Progress in corneal wound healing

Progress in Retinal and Eye Research - Tập 49 - Trang 17-45 - 2015
Alexander V. Ljubimov1, Mehrnoosh Saghizadeh1
1Eye Program, Board of Governors Regenerative Medicine Institute, Departments of Biomedical Sciences and Neurosurgery, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

Tài liệu tham khảo

Aberdam, 2008, A pure population of ectodermal cells derived from human embryonic stem cells, Stem Cells, 26, 440, 10.1634/stemcells.2007-0588 Abrams, 2000, Nanoscale topography of the corneal epithelial basement membrane and Descemet's membrane of the human, Cornea, 19, 57, 10.1097/00003226-200001000-00012 Adijanto, 2015, Nanoparticle-based technologies for retinal gene therapy, Eur. J. Pharm. Biopharm., 12, S0939 Ahmad, 2010, Stem cell therapies for ocular surface disease, Drug Discov. Today, 15, 306, 10.1016/j.drudis.2010.02.001 Alio, 2007, Treatment of ocular surface syndrome after LASIK with autologous platelet-rich plasma, J. Refract. Surg., 23, 617, 10.3928/1081-597X-20070601-13 Alio, 2012, The role of “eye platelet rich plasma” (E-PRP) for wound healing in ophthalmology, Curr. Pharm. Biotechnol., 13, 1257, 10.2174/138920112800624355 Amitai-Lange, 2015, Lineage tracing of stem and progenitor cells of the murine corneal epithelium, Stem Cells, 33, 230, 10.1002/stem.1840 An, 2015, MicroRNA expression profile and the role of miR-204 in corneal wound healing, Invest. Ophthalmol. Vis. Sci., 56, 3673, 10.1167/iovs.15-16467 Anderson, 1977, Actin filaments in normal and migrating corneal epithelial cells, Invest. Ophthalmol. Vis. Sci., 16, 161 Anderson, 2002, Rho and Rho-kinase (ROCK) signaling in adherens and gap junction assembly in corneal epithelium, Invest. Ophthalmol. Vis. Sci., 43, 978 Andresen, 1997, Keratocyte migration and peptide growth factors: the effect of PDGF, bFGF, EGF, IGF-I, aFGF and TGF-β on human keratocyte migration in a collagen gel, Curr. Eye Res., 16, 605, 10.1076/ceyr.16.6.605.5081 Anitua, 2011, Plasma rich in growth factors (PRGF-Endoret) stimulates proliferation and migration of primary keratocytes and conjunctival fibroblasts and inhibits and reverts TGF-beta1-Induced myodifferentiation, Invest. Ophthalmol. Vis. Sci., 52, 6066, 10.1167/iovs.11-7302 Anitua, 2013, Plasma rich in growth factors (PRGF-Endoret) stimulates corneal wound healing and reduces haze formation after PRK surgery, Exp. Eye Res., 115, 153, 10.1016/j.exer.2013.07.007 Arranz-Valsero, 2014, IL-6 as a corneal wound healing mediator in an in vitro scratch assay, Exp. Eye Res., 25, 183, 10.1016/j.exer.2014.06.012 Azar, 1998, Gelatinase B and A expression after laser in situ keratomileusis and photorefractive keratectomy, Arch. Ophthalmol., 116, 1206, 10.1001/archopht.116.9.1206 Azar, 1992, Altered epithelial-basement membrane interactions in diabetic corneas, Arch. Ophthalmol., 110, 537, 10.1001/archopht.1992.01080160115045 Baldwin, 2002, Growth factors in corneal wound healing following refractive surgery: a review, Acta Ophthalmol. Scand., 80, 238, 10.1034/j.1600-0420.2002.800303.x Barak, 1980, Granulocyte-macrophage colonies incultures of human fetal liver cells: morphologic and ultrastructural analysis of proliferation and differentiation, Exp. Hematol., 8, 837 Barbosa, 2010, Corneal myofibroblast generation from bone marrow-derived cells, Exp. Eye Res., 91, 92, 10.1016/j.exer.2010.04.007 Bartakova, 2014, Regenerative cell therapy for corneal endothelium, Curr. Ophthalmol. Rep., 2, 81, 10.1007/s40135-014-0043-7 Basu, 2014, Human limbal biopsy-derived stromal stem cells prevent corneal scarring, Sci. Transl. Med., 6, 266ra172, 10.1126/scitranslmed.3009644 Baylis, 2011, 13 years of cultured limbal epithelial cell therapy: a review of the outcomes, J. Cell Biochem., 112, 993, 10.1002/jcb.23028 Bednarz, 1996, Influence of vascular endothelial growth factor on bovine corneal endothelial cells in a wound-healing model, Ger. J. Ophthalmol., 5, 127 Bertero, 2011, miR-483-3p controls proliferation in wounded epithelial cells, FASEB J., 25, 3092, 10.1096/fj.10-168401 Bettahi, 2014, Genome-wide transcriptional analysis of differentially expressed genes in diabetic, healing corneal epithelial cells: hyperglycemia-suppressed TGFβ3 expression contributes to the delay of epithelial wound healing in diabetic corneas, Diabetes, 63, 715, 10.2337/db13-1260 Bhowmick, 2001, Integrin β1 signaling is necessary for transforming growth factor-β activation of p38MAPK and epithelial plasticity, J. Biol. Chem., 276, 46707, 10.1074/jbc.M106176200 Biber, 2010, Management of ocular stem cell disease, Int. Ophthalmol. Clin., 50, 25, 10.1097/IIO.0b013e3181e20d64 Bilousova, 2010, Differentiation of mouse induced pluripotent stem cells into a multipotent keratinocyte lineage, J. Invest. Dermatol, 131, 857, 10.1038/jid.2010.364 Blanco-Mezquita, 2013, Nerve growth factor promotes corneal epithelial migration by enhancing expression of matrix metalloprotease-9, Invest. Ophthalmol. Vis. Sci., 54, 3880, 10.1167/iovs.12-10816 Blanco-Mezquita, 2013, Role of thrombospondin-1 in repair of penetrating corneal wounds, Invest. Ophthalmol. Vis. Sci., 54, 6262, 10.1167/iovs.13-11710 Block, 2004, Wounding induces motility in sheets of corneal epithelial cells through loss of spatial constraints: role of heparin-binding epidermal growth factor-like growth factor signaling, J. Biol. Chem., 279, 24307, 10.1074/jbc.M401058200 Bobba, 2015, Clinical outcomes of xeno-free expansion and transplantation of autologous ocular surface epithelial stem cells via contact lens delivery: a prospective case series, Stem Cell Res. Ther., 6, 23, 10.1186/s13287-015-0009-1 Bonini, 2000, Topical treatment with nerve growth factor for neurotrophic keratitis, Ophthalmology, 107, 1347, 10.1016/S0161-6420(00)00163-9 Bottaro, 1991, Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product, Science, 251, 802, 10.1126/science.1846706 Boucher, 2007, Injury and nucleotides induce phosphorylation of epidermal growth factor receptor: MMP and HB-EGF dependent pathway, Exp. Eye Res., 85, 130, 10.1016/j.exer.2007.03.009 Boucher, 2010, The P2Y2 receptor mediates the epithelial injury response and cell migration, Am. J. Physiol. Cell Physiol., 299, C411, 10.1152/ajpcell.00100.2009 Boucher, 2011, Distinct activation of epidermal growth factor receptor by UTP contributes to epithelial cell wound repair, Am. J. Pathol., 178, 1092, 10.1016/j.ajpath.2010.11.060 Buss, 2010, Gene delivery in the equine cornea: a novel therapeutic strategy, Vet. Ophthalmol., 13, 301, 10.1111/j.1463-5224.2010.00813.x Caldwell, 2009, The histology of graft adhesion in Descemet stripping with endothelial keratoplasty, Am. J. Ophthalmol., 148, 277, 10.1016/j.ajo.2009.03.025 Carlson, 2003, Altered KSPG expression by keratocytes following corneal injury, Mol. Vis., 9, 615 Carrington, 2005, Hepatocyte growth factor and keratinocyte growth factor regulation of epithelial and stromal corneal wound healing, J. Cataract. Refract. Surg., 31, 412, 10.1016/j.jcrs.2004.04.072 Casaroli-Marano, 2015, Potential role of induced pluripotent stem cells (iPSCs) for cell-based therapy of the ocular surface, J. Clin. Med., 4, 318, 10.3390/jcm4020318 Castro-Muñozledo, 2013, Review: corneal epithelial stem cells, their niche and wound healing, Mol. Vis., 24, 1600 Chandrasekher, 2001, HGF- and KGF-induced activation of PI-3K/p70 S6 kinase pathway in corneal epithelial cells: its relevance in wound healing, Exp. Eye Res., 73, 191, 10.1006/exer.2001.1026 Chaurasia, 2009, Reprint of “Dynamics of the expression of intermediate filaments vimentin and desmin during myofibroblast differentiation after corneal injury”, Exp. Eye Res., 89, 590, 10.1016/S0014-4835(09)00247-4 Chaurasia, 2013, Hevin plays a pivotal role in corneal wound healing, PLoS One, 8, e81544, 10.1371/journal.pone.0081544 Chen, 1990, Corneal epithelial wound healing in partial limbal deficiency, Invest. Ophthalmol. Vis. Sci., 31, 1301 Chen, 2009, Rho-mediated