Prolongation of skin graft survival in mice by in vitro PUVA treatment and failure of induction of specific immunological memory by PUVA-treated grafts

Springer Science and Business Media LLC - Tập 276 - Trang 82-85 - 1984
S. Gruner1, H. Meffert2, E. Karasek3, N. Sönnichsen2
1Department of Clinical Immunology, Humboldt University, Berlin, German Democratic Republic
2Department of Dermatology, Humboldt University, Berlin, German Democratic Republic
3Department for Laboratory Animal Breeding, Central Institute for Cancer Research, Academy of Sciences GDR, Berlin, German Democratic Republic

Tóm tắt

Treatment of murine skin grafts in vitro with 8-methoxypsoralen and longwave ultraviolet radiation prolonged their subsequent survival on allogeneic recipients, but not in cases where the recipients had been presensitized by a former skin graft of the same donor strain. In contrast to normal skin, grafts pretreated with 8-methoxypsoralen and longwave ultraviolet radiation were not able to induce an immunological memory as revealed by a second transplantation of normal skin. The results show that primary and secondary skin graft rejections can be affected by the combined action of psoralen and ultraviolet radiation.

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