Prolactin hormone exerts anti-tumorigenic effects in HER-2 overexpressing breast cancer cells through regulation of stemness

Stem Cell Research - Tập 40 - Trang 101538 - 2019
Ibrahim Y. Hachim1, Vanessa M. López-Ozuna1, Mahmood Y. Hachim2, Jean-Jacques Lebrun1, Suhad Ali1
1Department of Medicine, Cancer Research Program, McGill University Health Centre, Montreal, QC H4A 3J1, Canada
2Sharjah Institute for Medical Research, University of Sharjah, United Arab Emirates

Tài liệu tham khảo

Agarwal, 2016, Phase I study of the prolactin receptor antagonist LFA102 in metastatic breast and castration-resistant prostate cancer, Oncologist., 21, 535, 10.1634/theoncologist.2015-0502 Al-Hajj, 2003, Prospective identification of tumorigenic breast cancer cells, Proc. Natl. Acad. Sci. U. S. A., 100, 3983, 10.1073/pnas.0530291100 Baselga, 1996, Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer, J. Clin. Oncol., 14, 737, 10.1200/JCO.1996.14.3.737 Charafe-Jauffret, 2009, Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature, Cancer Res., 69, 1302, 10.1158/0008-5472.CAN-08-2741 Chen, 2015, The many faces of prolactin in breast cancer, Adv. Exp. Med. Biol., 846, 61, 10.1007/978-3-319-12114-7_3 Chen, 1999, A human prolactin antagonist, hPRL-G129R, inhibits breast cancer cell proliferation through induction of apoptosis, Clin. Cancer Res., 5, 3583 Chen, 2002, In vivo studies of the anti-tumor effects of a human prolactin antagonist, hPRL-G129R, Int. J. Oncol., 20, 813 Cheng, 2017, A prognostic 4-gene expression signature for patients with HER2-negative breast cancer receiving taxane and anthracycline-based chemotherapy, Oncotarget., 8, 103327, 10.18632/oncotarget.21872 Clevenger, 2003, The role of prolactin in mammary carcinoma, Endocr. Rev., 24, 1, 10.1210/er.2001-0036 Cobleigh, 1999, Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease, J. Clin. Oncol., 17, 2639, 10.1200/JCO.1999.17.9.2639 Cookson, 2012, Prolactin, hyperprolactinaemia and antipsychotic treatment: a review and lessons for treatment of early psychosis, J. Psychopharmacol., 26, 42, 10.1177/0269881112442016 Croker, 2012, Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44(+) human breast cancer cells, Breast Cancer Res. Treat., 133, 75, 10.1007/s10549-011-1692-y De Boer, 2008, Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events, Oncogene., 27, 4261, 10.1038/onc.2008.74 Duru, 2012, HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells, Clin. Cancer Res., 18, 6634, 10.1158/1078-0432.CCR-12-1436 Eyler, 2008, Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis, J. Clin. Oncol., 26, 2839, 10.1200/JCO.2007.15.1829 Fang, 2012, CCL2/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 protein- and p42/44 mitogen-activated protein kinase (MAPK)-dependent mechanisms, J. Biol. Chem., 287, 36593, 10.1074/jbc.M112.365999 Frank, 2010, The therapeutic promise of the cancer stem cell concept, J. Clin. Invest., 120, 41, 10.1172/JCI41004 Fumagalli, 2011, CD44+ CD24−/low phenotype and resistance to trastuzumab in HER2-positive breast cancer cell lines, Pharmacogenomics., 12, 12 Gajria, 2011, HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies, Expert. Rev. Anticancer. Ther., 11, 263, 10.1586/era.10.226 Galbaugh, 2010, Prolactin receptor-integrin cross-talk mediated by SIRPalpha in breast cancer cells, Mol. Cancer Res., 8, 1413, 10.1158/1541-7786.MCR-10-0130 Galsgaard, 2009, Re-evaluation of the prolactin receptor expression in human breast cancer, J. Endocrinol., 201, 115, 10.1677/JOE-08-0479 Ginestier, 2007, ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome, Cell Stem Cell, 1, 555, 10.1016/j.stem.2007.08.014 Ginsburg, 1995, Prolactin synthesis and secretion by human breast cancer cells, Cancer Res., 55, 2591 Goffin, 2015, The prolactin receptor as a therapeutic target in human diseases: browsing new potential indications, Expert Opin. Ther. Targets, 19, 1229, 10.1517/14728222.2015.1053209 Hachim, 2016, Prolactin receptor expression is an independent favorable prognostic marker in human breast Cancer, Appl. Immunohistochem. Mol. Morphol., 24, 238, 10.1097/PAI.0000000000000178 Hachim, 2016, A favorable role of prolactin in human breast cancer reveals novel pathway based gene signatures indicative of tumor differentiation and favorable patient outcome: prolactin-induced mammary differentiation program in breast cancer prognosis, Hum. Pathol., 53, 142, 10.1016/j.humpath.2016.02.010 Hennighausen, 2005, Information networks in the mammary gland, Nat. Rev. Mol. Cell Biol., 6, 715, 10.1038/nrm1714 Hu, 2006, The molecular portraits of breast tumors are conserved across microarray platforms, BMC Genomics, 7, 96, 10.1186/1471-2164-7-96 Incorvati, 2013, Targeted therapy for HER2 positive breast cancer, J. Hematol. Oncol., 6, 38, 10.1186/1756-8722-6-38 Inic, 2014, Difference between luminal a and luminal B subtypes according to Ki-67, tumor size, and