Prophylactic lithium treatment and cognitive performance in patients with a long history of bipolar illness: no simple answers in complex disease-treatment interplay

Andrea Pfennig1, Martin Alda2,3, Trevor Young4,3, Glenda MacQueen5,3, Janusz Rybakowski6,3, Aleksandra Suwalska6,3, Christian Simhandl7,3, Barbara König7,3, Tomáš Hájek2,3, Claire O’Donovan2,3, Dirk Alexander Wittekind1, Susanne von Quillfeldt8, Jana Ploch1, Cathrin Sauer1, Michael Bauer1
1Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Fetscherstrasse 74, Dresden, 01307, Germany
2Department of Psychiatry, Dalhousie University, Halifax, Canada
3International Group for the Study of Lithium-Treated Patients (IGSLi), Berlin, Germany
4Department of Psychiatry, University of British Columbia Faculty of Medicine, Vancouver, Canada
5Department of Psychiatry, Faculty of Medicine, University of Calgary, Calgary, Canada
6Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
7Department of Psychiatry, Hospital Neunkirchen, CS now: Bipolar Centre, Vienna, Austria
8Department of Psychiatry and Psychotherapy, Charité Berlin, Campus Mitte, Berlin, Germany

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Andreou C, Bozikas VP: The predictive significance of neurocognitive factors for functional outcome in bipolar disorder. Curr Opin Psychiatry 2013,26(1):54–59. 10.1097/YCO.0b013e32835a2acf

Bauer M, Alda M, Priller J, Young LT: The International Group for The Study of Lithium Treated Patients (IGSLi): Implications of the neuroprotective effects of lithium for the treatment of bipolar and neurodegenerative disorders. Pharmacopsychiatry 2003,36(Suppl 3):250–254.

Bearden CE, Hoffman KM, Cannon TD: The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review. Bipolar Disord 2001,3(3):106–150. 10.1034/j.1399-5618.2001.030302.x

Beck AT, WARD CH, MENDELSON M, MOCK J, ERBAUGH J: An inventory for measuring depression. Arch Gen Psychiatry 1961, 4: 561–571. 10.1001/archpsyc.1961.01710120031004

Blumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JH, Gore JC, Charney DS, Krystal JH, Peterson BS: Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Arch Gen Psychiatry 2003,60(12):1201–1208. 10.1001/archpsyc.60.12.1201

Bora E, Yucel M, Pantelis C: Cognitive impairment in affective psychoses: a meta-analysis. Schizophr Bull 2010,36(1):112–125. 10.1093/schbul/sbp093

Bourne C, Aydemir Ö, Balanzá-Martínez V, Bora E, Brissos S, Cavanagh JT, Clark L, Cubukcuoglu Z, Dias VV, Dittmann S, Ferrier IN, Fleck DE, Frangou S, Gallagher P, Jones L, Kieseppä T, Martínez-Aran A, Melle I, Moore PB, Mur M, Pfennig A, Raust A, Senturk V, Simonsen C, Smith DJ, Bio DS, Soeiro-de-Souza MG, Stoddart SD, Sundet K, Szöke A, Thompson JM, Torrent C, Zalla T, Craddock N, Andreassen OA, Leboyer M, Vieta E, Bauer M, Worhunsky PD, Tzagarakis C, Rogers RD, Geddes JR, Goodwin GM: Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis. Acta Psychiatr Scand 2013,128(3):149–162. 10.1111/acps.12133

Chepenik LG, Wang F, Spencer L, Spann M, Kalmar JH, Womer F, Kale EE, Pittman B, Blumberg HP: Structure-function associations in hippocampus in bipolar disorder. Biol Psychol 2012,90(1):18–22. 10.1016/j.biopsycho.2012.01.008

Daban C, Martinez-Aran A, Torrent C, Tabares-Seisdedos R, Balanza-Martinez V, Salazar-Fraile J, Selva-Vera G, Vieta E: Specificity of cognitive deficits in bipolar disorder versus schizophrenia. A systematic review. Psychother Psychosom 2006,75(2):72–84. 10.1159/000090891

Delis DC, Kramer JH, Kaplan E, Ober BA: California Verbal Learning Test. Tex. The Psychological Cooperation, San Antonio; 1988.

Engelsmann F, Katz J, Ghadirian AM, Schachter D: Lithium and memory: a long-term follow-up study. J Clin Psychopharmacol 1988,8(3):207–212.

Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH: Neurogenesis in the adult human hippocampus. Nat Med 1998,4(11):1313–1317. 10.1038/3305

Fleck DE, Shear PK, Zimmerman ME, Getz GE, Corey KB, Jak A, Lebowitz BK, Strakowski SM: Verbal memory in mania: effects of clinical state and task requirements. Bipolar Disord 2003,5(5):375–380. 10.1034/j.1399-5618.2003.00055.x

Fleming K, Green MF: Backward masking performance during and after manic episodes. J Abnorm Psychol 1995,104(1):63–68. 10.1037/0021-843X.104.1.63

Goldberg JF, Chengappa KN: Identifying and treating cognitive impairment in bipolar disorder. Bipolar Disord 2009,11(Suppl 2):123–137. 10.1111/j.1399-5618.2009.00716.x

Green MF, Nuechterlein KH, Mintz J: Backward masking in schizophrenia and mania. I. Specifying a mechanism. Arch Gen Psychiatry 1994,51(12):939–944. 10.1001/archpsyc.1994.03950120011003

Green MF, Nuechterlein KH, Mintz J: Backward masking in schizophrenia and mania. II. Specifying the visual channels. Arch Gen Psychiatry 1994,51(12):945–951. 10.1001/archpsyc.1994.03950120017004

Hajek T, Bauer M, Pfennig A, Cullis J, Ploch J, O’Donovan C, Bohner G, Klingebiel R, Young LT, MacQueen GM, Alda M: Large positive effect of lithium on prefrontal cortex N-acetylaspartate in patients with bipolar disorder: 2-centre study. J Psychiatry Neurosci 2012,37(3):185–192. 10.1503/jpn.110097

Hajek T, Bauer M, Simhandl C, Rybakowski J, O’Donovan C, Pfennig A, Konig B, Suwalska A, Yucel K, Uher R, Young LT, Macqueen G, Alda M: Neuroprotective effect of lithium on hippocampal volumes in bipolar disorder independent of long-term treatment response. Psychol Med 2014,44(3):507–517. 10.1017/S0033291713001165

Hamilton M: A rating scale for depression. J Neurol Neurosurg Psychiatry 1960, 23: 56–62. 10.1136/jnnp.23.1.56

Jamrozinski K: Do euthymic bipolar patients have normal cognitive functioning? Curr Opin Psychiatry 2010,23(3):255–260. 10.1097/YCO.0b013e328338620a

Jorm AF: History of depression as a risk factor for dementia: an updated review. Aust N Z J Psychiatry 2001,35(6):776–781. 10.1046/j.1440-1614.2001.00967.x

Kaplan RM, Ganiats TG, Sieber WJ, Anderson JP: The Quality of Well-Being Scale: critical similarities and differences with SF-36. Int J Qual Health Care 1998,10(6):509–520. 10.1093/intqhc/10.6.509

Kempermann G, Gage FH: Experience-dependent regulation of adult hippocampal neurogenesis: effects of long-term stimulation and stimulus withdrawal. Hippocampus 1999,9(3):321–332. 10.1002/(SICI)1098-1063(1999)9:3<321::AID-HIPO11>3.0.CO;2-C

Kessing LV, Andersen PK: Does the risk of developing dementia increase with the number of episodes in patients with depressive disorder and in patients with bipolar disorder? J Neurol Neurosurg Psychiatry 2004,75(12):1662–1666. 10.1136/jnnp.2003.031773

Kessing LV, Nilsson FM: Increased risk of developing dementia in patients with major affective disorders compared to patients with other medical illnesses. J Affect Disord 2003,73(3):261–269. 10.1016/S0165-0327(02)00004-6

Kessing LV, Forman JL, Andersen PK: Does lithium protect against dementia? Bipolar Disord 2010,12(1):87–94. 10.1111/j.1399-5618.2009.00788.x

Lyoo IK, Dager SR, Kim JE, Yoon SJ, Friedman SD, Dunner DL, Renshaw PF: Lithium-induced gray matter volume increase as a neural correlate of treatment response in bipolar disorder: a longitudinal brain imaging study. Neuropsychopharmacology 2010,35(8):1743–1750.

MacQueen GM, Young LT, Galway TM, Joffe RT: Backward masking task performance in stable, euthymic out-patients with bipolar disorder. Psychol Med 2001,31(7):1269–1277. 10.1017/S0033291701004597

MacQueen GM, Grof P, Alda M, Marriott M, Young LT, Duffy A: A pilot study of visual backward masking performance among affected versus unaffected offspring of parents with bipolar disorder. Bipolar Disord 2004,6(5):374–378. 10.1111/j.1399-5618.2004.00133.x

Martinez-Aran A, Vieta E, Reinares M, Colom F, Torrent C, Sanchez-Moreno J, Benabarre A, Goikolea JM, Comes M, Salamero M: Cognitive function across manic or hypomanic, depressed, and euthymic states in bipolar disorder. Am J Psychiatry 2004,161(2):262–270. 10.1176/appi.ajp.161.2.262

