Proposed biological linkages between obesity, stress, and inefficient uterine contractility during labor in humans

Hamilton, 2010, Births: preliminary data for 2008, Natl Vital Stat Rep, 58, 1

US Department of Health and Human Services. Healthy People 2010. McLean, VA: International Medical Publishing; 2001.

Centers for Disease Control and Prevention. DATA2010 Objective: 16-09a. The Healthy People 2010 Database, January, 2010 Edition.

Gifford, 2000, Lack of progress in labor as a reason for cesarean, Obstet Gynecol, 95, 589, 10.1016/S0029-7844(99)00575-X

Ness, 2005, Abnormalities of the first and second stages of labor, Obstet Gynecol Clin North Am, 32, 201, 10.1016/j.ogc.2005.01.007

Lowe, 2007, A review of factors associated with dystocia and cesarean section in nulliparous women, J Midwifery Womens Health, 52, 216, 10.1016/j.jmwh.2007.03.003

Wray, 2007, Insights into the uterus, Exp Physiol, 92, 621, 10.1113/expphysiol.2007.038125

Lowe, 2010, 1086

Friedman, 1979, Plasma catecholamines during pregnancy and parturition: a new approach to their relationship, vol. 2, 741

Sanborn, 2001, Hormones and calcium: mechanisms controlling uterine smooth muscle contractile activity, Exp Physiol, 86, 223, 10.1113/eph8602179

Neal, 2010, Active phase labor length and rate of cervical dilation in nulliparous women: a systematic review, J Midwifery Womens Health, 55, 308, 10.1016/j.jmwh.2009.08.004

Bergant, 1998, Childbirth as a biological model for stress? Associations with endocrine and obstetric factors, Gynecol Obstet Invest, 45, 181, 10.1159/000009952

Chan, 1993, Plasma corticotropin-releasing hormone, β-endorphin and cortisol inter-relationship during human pregnancy, Acta Endocrinol, 128, 339, 10.1530/acta.0.1280339

Jouppila, 1984, Maternal and umbilical cord plasma noradrenaline concentrations during labour with and without segmental extradural analgesia, and during caesarean section, Br J Anaesth, 56, 251, 10.1093/bja/56.3.251

Lederman, 1977, Endogenous plasma epinephrine and norepinephrine in last-trimester pregnancy and labor, Am J Obstet Gynecol, 129, 5, 10.1016/0002-9378(77)90809-2

Mahomed, 1995, Labor experience, maternal mood and cortisol and catecholamine levels in low-risk primiparaous women, J Psychosom Obstet Gynaecol, 16, 181, 10.3109/01674829509024467

Maltau, 1979, Effect of stress during labor on the concentration of cortisol and estriol in maternal plasma, Am J Obstet Gynecol, 134, 681, 10.1016/0002-9378(79)90650-1

Newmark, 1985, Effects of epidural analgesia on plasma catecholamines and cortisol in parturition, Acta Anaesthesiol Scand, 29, 555, 10.1111/j.1399-6576.1985.tb02253.x

Scull, 1998, Epidural analgesia in early labour blocks the stress response but uterine contractions remain unchanged, Can J Anaesth, 45, 626, 10.1007/BF03012090

Smith, 1990, Mood changes, obstetric experience and alterations in plasma cortisol, beta-endorphin and corticotrophin releasing hormone during pregnancy and the puerperium, J Psychosom Res, 34, 53, 10.1016/0022-3999(90)90008-R

Crammond, 1954, Psychological aspects of uterine dysfunction, Lancet, 2, 1241, 10.1016/S0140-6736(54)92044-9

Kapp, 1963, Some psychologic factors in prolonged labor due to inefficient uterine action, Compr Psychiatry, 4, 9, 10.1016/S0010-440X(63)80066-8

Mac Donald, 1963, Relationship of emotional adjustment during pregnancy to obstetric complications, Am J Obstet Gynecol, 86, 341, 10.1016/0002-9378(63)90010-3

Zuspan, 1962, Myometrial and cardiovascular responses to alterations in plasma epinephrine and norepinephrine, Am J Obstet Gynecol, 84, 841, 10.1016/0002-9378(62)90057-1