regulation of TGF-β1- and FGF-2-induced activation of corneal stromal keratocytes, Invest. Ophthalmol. Vis. Sci., 50, 3662, 10.1167/iovs.08-3276 Chen, 2009, ERK1/2 activation regulates the wound healing process of rabbit corneal endothelial cells, Curr. Eye Res., 34, 103, 10.1080/02713680802621741 Chen, 2006, Improved transduction of human corneal epithelial progenitor cells with cell-targeting adenoviral vectors, Exp. Eye Res., 83, 798, 10.1016/j.exer.2006.03.023 Chen, 2013, miR-146a inhibits cell growth, cell migration and induces apoptosis in non-small cell lung cancer cells, PLoS One, 8, e60317, 10.1371/journal.pone.0060317 Chen, 2012, Expression of angiogenesis-related factors in human corneas after cultivated oral mucosal epithelial transplantation, Invest. Ophthalmol. Vis. Sci., 17, 5615, 10.1167/iovs.11-9293 Chendrimada, 2007, MicroRNA silencing through RISC recruitment of eIF6, Nature, 447, 823, 10.1038/nature05841 Cheng, 2009, The growth-promoting effect of KGF on limbal epithelial cells is mediated by upregulation of ΔNp63α through the p38 pathway, J. Cell Sci., 122, 4473, 10.1242/jcs.054791 Chikama, 2007, Deviated mechanism of wound healing in diabetic corneas, Cornea, 26, S75, 10.1097/ICO.0b013e31812f6d8e Chowdhury, 2013, Pirfenidone nanoparticles improve corneal wound healing and prevent scarring following alkali burn, PLoS One, 8, e70528, 10.1371/journal.pone.0070528 Chung, 1995, Epithelial regeneration after limbus-to-limbus debridement. Expression of α-enolase in stem and transient amplifying cells, Invest. Ophthalmol. Vis. Sci., 36, 1336 Cortina, 2012, Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus docosahexaenoic acid after experimental surgery, Arch. Ophthalmol., 130, 76, 10.1001/archophthalmol.2011.287 Cotsarelis, 1989, Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells, Cell, 57, 201, 10.1016/0092-8674(89)90958-6 Crosson, 1986, Epithelial wound closure in the rabbit cornea. A biphasic process, Invest. Ophthalmol. Vis. Sci., 27, 464 Daniels, 2000, Temporal stimulation of corneal fibroblast wound healing activity by differentiating epithelium in vitro, Invest. Ophthalmol. Vis. Sci., 41, 3754 Daniels, 2006, Corneal epithelial stem cells in health and disease, Stem Cell Rev., 2, 247, 10.1007/s12015-006-0053-4 Daniels, 2003, Human corneal epithelial cells require MMP-1 for HGF-mediated migration on collagen I, Invest. Ophthalmol. Vis. Sci., 44, 1048, 10.1167/iovs.02-0442 Das, 2014, Vimentin knockdown decreases corneal opacity, Invest. Ophthalmol. Vis. Sci., 55, 4030, 10.1167/iovs.13-13494 Davanger, 1971, Role of the pericorneal papillary structure in renewal of corneal epithelium, Nature, 229, 560, 10.1038/229560a0 Dawson, 2008, Biomechanical and wound healing characteristics of corneas after excimer laser keratorefractive surgery: is there a difference between advanced surface ablation and sub-Bowman's keratomileusis?, J. Refract Surg., 24, S90, 10.3928/1081597X-20080101-16 Dedova, 2006, Thymosin β4 induces a conformational change in actin monomers, Biophys. J., 90, 985, 10.1529/biophysj.105.063081 Denk, 1997, The in vitro effect of platelet-derived growth factor isoforms on the proliferation of bovine corneal stromal fibroblasts depends on cell density, Graefes Arch. Clin. Exp. Ophthalmol., 235, 530, 10.1007/BF00947012 Di Girolamo, 2015, Moving epithelia: tracking the fate of mammalian limbal epithelial stem cells, Prog. Ret. Eye Res., 48, 203, 10.1016/j.preteyeres.2015.04.002 Di Girolamo, 2015, Tracing the fate of limbal epithelial progenitor cells in the murine cornea, Stem Cells, 33, 157, 10.1002/stem.1769 Diehl, 2005, Nanoscale topography modulates corneal epithelial cell migration, J. Biomed. Mater. Res. Part A, 75A, 603, 10.1002/jbm.a.30467 Dietrich-Ntoukas, 2012, Comparative analysis of the basement membrane composition of the human limbus epithelium and amniotic membrane epithelium, Cornea, 31, 564, 10.1097/ICO.0b013e3182254b78 Dirisamer, 2011, Patterns of corneal endothelialization and corneal clearance after Descemet membrane endothelial keratoplasty for Fuchs endothelial dystrophy, Am. J. Ophthalmol., 152, 543, 10.1016/j.ajo.2011.03.031 Du, 2005, Multipotent stem cells in human corneal stroma, Stem Cells, 23, 1266, 10.1634/stemcells.2004-0256 Du, 2009, Stem cell therapy restores transparency to defective murine corneas, Stem Cells, 27, 1635, 10.1002/stem.91 Dua, 1998, The conjunctiva in corneal epithelial wound healing, Br. J. Ophthalmol., 82, 1407, 10.1136/bjo.82.12.1407 Dua, 2005, Limbal epithelial crypts: a novel anatomical structure and a putative limbal stem cell niche, Br. J. Ophthalmol., 89, 529, 10.1136/bjo.2004.049742 Dunn, 2010, Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin β4, Ann. N. Y. Acad. Sci., 1194, 199, 10.1111/j.1749-6632.2010.05471.x Ebihara, 2011, Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing, Invest. Ophthalmol. Vis. Sci., 52, 8549, 10.1167/iovs.11-7956 Elmén, 2008, LNA-mediated microRNA silencing in non-human primates, Nature, 452, 896, 10.1038/nature06783 Elmén, 2008, Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver, Nucleic Acids Res., 36, 1153, 10.1093/nar/gkm1113 Enríquez-de-Salamanca, 2010, Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye disease, Mol. Vis., 16, 862 Er, 1998, Effects of transforming growth factor-β2, interleukin 6 and fibronectin on corneal epithelial wound healing, Eur. J. Ophthalmol., 8, 224, 10.1177/112067219800800404 Erie, 2003, Corneal wound healing after photorefractive keratectomy: a 3-year confocal microscopy study, Trans. Am. Ophthalmol. Soc., 101, 293 Eslani, 2014, The role of toll-like receptor 4 in corneal epithelial wound healing, Invest. Ophthalmol. Vis. Sci., 55, 6108, 10.1167/iovs.14-14736 Espana, 2003, Stromal niche controls the plasticity of limbal and corneal epithelial differentiation in a rabbit model of recombined tissue, Invest. Ophthalmol. Vis. Sci., 44, 5130, 10.1167/iovs.03-0584 Esquenazi, 2009, Immunohistological evaluation of the healing response at the flap interface in patients with LASIK ectasia requiring penetrating keratoplasty, J. Refract. Surg., 25, 739, 10.3928/1081597X-20090707-09 Fini, 1996, Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury, Am. J. Pathol., 149, 1287 Fini, 1999, Keratocyte and fibroblast phenotypes in the repairing cornea, Prog. Retin. Eye Res., 18, 529, 10.1016/S1350-9462(98)00033-0 Fini, 2005, How the cornea heals: cornea-specific repair mechanisms affecting surgical outcomes, Cornea, 24, S2, 10.1097/01.ico.0000178743.06340.2c Follenzi, 2007, Immune responses to lentiviral vectors, Curr. Gene Ther., 7, 306, 10.2174/156652307782151515 Fountain, 1994, Reassembly of corneal epithelial adhesion structures after excimer laser keratectomy in humans, Arch. Ophthalmol., 112, 967, 10.1001/archopht.1994.01090190115030 Fournié, 2010, Correlation between epithelial ingrowth and basement membrane remodeling in human corneas after laser-assisted in situ keratomileusis, Arch. Ophthalmol., 128, 426, 10.1001/archophthalmol.2010.23 Fujikawa, 1984, Basement membrane components in healing rabbit corneal epithelial wounds: immunofluorescence and ultrastructural studies, J. Cell Biol., 98, 128, 10.1083/jcb.98.1.128 Fujita, 2003, Prolonged exposure to high glucose impaired cellular behavior of normal human corneal epithelial cells, Curr. Eye Res., 27, 197, 10.1076/ceyr.27.4.197.16598 Funaki, 2008, Ex vivo transfer of Smad7 decreases damage to the corneal endothelium after penetrating keratoplasty, Jpn. J. Ophthalmol., 52, 204, 10.1007/s10384-007-0526-2 Funaki, 2003, Smad7 suppresses the inhibitory effect of TGF-β2 on corneal endothelial cell proliferation and accelerates corneal endothelial wound closure in vitro, Cornea, 22, 153, 10.1097/00003226-200303000-00015 Funari, 2013, Differentially expressed wound healing-related microRNAs in the human diabetic cornea, PLoS One, 8, e84425, 10.1371/journal.pone.0084425 Galal, 2007, Human anterior lens capsule as a biologic