Protective effect of Holothurian intestine against indomethacin induced gastric mucosal damage in rats

Xiaoyü Li1, Xuejing Qiao1, Cuiping Zhang1, Hua Gao2, Qinghui Niu1, Tong Wu1, Qi Zhang1, Zibin Tian1
1Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao, 266003, P. R. China
2College of Medicine of Qingdao University

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Abbas, A. M., and Sakr, H. F., 2013. Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats. Journal of Physiology and Biochemistry, 69: 527–537, DOI: 10.1007/s13105-013-0241-z.

Abdallah, D. M., 2010. Nicotinamide alleviates indomethacininduced gastric ulcers: A novel antiulcer agent. European Journal of Pharmacology, 627: 276–280, DOI: 10.1016/j.ejphar.2009.10.037.

Alarcón, L. C., Nieto, A., Martín, M. J., Cabré, F., Herrerías, J. M., and Motilva, V., 2002. Gastric toxicity of racemic ketoprofen and its enantiomers in rat: Oxygen radical generation and COX-expression. Inflammation Research, 51: 51–57.

Bahrami, Y., Zhang, W., and Franco, C., 2014. Discovery of novel saponins from the viscera of the sea cucumber Holothuria lessoni. Marine Drugs, 12: 2633–2667, DOI: 10.3390/md12052633.

Blandizzi, C., Fornai, M., Colucci, R., Natale, G., Lubrano, V., Vassalle, C., Antonioli, L., Lazzeri, G., and Del, T. M., 2005. Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatory drugs through a reduction of mucosal oxidative damage. World Journal of Gastroenterology, 11: 4052–4060.

Brancati, S. B., Zádori, Z. S., Né meth, J., and Gyires, K., 2013. Substance P induces gastric mucosal protection at supraspinal level via increasing the level of endomorphin-2 in rats. Brain Research Bulletin, 91: 38–45, DOI: 10.1016/j.brainresbull. 2013.01.004.

Chaturvedi, A., Kumar, M. M., Bhawanmi, G., Chaturvedi, H., Kumar, M., and Goel, R. K., 2007. Effect of ethanolic extract of Eugenia jambolana seeds on gastric ulceration and secretion in rats. Indian Journal of Physiology and Pharmacology, 51: 131–140.

Cheng, Y. T., Wu, C. H., Ho, C. Y., and Yen, G. C., 2013. Catechin protects against ketoprofen-induced oxidative damage of the gastric mucosa by up-regulating Nrf2 in vitro and in vivo. The Journal of Nutritional Biochemistry, 24: 475–483, DOI: 10.1016/j.jnutbio.2012.01.010.

Dean, A., Mungall, W., McKinnell, C., and Sharpe, R. M., 2013. Prostaglandins, masculinization and its disorders: Effects of fetal exposure of the rat to the cyclooxygenase inhibitorindomethacin. PloS One, 8: e62556, DOI: 10.1371/journal. pone.0062556.

Di, P. R., Impellizzeri, D., Torre, A., Mazzon, E., Cappellani, A., Faggio, C., Esposito, E., Trischitta, F., and Cuzzocrea, S., 2012. Effects of palmitoylethanolamide on intestinal injury and inflammation caused by ischemia-reperfusion in mice. Journal of Leukocyte Biology, 91: 911–920, DOI: 10.1189/jlb.0911485.

El-Abhar, H. S., 2010. Coenzyme Q10: A novel gastroprotective effect via modulation of vascular permeability, prostaglandin E2, nitric oxide and redox status in indomethacin-induced gastric ulcer model. The European Journal of Pharmacology, 649: 314–319, DOI: 10.1016/j.ejphar.2010.09.012.

Fujita, T., Kutsumi, H., Sanuki, T., Hayakumo, T., and Azuma, T., 2013. Adherence to the preventive strategies for nonsteroidal anti-inflammatory drug or low-dose aspirin-induced gastrointestinal injuries. The Journal of Gastroenterology, 48: 559–573, DOI: 10.1007/s00535-013-0771-8.

Hamaishi, K., Kojima, R., and Ito, M., 2006. Anti-ulcer effect of tea catechin in rats. Biological and Pharmaceutical Bulletin, 29: 2206–2213.

Handa, O., Majima, A., Onozawa, Y., Horie, H., Uehara, Y., Fukui, A., Omatsu, T., Naito, Y., and Yoshikawa, T., 2014. The role of mitochondria-derived reactive oxygen species in the pathogenesis of nonsteroidal anti-inflammatory druginduced small intestinal injury. Free Radical Research, 48: 1095–1099, DOI: 10.3109/10715762.2014.928411.

