Protective activity of defibrotide against lethal acute myocardial ischemia in the cat

Thrombosis Research - Tập 42 - Trang 363-374 - 1986
R. Niada1, R. Porta1, R. Pescador1, M. Mantovani1, G. Prino1
1Crinos Biological Research Laboratories - 22079 Villa Guardia, Como Italy

Tài liệu tham khảo

1981, Liste 21 Cronique OMS, 35, 4 U.S. Patent No 3,770,720 (1973) No 3,829,567 (1974) No 3,899,481 (1975) British Patent No 1,367,655 (1975) . Prino, 1978, Antithrombotic activity of a polydesoxynucleotidic-like substance (Fraction P), 282 Niada, 1979, Antithrombotic activity of polydeoxyribonucleotides of mammalian origin (laboratory code: Fraction P) in experimental animals, 42, 474 Mantovani, 1978, Activation of fibrinolytic processes by a substance of polydesoxynucleotidic nature (Fraction P), 274 Prino, 1977, Indagini preliminari sull'attivitA fibrinolitica, nell'animale e nell'uomo, di una nuova sostanza presente in diversi organi animali, 557 Pescador, 1983, Pharmacokinetics of Defibrotide and of its profibrinolytic activity in the rabbit, Thromb. Res., 30, 1, 10.1016/0049-3848(83)90391-2 Niada, 1981, Antithrombotic activity of a polydeoxyribonucleotidic substance extracted from mammalian organs: a possible link with prostacyclin, Thromb. Res., 23, 233, 10.1016/0049-3848(81)90013-X Niada, 1982, PGI2-generation and antithrombotic activity of orally administered Defibrotide, Pharmacol. Res. Commun., 14, 949, 10.1016/S0031-6989(82)80059-3 Mussoni, 1979, Activation of plasma and vascular fibrinolytic activity by a polydeoxyribonucleotidic substance, Fraction P, in rats and rabbits, 42, 388 Niada, 1985, Cardioprotective effects of Defibrotide in acute myocardial ischemia in the cat, Thromb. Res., 38, 71, 10.1016/0049-3848(85)90008-8 Bloor, 1975, Ventricular fibrillation threshold in acute myocardial infarction and its relation to myocardial infarct size, Cardiovascular Res., 9, 468, 10.1093/cvr/9.4.468 Endo, 1983, Relationship between the extent of the hypoperfused zone of the myocardium and the occurrence of ventricular fibrillation, Am. Heart J., 105, 915, 10.1016/0002-8703(83)90390-3 Jennings, 1983, Factors involved in salvaging ischemic myocardium: effect of reperfusion of arterial blood, Circulation, 68, I 25 Ogletree, 1979, Studies on the protective effect of prostacyclin in acute myocardial ischemia, Eur.J. Pharmacol., 56, 95, 10.1016/0014-2999(79)90438-2 Kjekshus, 1970, Depressed myocardial creatine phosphokinase activity following experimental myocardial infarction in rabbit, Circ. Res., 27, 403, 10.1161/01.RES.27.3.403 Lowry, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6 Gobel, 1978, The Rate-Pressure Product as an Index of Myocardial Oxigen Consumption during Exercise in Patients with Angina Pectoris, Circulation, 57, 549, 10.1161/01.CIR.57.3.549 Battle, 1974, Distinctive time course of ventricular vulnerability to fibrillation during and after release of coronary ligation, Am. J. Cardiol., 34, 42, 10.1016/0002-9149(74)90091-5 Sheehan, 1983, Determinants of arrhythmic death during artery reperfusion: effect of perfusion bed size, Am. Heart J., 105, 911, 10.1016/0002-8703(83)90389-7 Hale, 1984, Correlates of reperfusion ventricular fibrillation in dogs, Am. J. Cardiol., 53, 1397, 10.1016/0002-9149(84)90100-0 Roberts, 1975, Relation between infarct size and ventricular arrhythmia, Br. Heart J., 37, 1169, 10.1136/hrt.37.11.1169 Schwartz, 1982, The role of the autonomic nervous system in sudden coronary death, Ann. N.Y. Acad. Sci., 382, 162, 10.1111/j.1749-6632.1982.tb55214.x Starnes, 1982, Administration of prostacyclin prevents ventricular fibrillation following coronary occlusion in conscious dogs, J. Cardiovasc. Pharmacol., 4, 765, 10.1097/00005344-198209000-00011 Jugdutt, 1978, Reduction of infarct size by intravenous nitroglycerine infusion in conscious dogs, 58, 98 Fukuyama, 1980, The effect of Intravenous Nitroglycerin on Hemodynamics, Coronary Blood Flow and Morphologically and Enzymatically Estimated Infarct Size in Conscious Dogs, Circulation, 62, 1227, 10.1161/01.CIR.62.6.1227 Lin, 1974, Lidocaine in the prevention of primary ventricular fibrillation, 291, 1324 Brooks, 1980, Protective effect of Verapamil on vulnerability to ventricular fibrillation during myocardial ischemia and reperfusion, Cardiovasc. Res., 14, 295, 10.1093/cvr/14.5.295 Brunner, 1980, Reduction of mortality by sulphinpyrazone after experimental myocardial infarction in the rat, J. Pharm. Pharmacol., 32, 714, 10.1111/j.2042-7158.1980.tb13047.x Corbalan, 1976, Differing mechanism for ventricular vulnerability during coronary artery occlusion and release, Am. Heart J., 92, 223, 10.1016/S0002-8703(76)80258-X Sheridan, 1980, Alpha adrenergic contributions to dysrhythmia during myocardial ischemia and reperfusion in cats, J. Clin. Invest., 65, 161, 10.1172/JCI109647 Bush, 1980, Protective effects of β-adrenergic blockade in isolated ischemic hearts, Eur. J. Pharmacol., 67, 209, 10.1016/0014-2999(80)90500-2 Sharma, 1982, Thrombolytic therapy, New Engl. J. Med., 306, 1268, 10.1056/NEJM198205273062105 Löbel, 1985, Selective stimulation of coronary vascular PGI2 but not of platelet thromboxane formation by defibrotide in the platelet perfused heart, Naunyn-Schmiedeberg's Arch. Pharmacol., 331, 125, 10.1007/BF00634228 BERTI, F., ROSSONI, G., NIADA, R., FOLCO G., OMINI, C., TONDO C. Defibrotide an antithrombotic substance which preserves postsynaptic alpha and beta-adrenergic function in post acute infarcted hearts of the rabbit. J. Cardiovasc. Pharmacol. (in press). Araki, 1980, Role of prostacyclin in the preservation of ischemic myocardial tissue in the perfused cat heart, Circ. Res., 47, 757, 10.1161/01.RES.47.5.757 Schöffel, 1982, Blood coagulation changes during effective thrombolysis using urokinase and heparin, Thromb. Res., 25, 11, 10.1016/0049-3848(82)90210-9 Jewitt, 1968, Lignocaine in the management of arrhythmias after acute myocardial infarction, Lancet, I, 266, 10.1016/S0140-6736(68)90120-7 Carruth, 1982, Ventricular fibrillation complicating acute myocardial infarction: Reasons against the routine use of lidocaine, Am. Heart J., 104, 545, 10.1016/0002-8703(82)90225-3 Niada, 1985, Defibrotide's thrombolytic activity on thrombi of different ages in the rabbit, 106 Bergey, 1982, Acute coronary artery occlusion-reperfusion-induced arrhythmias in rats, dogs and pigs: antiarrhythmic evaluation of quinidine, procainamide and lidocaine, Eur. J. Pharmacol., 81, 205, 10.1016/0014-2999(82)90438-1