Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
Tóm tắt
Từ khóa
Tài liệu tham khảo
Alva, 2011, Phosphatase and tensin homolog regulates the pluripotent state and lineage fate choice in human embryonic stem cells, Stem Cells, 29, 1952, 10.1002/stem.748
Armstrong, 2006, The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis, Hum. Mol. Genet., 15, 1894, 10.1093/hmg/ddl112
Bar-Peled, 2012, Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1, Cell, 150, 1196, 10.1016/j.cell.2012.07.032
Betschinger, 2013, Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3, Cell, 153, 335, 10.1016/j.cell.2013.03.012
Bi, 1999, Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase, J. Biol. Chem., 274, 10963, 10.1074/jbc.274.16.10963
Bi, 2002, Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase, Mamm. Genome, 13, 169, 10.1007/s00335-001-2123-x
Carey, 2015, Intracellular alpha-ketoglutarate maintains the pluripotency of embryonic stem cells, Nature, 518, 413, 10.1038/nature13981
Carroll, 2016, Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity, eLife, 5, e11058, 10.7554/eLife.11058
Chen, 2001, Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene, Genes Dev., 15, 2203, 10.1101/gad.913901
Cheng, 2014, mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity, Science, 345, 1250684, 10.1126/science.1250684
Cho, 2001, Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta), Science, 292, 1728, 10.1126/science.292.5522.1728
Cho, 2014, Autophagy regulates homeostasis of pluripotency-associated proteins in hESCs, Stem Cells, 32, 424, 10.1002/stem.1589
Ciraolo, 2008, Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development, Sci. Signal., 1, ra3, 10.1126/scisignal.1161577
Clayton, 2002, A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation, J. Exp. Med., 196, 753, 10.1084/jem.20020805
Cowan, 2005, Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells, Science, 309, 1369, 10.1126/science.1116447
Curatolo, 1991, Neuropsychiatric aspects of tuberous sclerosis, Ann. N. Y. Acad. Sci., 615, 8, 10.1111/j.1749-6632.1991.tb37743.x
Davidson, 2012, Wnt/beta-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4, Proc. Natl. Acad. Sci. USA, 109, 4485, 10.1073/pnas.1118777109
Deglincerti, 2016, Self-organization of the in vitro attached human embryo, Nature, 533, 251, 10.1038/nature17948
Di Cristofano, 1998, Pten is essential for embryonic development and tumour suppression, Nat. Genet., 19, 348, 10.1038/1235
Dummler, 2006, Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies, Mol. Cell. Biol., 26, 8042, 10.1128/MCB.00722-06
Fishwick, 2010, Initiation of neuronal differentiation requires PI3-kinase/TOR signalling in the vertebrate neural tube, Dev. Biol., 338, 215, 10.1016/j.ydbio.2009.12.001
Foukas, 2006, Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation, Nature, 441, 366, 10.1038/nature04694
Freund, 2008, Insulin redirects differentiation from cardiogenic mesoderm and endoderm to neuroectoderm in differentiating human embryonic stem cells, Stem Cells, 26, 724, 10.1634/stemcells.2007-0617
Fritsch, 2013, RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms, Cell, 153, 1050, 10.1016/j.cell.2013.04.031
Fruman, 2000, Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha, Nat. Genet., 26, 379, 10.1038/81715
Goorden, 2011, Rheb is essential for murine development, Mol. Cell. Biol., 31, 1672, 10.1128/MCB.00985-10
Guertin, 2006, Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1, Dev. Cell, 11, 859, 10.1016/j.devcel.2006.10.007
Harada, 2005, The class II phosphoinositide 3-kinase C2beta is not essential for epidermal differentiation, Mol. Cell. Biol., 25, 11122, 10.1128/MCB.25.24.11122-11130.2005
Harris, 2011, Requirement for class II phosphoinositide 3-kinase C2alpha in maintenance of glomerular structure and function, Mol. Cell. Biol., 31, 63, 10.1128/MCB.00468-10
Hishida, 2015, Functional compensation between Myc and PI3K signaling supports self-renewal of embryonic stem cells, Stem Cells, 33, 713, 10.1002/stem.1893
Ho, 2015, ELABELA Is an endogenous growth factor that sustains hESC SELF-RENEwal via the PI3K/AKT pathway, Cell Stem Cell, 17, 435, 10.1016/j.stem.2015.08.010
Honda, 2014, Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes, Nat. Commun., 5, 4004, 10.1038/ncomms5004
Jacinto, 2006, SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity, Cell, 127, 125, 10.1016/j.cell.2006.08.033
Jewell, 2015, Metabolism. Differential regulation of mTORC1 by leucine and glutamine, Science, 347, 194, 10.1126/science.1259472
Kim, 2006, HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia, Cell Metab., 3, 177, 10.1016/j.cmet.2006.02.002
