Prophylaxis of acute GVHD: manipulate the graft or the environment?

Billingham, 1966, The biology of graft-versus-host reactions, Harvey Lectures, 62, 21 Hensel, 1999, A technique for dual determination of cytotoxic and helper lymphocyte precursor frequency by a miniaturized dye release method, Bone Marrow Transplantation, 23, 71, 10.1038/sj.bmt.1701528 Holler, 2007, Risk assessment in haematopoietic stem cell transplantation: GVHD prevention and treatment, Best Practice & Research. Clinical Haematology, 20, 281, 10.1016/j.beha.2006.10.001 Barrett, 1998, T cell-depleted bone marrow transplantation and delayed T cell add-back to control acute GVHD and conserve a graft-versus-leukemia effect, Bone Marrow Transplantation, 21, 543, 10.1038/sj.bmt.1701131 Elhasid, 2007, Safe and efficacious allogeneic bone marrow transplantation for nonmalignant disorders using partial T cell depletion and no posttransplantation graft-versus-host-disease prophylaxis, Biology of Blood and Marrow Transplantaion, 13, 329, 10.1016/j.bbmt.2006.10.028 Drobyski, 1999, T-cell depletion plus salvage immunotherapy with donor leukocyte infusions as a strategy to treat chronic-phase chronic myelogenous leukemia patients undergoing HLA-identical sibling marrow transplantation, Blood, 94, 434, 10.1182/blood.V94.2.434 Kalaycio, 2005, CD8+ T-cell-depleted, matched unrelated donor, allogeneic bone marrow transplantation for advanced AML using busulfan-based preparative regimens, Bone Marrow Transplantation, 35, 247, 10.1038/sj.bmt.1704736 Meyer, 2007, Prophylactic transfer of CD8-depleted donor lymphocytes after T-cell-depleted reduced-intensity transplantation, Blood, 109, 374, 10.1182/blood-2006-03-005769 Bishop, 2004, Targeted pretransplant host lymphocyte depletion prior to T-cell depleted reduced-intensity allogeneic stem cell transplantation, British Journal of Haematology, 126, 837, 10.1111/j.1365-2141.2004.05133.x Mielke, 2005, Selective depletion strategies in allogeneic stem cell transplantation, Cytotherapy, 7, 109, 10.1080/14653240510018172 André-Schmutz, 2002, Immune reconstitution without graft-versus-host disease after haemopoietic stem-cell transplantation: a phase 1/2 study, Lancet, 360, 130, 10.1016/S0140-6736(02)09413-8 Solomon, 2005, Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation, Blood, 106, 1123, 10.1182/blood-2005-01-0393 Amrolia, 2003, Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses, Blood, 102, 2292, 10.1182/blood-2002-11-3516 Mielke, 2007, A clinical scale selective allodepletion approach for the treatment of HLA-mismatched and matched donor-recipient pairs using expanded T lymphocytes as antigen-presenting cells and a TH9402-based photodepletion technique, Blood Bondanza, 2006, Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes, Blood, 107, 1828, 10.1182/blood-2005-09-3716 Bonini, 2007, The suicide gene therapy challenge: how to improve a successful gene therapy approach, Molecular Therapy, 15, 1248, 10.1038/sj.mt.6300190 Schmitz, 2002, Optimizing engraftment–source and dose of stem cells, Seminars in Hematology, 39, 3, 10.1053/shem.2002.29245 Heimfeld, 2003, HLA-identical stem cell transplantation: is there an optimal CD34 cell dose?, Bone Marrow Transplantation, 31, 839, 10.1038/sj.bmt.1704019 Ruggeri, 2006, Natural killer cell alloreactivity and haplo-identical hematopoietic transplantation, Cytotherapy, 8, 554, 10.1080/14653240601078721 Savani, 2007, Rapid natural killer cell recovery determines outcome after T-cell-depleted HLA-identical stem cell transplantation in patients with myeloid leukemias but not with acute lymphoblastic leukemia, Leukemia, 21, 2145, 10.1038/sj.leu.2404892 Miller, 2005, Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer, Blood, 105, 3051, 10.1182/blood-2004-07-2974 Koç, 2000, Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy, Journal of Clinical Oncology, 18, 307, 10.1200/JCO.2000.18.2.307 Lazarus, 2005, Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients, Biology of Blood and Marrow Transplantation, 11, 389, 10.1016/j.bbmt.2005.02.001 Le Blanc, 2007, Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells, Leukemia, 21, 1733, 10.1038/sj.leu.2404777 Ball, 2007, Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation, Blood, 