Protective effect of mesalamine against oxidativeinjury in a rat model of radiation rectitis

Ajlouni, 1999, Radiation-induced proctitis, Curr Treat Options Gastroenterol, 2, 20, 10.1007/s11938-999-0014-5 Hovdenak, 2000, Acute radiation proctitis: A sequential clinic opathologic study during pelvic radiotherapy, Int J Radiat Oncol Biol Phys, 48, 1111, 10.1016/S0360-3016(00)00744-6 Chevion, 1999, The antioxidant status of patients subjected to total body irradiation, Biochem Mol Biol Int, 47, 1019 Reiter, 1995, Oxidative processes and antioxidative defense mechanisms in the aging brain, FASEB J, 9, 526, 10.1096/fasebj.9.7.7737461 Cavcic, 2000, Metronidazole in the treatment of chronic radiation proctitis: Clinical trial, Croat Med J, 41, 314 Sanguineti, 2003, Sucralfate versus mesalazine versus hydrocortisone in the prevention of acute radiation proctitis during conformal radiotherapy for prostate carcinoma. A randomized study, Strahlenther Onkol, 179, 464, 10.1007/s00066-003-1082-4 Denton, 2002, Systematic review for non-surgical interventions for the management of late radiation proctitis, Br J Cancer, 87, 134, 10.1038/sj.bjc.6600360 Kneebone, 2001, The effect of oral sucralfate on the acute proctitis associated with prostate radiotherapy: A double-blind, randomized trial, Int J Radiat Oncol Biol Phys, 51, 628, 10.1016/S0360-3016(01)01660-1 Zimmermann, 1998, Radiation proctitis. Clinical and pathological manifestations, therapy and prophylaxis of acute and late injurious effects of radiation on the rectal mucosa, Strahlenther Onkol, 174, 85 Cotti, 2003, Conservative therapies for hemorrhagic radiation proctitis: A review, Rev Hosp Clin Fac Med Sao Paulo, 58, 284, 10.1590/S0041-87812003000500008 Schoonjans, 1996, Distribution and concentrations of 5-aminosalicylic acid in rectosigmoid biopsy specimens after rectal administration, Dis Colon Rectum, 39, 788, 10.1007/BF02054445 Stockdale, 1997, Long-term control of radiation proctitis following treatment with sucralfate enemas, Br J Surg, 84, 379, 10.1002/bjs.1800840333 Kan, 2000, A rat model for radiation-induced proctitis, J Korean Med Sci, 15, 682, 10.3346/jkms.2000.15.6.682 Beutler, 1975, Glutathione in red blood cell metabolism, 112 Buege, 1978, Microsomal lipid peroxidation, Method Enzymol, 52, 302, 10.1016/S0076-6879(78)52032-6 Hillegass, 1990, Assessment of myeloperoxidase activity in whole rat kidney, J Pharmacol Method, 24, 285, 10.1016/0160-5402(90)90013-B Ward, 1988, DNA damage produced by ionizing radiation in mammalian cells: Identities, mechanisms of formation, and reparability, Prog Nucleic Acid Res Mot Biol, 35, 95, 10.1016/S0079-6603(08)60611-X Vijayalaxmi Reiter, 1998, Melatonin reduces gamma radiationinduced primary DNA damage in human blood lymphocytes, Mutat Res, 397, 203, 10.1016/S0027-5107(97)00211-X Ross, 1988, Glutathione, free radicals and chemotherapeutic agents. Mechanisms of free-radical induced toxicity and glutathione-dependent protection, Pharmacol Ther, 37, 231, 10.1016/0163-7258(88)90027-7 Mandel, 1990, Intracellular glutathione in the protection from anoxic injury in renal proximal tubules, J Clin Invest, 85, 316, 10.1172/JCI114440 Sudheer Kumar, 2003, Effect of 5-aminosalicylic acid on radiation-induced micronuclei in mouse bone marrow, Mutat Res, 527, 7, 10.1016/S0027-5107(03)00052-6 Kettle, 1997, Mycloperoxidase: A key regulator of neutrophil oxidant product, Redox Rep, 3, 3, 10.1080/13510002.1997.11747085 Şever, 2003, Melatonin ameliorates ionizing radiation-induced oxidative organ damage in rats, Life Sci, 74, 563, 10.1016/j.lfs.2003.05.011 Kanski, 2001, 5-Aminosalicylic acid protection against oxidative damage to synaptosomal membranes by alkoxyl radicals in vitro, Neurochem Res, 26, 23, 10.1023/A:1007620330168 Goncalves, 1998, Antioxidant activity of 5-aminosalicylic acid against peroxidation of phosphatidylcholine liposomes in the presence of alphatocopherol: Asynergistic interaction?, Free Radic Res, 29, 53, 10.1080/10715769800300071