substrate for the ex vivo expansion of limbal stem cells in ocular surface reconstruction, Cornea, 26, 473, 10.1097/ICO.0b013e318033bd0f Gallar, 1990, Effects of capsaicin on corneal wound healing, Invest. Ophthalmol. Vis. Sci., 31, 1968 Gambaro, 1998, Growth factors and the kidney in diabetes mellitus, Crit. Rev. Clin. Lab. Sci., 35, 117, 10.1080/10408369891234174 Gan, 1999, Effect of leukocytes on corneal cellular proliferation and wound healing, Invest. Ophthalmol. Vis. Sci., 40, 575 Gao, 2011, Dendritic cell-epithelium interplay is a determinant factor for corneal epithelial wound repair, Am. J. Pathol., 179, 2243, 10.1016/j.ajpath.2011.07.050 Gao, 2015, Biomimetic stochastic topography and electric fields synergistically enhance directional migration of corneal epithelial cells in a MMP-3-dependent manner, Acta Biomater., 12, 102, 10.1016/j.actbio.2014.10.007 Gao, 2015, MicroRNA-204-5p-mediated regulation of SIRT1 contributes to the delay of epithelial cell-cycle traversal in diabetic corneas, Invest. Ophthalmol. Vis. Sci., 56, 1493, 10.1167/iovs.14-15913 Girard, 1991, Transforming growth factor-β and interleukin-1 modulate metalloproteinase expression by corneal stromal cells, Invest. Ophthalmol. Vis. Sci., 32, 2441 Griffith, 2014, Recent advances in the design of artificial corneas, Curr. Opin. Ophthalmol., 25, 240, 10.1097/ICU.0000000000000049 Göbbels, 1989, Impairment of corneal epithelial barrier function in diabetics, Graefes Arch. Clin. Exp. Ophthalmol., 227, 142, 10.1007/BF02169787 Goldberg, 1982, Limbal palisades of Vogt, Trans. Am. Ophthalmol. Soc., 80, 155 Gordon, 1994, Cytological and immunocytochemical approaches to the study of corneal endothelial wound repair, Prog. Histochem. Cytochem, 28, 1, 10.1016/S0079-6336(11)80033-1 Gordon, 2011, Comprehensive gene expression profiling and functional analysis of matrix metalloproteinases and TIMPs, and identification of ADAM-10 gene expression, in a corneal model of epithelial resurfacing, J. Cell Physiol., 226, 1461, 10.1002/jcp.22306 Gundorova, 1994, Stimulation of penetrating corneal wound healing by exogenous fibronectin, Eur. J. Ophthalmol., 4, 202, 10.1177/112067219400400403 Haber, 2003, Effects of growth factors (EGF, PDGF-BB and TGF-β1) on cultured equine epithelial cells and keratocytes: implications for wound healing, Vet. Ophthalmol., 6, 211, 10.1046/j.1463-5224.2003.00296.x Han, 2011, AAV and compacted DNA nanoparticles for the treatment of retinal disorders: challenges and future prospects, Invest. Ophthalmol. Vis. Sci., 52, 3051, 10.1167/iovs.10-6916 Han, 2012, Comparative analysis of DNA nanoparticles and AAVs for ocular gene delivery, PLoS One, 7, e52189, 10.1371/journal.pone.0052189 Hattori, 2012, Effects of all-trans retinoic acid nanoparticles on corneal epithelial wound healing, Graefes Arch. Clin. Exp. Ophthalmol., 250, 557, 10.1007/s00417-011-1849-8 Hayashi, 2010, Lumican is required for neutrophil extravasation following corneal injury and wound healing, J. Cell Sci., 123, 2987, 10.1242/jcs.068221 Hayashi, 2012, Generation of corneal epithelial cells from induced pluripotent stem cells derived from human dermal fibroblast and corneal limbal epithelium, PLoS One, 7, e45435, 10.1371/journal.pone.0045435 Heldin, 1990, Platelet-derived growth factor: mechanism of action and possible in vivo function, Cell Regul., 1, 555, 10.1091/mbc.1.8.555 Hellmich, 2000, Activation of transforming growth factor-β1 in diabetic kidney disease, Metabolism, 49, 353, 10.1016/S0026-0495(00)90264-6 Ho, 2013, PEDF promotes self-renewal of limbal stem cell and accelerates corneal epithelial wound healing, Stem Cells, 31, 1775, 10.1002/stem.1393 Ho, 2010, Protection of thymosin β-4 on corneal endothelial cells from UVB-induced apoptosis, Chin. J. Physiol., 53, 190, 10.4077/CJP.2010.AMH091 Honma, 1997, Effect of transforming growth factor-β1 and -β2 on in vitro rabbit corneal epithelial cell proliferation promoted by epidermal growth factor, keratinocyte growth factor, or hepatocyte growth factor, Exp. Eye Res., 65, 391, 10.1006/exer.1997.0338 Hoppenreijs, 1994, Basic fibroblast growth factor stimulates corneal endothelial cell growth and endothelial wound healing of human corneas, Invest. Ophthalmol. Vis. Sci., 35, 931 Hoppenreijs, 1994, Effects of platelet-derived growth factor on endothelial wound healing of human corneas, Invest. Ophthalmol. Vis. Sci., 35, 150 Hoppenreijs, 1996, Corneal endothelium and growth factors, Surv. Ophthalmol., 41, 155, 10.1016/S0039-6257(96)80005-1 Hsu, 2015, Stem cell therapy for corneal regeneration medicine and contemporary nanomedicine for corneal disorders, Cell Transpl., 10.3727/096368914X685744 Huang, 2014, MicroRNA regulation and therapeutic targeting of survivin in cancer, Am. J. Cancer Res., 5, 20 Huh, 2009, Distribution of TGF-β isoforms and signaling intermediates in corneal fibrotic wound repair, J. Cell Biochem., 108, 476, 10.1002/jcb.22277 Humphreys, 2005, MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function, Proc. Natl. Acad. Sci. U. S. A., 102, 16961, 10.1073/pnas.0506482102 Huxlin, 2013, Topical rosiglitazone is an effective anti-scarring agent in the cornea, PLoS One, 8, e70785, 10.1371/journal.pone.0070785 Ichijima, 1993, Actin filament organization during endothelial wound healing in the rabbit cornea: comparison between transcorneal freeze and mechanical scrape injuries, Invest. Ophthalmol. Vis. Sci., 34, 2803 Ichijima, 1993, In vivo confocal microscopic studies of endothelial wound healing in rabbit cornea, Cornea, 12, 369, 10.1097/00003226-199309000-00001 Imanishi, 2000, Growth factors: importance in wound healing and maintenance of transparency of the cornea, Prog. Retin Eye Res., 19, 113, 10.1016/S1350-9462(99)00007-5 Inai, 2013, BMP-2 induces versican and hyaluronan that contribute to post-EMT AV cushion cell migration, PLoS One, 8, e77593, 10.1371/journal.pone.0077593 Ishizaki, 1996, The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase, EMBO J., 15, 1885, 10.1002/j.1460-2075.1996.tb00539.x Ishizaki, 1997, Stromal fibroblasts are associated with collagen IV in scar tissues of alkali-burned and laceraed corneas, Curr. Eye Res., 16, 339, 10.1076/ceyr.16.4.339.10684 Ishizaki, 1993, Expression of collagen I, smooth muscle alpha-actin, and vimentin during the healing of alkali-burned and lacerated corneas, Invest. Ophthalmol. Vis. Sci., 34, 3320 Ivarsen, 2003, Characterisation of corneal fibrotic wound repair at the LASIK flap margin, Br. J. Ophthalmol., 87, 1272, 10.1136/bjo.87.10.1272 Iwamoto, 2003, Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function, Proc. Natl. Acad. Sci. U. S. A., 100, 3221, 10.1073/pnas.0537588100 Izumi, 2006, Involvement of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in corneal fibroblasts during corneal wound healing, Invest. Ophthalmol. Vis. Sci., 47, 591, 10.1167/iovs.05-0097 Janssen, 2013, Treatment of HCV infection by targeting microRNA, N. Engl. J. Med., 368, 1685, 10.1056/NEJMoa1209026 Javier, 2006, Basement membrane and collagen deposition after laser subepithelial keratomileusis and photorefractive keratectomy in the leghorn chick eye, Arch. Ophthalmol., 124, 703, 10.1001/archopht.124.5.703 Jester, 1995, Expression of alpha-smooth muscle (α-SM) actin during corneal stromal wound healing, Invest. Ophthalmol. Vis. Sci., 36, 809 Jester, 1999, Corneal stromal wound healing in refractive surgery: the role of myofibroblasts, Prog. Retin. Eye Res., 18, 311, 10.1016/S1350-9462(98)00021-4 Jester, 2003, Modulation of cultured corneal keratocyte phenotype by growth factors/cytokines control in vitro contractility and extracellular matrix contraction, Exp. Eye Res., 77, 581, 10.1016/S0014-4835(03)00188-X Ji, 2014, Rho/Rock cross-talks with transforming growth factor-β/Smad pathway participates in lung fibroblast-myofibroblast differentiation, Biomed. Rep., 2, 787, 10.3892/br.2014.323 Jin, 2007, The chemokine receptor CCR7 mediates corneal antigen-presenting