Proteasomal Degradation of Human Peptidyl Prolyl Isomerase Pin1-pointing Phospho Bcl2 toward Dephosphorylation

Vaux, 1999, Cell death in development, Cell, 96, 245, 10.1016/S0092-8674(00)80564-4 Thomberry, 1998, Caspases enemies within, Science, 281, 1312, 10.1126/science.281.5381.1312 Green, 1998, Mitochondria and apoptosis, Science, 281, 1309, 10.1126/science.281.5381.1309 White, 1996, Life, death and pursuit of apoptosis, Genes Dev, 10, 1, 10.1101/gad.10.1.1 Tsujimoto, 1985, Involvement of the Bcl2 gene in follicular lymphoma, Science, 228, 1440, 10.1126/science.3874430 Bakshi, 1985, Cloning the chromosomal breakpoint of the t (14; 18) human lymphomas, clustering around JH on chromosome 14 and near a transcriptional unit 18, Cell, 41, 899, 10.1016/S0092-8674(85)80070-2 Oltvai, 1994, Checkpointing of dueling dimers foil death wishes, Cell, 79, 189, 10.1016/0092-8674(94)90188-0 Zha, 1996, Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X (L), Cell, 87, 619, 10.1016/S0092-8674(00)81382-3 Basu, 2000, Regulation of Bcl2 phosphorylation by stress response kinase pathway, Int J Oncol, 16, 497 Yamamoto K, Ichijo H, Korsmeyer SJ. Bcl2 is phosphorylated and inactivated by an Ask1/Jun N-terminal protein kinase pathway. Mol Cell Biol 19, 8469-8478. Wang, 1999, Loss of the bcl2 phosphorylation loop domain increases resistance of human leukemia cells (U937) to paclitaxel-mediated mitochondrial dysfunction and apoptosis, Biochem Biophys Res Commun, 259, 67, 10.1006/bbrc.1999.0669 Domina, 2000, Myeloid cell leukemia 1 is phosphorylated through two distinct pathways, one associated with extracellular signal-regulated kinase activation and the other with G2/M accumulation or protein phosphatase 1/2A inhibition, J Biol Chem, 275, 21688, 10.1074/jbc.M000915200 Srivastava, 1999, Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis, Proc Natl Acad Sci USA, 96, 3775, 10.1073/pnas.96.7.3775 Srivastava, 1998, Involvement of microtubules in the regulation of Bcl-2 phosphorylation and apoptosis through cyclic AMPdependent protein kinase, Mol Cell Biol, 18, 3509, 10.1128/MCB.18.6.3509 Haldar, 1998, Serine-70 is one of the critical sites for drug-induced Bcl2 phosphorylation in cancer cells, Cancer Res, 58, 1609 Basu, 1998, Microtubule-damaging drugs triggered Bcl2 phosphorylation-requirement of phosphorylation on both serine70 and serine-87 residues of Bcl2 protein, Int J Oncol, 13, 659 Poruchynsky, 1998, Bcl-xL is phosphorylated in malignant cells following microtubule disruption, Cancer Res, 58, 3331 Blagosklonny, 1997, Raf-1 /bcl-2 phosphorylation: a step from microtubule damage to cell death, Cancer Res, 57, 130 Chang, 1997, Identification of a novel regulatory domain in Bcl-X (L) and Bcl-2, EMBO J, 16, 968, 10.1093/emboj/16.5.968 Haldar, 1997, Bcl2 is the guardian of microtubule integrity, Cancer Res, 57, 229 Haldar, 1996, Taxol induces Bcl2 phosphorylation and death of prostate cancer cells, Cancer Res, 56, 1253 Blagosklonny, 1996, Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 transduction pathway, Cancer Res, 56, 1851 Haldar, 1995, Inactivation of Bcl2 by phosphorylation, Proc Natl Acad Sci USA, 92, 4507, 10.1073/pnas.92.10.4507 Wang, 1998, Effect of bryostatin 1 on taxol-induced apoptosis and cytotoxicity in human leukemia cells (U937), Biochem Pharmacol, 56, 635, 10.1016/S0006-2952(98)00188-9 Hockenbery, 1990, Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death, Nature, 348, 334, 10.1038/348334a0 Haldar, 1994, Cellular localization of bcl2 protein and response to glucocorticoid stress, Cell Death Differ, 1, 109 Krajewski, 1993, Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, outer mitochondrial membranes, Cancer Res, 53, 4701 Pathan, 2001, Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pini, Neoplasia, 3, 550, 10.1038/sj.neo.7900213 Hsu, 2001, Drosophila NO prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis, Nat Cell Biol, 3, 538, 10.1038/35078508 Lu, 1996, A human peptidyl-prolyl isomerase essential for regulation of mitosis, Nature, 