Proteasomal inhibition reduces parkin mRNA in PC12 and SH-SY5Y cells

Parkinsonism & Related Disorders - Tập 15 - Trang 220-225 - 2009
Andreas Koch1, Klaus Lehmann-Horn1, Justus C. Dächsel1, Thomas Gasser2, Philipp J. Kahle2, Christoph B. Lücking1
1Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr. 15, 81377 Munich, Germany
2Hertie Institute for Clinical Brain Research, Department for Neurodegenerative Diseases, University Clinics Tübingen, Otfried-Müller-Strasse 27, 72076 Tübingen, Germany

Tài liệu tham khảo

Gasser, 2005, Genetics of Parkinson's disease, Curr Opin Neurol, 18, 363, 10.1097/01.wco.0000170951.08924.3d Tan, 2007, Pathogenic mutations in Parkinson disease, Hum Mutat, 28, 641, 10.1002/humu.20507 Shimura, 2000, Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase, Nat Genet, 25, 302, 10.1038/77060 McNaught, 2003, Altered proteasomal function in sporadic Parkinson's disease, Exp Neurol, 179, 38, 10.1006/exnr.2002.8050 Haywood, 2006, Mutant alpha-synuclein-induced degeneration is reduced by parkin in a fly model of Parkinson's disease, Genome, 49, 505, 10.1139/G06-011 Lo Bianco, 2004, Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease, Proc Natl Acad Sci USA, 101, 17,510, 10.1073/pnas.0405313101 Yang, 2005, Neuroprotection of Parkin against apoptosis is independent of inclusion body formation, Neuroreport, 16, 1117, 10.1097/00001756-200507130-00017 Yang, 2006, Induction of parkin expression in the presence of oxidative stress, Eur J Neurosci, 24, 1366, 10.1111/j.1460-9568.2006.04998.x Jiang, 2004, Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis, Hum Mol Genet, 13, 1745, 10.1093/hmg/ddh180 Cha, 2005, Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila, Proc Natl Acad Sci USA, 102, 10,345, 10.1073/pnas.0500346102 Henn, 2007, Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling, J Neurosci, 27, 1868, 10.1523/JNEUROSCI.5537-06.2007 Chung, 2001, Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease, Nat Med, 7, 1144, 10.1038/nm1001-1144 Ito, 2003, Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1, J Biol Chem, 278, 29,106, 10.1074/jbc.M302763200 Liani, 2004, Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease, Proc Natl Acad Sci U S A, 101, 5500, 10.1073/pnas.0401081101 Engelender, 1999, Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions, Nat Genet, 22, 110, 10.1038/8820 Dächsel, 2005, Parkin interacts with the proteasome subunit alpha4, FEBS Lett, 579, 3913, 10.1016/j.febslet.2005.06.003 West, 2003, Identification of a novel gene linked to parkin via a bi-directional promoter, J Mol Biol, 326, 11, 10.1016/S0022-2836(02)01376-1 Junn, 2002, Parkin accumulation in aggresomes due to proteasome impairment, J Biol Chem, 277, 47,870, 10.1074/jbc.M203159200 Imai, 2000, Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity, J Biol Chem, 275, 35,661, 10.1074/jbc.C000447200 West, 2003, Parkin is not regulated by the unfolded protein response in human neuroblastoma cells, Neurosci Lett, 341, 139, 10.1016/S0304-3940(03)00188-5 Wang, 2007, Cell type-specific upregulation of Parkin in response to ER stress, Antioxid Redox Signal, 9, 533, 10.1089/ars.2006.1522 Yamamoto, 2005, Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity, J Biol Chem, 280, 3390, 10.1074/jbc.M407724200 McNaught, 2004, Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease, Ann Neurol, 56, 149, 10.1002/ana.20186 Schapira, 2006, Proteasomal inhibition causes loss of nigral tyrosine hydroxylase neurons, Ann Neurol, 60, 253, 10.1002/ana.20934 Kordower, 2006, Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys, Ann Neurol, 60, 264, 10.1002/ana.20935 Manning-Bog, 2006, Lack of nigrostriatal pathology in a rat model of proteasome inhibition, Ann Neurol, 60, 256, 10.1002/ana.20938 Hampe, 2006, Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity, Hum Mol Genet, 15, 2059, 10.1093/hmg/ddl131 Wang, 2005, Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function, Hum Mol Genet, 14, 3885, 10.1093/hmg/ddi413 Tan, 2005, Impaired transcriptional upregulation of Parkin promoter variant under oxidative stress and proteasomal inhibition: clinical association, Hum Genet, 118, 484, 10.1007/s00439-005-0038-4 Biasini, 2004, Proteasome inhibition and aggregation in Parkinson's disease: a comparative study in untransfected and transfected cells, J Neurochem, 88, 545, 10.1046/j.1471-4159.2003.02152.x