Prospective antibacterial inhibition of c-type cytochrome synthesis

Trends in Molecular Medicine - Tập 27 - Trang 928-930 - 2021
João Pessoa1
1Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal

Tài liệu tham khảo

Varela, 2021, Bacterial resistance to antimicrobial agents, Antibiotics, 10, 593, 10.3390/antibiotics10050593 Sutherland, 2021, In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases, eLife, 10, 10.7554/eLife.64891 Pérez-Mejías, 2019, Cytochrome c: surfing off of the mitochondrial membrane on the tops of complexes III and IV, Comput. Struct. Biotechnol. J., 17, 654, 10.1016/j.csbj.2019.05.002 Zou, 1997, Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3, Cell, 90, 405, 10.1016/S0092-8674(00)80501-2 Frawley, 2009, CcsBA is a cytochrome c synthetase that also functions in heme transport, Proc. Natl. Acad. Sci. U. S. A., 106, 10201, 10.1073/pnas.0903132106 Rončević, 2019, Antimicrobial peptides as anti-infective agents in pre-post-antibiotic era?, Int. J. Mol. Sci., 20, 5713, 10.3390/ijms20225713 Iyisan, 2019, Modular approach for the design of smart polymeric nanocapsules, Macromol. Rapid Commun., 40, 10.1002/marc.201800577 Pethe, 2013, Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis, Nat. Med., 19, 1157, 10.1038/nm.3262 Lu, 2018, The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd, Sci. Rep., 8, 265 Rajagopal, 2013, The hydrogen-peroxide-induced radical behaviour in human cytochrome c-phospholipid complexes: implications for the enhanced pro-apoptotic activity of the G41S mutant, Biochem. J., 456, 441, 10.1042/BJ20130758