Kingham, 2009, Distinct roles for isoforms of the catalytic subunit of class-IA PI3K in the regulation of behaviour of murine embryonic stem cells, J. Cell Sci., 122, 2311, 10.1242/jcs.046557
Kobayashi, 2001, A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice, Proc. Natl. Acad. Sci. USA, 98, 8762, 10.1073/pnas.151033798
Ktistakis, 2016, Digesting the expanding mechanisms of autophagy, Trends Cell Biol., 26, 624, 10.1016/j.tcb.2016.03.006
Kundu, 2008, Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation, Blood, 112, 1493, 10.1182/blood-2008-02-137398
Laplante, 2012, mTOR signaling in growth control and disease, Cell, 149, 274, 10.1016/j.cell.2012.03.017
Le Bacquer, 2007, Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2, J. Clin. Invest., 117, 387, 10.1172/JCI29528
Lee, 2014, Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation, Cell Metab., 20, 306, 10.1016/j.cmet.2014.06.004
Li, 2016, ULK1/2 constitute a bifurcate node controlling glucose metabolic fluxes in addition to autophagy, Mol. Cell, 62, 359, 10.1016/j.molcel.2016.04.009
Liu, 2015, PtdIns(3,4,5)P3-dependent activation of the mTORC2 kinase complex, Cancer Discov., 5, 1194, 10.1158/2159-8290.CD-15-0460
Ma, 2009, Molecular mechanisms of mTOR-mediated translational control, Nat. Rev. Mol. Cell Biol., 10, 307, 10.1038/nrm2672
Ma, 2015, Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming, Nat. Cell Biol., 17, 1379, 10.1038/ncb3256
McLean, 2007, Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed, Stem Cells, 25, 29, 10.1634/stemcells.2006-0219
Mizushima, 2010, Autophagy in mammalian development and differentiation, Nat. Cell Biol., 12, 823, 10.1038/ncb0910-823
Mizushima, 2001, Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells, J. Cell Biol., 152, 657, 10.1083/jcb.152.4.657
Morita, 2013, mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation, Cell Metab., 18, 698, 10.1016/j.cmet.2013.10.001
Moussaieff, 2015, Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells, Cell Metab., 21, 392, 10.1016/j.cmet.2015.02.002
Murakami, 2004, mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells, Mol. Cell. Biol., 24, 6710, 10.1128/MCB.24.15.6710-6718.2004
Neuman, 2011, Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis, EMBO Mol. Med., 3, 189, 10.1002/emmm.201100131
Niwa, 2009, A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells, Nature, 460, 118, 10.1038/nature08113
Paling, 2004, Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling, J. Biol. Chem., 279, 48063, 10.1074/jbc.M406467200
Pende, 2004, S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway, Mol. Cell. Biol., 24, 3112, 10.1128/MCB.24.8.3112-3124.2004
Peng, 2003, Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2, Genes Dev., 17, 1352, 10.1101/gad.1089403
Petropoulos, 2016, Single-cell RNA-Seq reveals lineage and X chromosome dynamics in human preimplantation embryos, Cell, 165, 1012, 10.1016/j.cell.2016.03.023
Prigione, 2010, The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells, Stem Cells, 28, 721, 10.1002/stem.404
Rebsamen, 2015, SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1, Nature, 519, 477, 10.1038/nature14107
Rennebeck, 1998, Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development, Proc. Natl. Acad. Sci. USA, 95, 15629, 10.1073/pnas.95.26.15629
Ryu, 2011, L-threonine regulates G1/S phase transition of mouse embryonic stem cells via PI3K/Akt, MAPKs, and mTORC pathways, J. Biol. Chem., 286, 23667, 10.1074/jbc.M110.216283
Sarbassov, 2006, Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB, Mol. Cell, 22, 159, 10.1016/j.molcel.2006.03.029
Sasaki, 2000, Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration, Science, 287, 1040, 10.1126/science.287.5455.1040
Shahbazi, 2016, Self-organization of the human embryo in the absence of maternal tissues, Nat. Cell Biol., 18, 700, 10.1038/ncb3347
Shiota, 2006, Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability, Dev. Cell, 11, 583, 10.1016/j.devcel.2006.08.013
Shiraki, 2014, Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells, Cell Metab., 19, 780, 10.1016/j.cmet.2014.03.017
Shyh-Chang, 2013, Influence of threonine metabolism on S-adenosylmethionine and histone methylation, Science, 339, 222, 10.1126/science.1226603
Silva, 2008, Promotion of reprogramming to ground state pluripotency by signal inhibition, PLoS Biol., 6, e253, 10.1371/journal.pbio.0060253
Singh, 2012, Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation, Cell Stem Cell, 10, 312, 10.1016/j.stem.2012.01.014
Sperber, 2015, The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition, Nat. Cell Biol., 17, 1523, 10.1038/ncb3264