380, 544, 10.1038/380544a0 Yaffe, 1997, Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism, Science, 278, 1957, 10.1126/science.278.5345.1957 Palombella, 1994, The ubiquitin-proteasome pathway is required for processing the NFkappa B1 precursor protein and the activation of NF-kappa B, Cell, 78, 773, 10.1016/S0092-8674(94)90482-0 Chen, 1995, Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway, Genes Dev, 9, 1586, 10.1101/gad.9.13.1586 Lo, 1999, Ubiquitin-dependent degradation of TGF-beta-activated smad2, Nat Cell Biol, 1, 472, 10.1038/70258 Graham, 1973, Transformation of rat cells by DNA of human adenovirus 5, Virology, 52, 456, 10.1016/0042-6822(73)90341-3 Basu, 1997, Regulation of murine cytochrome oxidase Vb gene expression in different tissues and during myogenesis, Role of a YY-1 factor-binding negative enhancer. J Biol Chem, 272, 5899 Harlow, 1988, 78 Ling, 1998, Phosphorylation of Bcl2 is a marker of M phase events and not a determinant of apoptosis, J Biol Chem, 273, 18984, 10.1074/jbc.273.30.18984 Kumeda, 1999, Induction of G1 arrest and selective growth inhibition by lactacystin in human umbilical vein endothelial cells, Anticancer Res, 19, 3961 Zhao, 2000, The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner, J Cell Sci, 113, 4363, 10.1242/jcs.113.23.4363 Persons, 2000, Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin, J Biol Chem, 275, 35778, 10.1074/jbc.M004267200 Liebmann, 1994, Cycloheximide inhibits the cytotoxicity of paclitaxel (Taxol), Anticancer Drugs, 5, 287, 10.1097/00001813-199406000-00004 Sherwood, 1994, Induction of apoptosis by the anti-tubulin drug colcemid: relationship of mitotic checkpoint control to the induction of apoptosis in HeLa S3 cells, Exp Cell Res, 215, 373, 10.1006/excr.1994.1354 Schiff, 1979, Promotion of microtubule assembly in vitro by taxol, Nature, 22, 665, 10.1038/277665a0 Schiff, 1980, Taxol stabilizes microtubules in mouse fibroblast cells, Proc Natl Acad Sci USA, 77, 1561, 10.1073/pnas.77.3.1561 Jordan, 1993, Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death, Proc Natl Acad Sci USA, 90, 9552, 10.1073/pnas.90.20.9552 King, 1995, Cell cycle and apoptosis: common pathways to life and death, J Cell Biochem, 58, 175, 10.1002/jcb.240580206 Scatena, 1998, Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and Taxol-induced growth arrest, J Biol Chem, 273, 30777, 10.1074/jbc.273.46.30777 Ito, 1997, Bcl2 phosphorylation required for its antiapoptotic function, J Biol Chem, 272, 11671, 10.1074/jbc.272.18.11671 Matassa, 2001, PKCdelta is required for mitochondrial-dependent apoptosis in salivary epithelial cells, J Biol Chem, 276, 29719, 10.1074/jbc.M100273200 Stukenberg, 2001, Pini acts catalytically to promote a conformational change in Cdc25, Mol Cell, 7, 1071, 10.1016/S1097-2765(01)00245-3 Zhou, 1999, Phosphorylationdependent prolyl isomerization: a novel signaling regulatory mechanism, Cell Mol Life Sci, 56, 788, 10.1007/s000180050026 Zhou, 2000, Pini-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins, Mol Cell, 6, 873, 10.1016/S1097-2765(05)00083-3 Rippmann, 2000, Phosphorylationdependent proline isomerization catalyzed by Pini is essential for tumor cell survival and entry into mitosis, Cell Growth Differ, 11, 409 O'Connor, 2001, Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin, Proc Natl Acad Sci USA, 97, 13103, 10.1073/pnas.240390697 Rowinsky, 1990, Taxol: a novel investigational antimicrotubule agent, J Natl Cancer Inst, 82, 1247, 10.1093/jnci/82.15.1247 Boise, 1993, bcl-x, a bcl-2related gene that functions as a dominant regulator of apoptotic cell death, Cell, 74, 597, 10.1016/0092-8674(93)90508-N Soengas, 2001, Inactivation of the apoptosis effector Apaf-1 in malignant melanoma, Nature, 409, 207, 10.1038/35051606 Soengas, 1999, Apaf-1 and Caspase-9 in p53-dependent apoptosis and tumor inhibition, Science, 284, 156, 10.1126/science.284.5411.156 Wulf, 2001, Pini is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1, EMBO J, 20, 3459, 10.1093/emboj/20.13.3459