Prostatic intraepithelial neoplasia

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Garabedian EM, Humphrey PA, Gordon JI: A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cells. Proc Natl Acad Sci USA 1998, 95:15382–15387. An excellent report.

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Qian J, Wollan P, Bostwick DG: The extent and multicentricity of high grade prostatic intraepithelial neoplasia in clinically localized prostatic adenocarcinoma. Hum Pathol 1997, 28:143–148.

Bostwick DG, Brawer MK: Prostatic intra-epithelial neoplasia and early invasion in prostate cancer. Cancer 1987. 59:788–794,

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Algaba F, Epstein JI, Fabus G, et al.: Working standards in prostatic intraepithelial neoplasia and atypical adenomatous hyperplasia. Pathol Res Pract 1995, 191:836–837.

Montironi R, Bostwick DG, Bonkhoff H, et al.: Workgroup 1. Origins of prostate cancer. Cancer 1996, 78:362–365.

Bostwick DG, Amin MB, Dundore P, et al.: Architectural patterns of high-grade prostatic intraepithelial neoplasia. Hum Pathol 1993, 24:298–310.

Reyes AO, Swanson PE, Carbone JM, Humphrey PA: Unusual histologic types of high-grade prostatic intraepithelial neoplasia. Am J Surg Pathol 1997, 21:1215–1222.

Bock B, Bostwick DG: Does prostatic ductal adenocarcinoma exist? Am J Surg Pathol, 1999, 23:781–785.

Kilic S, Kukul E, Danisman A, et al.: Ratio of free to total prostate-specific antigen in patients with prostatic intraepithelial neoplasia. Eur Urol 1998, 34:176–180.

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Alexander EE, Qian J, Wollan PC, et al.: Prostatic intraepithelial neoplasia does not appear to raise serum prostatespecific antigen concentration. Urology1996, 47:693–698.

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Brawer MK, Lange PH: Prostate-specific antigen and premalignant change: Implications for early detection. CA Cancer J Clin 1989, 39:361–375.

Davidson D, Bostwick DG, Qian J, et al.: Prostatic intraepithelial neoplasia is a risk factor for adenocarcinoma: Predictive accuracy in needle biopsies. J Urol 1995, 154:1295–1299.

Bostwick DG, Qian J, Frankel K: The incidence of high grade prostatic intraepithelial neoplasia in needle biopsies. J Urol 1996, 154:1791–1794.

Langer JE, Rovner ES, Coleman BG, et al.: Strategy for repeat biopsy of patients with prostatic intraepithelial neoplasia detected by prostate needle biopsy. J Urol 1996, 155:228–231.

Wills ML, Hamper UM, Partin AW, et al.: Incidence of highgrade prostatic intraepithelial neoplasia in sextant needle biopsy specimens. Urology 1997, 49:367–373.

Skjorten FJ, Berner A, Harvei S, et al.: Prostatic intraepithelial neoplasia in surgical resections. Relationship to coexistent adenocarcinoma and atypical adenomatous hyperplasia of the prostate. Cancer 1997, 79:1172–1179.

Pacelli A, Bostwick DG: The clinical significance of high-grade prostatic intraepithelial neoplasia in transurethral resection specimens. Urology 1997, 50:355–359.

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Shepherd D, Keetch DW, Humphrey PA, et al.: Repeat biopsy strategy in men with isolated prostatic intraepithelial neoplasia on prostate needle biopsy. J Urol 1996, 156:460–463.

Harvei S, Skjorten FJ, Robsahm TE, et al.: Is prostatic intraepithelial neoplasia in the transition/central zone a true precursor of cancer? A long-term retrospective study in Norway. Br J Cancer 1998, 78:46–49.

Bostwick DG, Burke HB, Wheeler TM, et al.: The most promising surrogate endpoint biomarkers for screening candidate chemopreventive compounds for prostatic adenocarcinoma in short-term phase II clinical trials. J Cell Biochem 1994, 19 (suppl):283–289.

Aquilina JW, Lipsky JJ, Bostwick DG: Androgen deprivation as a strategy for prostate cancer chemoprevention. J Natl Cancer Inst 1997, 89:689–696.