Sumi, 2008, Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/beta-catenin, Activin/Nodal and BMP signaling, Development, 135, 2969, 10.1242/dev.021121
Takahashi, 2006, Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors, Cell, 126, 663, 10.1016/j.cell.2006.07.024
Takahashi, 2003, Role of ERas in promoting tumour-like properties in mouse embryonic stem cells, Nature, 423, 541, 10.1038/nature01646
Tang, 2014, Differential effects of Akt isoforms on somatic cell reprogramming, J. Cell Sci., 127, 3998, 10.1242/jcs.150029
Terauchi, 1999, Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase, Nat. Genet., 21, 230, 10.1038/6023
Thorpe, 2015, PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting, Nat. Rev. Cancer, 15, 7, 10.1038/nrc3860
Tohyama, 2016, Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells, Cell Metab., 23, 663, 10.1016/j.cmet.2016.03.001
Tschopp, 2005, Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis, Development, 132, 2943, 10.1242/dev.01864
Ueki, 2002, Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase, Proc. Natl. Acad. Sci. USA, 99, 419, 10.1073/pnas.012581799
Vanhaesebroeck, 2010, The emerging mechanisms of isoform-specific PI3K signalling, Nat. Rev. Mol. Cell Biol., 11, 329, 10.1038/nrm2882
Varum, 2011, Energy metabolism in human pluripotent stem cells and their differentiated counterparts, PLoS ONE, 6, e20914, 10.1371/journal.pone.0020914
Wang, 2009, Dependence of mouse embryonic stem cells on threonine catabolism, Science, 325, 435, 10.1126/science.1173288
Wang, 2013, Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency, Cell Stem Cell, 13, 617, 10.1016/j.stem.2013.10.005
Wang, 2015, Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1, Science, 347, 188, 10.1126/science.1257132
Ward, 2012, Signaling in control of cell growth and metabolism, Cold Spring Harb. Perspect. Biol., 4, a006783, 10.1101/cshperspect.a006783
Watanabe, 2006, Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells, Oncogene, 25, 2697, 10.1038/sj.onc.1209307
Wilmut, 1997, Viable offspring derived from fetal and adult mammalian cells, Nature, 385, 810, 10.1038/385810a0
Wray, 2011, Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation, Nat. Cell Biol., 13, 838, 10.1038/ncb2267
Wu, 2015, Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming, Nat. Cell Biol., 17, 715, 10.1038/ncb3172
Wulff, 2002, Impaired renal Na(+) retention in the sgk1-knockout mouse, J. Clin. Invest., 110, 1263, 10.1172/JCI0215696
Yan, 2013, Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells, Nat. Struct. Mol. Biol., 20, 1131, 10.1038/nsmb.2660
Yang, 2005, Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice, Mol. Cell. Biol., 25, 10407, 10.1128/MCB.25.23.10407-10418.2005
Ying, 2008, The ground state of embryonic stem cell self-renewal, Nature, 453, 519, 10.1038/nature06968
Yoshioka, 2012, Endothelial PI3K-C2alpha, a class II PI3K, has an essential role in angiogenesis and vascular barrier function, Nat. Med., 18, 1560, 10.1038/nm.2928
Yu, 2014, Stimulation of somatic cell reprogramming by ERas-Akt-FoxO1 signaling axis, Stem Cells, 32, 349, 10.1002/stem.1447
Yu, 2015, PI3K/mTORC2 regulates TGF-beta/Activin signalling by modulating Smad2/3 activity via linker phosphorylation, Nat. Commun., 6, 7212, 10.1038/ncomms8212
Zhang, 2016, LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency, Cell Stem Cell, 19, 66, 10.1016/j.stem.2016.05.009
Zhao, 2014, Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice, Mol. Cell. Biol., 34, 1966, 10.1128/MCB.00144-14
Zhou, 2009, mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells, Proc. Natl. Acad. Sci. USA, 106, 7840, 10.1073/pnas.0901854106
Zhou, 2011, The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation, PLoS ONE, 6, e16358, 10.1371/journal.pone.0016358
Zhou, 2012, HIF1alpha induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition, EMBO J., 31, 2103, 10.1038/emboj.2012.71
Zhu, 2013, Human pluripotent stem cells: an emerging model in developmental biology, Development, 140, 705, 10.1242/dev.086165
Zhu, 2010, Reprogramming of human primary somatic cells by OCT4 and chemical compounds, Cell Stem Cell, 7, 651, 10.1016/j.stem.2010.11.015
Zhu, 2011, The Lin28/let-7 axis regulates glucose metabolism, Cell, 147, 81, 10.1016/j.cell.2011.08.033
Zinzalla, 2011, Activation of mTORC2 by association with the ribosome, Cell, 144, 757, 10.1016/j.cell.2011.02.014
Zoumaro-Djayoon, 2011, Investigating the role of FGF-2 in stem cell maintenance by global phosphoproteomics profiling, Proteomics, 11, 3962, 10.1002/pmic.201100048