cell trafficking, Mol. Vis., 13, 626 Joko, 2013, Involvement of P38MAPK in human corneal endothelial cell migration induced by TGF-β2, Exp. Eye Res., 108, 23, 10.1016/j.exer.2012.11.018 Joe, 2014, Concise review: identifying limbal stem cells: classical concepts and new challenges, Stem Cells Trans. Med., 3, 318, 10.5966/sctm.2013-0137 Joyce, 2012, Potential of human umbilical cord blood mesenchymal stem cells to heal damaged corneal endothelium, Mol. Vis., 18, 547 Joyce, 1990, In vitro pharmacologic separation of corneal endothelial migration and spreading responses, Invest. Ophthalmol. Vis. Sci., 31, 1816 Joyce, 1994, PGE2: a mediator of corneal endothelial wound repair in vitro, Am. J. Physiol., 266, C269, 10.1152/ajpcell.1994.266.1.C269 Jung, 2007, Constitutive collagenase-1 synthesis through MAPK pathways is mediated, in part, by endogenous IL-1α during fibrotic repair in corneal stroma, J. Cell Biochem., 102, 453, 10.1002/jcb.21309 Kabosova, 2003, Human diabetic corneas preserve wound healing, basement membrane, integrin and MMP-10 differences from normal corneas in organ culture, Exp. Eye Res., 77, 211, 10.1016/S0014-4835(03)00111-8 Kabosova, 2007, Compositional differences between infant and adult human corneal basement membranes, Invest. Ophthalmol. Vis. Sci., 48, 4989, 10.1167/iovs.07-0654 Kaji, 2003, Corneal wound healing after excimer laser keratectomy, Semin. Ophthalmol., 18, 11, 10.1076/soph.18.1.11.14075 Kakazu, 2004, HGF protects corneal epithelial cells from apoptosis by the PI-3K/Akt-1/Bad- but not the ERK1/2-mediated signaling pathway, Invest. Ophthalmol. Vis. Sci., 45, 3485, 10.1167/iovs.04-0372 Kakazu, 2012, Lipoxin A₄ inhibits platelet-activating factor inflammatory response and stimulates corneal wound healing of injuries that compromise the stroma, Exp. Eye Res., 103, 9, 10.1016/j.exer.2012.07.008 Kakazu, 2008, Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing, Invest. Ophthalmol. Vis. Sci., 49, 2927, 10.1167/iovs.07-0709 Kamiyama, 1998, Effects of PDGF on the migration of rabbit corneal fibroblasts and epithelial cells, Cornea, 17, 315, 10.1097/00003226-199805000-00013 Kamma-Lorger, 2009, Collagen ultrastructural changes during stromal wound healing in organ cultured bovine corneas, Exp. Eye Res., 88, 953, 10.1016/j.exer.2008.12.005 Karali, 2010, miRNeye: a microRNA expression atlas of the mouse eye, BMC Genomics, 11, 715, 10.1186/1471-2164-11-715 Karamichos, 2011, Transforming growth factor-β3 regulates assembly of a non-fibrotic matrix in a 3D corneal model, J. Tissue Eng. Regen. Med., 5, e228, 10.1002/term.429 Karamichos, 2014, A role for topographic cues in the organization of collagenous matrix by corneal fibroblasts and stem cells, PLoS One, 9, e86260, 10.1371/journal.pone.0086260 Karamichos, 2014, Reversal of fibrosis by TGF-β3 in a 3D in vitro model, Exp. Eye Res., 124, 31, 10.1016/j.exer.2014.04.020 Karuri, 2004, Biological length scale topography enhances cell-substratum adhesion of human corneal epithelial cells, J. Cell Sci., 117, 3153, 10.1242/jcs.01146 Kato, 2003, Expression of type XVIII collagen during healing of corneal incisions and keratectomy wounds, Invest. Ophthalmol. Vis. Sci., 44, 78, 10.1167/iovs.01-1257 Kaur, 2009, Corneal myofibroblast viability: opposing effects of IL-1 and TGF-β1, Exp. Eye Res., 89, 152, 10.1016/j.exer.2009.03.001 Kaur, 2009, Corneal stroma PDGF blockade and myofibroblast development, Exp. Eye Res., 88, 960, 10.1016/j.exer.2008.12.006 Keadle, 2000, IL-1 and TNF-α are important factors in the pathogenesis of murine recurrent herpetic stromal keratitis, Invest. Ophthalmol. Vis. Sci., 41, 96 Kenyon, 1989, Limbal autograft transplantation for ocular surface disorders, Ophthalmology, 96, 709, 10.1016/S0161-6420(89)32833-8 Kim, 2004, TGF-β 1 stimulates production of gelatinase (MMP-collagenases (MMP-1, -13) and stromelysins (MMP-3, -10, -11) by human corneal epithelial cells, Exp. Eye Res., 79, 263, 10.1016/j.exer.2004.05.003 Kim, 2006, Quantitative assessment of local collagen matrix remodeling in 3-D culture: the role of Rho kinase, Exp. Cell Res., 312, 3683, 10.1016/j.yexcr.2006.08.009 Kim, 2007, Microtubule regulation of corneal fibroblast morphology and mechanical activity in 3-D culture, Exp. Eye Res., 85, 546, 10.1016/j.exer.2007.07.008 Kimura, 2008, Role of JNK-dependent serine phosphorylation of paxillin in migration of corneal epithelial cells during wound closure, Invest. Ophthalmol. Vis. Sci., 49, 125, 10.1167/iovs.07-0725 Klausner, 2010, Ultrapure chitosan oligomers as carriers for corneal gene transfer, Biomaterials, 31, 1814, 10.1016/j.biomaterials.2009.10.031 Klocek, 2009, Naltrexone and insulin are independently effective but not additive in accelerating corneal epithelial healing in type I diabetic rats, Exp. Eye Res., 89, 686, 10.1016/j.exer.2009.06.010 Kogo, 2011, Clinical significance of miR-146a in gastric cancer cases, Clin. Cancer Res., 17, 4277, 10.1158/1078-0432.CCR-10-2866 Koizumi, 2014, New therapeutic modality for corneal endothelial disease using Rho-associated kinase inhibitor eye drops, Cornea, 33, S25, 10.1097/ICO.0000000000000240 Kolli, 2014, Successful application of ex vivo expanded human autologous oral mucosal epithelium for the treatment of total bilateral limbal stem cell deficiency, Stem Cells., 32, 2135, 10.1002/stem.1694 Kostarnoy, 2013, Topical bacterial lipopolysaccharide application affects inflammatory response and promotes wound healing, J. Interferon Cytokine Res., 33, 514, 10.1089/jir.2012.0108 Koulikovska, 2015, Enhanced regeneration of corneal tissue via a bioengineered collagen construct implanted by a nondisruptive surgical technique, Tissue Eng. Part A, 21, 1116, 10.1089/ten.tea.2014.0562 Krutzfeldt, 2005, Silencing of microRNAs in vivo with ‘antagomirs’, Nature, 438, 685, 10.1038/nature04303 Ksander, 2014, ABCB5 is a limbal stem cell gene required for corneal development and repair, Nature, 511, 353, 10.1038/nature13426 Kumagai, 2010, Induction of corneal epithelium–like cells from cynomolgus monkey embryonic stem cells and their experimental transplantation to damaged cornea, Cornea, 29, 432, 10.1097/ICO.0b013e3181b9ffcc Kureshi, 2014, Challenges in the development of a reference standard and potency assay for the clinical production of RAFT tissue equivalents for the cornea, Regen. Med., 9, 167, 10.2217/rme.13.92 Kurpakus, 1992, The role of the basement membrane in differential expression of keratin proteins in epithelial cells, Dev. Biol., 150, 243, 10.1016/0012-1606(92)90239-D Kuwabara, 1976, Sliding of the epithelium in experimental corneal wounds, Invest. Ophthalmol., 15, 4 Kyriakides, 2009, Mice that lack matrix metalloproteinase-9 display delayed wound healing associated with delayed reepithelization and disordered collagen fibrillogenesis, Matrix Biol., 28, 65, 10.1016/j.matbio.2009.01.001 Lai, 2004, Mitomycin C alters corneal stromal wound healing and corneal haze in rabbits after argon-fluoride excimer laser photorefractive keratectomy, J. Ocul. Pharmacol. Ther., 20, 129, 10.1089/108076804773710803 Lam, 2011, Platelets enhance neutrophil transendothelial migration via P-selectin glycoprotein ligand-1, Am. J. Physiol. Heart Circ. Physiol., 300, H468, 10.1152/ajpheart.00491.2010 Lambiase, 1998, Expression of nerve growth factor receptors on the ocular surface in healthy subjects and during manifestation of inflammatory diseases, Invest. Ophthalmol. Vis. Sci., 39, 1272 Lambiase, 1998, Topical treatment with nerve growth factor for corneal neurotrophic ulcers, N. Eng. J. Med., 338, 1174, 10.1056/NEJM199804233381702 Lambiase, 1999, Management of neurotrophic keratopathy, Curr. Opin. Ophthalmol., 10, 270, 10.1097/00055735-199908000-00009 Lambiase, 2004, Nerve growth factor and the immune system: old and new concepts in the cross-talk between immune and resident cells during pathophysiological conditions, Curr. Opin. Allergy Clin. Immunol., 4, 425, 10.1097/00130832-200410000-00015 Lan, 