Martino DJ, Strejilevich SA, Marengo SA, Marengo E, Ibanez A, Scapola M, Igoa A: Toward the identification of neurocognitive subtypes in euthymic patients with bipolar disorder. J Affect Disord 2014, 167: 118–124. 10.1016/j.jad.2014.05.059

Moore GJ, Bebchuk JM, Wilds IB, Chen G, Manji HK, Menji HK: Lithium-induced increase in human brain grey matter. Lancet 2000,356(9237):1241–1242. 10.1016/S0140-6736(00)02793-8

Mora E, Portella MJ, Forcada I, Vieta E, Mur M: Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study. Psychol Med 2013,43(6):1187–1196. 10.1017/S0033291712001948

Pachet AK, Wisniewski AM: The effects of lithium on cognition: an updated review. Psychopharmacology (Berl) 2003,170(3):225–234. 10.1007/s00213-003-1592-x

Reischies FM, Neu P: Comorbidity of mild cognitive disorder and depression - a neuropsychological analysis. Eur Arch Psychiatry Clin Neurosci 2000,250(4):186–193. 10.1007/s004060070023

Robinson LJ, Thompson JM, Gallagher P, Goswami U, Young AH, Ferrier IN, Moore PB: A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. J Affect Disord 2006,93(1–3):105–115. 10.1016/j.jad.2006.02.016

Rybakowski JK, Suwalska A: Excellent lithium responders have normal cognitive functions and plasma BDNF levels. Int J Neuropsychopharmacol 2010,13(5):617–622. 10.1017/S1461145710000404

Selvaraj S, Arnone D, Job D, Stanfield A, Farrow TF, Nugent AC, Scherk H, Gruber O, Chen X, Sachdev PS, Dickstein DP, Malhi GS, Ha TH, Ha K, Phillips ML, McIntosh AM: Grey matter differences in bipolar disorder: a meta-analysis of voxel-based morphometry studies. Bipolar Disord 2012,14(2):135–145. 10.1111/j.1399-5618.2012.01000.x

Smigan L, Perris C: Memory functions and prophylactic treatment with lithium. Psychol Med 1983,13(3):529–536. 10.1017/S0033291700047954

Spearing MK, Post RM, Leverich GS, Brandt D, Nolen W: Modification of the Clinical Global Impressions (CGI) Scale for use in bipolar illness (BP): the CGI-BP. Psychiatry Res 1997,73(3):159–171. 10.1016/S0165-1781(97)00123-6

Sutton LP, Rushlow WJ: The effects of neuropsychiatric drugs on glycogen synthase kinase-3 signaling. Neuroscience 2011, 199: 116–124. 10.1016/j.neuroscience.2011.09.056

Tariot PN, Schneider LS, Cummings J, Thomas RG, Raman R, Jakimovich LJ, Loy R, Bartocci B, Fleisher A, Ismail MS, Porsteinsson A, Weiner M, Jack CR Jr, Thal L, Aisen PS: Alzheimer’s disease cooperative study group. Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease. Arch Gen Psychiatry 2011,68(8):853–861. 10.1001/archgenpsychiatry.2011.72

Tewes U: Hamburg-Wechsler-Intelligenztest für Erwachsene - Revision 1991 (HAWIE-R). Huber, Bern, Stuttgart, Toronto; 1991.

Trivedi JK, Goel D, Sharma S, Singh AP, Sinha PK, Tandon R: Cognitive functions in stable schizophrenia & euthymic state of bipolar disorder. Indian J Med Res 2007,126(5):433–439.

Turner AD, Furey ML, Drevets WC, Zarate C Jr, Nugent AC: Association between subcortical volumes and verbal memory in unmedicated depressed patients and healthy controls. Neuropsychologia 2012,50(9):2348–2355. 10.1016/j.neuropsychologia.2012.06.003

Ware JJ, Snow K, Kosinski M, Gandek B: SF-36 Health Survey: manual and interpretation guide. Nimrod Press, Boston; 1993.

Ware J, Kosinski M, Keller S: SF-36 Physical and Mental Health Summary Scales: a user’s manual. The Health Institute, New England Medical Center, Boston, MA; 1994.

Wingo AP, Wingo TS, Harvey PD, Baldessarini RJ: Effects of lithium on cognitive performance: a meta-analysis. J Clin Psychiatry 2009,70(11):1588–1597. 10.4088/JCP.08r04972

Young RC, Biggs JT, Ziegler VE, Meyer DA: A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978, 133: 429–435. 10.1192/bjp.133.5.429