Protective effect of icaritin on focal cerebral ischemic–reperfusion mice

Alexandrova, 2005, Oxidative stress during the chronic phase after stroke, Free Radical Biology and Medicine, 39, 297, 10.1016/j.freeradbiomed.2005.04.017

Baeuerle, 1994, Function and activation of NF-κB in the immune system, Annual Review of Immunology, 12, 141, 10.1146/annurev.iy.12.040194.001041

Bulua, 2011, Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1- associated periodic syndrome (TRAPS), Journal of Experimental Medicine, 208, 519, 10.1084/jem.20102049

Eltzschig, 2011, Ischemia and reperfusion [mdash] from mechanism to translation, Nature Medicine, 17, 1391, 10.1038/nm.2507

Gehrmann, 1995, Microglia: Intrinsic immuneffector cell of the brain, Brain Research Brain Research Reviews, 20, 269, 10.1016/0165-0173(94)00015-H

Granger, 1988, Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury, American Journal of Physiology, 255, H1269

Guo, 2011, An anticancer agent icaritin induces sustained activation of the extracellular signal-regulated kinase (ERK) pathway and inhibits growth of breast cancer cells, European Journal of Pharmacology, 658, 114, 10.1016/j.ejphar.2011.02.005

Hedley, 2002, Inflammation and infection in clinical stroke, Journal of Cerebral Blood Flow & Metabolism, 22, 1399, 10.1097/01.WCB.0000037880.62590.28

Keynes, 2004, Nitric oxide and its role in ischaemic brain injury, Current Molecular Medicine, 4, 179, 10.2174/1566524043479176

Kleinig, 2009, Suppression of inflammation in ischemic and hemorrhagic stroke: Therapeutic options, Current Opinion in Neurology, 22, 294, 10.1097/WCO.0b013e32832b4db3

Lai, 2013, Icaritin exhibits anti-inflammatory effects in the mouse peritoneal macrophages and peritonitis model, International Immunopharmacology, 16, 41, 10.1016/j.intimp.2013.03.025

Li, 2012, Icaritin inhibits T cell activation and prolongs skin allograft survival in mice, International Immunopharmacology, 13, 1, 10.1016/j.intimp.2012.02.011

Liu, 2005, Determination of rat urinary metabolites of icariin in vivo and estrogenic activities of its metabolites on MCF-7 cells, Die Pharmazie, 60, 120

Longa, 1989, Reversible middle cerebral artery occlusion without craniectomy in rats, Stroke, 20, 84, 10.1161/01.STR.20.1.84

Paczynski, 1997, Multiple-dose mannitol reduces brain water content in a rat model of cortical infarction, Stroke, 28, 1437, 10.1161/01.STR.28.7.1437

Petrea, 2009, Gender differences in stroke incidence and post stroke disability in the Framingham heart study, Stroke, 40, 1032, 10.1161/STROKEAHA.108.542894

Reiter, 2001, Biochemical reactivity of melatonin with reactive oxygen and nitrogen species, Cell Biochemistry and Biophysics, 34, 237, 10.1385/CBB:34:2:237

Samdani, 1997, Nitric oxide synthase in models of focal ischemia, Stroke; A Journal of Cerebral Circulatio, 28, 1283, 10.1161/01.STR.28.6.1283

Song, 2012, Bererine induces peripheral lymphocytes immune regulations to realize its neuroprotective effects in the cerebral ischemia/reperfusion mice, Cellular Immunology, 276, 91, 10.1016/j.cellimm.2012.04.006

Sun, 2013, Protective effects of ginsenoside Rg1 on astrocytes and cerebral ischemic–reperfusion mice, Biological and Pharmaceutical Bulletin, 37, 1891, 10.1248/bpb.b14-00394

Sun, 2010, Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties, Journal of Asian Natural Products Research, 12, 1051, 10.1080/10286020.2010.535520

Szabó, 1996, Physiological and pathophysiological roles of nitric oxide in the central nervous system, Brain Research Bulletin, 41, 131, 10.1016/0361-9230(96)00159-1

Tan, 2012, Research progress of the relationship between microglia and cerebral ischemia, Acta Pharmaceutica Sinica, 47, 346

Terai, 1996, Enhancement of immunoreactivity for NF-κB in human cerebral infarctions, Brain Research, 739, 343, 10.1016/S0006-8993(96)01073-6

Theodore, 2012, Cell biology of ischemia/reperfusion injury, International Review of Cell and Molecular Biology, 298, 229, 10.1016/B978-0-12-394309-5.00006-7

Tong, 2011, Icaritin causes sustained ERK1/2 activation and induces apoptosis in human endometrial cancer cells, PLoS One, 6, E16781, 10.1371/journal.pone.0016781

Zhang, 2009, A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner, Bone, 44, 345, 10.1016/j.bone.2008.10.035

Zhu, 2011, Icaritin shows potent anti-leukemia activity on chronicmyeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3/AKT signalings, PLoS One, 6, E23720, 10.1371/journal.pone.0023720