Hu, X. Q., Xu, J., Xue, Y., Li, Z. J., Wang, J. F., Wang, J. H., Xue, C. H., and Wang, Y. M., 2012. Effects of bioactive components of sea cucumber on the serum, liver lipid profile and lipid absorption. Journals Bioscience, Biotechnology, & Biochemistry, 76: 2214–2218.

Kato, S., Ohkawa, F., Ito, Y., Amagase, K., and Takeuchi, K., 2009. Role of endothelial nitric oxide aynthase in aggravation of indomethacin-induced gastric damage in adjuvantarthritic rats. Journal of Physiology and Pharmacology, 60: 147–155.

Kim, T. H., Jeon, E. J., Cheung, D. Y., Kim, C. W., Kim, S. S., Park, S. H., Han, S. W., Kim, M. J., Lee, Y. S., Cho, M. L., Chang, J. H., Min, J. K., and Kim, J. I., 2013. Gastroprotective effects of grape seed proanthocyanidin extracts against nonsteroid anti-inflammatory drug-induced gastric injury in rats. Gut Liver, 7: 282–289, DOI: 10.5009/gnl.2013.7.3.282.

Kuwano, T., Nakao, S., Yamamoto, H., Tsuneyoshi, M., Yamamoto, T., Kuwano, M., and Ono, M., 2004. Cyclo-oxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis. FASEB Journal, 18: 300–310.

Lee, H. J., Han, Y. M., Kim, E. H., Kim, Y. J., and Hahm, K. B., 2012. A possible involvement of Nrf2-mediated heme oxygenase-1 up-regulation in protective effect of the proton pump inhibitor pantoprazole against indomethacin-induced gastric damage in rats. BMC Gastroenterology, 12: 143, DOI: 10.1186/1471-230X-12-143.

Livak, K. J., and Schmittgen, T. D., 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 25: 402–408.

Maity, P., Bindu, S., Dey, S., Goyal, M., Alam, A., Pal, C., Mitra, K., and Bandyopadhyay, U., 2009. Indomethacin, a nonsteroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel role of mitochondrial aconitase oxidation. Journal of Biological Chemistry, 284: 3058–3068, DOI: 10.1074/jbc.M805329200.

Miranda, K. M., Espey, M. G., and Wink, D. A., 2001. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide, 5: 62–71.

Montorfano, I., Becerra, A., Cerro, R., Echeverría, C., Sáez, E., Morales, M. G., Fernández, R., Cabello-Verrugio, C., and Simon, F., 2014. Oxidative streßs mediates the conversion of endothelial cells into myofibroblasts via a TGF-ß1 and TGF-ß2-dependent pathway. Laboratory Investigation, 94: 1068–1082, DOI: 10.1038/labinvest.2014.100.

Nasadyuk, C., and Sklyarov, A., 2013. Thymohexin exhibits cytoprotective effect in experimental gastric lesions in rats both through the inhibition of inducible nitric oxide synthase and reduction of oxidative mucosal damage. Regulatory Peptides, 180: 50–57, DOI: 10.1016/j.regpep.2012.11.004.

Ning, J. W., Lin, G. B., Ji, F., Xu, J., and Sharify, N., 2012. Preventive effects of geranylgeranylacetone on rat ethanolinduced gastritis. World Journal of Gastroenterology, 18: 2262–2269, DOI: 10.3748/wjg.v18.i18.2262.

Ohkawa, H., Ohishi, N., and Yagi, K., 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95: 351–358.

Ohkawara, T., Takeda, H., Ohnishi, S., Kato, M., Nishihira, J., and Asaka, M., 2011. Macrophage migration inhibitory factor contributes to development of nonsteroidal anti-inflammatory drugs-induced gastric injury in mice. International Immunopharmacology, 11: 418–423, DOI: 10.1016/j.intimp.2010.12. 009.

Ott, M., Gogvadze, V., Orrenius, S., and Zhivotovsky, B., 2007. Mitochondria, oxidative stress and cell death. Apoptosis, 12: 913–22.

Pastoris, O., Verri, M., Boschi, F., Kastsiuchenka, O., Balestra, B., Pace, F., Tonini, M., and Natale, G., 2008. Effects of esomeprazole on glutathione levels and mitochondrial oxidative phosphorylation in the gastric mucosa of rats treated with indomethacin. Naunyn Schmiedebergs Archives of Pharmacology, 378: 421–429, DOI: 10.1007/s00210-008-0314-7.

