Prostaglandins of J Series Control Heme Oxygenase Expression

Annals of the New York Academy of Sciences - Tập 993 Số 1 - Trang 208-216 - 2003
Hean Zhuang1, Yun‐Sook Kim1, Khodadad Namiranian1, Sylvain Doré1
1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA

Tóm tắt

Abstract: Cyclopentenone prostaglandins (cyPGs) are a subfamily of prostaglandins that are characterized by the cyclopentenone ring in their structure. They exert their effect after active transportation into the cell, probably by interacting with cellular target proteins or DNA sequences. The cyPGs have anti‐inflammatory activities, especially important during the resolution of inflammation, anticancer, and cytoprotective properties. Here, we show that the cyPGs, especially the 15‐deoxy‐Δ12,14 PGJ2, can specifically induce heme oxygenase 1 in mouse primary neuronal cells. Heme oxygenase is the enzyme responsible for the degradation of heme into biliverdin, ferrous iron, and carbon monoxide. This enzyme conveys protection to oxidative cellular injury by degrading the pro‐inflammatory heme; producing biliverdin and bilirubin, potent antioxidants; producing carbon monoxide, a neurotransmitter that also has anti‐inflammatory and vasodilatory properties; and assisting in keeping iron cellular homeostasis. CyPGs appear to possess a promising future in designing therapeutics for many neurologic diseases, such as Alzheimer's disease, vascular‐related dementia, multiple sclerosis, ischemic conditions, and many others in which inflammation is a part of the pathophysiology.

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Tài liệu tham khảo

10.1002/med.1006

10.1124/mol.61.5.997

10.1016/S1567-5769(01)00133-3

10.1006/bbrc.2001.4783

10.1097/00008390-199808000-00005

Campo P.A., 2002, Translational regulation of cyclin D1 by 15‐deoxy‐delta(12,14)‐prostaglandin J(2), Cell Growth Differ., 13, 409

10.1007/BF02052264

10.1210/en.138.3.985

Eligini S., 2002, 15‐Deoxy‐delta12,14‐prostaglandin J2 inhibits tissue factor expression in human macrophages and endothelial cells: evidence for ERK1/2 signaling pathway blockade, Thromb. Haemost., 88, 524, 10.1055/s-0037-1613247

10.1016/0006-2952(92)90477-Z

10.1006/bbrc.2000.2289

Amici C., 2001, Activation of I kappa b kinase by herpes simplex virus type 1, A novel target for anti-herpetic therapy. J. Biol. Chem., 276, 28759

10.1172/JCI118609

10.1073/pnas.96.8.4668

10.1152/ajpheart.2000.278.5.H1613

Wagener F.A., 1999, Differential effects of heme oxygenase isoforms on heme mediation of endothelial intracellular adhesion molecule 1 expression, J. Pharmacol. Exp. Ther., 291, 416

10.1073/pnas.96.5.2445

10.1016/S0024-3205(01)01417-5

10.1089/15230860260220049

10.1007/BF03401984

10.1016/S0306-4522(00)00216-5

10.1111/j.1471-4159.1999.721187.x

10.1182/blood.V98.6.1802

10.1016/S0002-9440(10)65024-9

10.1046/j.1523-1755.2000.00101.x

10.1152/ajplung.00446.2001

10.1016/0304-4165(93)90013-X

10.1016/S1566-2772(00)00006-2

10.1089/152308602753666334

10.1017/S0952523800173018

10.1016/S1074-5521(98)90618-4

10.1126/science.7678352

10.1152/ajpheart.1999.276.5.H1641

10.1089/152308602753666361

10.1007/s000110050238

10.1172/JCI0215316

10.1152/ajpheart.2001.281.1.H350

10.1038/11072

10.1074/jbc.275.20.15166

10.1002/(SICI)1097-4652(199901)178:1<1::AID-JCP1>3.0.CO;2-Q

10.1002/jnr.490310214

10.1016/0140-6736(91)92978-B

10.1046/j.1432-1327.1999.00610.x

10.1046/j.1471-4159.2002.00899.x

10.1016/S0166-2236(99)01401-0

10.1046/j.1440-1681.2000.03200.x

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Annals of the New York Academy of Sciences

Tập 993 Số 1

208-216

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