Prospective Randomized Study of Doxorubicin-Eluting-Bead Embolization in the Treatment of Hepatocellular Carcinoma: Results of the PRECISION V Study

Springer Science and Business Media LLC - Tập 33 Số 1 - Trang 41-52 - 2010
Johannes Lämmer1, Katarina Malagari2, Thomas J. Vogl3, F. Pilleul4, Alban Denys5, A. Watkinson6, M Pitton7, Géraldine Sergent8, Thomas Pfammatter9, Sylvain Terraz10, Yves Benhamou11, Yves Avajon12, Thomas Gruenberger13, Maria Pomoni2, Herbert Langenberger1, Jérôme Dumortier4, Christian Loewe13, P. Chevallier14, Riccardo Lencioni15
1Cardiovascular and Interventional Radiology, Medical University Vienna, Vienna, Austria
2Univ. of Athens, Athens, Greece
3Goethe University Frankfurt, Germany
4Hospices Civils de Lyon, CHU, Hopital Edouard Herriot, Lyon, France
5CHU Vaudois, Lausanne, Switzerland
6The Peninsula Medical School, Royal Devon and Exeter Hospital, Exeter, UK
7Guttenberg University, Mainz, Germany
8Hôpital Huriez, Lille, France
9Universitätsspital Zurich, Zurich, Switzerland
10Hopitaux Universitaires de Geneve, Geneve, Switzerland
11Hôpital La Pitiè-Salpetrière, Paris, France
12Hôpital Paul Brousse, Paris, France
13Medical University Vienna, Vienna, Austria
14Hôpital Archet II, Nice, France
15“Cisanello” University Hospital, Pisa, Italy

Tóm tắt

Từ khóa


Tài liệu tham khảo

Altekruse SF, McGlynn KA, Reichman ME (2009) Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 27:1485–1491

Höpfner M, Schuppan D, Scherübl H (2008) Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer. World J Gastroenterol 14:1–14

Llovet JM, Bru C, Bruix J (1999) Prognosis of hepatocellular carcinoma: The BCLC staging classification. Semin Liver Dis 19:329–338

Bruix J, Llovet JM (2002) Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology 35:519–524

O’Neil BH, Venook AP (2007) Hepatocellular carcinoma: the role of the North American GI Steering Committee Hepatobiliary Task Force and the advent of effective drug therapy. Oncologist 12:1425–1432

Bruix J, Sherman M (2005) Practice Guidelines Committee, American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma. Hepatology 42:1208–1236

Gish RG, Porta C, Lazar L et al (2007) Phase III randomized controlled trial comparing the survival of patients with unresectable hepatocellular carcinoma treated with nolatrexed or doxorubicin. J Clin Oncol 25:3069–3075

Llovet JM, Ricci S, Mazzaferro V et al (2008) Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359:378–390

Raoul JL, Heresbach D, Bretagne JF et al (1992) Chemoembolisation of hepatocellular carcinomas. A study of the biodistribution and pharmacokinetics of doxorubicin. Cancer 70:585–590

Lin DY, Liaw YF, Lee TY, Lai CM (1988) Hepatic arterial embolisation in patients with unresectable hepatocellular carcinoma—a randomised controlled trial. Gastroenterology 94:453–456

Group d’Etude et de Traitment du Carcinome Hépatocellulaire (1995) A comparison of lipiodol chemoembolisation and conservative treatment for unresectable hepatocellular carcinoma. N Engl J Med 332:1256–1261

Raoul JL, Guyader D, Bretagne JF et al (1997) Prospective randomized trial of chemoembolisation versus intra-arterial injection of 131I-labeled-iodized oil in the treatment of hepatocellular carcinoma. Hepatology 26:1156–1161

Bruix J, Llovet JM, Castells A et al (1998) Transarterial embolisation versus symptomatic treatment in patients with advanced hepatocellular carcinoma: results of a randomised, controlled trial in a single institution. Hepatology 27:1578–1583

Pelletier G, Ducreux M, Gay F et al (1998) Treatment of unresectable hepatocellular carcinoma with lipiodol chemoembolisation: a multicentre randomised trial. J Hepatol 29:129–134

Lo CM, Ngan H, Tso WK et al (2002) Randomised controlled trial of transarterial lipiodol chemoembolisation for unresectable hepatocellular carcinoma. Hepatology 35:1164–1171

Llovet JM, Real MI, Montana X et al (2002) Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet 359:1734–1739

Llovet JM, Bruix J, for the Barcelona-Clínic Liver Cancer Group (2003) Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolisation improves survival. Hepatology 37:429–442

Marelli L, Stigliano R, Triantos C et al (2007) Transarterial therapy for hepatocellular carcinoma: Which technique is more effective? A systematic review of cohort and randomized studies. Cardiovasc Interv Radiol 30:6–25

Lewis AL, Gonzales MV, Lloyd AW et al (2006) DC Bead: in vitro characterisation of a drug-delivery device for transarterial chemoembolisation. J Vasc Interv Radiol 17:335–342

Lewis AL, Gonzalez MV, Leppard SW et al (2007) Doxorubicin eluting beads. 1. Effects of drug loading on bead characteristics and drug distribution. J Mater Sci Mater Med 18:1691–1699

Lewis AL, Taylor RR, Hall B et al (2006) Pharmacokinetic and safety study of doxorubicin-eluting beads in a porcine model of hepatic arterial embolisation. J Vasc Interv Radiol 17:1335–1343

Hong K, Khwaja A, Liapi E et al (2006) New intra-arterial drug delivery system for the treatment of liver cancer: preclinical assessment in a rabbit model of liver cancer. Clin Cancer Res 12:2563–2567

Varela M, Real MI, Burrel M et al (2007) Chemoembolisation of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics. J Hepatol 46:474–481

Poon RT, Tso WK, Pang RW et al (2007) A phase I/II trial of chemoembolisation for hepatocellular carcinoma using a novel intra-arterial drug-eluting bead. Clin Gastroenterol Hepatol 5:1100–1108

Kettenbach J, Stadler A, Katzler IV et al (2008) Drug-loaded microspheres for the treatment of liver cancer: review of current results. Cardiovasc Interv Radiol 31:468–476

Malagari K, Chatzimichael K, Alexopöulou E et al (2008) Transarterial chemoembolisation of unresectable hepatocellular carcinoma with drug eluting beads: results of an open-label study of 62 patients. Cardiovasc Interv Radiol 31:269–280

Llovet JM, Di Bisceglie AM, Bruix J, Panel of Experts in HCC-Design Clinical Trials et al (2008) Design and endpoints of clinical trials in hepatocellular carcinoma. J Natl Cancer Inst 100:698–711

Moher D, Schulz KF, Altman DG (2001) The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet 357:1191–1194

Hopewell S, Clarke M, Moher D et al (2008) CONSORT Group. CONSORT for reporting randomised trials in journal and conference abstracts. Lancet 371:281–283

Bruix J, Sherman M, Llovet JM et al (2001) Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 35:421–430

Wang SK, Tsiatis AA (1987) Approximately optional one-parameter boundaries for group sequential trials. Biometrics 43:193–199

Satake M, Uchida H, Arai Y et al (2008) Transcatheter arterial chemoembolization (TACE) with lipiodol to treat hepatocellular carcinoma: survey results from the TACE study group of Japan. Cardiovasc Interv Radiol 31:756–761

Grosso M, Vignali C, Quaretti P et al (2008) Transarterial chemoembolization of hepatocellular carcinoma with drug-eluting microspheres: preliminary results from an Italian multicenter study. Cardiovasc Interv Radiol 31:1141–1149