Protective vascular and myocardial effects of adiponectin

Springer Science and Business Media LLC - Tập 6 Số 1 - Trang 27-35 - 2009
Barry J. Goldstein1, Rosario Scalia2, Xin L.2
1Harvard Medical School and the Joslin Diabetes Center in Boston, USA.
2RG Scalia is an Associate Professor in the Department of Molecular Physiology and Biophysics, and XL Ma is a Professor in the Department of Emergency Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA.,

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Goldstein BJ and Scalia R (2007) Adipokines and vascular disease in diabetes. Curr Diab Rep 7: 25–33

Zhu W et al. (2008) Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention. Clin Sci (Lond) 114: 361–374

Jay D et al. (2006) Oxidative stress and diabetic cardiovascular complications. Free Radic Biol Med 40: 183–192

Granger DN et al. (2004) Modulation of the inflammatory response in cardiovascular disease. Hypertension 43: 924–931

Ouchi N et al. (2003) Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 42: 231–234

Shimabukuro M et al. (2003) Hypoadiponectinemia is closely linked to endothelial dysfunction in man. J Clin Endocrinol Metab 88: 3236–3240

Tan KC et al. (2004) Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation. J Clin Endocrinol Metab 89: 765–769

Fernandez-Real JM et al. (2004) Adiponectin is associated with vascular function independent of insulin sensitivity. Diabetes Care 27: 739–745

Halperin F et al. (2005) The role of total and high-molecular-weight complex of adiponectin in vascular function in offspring whose parents both had type 2 diabetes. Diabetologia 48: 2147–2154

Kubota N et al. (2002) Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 277: 25863–25866

Matsuda M et al. (2002) Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem 277: 37487–37491

Okamoto Y et al. (2002) Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 106: 2767–2770

Yamauchi T et al. (2003) Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem 278: 2461–2468

Ohashi K et al. (2006) Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension 47: 1108–1116

Okamoto Y et al. (2000) An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm Metab Res 32: 47–50

Shibata R et al. (2005) Adiponectin protects against myocardial ischemia–reperfusion injury through AMP kinase- and COX-2-dependent mechanisms. Nat Med 11: 1096–1103

Tao L et al. (2007) Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress. Circulation 115: 1408–1416

Scherer PE (2006) Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 55: 1537–1545

Wang Y et al. (2002) Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem 277: 19521–19529

Pajvani UB et al. (2003) Structure–function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. J Biol Chem 278: 9073–9085

Schraw T et al. (2008) Plasma adiponectin complexes have distinct biochemical characteristics. Endocrinology 149: 2270–2282

Neumeier M et al. (2006) Different effects of adiponectin isoforms in human monocytic cells. J Leukoc Biol 79: 803–808

Fruebis J et al. (2001) Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 98: 2005–2010

Ouedraogo R et al. (2007) Adiponectin deficiency increases leukocyte–endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J Clin Invest 117: 1718–1726

Hopkins TA et al. (2006) Adiponectin actions in the cardiovascular system. Cardiovasc Res 74: 11–18

Waki H et al. (2005) Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology 146: 790–796

Kadowaki T et al. (2006) Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116: 1784–1792

Ouedraogo R et al. (2006) Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway. Diabetes 55: 1840–1846

Motoshima H et al. (2004) Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL. Biochem Biophys Res Commun 315: 264–271

Ding G et al. (2007) Adiponectin and its receptors are expressed in adult ventricular cardiomyocytes and upregulated by activation of peroxisome proliferator-activated receptor γ. J Mol Cell Cardiol 43: 73–84

Hug C et al. (2004) T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci USA 101: 10308–10313

Williams JK et al. (1988) Vasa vasorum in atherosclerotic coronary arteries: responses to vasoactive stimuli and regression of atherosclerosis. Circ Res 62: 515–523

Herrmann J et al. (2001) Coronary vasa vasorum neovascularization precedes epicardial endothelial dysfunction in experimental hypercholesterolemia. Cardiovasc Res 51: 762–766

Libby P (2002) Inflammation in atherosclerosis. Nature 420: 868–874

Moulton KS (2006) Angiogenesis in atherosclerosis: gathering evidence beyond speculation. Curr Opin Lipidol 17: 548–555