2012, Kinetics and function of mesenchymal stem cells in corneal injury, Invest. Ophthalmol. Vis. Sci., 53, 3638, 10.1167/iovs.11-9311 Landshman, 1989, Cell division in the healing of the corneal endothelium of cats, Arch. Ophthalmol., 107, 1804, 10.1001/archopht.1989.01070020886032 Latvala, 1995, Expression of cellular fibronectin and tenascin in the rabbit cornea after excimer laser photorefractive keratectomy: a 12 month study, Br. J. Ophthalmol., 79, 65, 10.1136/bjo.79.1.65 Latvala, 1995, Reassembly of the α6β4 integrin and laminin in rabbit corneal basement membrane after excimer laser surgery: a 12-month follow-up, CLAO J., 21, 125 Lavker, 1983, Epidermal stem cells, J. Invest. Dermatol., 81, 121s, 10.1111/1523-1747.ep12540880 Lavker, 1998, Phorbol ester preferentially stimulates mouse fornical conjunctival and limbal epithelial cells to proliferate in vivo, Invest. Ophthalmol. Vis. Sci., 39, 301 Leask, 2004, TGF-beta signaling and the fibrotic response, FASEB J., 18, 816, 10.1096/fj.03-1273rev Lee, 2014, Hypoxia-induced changes in Ca2+ mobilization and protein phosphorylation implicated in impaired wound healing, Am. J. Physiol. Cell. Physiol., 306, C972, 10.1152/ajpcell.00110.2013 Lee, 2013, Interleukin-1β enhances cell migration through AP-1 and NF-κB pathway-dependent FGF2 expression in human corneal endothelial cells, Biol. Cell, 105, 175, 10.1111/boc.201200077 Lee, 2014, Interleukin-1β-induced Wnt5a enhances human corneal endothelial cell migration through regulation of Cdc42 and RhoA, Mol. Cell Biol., 34, 3535, 10.1128/MCB.01572-13 Lee, 1995, Ocular surface squamous neoplasia, Surv. Ophthalmol., 39, 429, 10.1016/S0039-6257(05)80054-2 Lee, 2006, FGF-2-induced wound healing in corneal endothelial cells requires Cdc42 activation and Rho inactivation through the phosphatidylinositol 3-kinase pathway, Invest. Ophthalmol. Vis. Sci., 47, 1376, 10.1167/iovs.05-1223 Lee, 2012, Endothelial mesenchymal transformation mediated by IL-1β-induced FGF-2 in corneal endothelial cells, Exp. Eye Res., 95, 35, 10.1016/j.exer.2011.08.003 Lee, 2004, FGF-2 induced by interleukin-1 beta through the action of phosphatidylinositol 3-kinase mediates endothelial mesenchymal transformation in corneal endothelial cells, J. Biol. Chem., 279, 32325, 10.1074/jbc.M405208200 Lee, 2006, Insulin-like growth factor-1 induces migration and expression of laminin-5 in cultured human corneal epithelial cells, Invest. Ophthalmol. Vis. Sci., 47, 873, 10.1167/iovs.05-0826 Lee, 2009, Bevacizumab accelerates corneal wound healing by inhibiting TGF-β2 expression in alkali-burned mouse cornea, BMB Rep., 42, 800, 10.5483/BMBRep.2009.42.12.800 Lehrer, 1998, Strategies of epithelial repair: modulation of stem cell and transit amplifying cell proliferation, J. Cell Sci., 111, 2867, 10.1242/jcs.111.19.2867 Leung, 1995, A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes, J. Biol. Chem., 270, 29051, 10.1074/jbc.270.49.29051 Levis, 2009, New technologies in limbal epithelial stem cell transplantation, Curr. Opin. Biotechnol., 20, 593, 10.1016/j.copbio.2009.09.002 Li, 1995, Three patterns of cytokine expression potentially involved in epithelial-fibroblast interactions of human ocular surface, J. Cell. Physiol., 163, 61, 10.1002/jcp.1041630108 Li, 1996, Hepatocyte growth factor and hepatocyte growth factor receptor in the lacrimal gland, tears, and cornea, Invest. Ophthalmol. Vis. Sci., 37, 727 Li, 2000, The role of apoptosis in the early corneal wound healing after excimer laser keratectomy in the rat, Graefes Arch. Clin. Exp. Ophthalmol., 238, 853, 10.1007/s004170000182 Li, 2005, Epidermal growth factor-induced proliferation requires down-regulation of Pax6 in corneal epithelial cells, J. Biol. Chem., 280, 12988, 10.1074/jbc.M412458200 Li, 2007, Non-viral is superior to viral gene delivery, J. Control Release, 123, 181, 10.1016/j.jconrel.2007.09.004 Li, 2007, γδ T cells are necessary for platelet and neutrophil accumulation in limbal vessels and efficient epithelial repair after corneal abrasion, Am. J. Pathol., 171, 838, 10.2353/ajpath.2007.070008 Li, 2006, Lymphocyte function-associated antigen-1-dependent inhibition of corneal wound healing, Am. J. Pathol., 169, 1590, 10.2353/ajpath.2006.060415 Li, 2006, Platelet response to corneal abrasion is necessary for acute inflammation and efficient re-epithelialization, Invest. Ophthalmol. Vis. Sci., 47, 4794, 10.1167/iovs.06-0381 Li, 2010, Antagomir dependent microRNA-205 reduction enhances adhesion ability of human corneal epithelial keratinocytes, Chin. Med. Sci. J., 25, 65, 10.1016/S1001-9294(10)60024-7 Li, 2011, IL-17 and VEGF are necessary for efficient corneal nerve regeneration, Am. J. Pathol., 178, 1106, 10.1016/j.ajpath.2010.12.001 Li, 2013, Macrophage depletion impairs corneal wound healing after autologous transplantation in mice, PLoS One, 8, e61799, 10.1371/journal.pone.0061799 Li, 2009, Targeted deletion of Dicer disrupts lens morphogenesis, corneal epithelium stratification, and whole eye development, Dev. Dyn., 238, 2388, 10.1002/dvdy.22056 Li, 2003, Regulated expression of collagenases MMP-1, -8, and -13 and stromelysins MMP-3, -10, and -11 by human corneal epithelial cells, Invest. Ophthalmol Vis Sci., 44, 2928, 10.1167/iovs.02-0874 Liang, 2009, Limbal stem cell transplantation: new progresses and challenges, Eye, 23, 1946, 10.1038/eye.2008.379 Liliensiek, 2006, The scale of substratum topographic features modulates proliferation of corneal epithelial cells and corneal fibroblasts, J. Biomed. Mater. Res. A, 79, 185, 10.1002/jbm.a.30744 Lim, 2009, Limbal stem cell deficiency and corneal neovascularization, Sem. Ophthalmol., 24, 139, 10.1080/08820530902801478 Lin, 2013, Inhibition of miR-205 impairs the wound-healing process in human corneal epithelial cells by targeting KIR4.1 (KCNJ10), Invest. Ophthalmol. Vis. Sci., 54, 6167, 10.1167/iovs.12-11577 Lin, 2013, Topical administration of orbital fat-derived stem cells promotes corneal tissue regeneration, Stem Cell Res. Ther., 4, 72, 10.1186/scrt223 Linna, 1997, Real-time confocal microscopic observations on human corneal nerves and wound healing after excimer laser photorefractive keratectomy, Curr. Eye Res., 16, 640, 10.1076/ceyr.16.7.640.5058 Liu, 2001, Expression of the receptor tyrosine kinases, epidermal growth factor receptor, ErbB2, and ErbB3, in human ocular surface epithelia, Cornea, 20, 81, 10.1097/00003226-200101000-00016 Liu, 2008, Different tropism of adenoviruses and adeno-associated viruses to corneal cells: implications for corneal gene therapy, Mol. Vis., 14, 2087 Liu, 2012, NK cells modulate the inflammatory response to corneal epithelial abrasion and thereby support wound healing, J. Pathol., 181, 452, 10.1016/j.ajpath.2012.04.010 Ljubimov, 1995, Human corneal basement membrane heterogeneity: topographical differences in the expression of type IV collagen and laminin isoforms, Lab. Invest, 72, 461 Ljubimov, 1996, Extracellular matrix alterations in human corneas with bullous keratopathy, Invest. Ophthalmol. Vis. Sci., 37, 997 Ljubimov, 1996, Basement membrane abnormalities in human eyes with diabetic retinopathy, J. Histochem. Cytochem, 44, 1469, 10.1177/44.12.8985139 Ljubimov, 1998, Human corneal epithelial basement membrane and integrin alterations in diabetes and diabetic retinopathy, J. Histochem. Cytochem., 46, 1033, 10.1177/002215549804600907 Ljubimov, 1998, Extracellular matrix changes in human corneas after radial keratotomy, Exp. Eye Res., 67, 265, 10.1006/exer.1998.0511 Low, 1981, Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces terminal deoxynucleotidyltransferase activity in thymocyte populations, Proc. Natl. Acad. Sci. U. S. A., 78, 1162, 10.1073/pnas.78.2.1162 Lu, 2001, Corneal epithelial wound healing, Exp. Biol. Med., 226, 653, 10.1177/153537020222600711 Lu, 2010, NF-κB subtypes regulate CCCTC binding factor affecting corneal epithelial cell fate, J. Biol. Chem., 285, 9373, 10.1074/jbc.M109.094425 Lyu, 