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Bostwick DG, Shan A, Qian J, et al.: Independent origin of multiple foci of prostatic intraepithelial neoplasia: comparison with matched foci of prostate carcinoma. Cancer 1998, 83:1995–2002.

Cheng L, Song S-Y, Pretlow TG, et al.: Evidence of independent origin of multiple tumors from patients with prostate cancer. J Natl Cancer Instit 1998, 90:233–237.

Humphrey PA, Frazier HA, Paulson DF, et al.: Extent of severe dysplasia in the prostate is inversely related to pathologic stage. Mod Pathol 1992, 5:54A.

Bostwick DG: Prostatic intraepithelial neoplasia is a risk factor for cancer. Semin Urol Oncol 1999, 17:187–98. An interesting and important study.

Dubbink HJ, Hoedemaeker RF, van der Kwast TH, et al.: Human prostate-specific transglutaminase: a new prostatic marker with a unique distribution pattern. Lab Invest 1999, 79:141–150.

Sweat SD, Pacelli A, Bergstralh E, et al.: Androgen receptor expression in prostatic intraepithelial neoplasia and cancer. J Urol 1999, 161:1229–1232.

Erdamar S, Yang G, Harper JW, et al.: Levels of expression of p27KIP1 protein in human prostate and prostate cancer: an immunohistochemical analysis. Mod Pathol 1999, 12:751–755.

Haussler O, Epstein JI, Amin MB, Heitz PU, Hailemariam S: Cell proliferation, apoptosis, oncogenes, and tumor suppressor gene status in adenosis with comparison to benign prostatic hyperplasia, prostatic intraepithelial neoplasia, and cancer. Human Pathol 1999, 30:1077–1086.

Qian J, Jenkins RB, Bostwick DG: Genetic and chromosomal alterations in prostatic intraepithelial neoplasia and carcinoma detected by fluorescence in situ hybridization. Eur Urol 1999, 35:479–83.

Poczatek RB, Myers RB, Manne U: Ep-Cam levels in prostatic adenocarcinoma and prostatic intraepithelial neoplasia. 1999, J Urol 162:1462–1466.

Bostwick DG, Pacelli A, Blute M, et al.: Prostate specific membrane antigen expression in prostatic intraepithelial neoplasia and adenocarcinoma: a study of 184 cases. Cancer 1998, 82:2256–226.

Bonkhoff H, Fixemer T, Hunsicker I, Remberger K: Estrogen receptor expression in prostate cancer and premalignant prostatic lesions.Am J Pathol 1999, 155:641–647.

Leav I, Merk FB, Lee KF, et al.: Prolactin receptor expression in the developing human prostate and in hyperplastic, dysplastic, and neoplastic lesions. Am J Pathol 1999, 154:863–870.

Balaji KC, Rabbani F, Tsai H, et al.: Effect of neoadjuvant hormonal therapy on prostatic intraepithelial neoplasia and its prognostic significance. J Urol 1999, 162:753–757.

Ferguson J, Zincke H, Ellison E, et al.: Decrease of prostatic intraepithelial neoplasia (PIN) following androgen deprivation therapy in patients with stage T3 carcinoma treated by radical prostatectomy. Urology 1994, 44:91–95.

Yang XJ, Lecksell K, Short K, et al.: Does long-term finasteride therapy affect the histologic features of benign prostatic tissue and prostate cancer on needle biopsy? Urology 1999, 53:696–700.

Cheng L, Cheville JC, Pisansky TM, et al.: Prevalence and distribution of prostatic intraepithelial neoplasia in salvage radical prostatectomy specimens after radiation therapy Am J Surg Pathol 1999, 23:803–808.

Holash J, Maisonpierre PC, Compton D, et al.: Vessel cooption, regression, and growth mediated by angiopoietins and VEGF. Science 1999, 284:1994–1999.

Bostwick DG, Neumann R, Qian J, Cheng L: Reversibility of prostatic intraepithelial neoplasia: Implications for chemoprevention. Eur Urol 1999, 35:492–495.