Lautamaki R et al. (2007) Low serum adiponectin is associated with high circulating oxidized low-density lipoprotein in patients with type 2 diabetes mellitus and coronary artery disease. Metabolism 56: 881–886

Furukawa S et al. (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114: 1752–1761

Brownlee M (2005) The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54: 1615–1625

Rask-Madsen C and King GL (2007) Mechanisms of disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab 3: 46–56

Ouchi N et al. (1999) Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100: 2473–2476

Ouchi N et al. (2000) Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 102: 1296–1301

Xu SQ et al. (2008) Adiponectin protects against angiotensin II or tumor necrosis factor alpha-induced endothelial cell monolayer hyperpermeability: role of cAMP/PKA signaling. Arterioscler Thromb Vasc Biol 28: 899–905

Chen H et al. (2003) Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 278: 45021–45026

Hattori Y et al. (2003) Globular adiponectin upregulates nitric oxide production in vascular endothelial cells. Diabetologia 46: 1543–1549

Xi W et al. (2005) Stimulated HSP90 binding to eNOS and activation of the PI3-Akt pathway contribute to globular adiponectin-induced NO production: vasorelaxation in response to globular adiponectin. Biochem Biophys Res Commun 332: 200–205

Kobayashi H et al. (2004) Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res 94: e27–e31

Ouchi N et al. (2004) Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem 279: 1304–1309

Kadowaki T et al. (2007) The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS. FEBS Lett 582: 74–80

Goldstein BJ and Scalia R (2004) Adiponectin: a novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab 89: 2563–2568

Wu X et al. (2007) Adiponectin suppresses IkappaB kinase activation induced by tumor necrosis factor-alpha or high glucose in endothelial cells: role of cAMP and AMP kinase signaling. Am J Physiol Endocrinol Metab 293: E1836–E1844

Mahadev K et al. (2008) Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells. Cardiovasc Res 78: 376–384

Collins SP et al. (2000) LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem J 345: 673–680

Shibata R (2004) Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of AMP-activated protein kinase signaling. J Biol Chem 279: 28670–28674

Brååkenhielm E et al. (2004) Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci USA 101: 2476–2481

Bora PS et al. (2007) Expression of adiponectin in choroidal tissue and inhibition of laser induced choroidal neovascularization by adiponectin. FEBS Lett 58: 1977–1982

Natarajan R et al. (2008) Hypoxia inducible factor-1 upregulates adiponectin in diabetic mouse hearts and attenuates post-ischemic injury. J Cardiovasc Pharmacol 51: 178–187

Date H et al. (2006) Adiponectin produced in coronary circulation regulates coronary flow reserve in nondiabetic patients with angiographically normal coronary arteries. Clin Cardiol 29: 211–214

Sharma K et al. (2008) Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest 118: 1645–1656

Frystyk, J et al. (2005) Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications. Diabetologia 48: 1911–1918

Schalkwijk CG et al. (2005) Adiponectin is inversely associated with renal function in Type 1 diabetic patients. J Clin Endocrinol Metab 91: 129–135

Koshimura J et al. (2004) Urinary adiponectin excretion is increased in patients with overt diabetic nephropathy. Biochem Biophys Res Commun 316: 165–169

Shinmura K et al. (2007) Cardioprotective effects of short-term caloric restriction are mediated by adiponectin via activation of AMP-activated protein kinase. Circulation 116: 2809–2817

Ikeda Y et al. (2008) Cyclooxygenase-2 induction by adiponectin is regulated by a sphingosine kinase-1 dependent mechanism in cardiac myocytes. FEBS Lett 582: 1147–1150

Gao F et al. (2002) Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia–reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation 105: 1497–1502

Li R et al. (2007) Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity. Am J Physiol Endocrinol Metab 293: E1703–E1708

Kim YM et al. (1999) Nitric oxide as a bifunctional regulator of apoptosis. Circ Res 84: 253–256

Beckman JS and Koppenol WH (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 271: C1424–C1437

Ferdinandy P et al. (2000) Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure. Circ Res 87: 241–247