2006, Transactivation of EGFR mediates insulin-stimulated ERK1/2 activation and enhanced cell migration in human corneal epithelial cells, Mol. Vis., 12, 1403 Ma, 2006, Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells, Stem Cells, 24, 315, 10.1634/stemcells.2005-0046 Ma, 2013, The graft of autologous adipose-derived stem cells in the corneal stromal after mechanic damage, PLoS One, 8, e76103, 10.1371/journal.pone.0076103 Madhyastha, 2012, MicroRNA signature in diabetic wound healing: promotive role of miR-21 in fibroblast migration, Int. Wound J., 9, 355, 10.1111/j.1742-481X.2011.00890.x Maguen, 1997, Alterations of corneal extracellular matrix after multiple refractive procedures: a clinical and immunohistochemical study, Cornea, 16, 675, 10.1097/00003226-199711000-00012 Maguen, 2002, Extracellular matrix and matrix metalloproteinase changes in human corneas after complicated laser-assisted in situ keratomileusis (LASIK), Cornea, 21, 95, 10.1097/00003226-200201000-00020 Maguen, 2007, Immunohistochemical evaluation of two corneal buttons with post-LASIK keratectasia, Cornea, 26, 983, 10.1097/ICO.0b013e3180de1d91 Maguen, 2008, Alterations of extracellular matrix components and proteinases in human corneal buttons with INTACS for post-laser in situ keratomileusis keratectasia and keratoconus, Cornea, 27, 565, 10.1097/ICO.0b013e318165b1cd Malecaze, 2014, Upregulation of bone morphogenetic protein-1/mammalian tolloid and procollagen C-proteinase enhancer-1 in corneal scarring, Invest. Ophthalmol. Vis. Sci., 55, 6712, 10.1167/iovs.13-13800 Mann, 1993, Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation, Cell, 73, 249, 10.1016/0092-8674(93)90227-H Márquez, 2011, Epidermal growth factor receptor in corneal damage: update and new insights from recent reports, Cutan. Ocul. Toxicol., 30, 7, 10.3109/15569527.2010.498398 Martin, 1987, Laminin and other basement membrane components, Annu. Rev. Cell Biol., 3, 57, 10.1146/annurev.cb.03.110187.000421 Matsuba, 2011, Localization of thrombospondin-1 and myofibroblasts during corneal wound repair, Exp. Eye Res., 93, 534, 10.1016/j.exer.2011.06.018 Mauris, 2014, Molecular basis for MMP9 induction and disruption of epithelial cell-cell contacts by galectin-3, J. Cell Sci., 127, 3141, 10.1242/jcs.148510 Maycock, 2014, Genomics of corneal wound healing: a review of the literature, Acta Ophthalmol., 92, e170, 10.1111/aos.12227 Mayer, 2014, In vitro immunohistochemical and morphological observations of penetrating corneal incisions created by a femtosecond laser used for assisted intraocular lens surgery, J. Cataract Refract. Surg., 40, 632, 10.1016/j.jcrs.2014.02.015 Mayo, 2008, Regulation by P2X7: epithelial migration and stromal organization in the cornea, Invest. Ophthalmol. Vis. Sci., 49, 4384, 10.1167/iovs.08-1688 McClintock, 2010, Transforming growth factor-α enhances corneal epithelial cell migration by promoting EGFR recycling, Invest. Ophthalmol. Vis. Sci., 51, 3455, 10.1167/iovs.09-4386 McLaughlin, 2010, Diabetic keratopathy and treatment by modulation of the opioid growth factor (OGF) – OGF receptor (OGFr) axis with naltrexone: a review, Brain Res. Bull., 81, 236, 10.1016/j.brainresbull.2009.08.008 Meduri, 2012, Effect of basic fibroblast growth factor on corneal epithelial healing after photorefractive keratectomy, J. Refract. Surg., 28, 220, 10.3928/1081597X-20120103-02 Melles, 2006, Descemet membrane endothelial keratoplasty (DMEK), Cornea, 25, 987, 10.1097/01.ico.0000248385.16896.34 Melles, 1995, Immunohistochemical analysis of unsutured and sutured corneal wound healing, Curr. Eye Res., 14, 809, 10.3109/02713689508995803 Meltendorf, 2009, Intrastromal keratotomy with femtosecond laser avoids profibrotic TGF-β1 induction, Invest. Ophthalmol. Vis. Sci., 50, 3688, 10.1167/iovs.08-2699 Meyer-Blazejewska, 2011, From hair to cornea: toward the therapeutic use of hair follicle-derived stem cells in the treatment of limbal stem cell deficiency, Stem Cells, 29, 57, 10.1002/stem.550 Mi, 2013, The formation of a tissue-engineered cornea using plastically compressed collagen scaffolds and limbal stem cells, Methods Mol. Biol., 1014, 143, 10.1007/978-1-62703-432-6_9 Micera, 2004, Nerve growth factor involvement in the visual system: implications in allergic and neurodegenerative diseases, Cytokine Growth Factor Rev., 15, 411, 10.1016/j.cytogfr.2004.09.003 Micera, 2006, Nerve growth factor effect on human primary fibroblastic-keratocytes: possible mechanism during corneal healing, Exp. Eye Res., 83, 747, 10.1016/j.exer.2006.03.010 Milani, 2013, Rapamycin inhibits the production of myofibroblasts and reduces corneal scarring after photorefractive keratectomy, Invest. Ophthalmol. Vis. Sci., 54, 7424, 10.1167/iovs.13-12674 Mimura, 2013, Corneal endothelial regeneration and tissue engineering, Prog. Retin. Eye Res., 35, 1, 10.1016/j.preteyeres.2013.01.003 Minns, 2015, P2X7 is necessary for wound-induced Ca2+ mobilization and cytoskeletal rearrangements in the corneal epithelium, Invest. Ophthalmol. Vis. Sci., 56, 5829 Mishima, 1992, Transforming growth factor-beta modulates effects of epidermal growth factor on corneal epithelial cells, Curr. Eye Res., 11, 691, 10.3109/02713689209000742 Miyamoto, 2010, Endothelial mesenchymal transition: a therapeutic target in retrocorneal membrane, Cornea, 29, S52, 10.1097/ICO.0b013e3181efe36a Miyazaki, 2008, Corneal wound healing in an osteopontin-deficient mouse, Invest. Ophthalmol. Vis. Sci., 49, 1367, 10.1167/iovs.07-1007 Mohan, 2002, Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration, J. Biol. Chem., 277, 2065, 10.1074/jbc.M107611200 Mohan, 2010, Decorin transfection suppresses profibrogenic genes and myofibroblast formation in human corneal fibroblasts, Exp. Eye Res., 91, 238, 10.1016/j.exer.2010.05.013 Mohan, 2003, Gene transfer into rabbit keratocytes using AAV and lipid-mediated plasmid DNA vectors with a lamellar flap for stromal access, Exp. Eye Res., 76, 373, 10.1016/S0014-4835(02)00275-0 Mohan, 2005, Gene therapy in the cornea, Prog. Retin. Eye Res., 24, 537, 10.1016/j.preteyeres.2005.04.001 Mohan, 2011, Significant inhibition of corneal scarring in vivo with tissue-selective, targeted AAV5 decorin gene therapy, Invest. Ophthalmol. Vis. Sci., 52, 4833, 10.1167/iovs.11-7357 Møller-Pedersen, 1998, Neutralizing antibody to TGFβ modulates stromal fibrosis but not regression of photoablative effect following PRK, Curr. Eye Res., 17, 736, 10.1076/ceyr.17.7.736.5163 Møller-Pedersen, 2000, Stromal wound healing explains refractive instability and haze development after photorefractive keratectomy: a 1-year confocal microscopic study, Ophthalmology, 107, 1235, 10.1016/S0161-6420(00)00142-1 Monteiro, 2009, Human immature dental pulp stem cells share key characteristic features with limbal stem cells, Cell Prolif., 42, 587, 10.1111/j.1365-2184.2009.00623.x Morishige, 2008, Corneal response to femtosecond laser photodisruption in the rabbit, Exp. Eye Res., 86, 835, 10.1016/j.exer.2008.02.012 Morita, 2007, Human corneal epithelial cell proliferation by epiregulin and its cross-induction by other EGF family members, Mol. Vis., 13, 2119 Mott, 2004, Regulation of matrix biology by matrix metalloproteinases, Curr. Opin. Cell Biol., 16, 558, 10.1016/j.ceb.2004.07.010 Mulik, 2013, Potential function of miRNAs in herpetic stromal keratitis, Invest. Ophthalmol. Vis. Sci., 54, 563, 10.1167/iovs.12-11094 Munjal, 1990, Thrombospondin: biosynthesis, distribution, and changes associated with wound repair in corneal endothelium, Eur. J. Cell Biol., 52, 252 Murakami, 1992, Coordinated appearance of beta 1 integrins and fibronectin during corneal wound healing, J. Lab. Clin. Med., 120, 86 Nagano, 2003, Effects of substance P and IGF-1 in corneal epithelial barrier function and wound healing in a rat model of neurotrophic keratopathy, Invest. Ophthalmol. Vis. Sci., 44, 3810, 10.1167/iovs.03-0189 Nagase, 2003, Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors, Biochem. Soc. Symp., 