Prostate Brachytherapy
Tóm tắt
Prostate brachytherapy has been practiced for nearly 100 years in various forms. However, technological advances over the past 20 years in imaging, computing, and devices have propelled this technique into the mainstream of prostate cancer treatments. A discussion of radiobiology principles is important to the understanding of modern brachytherapy technique. For low risk tumors, brachytherapy may be administered as monotherapy. For high risk tumors combination therapy with external beam therapy is indicated. Androgen ablation therapy is used for hormonal downsizing or for select high risk tumors. Diseases free survival appears similar to that seen with other definitive therapies for clinically localized prostate cancer. The short term morbidity of the procedure includes significant obstructive and irritative voiding symptoms. Future brachytherapy goals are discussed.
Tài liệu tham khảo
Flocks RH: Present status of interstitial irradiation in managing prostatic cancer. JAMA 210: 328–330, 1969
Whitmore WF Jr., Hilaris B, Grabstald H: Retropubic implantation to iodine 125 in the treatment of prostatic cancer. J Urol 108: 918–920, 1972
Zelefsky MJ, Whitmore WF Jr.: Long-term results of retropubic permanent 125iodine implantation of the prostate for clinically localized prostatic cancer. J Urol 158: 23–29, 1997
Holm HH, Juul N, Pedersen JF, Hansen H, Stroyer I: Transperineal 125iodine seed implantation in prostatic cancer guided by transrectal ultrasonography. J Urol 130: 283–286, 1983
Sohayda C, Kupelian PA, Levin HS, Klein EA: Extent of extracapsular extension in localized prostate cancer. Urology 55: 382–386, 2000
Critz FA, Levinson AK, Williams WH, Holladay DA, Holladay CT: The PSA nadir that indicates potential cure after radiotherapy for prostate cancer. Urology 49: 322–326, 1997
Grimm PD, Blasko JC, Sylvester JE, Meier RM, Cavanagh W: 10-year biochemical (prostate-specific antigen) control of prostate cancer with (125)I brachytherapy. Int J Radiat Oncol Biol Phys 51: 31–40, 2001
Stock RG, Stone NN, Lo YC: Intraoperative dosimetric representation of the real-time ultrasound-guided prostate implant. Tech Urol 6: 95–98, 2000
Cormack RA, Tempany CM, D'Amico AV: Optimizing target coverage by dosimetric feedback during prostate brachytherapy. Int J Radiat Oncol Biol Phys 48: 1245–1249, 2000