Proteasome Inhibitors and Bone Disease

Seminars in Hematology - Tập 49 - Trang 243-248 - 2012
Ya-Wei Qiang1, Christoph J. Heuck1, John D. Shaughnessy1, Bart Barlogie1, Joshua Epstein1
1Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR. Current address for John D. Shaughness Jr is Signal Genetics, LLC, 667 Madison Ave, New York, NY 10065

Tài liệu tham khảo

Roodman, 2004, Pathogenesis of myeloma bone disease, Blood Cells Mol Dis, 32, 290, 10.1016/j.bcmd.2004.01.001 Giuliani, 2001, Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment, Blood, 98, 3527, 10.1182/blood.V98.13.3527 Pearse, 2001, Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression, Proc Natl Acad Sci U S A, 98, 11581, 10.1073/pnas.201394498 Bataille, 1989, Mechanisms of bone destruction in multiple myeloma: the importance of an unbalanced process in determining the severity of lytic bone disease, J Clin Oncol, 7, 1909, 10.1200/JCO.1989.7.12.1909 Richardson, 2006, Bortezomib: proteasome inhibition as an effective anticancer therapy, Annu Rev Med, 57, 33, 10.1146/annurev.med.57.042905.122625 Terpos, 2007, Myeloma bone disease and proteasome inhibition therapies, Blood, 110, 1098, 10.1182/blood-2007-03-067710 Zangari, 2005, Response to bortezomib is associated to osteoblastic activation in patients with multiple myeloma, Br J Haematol, 131, 71, 10.1111/j.1365-2141.2005.05733.x Garrett, 2003, Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro, J Clin Invest, 111, 1771, 10.1172/JCI16198 Giuliani, 2007, The proteasome inhibitor bortezomib affects osteoblast differentiation in vitro and in vivo in multiple myeloma patients, Blood, 110, 334, 10.1182/blood-2006-11-059188 Mukherjee, 2008, Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice, J Clin Invest, 118, 491 Qiang, 2009, Bortezomib induces osteoblast differentiation via Wnt-independent activation of beta-catenin/TCF signaling, Blood, 113, 4319, 10.1182/blood-2008-08-174300 Oyajobi, 2007, Stimulation of new bone formation by the proteasome inhibitor, bortezomib: implications for myeloma bone disease, Br J Haematol, 139, 434, 10.1111/j.1365-2141.2007.06829.x Pennisi, 2009, The proteasome inhibitor, bortezomib suppresses primary myeloma and stimulates bone formation in myelomatous and nonmyelomatous bones in vivo, Am J Hematol, 84, 6, 10.1002/ajh.21310 Heider, 2006, Bortezomib increases osteoblast activity in myeloma patients irrespective of response to treatment, Eur J Haematol, 77, 233, 10.1111/j.1600-0609.2006.00692.x Shimazaki, 2005, High serum bone-specific alkaline phosphatase level after bortezomib-combined therapy in refractory multiple myeloma: possible role of bortezomib on osteoblast differentiation, Leukemia, 19, 1102, 10.1038/sj.leu.2403758 Zangari, 2006, Response to bortezomib and activation of osteoblasts in multiple myeloma, Clin Lymphoma Myeloma, 7, 109, 10.3816/CLM.2006.n.047 Lund, 2010, First-line treatment with bortezomib rapidly stimulates both osteoblast activity and bone matrix deposition in patients with multiple myeloma, and stimulates osteoblast proliferation and differentiation in vitro, Eur J Haematol, 85, 290, 10.1111/j.1600-0609.2010.01485.x Zangari, 2011, Alkaline phosphatase variation during carfilzomib treatment is associated with best response in multiple myeloma patients, Eur J Haematol, 86, 484, 10.1111/j.1600-0609.2011.01602.x Silvestris, 2004, Impaired osteoblastogenesis in myeloma bone disease: role of upregulated apoptosis by cytokines and malignant plasma cells, Br J Haematol, 126, 475, 10.1111/j.1365-2141.2004.05084.x Silvestris, 2003, Upregulation of osteoblast apoptosis by malignant plasma cells: a role in myeloma bone disease, Br J Haematol, 122, 39, 10.1046/j.1365-2141.2003.04374.x Prockop, 1997, Marrow stromal cells as stem cells for nonhematopoietic tissues, Science, 276, 71, 10.1126/science.276.5309.71 Barille, 1995, Myeloma cells upregulate interleukin-6 secretion in osteoblastic cells through cell-to-cell contact but downregulate osteocalcin, Blood, 86, 3151, 10.1182/blood.V86.8.3151.3151 Giuliani, 2005, Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation, Blood, 106, 2472, 10.1182/blood-2004-12-4986 Evans, 1992, Myeloma affects both the growth and function of human osteoblast-like cells, Clin Exp Metastasis, 10, 33, 10.1007/BF00163574 Krishnan, 2006, Regulation of bone mass by Wnt signaling, J Clin Invest, 116, 1202, 10.1172/JCI28551 Ducy, 1997, Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation, Cell, 89, 747, 10.1016/S0092-8674(00)80257-3 Qiang, 2003, Wnt signaling in B-cell neoplasia, Oncogene, 22, 1536, 10.1038/sj.onc.1206239 Qiang, 2005, Wnts induce migration and invasion of myeloma plasma cells, Blood, 106, 1786, 10.1182/blood-2005-01-0049 Aberle, 1997, beta-catenin is a target for the ubiquitin-proteasome pathway, EMBO J, 16, 3797, 10.1093/emboj/16.13.3797 Kisselev, 2001, Proteasome inhibitors: from research tools to drug candidates, Chem Biol, 8, 739, 10.1016/S1074-5521(01)00056-4 Day, 2005, Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis, Dev Cell, 8, 739, 10.1016/j.devcel.2005.03.016 Qiang, 2010, Wnt signaling pathways in multiple myeloma (chapter 2), 51 Heider, 2009, Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment, Eur J Haematol, 82, 31, 10.1111/j.1600-0609.2008.01164.x Kaiser, 2008, Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma, Eur J Haematol, 80, 490, 10.1111/j.1600-0609.2008.01065.x Pinzone, 2009, The role of Dickkopf-1 in bone development, homeostasis, and disease, Blood, 113, 517, 10.1182/blood-2008-03-145169 Politou, 2006, Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation, Int J Cancer, 119, 1728, 10.1002/ijc.22033 Tian, 2003, The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma, N Engl J Med, 349, 2483, 10.1056/NEJMoa030847 Qiang, 2008, Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma, Bone, 42, 669, 10.1016/j.bone.2007.12.006 Qiang, 2008, Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth, Blood, 112, 374, 10.1182/blood-2007-10-120253 Yaccoby, 2007, Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo, Blood, 109, 2106, 10.1182/blood-2006-09-047712 Edwards, 2008, Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo, Blood, 111, 2833, 10.1182/blood-2007-03-077685 Ng, 2011, Bone microstructural changes revealed by HRpQCT imaging and elevated DKK1 and MIP-1alpha levels in patients with monoclonal gammopathy of undetermined significance, Blood, 118, 6529, 10.1182/blood-2011-04-351437 Oshima, 2005, Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2, Blood, 106, 3160, 10.1182/blood-2004-12-4940 Qiang, 2008, Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma, Blood, 112, 196, 10.1182/blood-2008-01-132134 Terpos, 2006, Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-kappaB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma, Br J Haematol, 135, 688, 10.1111/j.1365-2141.2006.06356.x Komori, 2002, Runx2, a multifunctional transcription factor in skeletal development, J Cell Biochem, 87, 1, 10.1002/jcb.10276 Zhao, 2003, E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation, J Biol Chem, 278, 27939, 10.1074/jbc.M304132200 Shui, 2003, Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells, J Bone Miner Res, 18, 213, 10.1359/jbmr.2003.18.2.213 Giuliani, 2006, Multiple myeloma bone disease: pathophysiology of osteoblast inhibition, Blood, 108, 3992, 10.1182/blood-2006-05-026112 Sezer, 2003, RANK ligand and osteoprotegerin in myeloma bone disease, Blood, 101, 2094, 10.1182/blood-2002-09-2684 Simonet, 1997, Osteoprotegerin: a novel secreted protein involved in the regulation of bone density, Cell, 89, 309, 10.1016/S0092-8674(00)80209-3 O'Brien, 2010, Control of RANKL gene expression, Bone, 46, 911, 10.1016/j.bone.2009.08.050 Terpos, 2003, Soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index, Blood, 102, 1064, 10.1182/blood-2003-02-0380 Zavrski, 2005, Proteasome inhibitors abrogate osteoclast differentiation and osteoclast function, Biochem Biophys Res Commun, 333, 200, 10.1016/j.bbrc.2005.05.098 Ang, 2009, Proteasome inhibitors impair RANKL-induced NF-kappaB activity in osteoclast-like cells via disruption of p62, TRAF6, CYLD, and IkappaBalpha signaling cascades, J Cell Physiol, 220, 450, 10.1002/jcp.21787 von Metzler, 2007, Bortezomib inhibits human osteoclastogenesis, Leukemia, 21, 2025, 10.1038/sj.leu.2404806 Breitkreutz, 2008, Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma, Leukemia, 22, 1925, 10.1038/leu.2008.174 Boissy, 2008, Pulse treatment with the proteasome inhibitor bortezomib inhibits osteoclast resorptive activity in clinically relevant conditions, Leuk Res, 32, 1661, 10.1016/j.leukres.2008.02.019 Terpos, 2008, The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide is an effective regimen for relapsed/refractory myeloma and is associated with improvement of abnormal bone metabolism and angiogenesis, Leukemia, 22, 2247, 10.1038/leu.2008.235 Uy, 2007, Bortezomib inhibits osteoclast activity in patients with multiple myeloma, Clin Lymphoma Myeloma, 7, 587, 10.3816/CLM.2007.n.045 Glass, 2005, Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation, Dev Cell, 8, 751, 10.1016/j.devcel.2005.02.017 Holmen, 2005, Essential role of beta-catenin in postnatal bone acquisition, J Biol Chem, 280, 21162, 10.1074/jbc.M501900200 Spencer, 2006, Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro, J Cell Sci, 119, 1283, 10.1242/jcs.02883 Willert, 2002, A transcriptional response to Wnt protein in human embryonic carcinoma cells, BMC Dev Biol, 2, 8, 10.1186/1471-213X-2-8 Qiang, 2010, Characterization of Wnt/beta-catenin signalling in osteoclasts in multiple myeloma, Br J Haematol, 148, 726, 10.1111/j.1365-2141.2009.08009.x Hongming, 2009, Bortezomib inhibits maturation and function of osteoclasts from PBMCs of patients with multiple myeloma by downregulating TRAF6, Leuk Res, 33, 115, 10.1016/j.leukres.2008.07.028 Meller, 2006, Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons, J Biol Chem, 281, 7429, 10.1074/jbc.M512138200 Akiyama, 2003, Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim, EMBO J, 22, 6653, 10.1093/emboj/cdg635 Roccaro, 2006, Bortezomib mediates antiangiogenesis in multiple myeloma via direct and indirect effects on endothelial cells, Cancer Res, 66, 184, 10.1158/0008-5472.CAN-05-1195