70, 201, 10.1042/bss0700201 Nakamura, 1997, Combined effects of substance P and insulin-like growth factor-1 on corneal epithelial wound closure of rabbit in vivo, Curr. Eye Res., 16, 275, 10.1076/ceyr.16.3.275.15409 Nakamura, 1999, Differential effects of epidermal growth factor and interleukin 6 on corneal epithelial cells and vascular endothelial cells, Cornea, 18, 452, 10.1097/00003226-199907000-00011 Nakamura, 2001, The epidermal growth factor receptor (EGFR): role in corneal wound healing and homeostasis, Exp. Eye Res., 72, 511, 10.1006/exer.2000.0979 Nakamura, 2003, Promotion of corneal epithelial wound healing in diabetic rats by the combination of a substance P-derived peptide (FGLM-NH2) and insulin-like growth factor-1, Diabetologia, 46, 839, 10.1007/s00125-003-1105-9 Nakamura, 2011, Long-term results of autologous cultivated oral mucosal epithelial transplantation in the scar phase of severe ocular surface disorders, Br. J. Ophthalmol., 95, 942, 10.1136/bjo.2010.188714 Nakano, 2008, Connexin 43 knockdown accelerates wound healing but inhibits mesenchymal transition after corneal endothelial injury in vivo, Invest. Ophthalmol. Vis. Sci., 49, 93, 10.1167/iovs.07-0255 Nakayasu, 1988, Stromal changes following removal of epithelium in rat cornea, Jpn. J. Ophthalmol., 32, 113 Nakayasu, 1986, Distribution of types I, II, III, IV and V collagen in normal and keratoconus corneas, Ophthalmic Res., 18, 1, 10.1159/000265406 Nelson, 2000, Matrix metalloproteinases: biologic activity and clinical implications, J. Clin. Oncol., 18, 1135, 10.1200/JCO.2000.18.5.1135 Netto, 2005, Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy, Cornea, 24, 509, 10.1097/01.ico.0000151544.23360.17 Netto, 2006, Stromal haze, myofibroblasts, and surface irregularity after PRK, Exp. Eye Res., 82, 788, 10.1016/j.exer.2005.09.021 Nickeleit, 1996, Healing corneas express embryonic fibronectin isoforms in the epithelium, subepithelial stroma, and endothelium, Am. J. Pathol., 149, 549 Nishida, 2010, Translational research in corneal epithelial wound healing, Eye Contact Lens, 36, 300, 10.1097/ICL.0b013e3181f016d0 Nishida, 1990, Differential modes of action of fibronectin and epidermal growth factor on rabbit corneal epithelial migration, J. Cell Physiol., 145, 549, 10.1002/jcp.1041450323 Nishida, 1994, Immunohistochemical localization of transforming growth factor-β1, -β2, and -β3 latency-associated peptide in human cornea, Invest. Ophthalmol. Vis. Sci., 35, 3289 Nishida, 1996, Synergistic effects of substance P with insulin-like growth factor-1 on epithelial migration of the cornea, J. Cell. Physiol., 169, 159, 10.1002/(SICI)1097-4652(199610)169:1<159::AID-JCP16>3.0.CO;2-8 Noisa, 2012, Identification and characterisation of the early differentiating cells in neural differentiation of human embryonic stem cells, PLoS One, 7, e37129, 10.1371/journal.pone.0037129 Okadal, 1996, Expression of fos family and jun family proto-oncogenes during corneal epithelial wound healing, Curr. Eye Res., 15, 824, 10.3109/02713689609017623 Okumura, 2011, Enhancement of corneal endothelium wound healing by Rho-associated kinase (ROCK) inhibitor eye drops, Br. J. Ophthalmol., 95, 1006, 10.1136/bjo.2010.194571 Okumura, 2013, The ROCK inhibitor eye drop accelerates corneal endothelium wound healing, Invest. Ophthalmol. Vis. Sci., 54, 2493, 10.1167/iovs.12-11320 Okumura, 2013, Inhibition of TGF-β signaling enables human corneal endothelial cell expansion in vitro for use in regenerative medicine, PLoS One, 8, e58000, 10.1371/journal.pone.0058000 Okumura, 2014, Involvement of cyclin D and p27 in cell proliferation mediated by ROCK inhibitors Y-27632 and Y-39983 during corneal endothelium wound healing, Invest. Ophthalmol. Vis. Sci., 55, 318, 10.1167/iovs.13-12225 Oliveira, 2010, Gene transfer to primary corneal epithelial cells with an integrating lentiviral vector, Arq. Bras. Oftalmol., 73, 447, 10.1590/S0004-27492010000500012 Ono, 2007, Autologous transplantation of conjunctival epithelial cells cultured on amniotic membrane in a rabbit model, Mol. Vis., 13, 1138 Ordonez, 2012, Limbal epithelial stem cells: role of the niche microenvironment, Stem Cells, 30, 100, 10.1002/stem.794 Ottino, 2002, Platelet-activating factor induces the gene expression of TIMP-1, -2, and PAI-1: imbalance between the gene expression of MMP-9 and TIMP-1 and -2, Exp. Eye Res., 74, 393, 10.1006/exer.2001.1135 Pal-Ghosh, 2011, MMP9 cleavage of the β4 integrin ectodomain leads to recurrent epithelial erosions in mice, J. Cell Sci., 124, 2666, 10.1242/jcs.085480 Pal-Ghosh, 2011, Removal of the basement membrane enhances corneal wound healing, Exp. Eye Res., 93, 927, 10.1016/j.exer.2011.10.012 Pancholi, 1998, The effects of growth factors and conditioned media on the proliferation of human corneal epithelial cells and keratocytes, Graefes Arch. Clin. Exp. Ophthalmol., 236, 1, 10.1007/s004170050034 Parker, 2010, Lentivirus-mediated gene transfer of interleukin 10 to the ovine and human cornea, Clin. Exp. Ophthalmol., 38, 405, 10.1111/j.1442-9071.2010.02261.x Pearlman, 2008, Toll-like receptors at the ocular surface, Ocul. Surf., 6, 108, 10.1016/S1542-0124(12)70279-3 Pellegrini, 1997, Lancet, 349, 990, 10.1016/S0140-6736(96)11188-0 Pellegrini, 1999, Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface, J. Cell Biol., 145, 769, 10.1083/jcb.145.4.769 Pellegrini, 2009, Epithelial stem cells in corneal regeneration and epidermal gene therapy, J. Pathol., 217, 217, 10.1002/path.2441 Pellegrini, 2011, Vision from the right stem, Trends Mol. Med., 17, 1, 10.1016/j.molmed.2010.10.003 Pellegrini, 2014, Concise review: hurdles in a successful example of limbal stem cell-based regenerative medicine, Stem Cells, 32, 26, 10.1002/stem.1517 Peng, 2015, microRNA-103/107 family regulates multiple epithelial stem cell characteristics, Stem Cells, 33, 1642, 10.1002/stem.1962 Pérez-Santonja, 1998, Corneal wound healing after laser in situ keratomileusis in rabbits, J. Refract Surg., 14, 602, 10.3928/1081-597X-19981101-06 Peterson, 2014, The role of endogenous epidermal growth factor receptor ligands in mediating corneal epithelial homeostasis, Invest. Ophthalmol. Vis. Sci., 55, 2870, 10.1167/iovs.13-12943 Petroll, 1997, ZO-1 reorganization and myofibroblast transformation of corneal endothelial cells after freeze injury in the cat, Exp. Eye Res., 64, 257, 10.1006/exer.1996.0211 Petroll, 2008, Assessment of keratocyte activation following LASIK with flap creation using the IntraLase FS60 laser, J. Refract Surg., 24, 847, 10.3928/1081597X-20081001-15 Petznick, 2013, Contributions of ocular surface components to matrix-metalloproteinases (MMP)-2 and MMP-9 in feline tears following corneal epithelial wounding, PLoS One, 8, e7194, 10.1371/journal.pone.0071948 Pınarlı, 2014, Keratinocyte growth factor-2 and autologous serum potentiate the regenerative effect of mesenchymal stem cells in cornea damage in rats, Int. J. Ophthalmol., 7, 211 Pipparelli, 2013, ROCK inhibitor enhances adhesion and wound healing of human corneal endothelial cells, PLoS One, 8, e62095, 10.1371/journal.pone.0062095 Power, 1995, Expression of collagens I, III, IV and V mRNA in excimer wounded rat cornea: analysis by semi-quantitative PCR, Curr. Eye Res., 14, 879, 10.3109/02713689508995127 Price, 2007, Descemet's stripping endothelial keratoplasty, Curr. Opin. Ophthalmol., 2007, 290, 10.1097/ICU.0b013e3281a4775b Priglinger, 2006, Immunohistochemical findings after LASIK confirm in vitro LASIK model, Cornea, 25, 331, 10.1097/01.ico.0000183535.99651.7b Proulx, 2010, Reconstruction of a human cornea by the self-assembly approach of tissue engineering using the three native cell types, Mol. Vis., 16, 2192 Qazi, 2012, Nanoparticle-mediated delivery of shRNA. VEGF-A plasmids regresses corneal neovascularization, Invest. Ophthalmol. Vis. Sci., 53, 2837, 10.1167/iovs.11-9139 Raphael, 1993, Enhanced healing of cat corneal