Lederman, 1978, The relationship of maternal anxiety, plasma catecholamines, and plasma cortisol to progress in labor, Am J Obstet Gynecol, 132, 495, 10.1016/0002-9378(78)90742-1

Lederman, 1979, Relationship of psychological factors in pregnancy to progress in labor, Nurs Res, 28, 94, 10.1097/00006199-197903000-00012

Lederman, 1981, Maternal psychological and physiologic correlates of fetal-newborn health status, Am J Obstet Gynecol, 139, 956, 10.1016/0002-9378(81)90967-4

Alehagen, 2001, Catecholamine and cortisol reaction to childbirth, Int J Behav Med, 8, 50, 10.1207/S15327558IJBM0801_04

Grenman, 1986, Epidural and paracervical blockades in obstetrics, Acta Obstet Gynecol Scand, 65, 699

Jones, 1985, Plasma catecholamines and modes of delivery: the relation between catecholamine levels and in-vitro platelet aggregation and adrenoreceptor radioligand binding characteristics, Br J Obstet Gynaecol, 92, 593, 10.1111/j.1471-0528.1985.tb01397.x

Shnider, 1983, Maternal catecholamines decrease during labor after lumbar epidural anesthesia, Am J Obstet Gynecol, 147, 13, 10.1016/0002-9378(83)90076-5

Lundberg, 2000, Catecholamines, 408

Alehagen, 2005, Fear, pain and stress hormones during childbirth, J Psychosom Obstet Gynaecol, 26, 153, 10.1080/01443610400023072

Westgren, 1986, Maternal and fetal endocrine stress response at vaginal delivery with and without an epidural block, J Perinat Med, 14, 235, 10.1515/jpme.1986.14.4.235

Price, 2000, Adenylyl cyclase isoforms in pregnant and non-pregnant human myometrium, J Endocrinol, 164, 21, 10.1677/joe.0.1640021

Adamsons, 1999, Reduction in the cesarean section rate in nulliparous patients after administration of intravenous propranolol, Puerto Rico Health Sci J, 18, 5

Sanchez-Ramos, 1996, Randomized trial of oxytocin along and with propranolol in the management of dysfunctional labor, Obstet Gynecol, 88, 517, 10.1016/0029-7844(96)00223-2

Simpkin, 1999, Effects of corticotrophin releasing hormone on contractile activity of myometrium from pregnant women, Br J Obstet Gynaecol, 106, 439, 10.1111/j.1471-0528.1999.tb08297.x

Vahratian, 2009, Prevalence of overweight and obesity among women of childbearing age: results from the 2002 National Survey of Family Growth, Matern Child Health J, 13, 268, 10.1007/s10995-008-0340-6

Heslehurst, 2010, A nationally representative study of maternal obesity in England, UK: trends in incidence and demographic inequalities in 619, 323 births, 1989–2007, Int J Obes (Lond), 34, 420, 10.1038/ijo.2009.250

Centers for Disease Control and Prevention. DATA2010 Objective: 19-02. Healthy People 2010 Database, January 2010 Edition.

Thomson, 1988, Factors predisposing to difficult labor in primiparas, Am J Obstet Gynecol, 158, 1074, 10.1016/0002-9378(88)90223-2

Denison, 2008, Maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term, Br J Obstet Gynaecol, 115, 720, 10.1111/j.1471-0528.2008.01694.x

Olsen, 2006, Prenatal risk indicators of a prolonged pregnancy. The Danish Birth Cohort 1998–2001, Acta Obstet Gynecol, 85, 1338, 10.1080/00016340600935508

Nuthalapaty, 2004, The association of maternal weight with cesarean risk, labor duration, and cervical dilation rate during labor induction, Obstet Gynecol, 103, 452

Pevzner, 2009, Effects of maternal obesity on duration and outcomes of prostaglandin cervical ripening and labor induction, Obstet Gynecol, 114, 1315, 10.1097/AOG.0b013e3181bfb39f

Vahratian, 2004, Maternal prepregnancy overweight and obesity and the pattern of labor progression in term nulliparous women, Obstet Gynecol, 104, 943, 10.1097/01.AOG.0000142713.53197.91

Baeten, 2001, Pregnancy complications and outcomes among overweight and obese nulliparous women, Am J Pub Health, 91, 436, 10.2105/AJPH.91.3.436