Qader, S. W., Abdulla, M. A., Chua, L. S., Sirat, H. M., and Handan, S., 2012. Pharmacological mechanisms underlying gastropro-tective activities of the fractions obtained from Polygonum minus in sprague dawley rats. International Journal of Molecular Sciences, 13: 1481–1496, DOI: 10.3390/ijms13021 481.

Santucci, L., Fiorucci, S., Giansanti, M., Brunori, P. M., Di, M. F. M., and Morelli, A., 1994. Pentoxifylline prevents indomethacin induced acute gastric mucosal damage in rats: Role of tumour necrosis factor alpha. Gut, 35: 909–915.

Sehirli, O., Sener, E., Sener, G., Cetinel, S., Erzik, C., and Yegen, B. C., 2008. Ghrelin improves burn-induced multiple organ injury by depressing neutrophil infiltration and the release of pro-inflammatory cytokines. Peptides, 29: 1231–1240, DOI: 10.1016/j.peptides.2008.02.012.

Shen, T., Yang, W. S., Yi, Y. S., Sung, G. H., Rhee, M. H., Poo, H., Kim, M. Y., Kim, K. W., Kim, J. H., and Cho, J. Y., 2013. AP-1/IRF-3 targeted anti-inflammatory activity of andrographolide isolated from Andrographis paniculata. Evidencebased Complementary and Alternative Medicine, 4): 210736, DOI: 10.1155/2013/210736.

Shimada, T., Watanabe, N., Ohtsuka, Y., Endoh, M., Kojima, K., Hiraishi, H., and Terano, A., 1999. Polaprezinc downregulates proinflammatory cytokine-induced nuclear factor-b activiation and interleukin-8 expression in gastric epithelial cells. The Journal of Pharmacology and Experimental Therapeutics, 291: 345–352.

Sklyarov, A. Y., Panasyuk, N. B., and Fomenko, I. S., 2011. Role of nitric oxide-synthase and cyclooxygenase/lipooxygenase systems in development of experimental ulcerative colitis. Journal of the Polish Physiological Society, 62: 65–73.

Slomiany, B. L., Piotrowski, J., and Slomiany, A., 1999. Role of endothelin-1 and constitutive nitric oxide synthase in gastric mucosal resistance to indomethacin injury: Effect of antiulcer agents. Scandinavian Journal of Gastroenterology, 34: 459–464.

Takeuchi, K., 2012. Pathogenesis of NSAID-induced gastric damage: Importance of cyclooxygenase inhibition and gastric hypermotility. World Journal of Gastroenterology, 18: 2147–2160, DOI: 10.3748/wjg.v18.i18.2147.

Wallace, J. L., 2013. Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug enteropathy. World Journal of Gastroenterology, 19: 1861–1876, DOI: 10.3748/wjg.v19.i12.1861.

Wallace, J. L., and Miller, M. J., 2000. Nitric oxide in mucosal defense: A little goes a long way. Gastroenterology, 119: 512–520.

Watanabe, K., Murakami, K., Sato, R., Kashimura, K., Miura, M., Ootsu, S., Miyajima, H., Nasu, M., Okimoto, T., Kodama, M., and Fujioka, T., 2004. Effect of sucralfate on a ntibiotic therapy for Helicobacter pylori infection in mice. Antimicrobial Agents and Chemotherapy, 48: 4582–4588.

Yuan, W. P., Liu, C. H., Wang, X. J., Meng, X. M., Xia, K., Zhang, M. S., and Hu, W., 2010. Evaluation and analysis of nutritional composition of different parts of sea cucumber Apostichopus joponicus. Technology Food Industry, 5: 348–350.

Zhang, J. Y., Wu, Q. F., Wan, Y., Song, S. D., Xu, J., Xu, X. S., Chang, H. L., Tai, M. H., Dong, Y. F., and Liu, C., 2014. Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats. World Journal of Gastroenterology, 20: 1614–1622, DOI: 10.3748/wjg.v20.i6.1614

Zhang, X., Tajima, K., Kageyama, K., and Kyoi, T., 2008. Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats. World Journal of Gastroenterology, 14: 4784.

Zheng, J., Wu, H. T., Zhu, B. W., and Dong, X. P., 2011. Antioxidant activities of autolytic hydrolysates from sea cucumber guts. Journal of Dalian Polytechnic University, 5: 313–317.