progesterone receptor negativity providing prognostic information, Clin. Med. Insights Oncol., 8, 107, 10.4137/CMO.S18006 Liu, 2012, Seventeen-gene signature from enriched Her2/Neu mammary tumor-initiating cells predicts clinical outcome for human HER2+:ERalpha- breast cancer, Proc. Natl. Acad. Sci. U. S. A., 109, 5832, 10.1073/pnas.1201105109 Liu, 2014, Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts, Stem Cell Rep., 2, 78, 10.1016/j.stemcr.2013.11.009 Liu, 2015, Prolactin/Jak2 directs apical/basal polarization and luminal linage maturation of mammary epithelial cells through regulation of the Erk1/2 pathway, Stem Cell Res., 15, 376, 10.1016/j.scr.2015.08.001 Lopez-Ozuna, 2016, Prolactin pro-differentiation pathway in triple negative breast cancer: impact on prognosis and potential therapy, Sci. Rep., 6, 10.1038/srep30934 Luque-Cabal, 2016, Mechanisms behind the resistance to trastuzumab in HER2-amplified breast cancer and strategies to overcome it, Clin. Med. Insights Oncol., 10, 21 Ma, 2016, Functional roles of sialylation in breast cancer progression through miR-26a/26b targeting ST8SIA4, Cell Death Dis., 7, e2561, 10.1038/cddis.2016.427 Majumdar, 2013, Hyperprolactinemia, J. Hum. Reprod. Sci., 6, 168, 10.4103/0974-1208.121400 Marcato, 2011, Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis, Stem Cells, 29, 32, 10.1002/stem.563 Martin-Castillo, 2015, Cancer stem cell-driven efficacy of trastuzumab (Herceptin): towards a reclassification of clinically HER2-positive breast carcinomas, Oncotarget., 6, 32317, 10.18632/oncotarget.6094 Menard, 2001, HER2 as a prognostic factor in breast cancer, Oncology., 61, 67, 10.1159/000055404 Morimoto, 2009, Stem cell marker aldehyde dehydrogenase 1-positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression, Cancer Sci., 100, 1062, 10.1111/j.1349-7006.2009.01151.x Nitze, 2013, Reevaluation of the proposed autocrine proliferative function of prolactin in breast cancer, Breast Cancer Res. Treat., 142, 31, 10.1007/s10549-013-2731-7 Nouhi, 2006, Defining the role of prolactin as an invasion suppressor hormone in breast cancer cells, Cancer Res., 66, 1824, 10.1158/0008-5472.CAN-05-2292 Oakes, 2008, Prolactin regulation of mammary gland development, J. Mammary Gland Biol. Neoplasia, 13, 13, 10.1007/s10911-008-9069-5 Petty, 1999, Prolactin and antipsychotic medications: mechanism of action, Schizophr. Res., 35, S67, 10.1016/S0920-9964(98)00158-3 Peuskens, 2014, The effects of novel and newly approved antipsychotics on serum prolactin levels: a comprehensive review, CNS Drugs., 28, 421 Ricardo, 2011, Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype, J. Clin. Pathol., 64, 937, 10.1136/jcp.2011.090456 Rizzolio, 2011, Multifaceted role of neuropilins in cancer, Curr. Med. Chem., 18, 3563, 10.2174/092986711796642544 Sato, 2014, Prolactin suppresses a progestin-induced CK5-positive cell population in luminal breast cancer through inhibition of progestin-driven BCL6 expression, Oncogene., 33, 2215, 10.1038/onc.2013.172 Schnitt, 2010, Classification and prognosis of invasive breast cancer: from morphology to molecular taxonomy, Mod. Pathol., 23, S60, 10.1038/modpathol.2010.33 Schroeder, 2003, Inhibition of prolactin (PRL)-induced proliferative signals in breast cancer cells by a molecular mimic of phosphorylated PRL, S179D-PRL, Endocrinology., 144, 5300, 10.1210/en.2003-0826 Slamon, 1987, Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene, Science., 235, 177, 10.1126/science.3798106 Smalley, 2003, Stem cells and breast cancer: a field in transit, Nat. Rev. Cancer, 3, 832, 10.1038/nrc1212 Smith, 2005, Overexpression of aurora B kinase (AURKB) in primary non-small cell lung carcinoma is frequent, generally driven from one allele, and correlates with the level of genetic instability, Br. J. Cancer, 93, 719, 10.1038/sj.bjc.6602779 Sultan, 2005, Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells, Oncogene., 24, 746, 10.1038/sj.onc.1208203 Tomita, 2016, Aldehyde dehydrogenase 1A1 in stem cells and cancer, Oncotarget., 7, 11018, 10.18632/oncotarget.6920 Tran, 2011, Luminal-B breast cancer and novel therapeutic targets, Breast Cancer Res., 13, 221, 10.1186/bcr2904 Vayrynen, 2016, Clinical impact and network of determinants of tumour necrosis in colorectal cancer, Br. J. Cancer, 114, 1334, 10.1038/bjc.2016.128 Vogel, 2002, Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer, J. Clin. Oncol., 20, 719, 10.1200/JCO.2002.20.3.719 Wang, 2013, PPARgamma maintains ERBB2-positive breast cancer stem cells, Oncogene., 32, 5512, 10.1038/onc.2013.217 Xu, 2015, Aldehyde dehydrogenases and cancer stem cells, Cancer Lett., 369, 50, 10.1016/j.canlet.2015.08.018 Zhang, 2015, Residue 146 regulates prolactin receptor folding, basal activity and ligand-responsiveness: potential implications in breast tumorigenesis, Mol. Cell. Endocrinol., 401, 173, 10.1016/j.mce.2014.12.006