Dietz, 2005, Population-based assessment of the risk of primary cesarean delivery due to excess prepregnancy weight among nulliparous women delivering term infants, Matern Child Health J, 9, 237, 10.1007/s10995-005-0003-9

Kaiser, 2001, Obesity as a risk factor for cesarean in a low-risk population, Obstet Gynecol, 97, 39, 10.1016/S0029-7844(00)01078-4

Rode, 2005, Obesity-related complications in Danish single cephalic term pregnancies, Obstet Gynecol, 105, 537, 10.1097/01.AOG.0000152304.39492.1c

Vahratian, 2005, Maternal pre-pregnancy overweight and obesity and the risk of cesarean delivery in nulliparous women, Ann Epidemiol, 15, 467, 10.1016/j.annepidem.2005.02.005

Weiss, 2004, Obesity, obstetric complications and cesarean delivery rate – a population-based screening study, Am J Obstet Gynecol, 190, 1091, 10.1016/j.ajog.2003.09.058

Young, 2002, Factors that are associated with cesarean delivery in a large private practice. the importance of prepregnancy body mass index and weight gain, Am J Obstet Gynecol, 187, 312, 10.1067/mob.2002.126200

Poobalan, 2009, Obesity as an independent risk factor for elective and emergency cesarean delivery in nulliparous women – systematic review and meta-analysis of cohort studies, Obes Rev, 10, 28, 10.1111/j.1467-789X.2008.00537.x

Smith, 2004, Increased cholesterol decreases uterine activity: functional effects of cholesterol alteration in pregnant rat myometrium, Am J Physiol Cell Physiol, 288, C932

Gostynski, 2004, Analysis of the relationship between total cholesterol, age, body mass index among males and females in the WHO MONICA project, Int J Obes, 28, 1082, 10.1038/sj.ijo.0802714

Zhang, 2007, Poor uterine contractility in obese women, Br J Obstet Gynaecol, 114, 343, 10.1111/j.1471-0528.2006.01233.x

Zhang, 2007, Contractility and calcium signaling of human myometrium are profoundly affected by cholesterol manipulation: implications for labor?, Reprod Sci, 14, 456, 10.1177/1933719107306229

Noble, 2006, Lipid rafts, the sarcoplasmic reticulum and uterine calcium signalling: an integrated approach, J Physiol, 570, 29, 10.1113/jphysiol.2005.098475

Brainard, 2005, Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current, Am J Physiol Cell Physiol, 289, C49, 10.1152/ajpcell.00399.2004

Hauner, 2005, Secretory factors from human adipose tissue and their functional role, Proc Nutr Soc, 64, 163, 10.1079/PNS2005428

Domali, 2002, Leptin in pregnancy, J Matern Fetal Neonatal Med, 12, 222, 10.1080/jmf.12.4.222.230

Hardie, 1997, Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy, Clin Endocrinol (Oxf), 47, 101, 10.1046/j.1365-2265.1997.2441017.x

Schubring, 1998, Longitudinal analysis of maternal serum leptin levels during pregnancy, at birth and up to six weeks after birth: relation to body mass index, skinfolds, sex steroids and umbilical cord blood leptin levels, Horm Res, 50, 276, 10.1159/000023290

Eriksson, 2010, Body fat, insulin resistance, energy expenditure and serum concentrations of leptin, adiponectin and resistin before, during and after pregnancy in healthy Swedish women, Br J Nutr, 103, 50, 10.1017/S0007114509991371

Highman, 1998, Longitudinal changes in maternal serum leptin concentrations, body composition, and resting metabolic rate in pregnancy, Am J Obstet Gynecol, 178, 1010, 10.1016/S0002-9378(98)70540-X

Moynihan, 2006, Inhibitory effect of leptin on human uterine contractility in vitro, Am J Obstet Gynecol, 195, 504, 10.1016/j.ajog.2006.01.106

Markowska, 2005, Leptin and leptin receptor expression in the myometrium and uterine myomas: is leptin involved in tumor development?, Int J Oncol, 27, 1505

O’Malley, 2005, Leptin-induced dynamic changes in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels, FASEB J, 19, 1917, 10.1096/fj.05-4166fje