110, 2764, 10.1182/blood-2007-04-087056 Le Blanc, 2004, Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells, Lancet, 363, 1439, 10.1016/S0140-6736(04)16104-7 Ringden, 2006, Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease, Transplantation, 81, 1390, 10.1097/01.tp.0000214462.63943.14 Storb, 1989, Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: long-term follow-up of a controlled trial, Blood, 73, 1729, 10.1182/blood.V73.6.1729.1729 Ringden, 1993, Methotrexate, cyclosporine, or both to prevent graft-versus-host disease after HLA-identical sibling bone marrow transplants for early leukemia?, Blood, 81, 1094, 10.1182/blood.V81.4.1094.1094 Bacigalupo, 1991, Increased risk of leukemia relapse with high-dose cyclosporine A after allogeneic marrow transplantation for acute leukemia, Blood, 77, 1423, 10.1182/blood.V77.7.1423.1423 Locatelli, 2000, Graft versus host disease prophylaxis with low-dose cyclosporine-A reduces the risk of relapse in children with acute leukemia given HLA-identical sibling bone marrow transplantation: results of a randomized trial, Blood, 95, 1572, 10.1182/blood.V95.5.1572.005k12_1572_1579 Nash, 2000, Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors, Blood, 96, 2062 Le Blanc, 2004, A comparison of nonmyeloablative and reduced-intensity conditioning for allogeneic stem-cell transplantation, Transplantation, 78, 1014, 10.1097/01.TP.0000129809.09718.7E Hartford, 2007, Rapamycin: something old, something new, sometimes borrowed and now renewed, Clinical Pharmacology & Therapeutics, 82, 381, 10.1038/sj.clpt.6100317 Cutler, 2007, Extended follow-up of methotrexate-free immunosuppression using sirolimus and tacrolimus in related and unrelated donor peripheral blood stem cell transplantation, Blood, 109, 3108, 10.1182/blood-2006-09-046219 Peggs, 2007, Reduced-intensity conditioning for allogeneic haematopoietic stem cell transplantation in relapsed and refractory Hodgkin lymphoma: impact of alemtuzumab and donor lymphocyte infusions on long-term outcomes, British Journal of Haematology, 139, 70, 10.1111/j.1365-2141.2007.06759.x Mohty, 2007, Mechanisms of action of antithymocyte globulin: T-cell depletion and beyond, Leukemia, 21, 1387, 10.1038/sj.leu.2404683 Ogawa, 2006, Unmanipulated HLA 2-3 antigen-mismatched (haploidentical) stem cell transplantation using nonmyeloablative conditioning, Biology of Blood and Marrow Transplantation, 12, 1073, 10.1016/j.bbmt.2006.06.007 Mielcarek, 2007, Comparable outcomes after nonmyeloablative hematopoietic cell transplantation with unrelated and related donors, Biology of Blood and Marrow Transplantation, 13, 1499, 10.1016/j.bbmt.2007.09.004 Remberger, 2007, Risk factors for acute graft-versus-host disease grades II-IV after reduced intensity conditioning allogeneic stem cell transplantation with unrelated donors-a single centre study, Bone Marrow Transplantation Hirshfeld, 2006, Bone Marrow Transplantation, 38, 359, 10.1038/sj.bmt.1705449 Chen, 2007, Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse, Blood, 109, 3115, 10.1182/blood-2006-04-016410 Salomon, 2006, Regulatory T cells in graft-versus-host disease, Springer Seminars in Immunopathology, 28, 25, 10.1007/s00281-006-0020-9 Mielke, 2007, Reconstitution of FOXP3+ regulatory T cells (Tregs) after CD25-depleted allotransplantation in elderly patients and association with acute graft-versus-host disease, Blood, 110, 1689, 10.1182/blood-2007-03-079160 Rezvani, 2006, High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT, Blood, 15, 1291, 10.1182/blood-2006-02-003996 Anderson, 2005, Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ, Blood, 105, 2227, 10.1182/blood-2004-08-3032 Dimitroff, 2003, Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen, The Journal of Clinical Investigation, 112, 980, 10.1172/JCI19220 Fry, 2005, Immune reconstitution following hematopoietic progenitor cell transplantation: challenges for the future, Bone Marrow Transplantation, 35, S53, 10.1038/sj.bmt.1704848 Barrett, 2006, Improving outcome of allogeneic stem cell transplantation by immunomodulation of the early post-transplant environment, Current Opinion in Immunology, 18, 592, 10.1016/j.coi.2006.06.002