 Tabuse, 1983, A gene involved in action of tumor promoters is identified and mapped in Caenorhabditis elegans, Carcinogenesis, 4, 783, 10.1093/carcin/4.6.783 Tabuse, 1989, Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans, Science, 243, 1713, 10.1126/science.2538925 Takai, 1977, Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum, J. biol. Chem., 252, 7603, 10.1016/S0021-9258(17)41009-X Takai, 1979, Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids, J. biol. Chem., 254, 3692, 10.1016/S0021-9258(18)50638-4 Takai, 1979, Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system, Biochem. biophys. Res. Commun., 91, 1218, 10.1016/0006-291X(79)91197-5 Tang, 1990, Isolation of cloned mouse protein kinase C beta-II cDNA and its sequence, Nucl. Acids Res., 18, 5310, 10.1093/nar/18.17.5310 Todaro, 1976, Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells, Nature, 264, 26, 10.1038/264026a0 Tyers, 1988, Molecular cloning and expression of the major protein kinase C substrate in platelets, Nature, 333, 470, 10.1038/333470a0 Van Dongen, 1985, Modulation of the activity of purified phosphatidylinositol 4-phosphate kinase by phosphorylated and dephosphorylated B-50 protein, Biochem. biophys. Res. Commun., 128, 1219, 10.1016/0006-291X(85)91070-8 Walsh, 1986, sn-1,2-Diacylglycerol kinase of Escherichia-Coli-structural and kinetic analysis of the lipid cofactor dependence, J. biol. Chem., 261, 5062 Walters, 1990, Terbium as a luminescent probe of metal-binding sites in protein kinase, J. biol. Chem., 265, 4223, 10.1016/S0021-9258(19)39550-X Wise, 1982, Phospholipid-sensitive Ca2+-dependent protein kinase from heart, J. biol. Chem., 257, 8481, 10.1016/S0021-9258(18)34357-6 Wolf, 1985, Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters and ATP, J. biol. Chem., 260, 15718, 10.1016/S0021-9258(17)36318-4 Wolfman, 1987, Elevated levels of diacylglycerol and decreased phorbol ester activity in ras-transfomed fibroblasts, Nature, 325, 359, 10.1038/325359a0 Woodgett, 1987, Immunological evidence for two physiological forms of protein kinase C, Molec. cell. Biol., 7, 85, 10.1128/MCB.7.1.85 Woodget, 1987, Protein kinase C and its role in cell growth, Vol. 3, 215 Wu, 1982, Calcium/phospholipid regulates phosphorylation of a Mr ‘87k’ substrate protein in brain synaptosomes, 79, 5248 Young, 1987, Down-regulation of protein kinase C is due to an increased rate of degradation, Biochem. J., 244, 775, 10.1042/bj2440775 Young, 1988, A monoclonal antibody recognising the site of limited proteolysis of protein kinase C, Eur. J. Biochem., 173, 247, 10.1111/j.1432-1033.1988.tb13991.x Yu, 1988, Cellular ras activity and phospholipid metabolism, Cell, 52, 63, 10.1016/0092-8674(88)90531-4 Zalewski, 1990, Synergy between zinc and phorbol ester in translocation of protein kinase C to cytoskeleton, FEBS Lett., 273, 131, 10.1016/0014-5793(90)81067-X