endothelial wounds by epidermal growth factor, Invest. Ophthalmol. Vis. Sci., 34, 2305 Rama, 2010, Limbal stem-cell therapy and longterm corneal regeneration, N. Engl. J. Med., 363, 147, 10.1056/NEJMoa0905955 Reinshagen, 2011, Corneal surface reconstruction using adult mesenchymal stem cells in experimental limbal stem cell deficiency in rabbits, Acta Ophthalmol., 89, 741, 10.1111/j.1755-3768.2009.01812.x Rieck, 2001, Intracellular signaling pathway of FGF-2-modulated corneal endothelial cell migration during wound healing in vitro, Exp. Eye Res., 73, 639, 10.1006/exer.2001.1067 Ríos, 2007, Role of neurotrophins and neurotrophin receptors in rat conjunctival goblet cell secretion and proliferation, Invest. Ophthalmol. Vis. Sci., 48, 1543, 10.1167/iovs.06-1226 Rosen, 1994, Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction, J. Cell Biol., 127, 1783, 10.1083/jcb.127.6.1783 Roy, 2011, MiRNA in innate immune responses: novel players in wound inflammation, Physiol. Genomics, 43, 557, 10.1152/physiolgenomics.00160.2010 Rush, 2014, Antagonizing c-Cbl enhances EGFR-dependent corneal epithelial homeostasis, Invest. Ophthalmol. Vis. Sci., 55, 4691, 10.1167/iovs.14-14133 Ruiz-Ederra, 2009, Aquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing models, Exp. Eye Res., 89, 159, 10.1016/j.exer.2009.03.002 Sabatier, 1996, Effects of human recombinant basic fibroblast growth factor on endothelial wound healing in organ culture of human cornea, J. Fr. Ophtalmol., 19, 200 Saghizadeh, 2001, Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations, Am. J. Pathol., 158, 723, 10.1016/S0002-9440(10)64015-1 Saghizadeh, 2001, Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas, Exp. Eye Res., 73, 179, 10.1006/exer.2001.1028 Saghizadeh, 2005, Proteinase and growth factor alterations revealed by gene microarray analysis of human diabetic corneas, Invest. Ophthalmol. Vis. Sci., 46, 3604, 10.1167/iovs.04-1507 Saghizadeh, 2010, Normalization of wound healing and diabetic markers in organ cultured human diabetic corneas by adenoviral delivery of c-met gene, Invest. Ophthalmol. Vis. Sci., 51, 1970, 10.1167/iovs.09-4569 Saghizadeh, 2010, Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes, Brain Res. Bull., 81, 262, 10.1016/j.brainresbull.2009.10.007 Saghizadeh, 2011, Alterations of epithelial stem cell marker patterns in human diabetic corneas and effects of c-met gene therapy, Mol. Vis., 17, 2177 Saghizadeh, 2013, miRNA expression profiling in central and limbal diabetic and normal human corneas using deep sequencing, Invest. Ophthalmol. Vis. Sci., 54 Saghizadeh, 2014, Normalization of wound healing and stem cell marker patterns in organ-cultured human diabetic corneas by gene therapy of limbal cells, Exp. Eye Res., 129, 66, 10.1016/j.exer.2014.10.022 Saghizadeh, 2013, Enhanced wound healing, kinase and stem cell marker expression in diabetic organ-cultured human corneas upon MMP-10 and cathepsin F gene silencing, Invest. Ophthalmol. Vis. Sci., 54, 8172, 10.1167/iovs.13-13233 Saika, 1993, Epithelial basement membrane in alkali-burned corneas in rats. Immunohistochemical study, Cornea, 12, 383, 10.1097/00003226-199309000-00003 Saika, 2002, Epithelial repair: roles of extracellular matrix, Cornea, 21, S23, 10.1097/00003226-200203001-00006 Saika, 2004, Smad3 signaling is required for epithelial–mesenchymal transition of lens epithelium after injury, Am. J. Pathol., 164, 651, 10.1016/S0002-9440(10)63153-7 Saika, 2004, Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium, Invest. Ophthalmol. Vis. Sci., 45, 100, 10.1167/iovs.03-0700 Saika, 2013, Wakayama symposium: modulation of wound healing response in the corneal stroma by osteopontin and tenascin-C, Ocul. Surf., 11, 12, 10.1016/j.jtos.2012.09.002 Sakurai, 2011, Induction of putative stratified epithelial progenitor cells in vitro from mouse-induced pluripotent stem cells, J. Artif. Organs, 14, 58, 10.1007/s10047-010-0547-3 Salani, 2009, IGF-I induced rapid recruitment of integrin β1 to lipid rafts is caveolin-1 dependent, Biochem. Biophys. Res. Commun., 380, 489, 10.1016/j.bbrc.2009.01.102 Sareen, 2014, Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium, Stem Cells Transl. Med., 3, 1002, 10.5966/sctm.2014-0076 Schlötzer-Schrehardt, 2007, Characterization of extracellular matrix components in the limbal epithelial stem cell compartment, Exp. Eye Res., 85, 845, 10.1016/j.exer.2007.08.020 Schmack, 2005, Cohesive tensile strength of human LASIK wounds with histologic, ultrastructural, and clinical correlations, J. Refract. Surg., 21, 433, 10.3928/1081-597X-20050901-04 Seomun, 2008, Lumican induces human corneal epithelial cell migration and integrin expression via ERK 1/2 signaling, Biochem. Biophys. Res. Commun., 372, 221, 10.1016/j.bbrc.2008.05.014 Shahdadfar, 2012, Ex vivo expanded autologous limbal epithelial cells on amniotic membrane using a culture medium with human serum as single supplement, Exp. Eye Res., 97, 1, 10.1016/j.exer.2012.01.013 Shanley, 2004, Insulin, not leptin, promotes in vitro cell migration to heal monolayer wounds in human corneal epithelium, Invest. Ophthalmol. Vis. Sci., 45, 1088, 10.1167/iovs.03-1064 Shanmuganathan, 2006, Epithelial proliferative potential of organ cultured corneoscleral rims; implications for allo-limbal transplantation and eye banking, Br. J. Ophthalmol., 90, 55, 10.1136/bjo.2005.071910 Sharma, 2003, p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades, J. Biol. Chem., 278, 21989, 10.1074/jbc.M302650200 Sharma, 2009, Trichostatin A inhibits corneal haze in vitro and in vivo, Invest. Ophthalmol. Vis. Sci., 50, 2695, 10.1167/iovs.08-2919 Shi, 2012, Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing, PLoS One, 7, e32128, 10.1371/journal.pone.0032128 Singh, 2014, Transforming growth factor β and platelet-derived growth factor modulation of myofibroblast development from corneal fibroblasts in vitro, Exp. Eye Res., 120, 152, 10.1016/j.exer.2014.01.003 Singh, 2011, Effect of TGFβ and PDGF-B blockade on corneal myofibroblast development in mice, Exp. Eye Res., 93, 810, 10.1016/j.exer.2011.09.012 Singh, 2013, Mouse strain variation in SMA(+) myofibroblast development after corneal injury, Exp. Eye Res., 115, 27, 10.1016/j.exer.2013.06.006 Sivak, 2002, MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology, Prog. Retin. Eye Res., 21, 1, 10.1016/S1350-9462(01)00015-5 Soltau, 1993, Effects of growth factors on wound healing in serum-deprived kitten corneal endothelial cell cultures, Cornea, 12, 208, 10.1097/00003226-199305000-00005 Sosne, 2015, Thymosin β4 significantly improves signs and symptoms of severe dry eye in a phase 2 randomized trial, Cornea, 34, 491, 10.1097/ICO.0000000000000379 Sosne, 2002, Thymosin β4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury, Exp. Eye Res., 74, 293, 10.1006/exer.2001.1125 Sosne, 2004, Thymosin β-4 inhibits corneal epithelial cell apoptosis after ethanol exposure in vitro, Invest. Ophthalmol. Vis. Sci., 45, 1095, 10.1167/iovs.03-1002 Sosne, 2012, Thymosin β4: a potential novel dry eye therapy, Ann. N. Y. Acad. Sci., 1270, 45, 10.1111/j.1749-6632.2012.06682.x Sotozono, 1995, Keratinocyte growth factor accelerates corneal epithelial wound healing in vivo, Invest. Ophthalmol. Vis. Sci., 36, 1524 Sotozono, 2014, Cultivated oral mucosal epithelial transplantation for persistent epithelial defect in severe ocular surface diseases with acute inflammatory activity, Acta Ophthalmol., 92, e447, 10.1111/aos.12397 Sotozono, 1994, Paracrine role of keratinocyte growth factor in rabbit corneal epithelial cell growth, Exp. Eye Res., 59, 385, 10.1006/exer.1994.1122 Spix, 2007, Hepatocyte growth factor induces epithelial cell motility through transactivation of the epidermal growth factor receptor, Exp. Cell Res., 313, 3319, 10.1016/j.yexcr.2007.06.006 Sriram, 2014, Assessment of anti-scarring therapies in ex vivo organ cultured rabbit corneas, Exp. Eye Res., 125, 173, 10.1016/j.exer.2014.06.014 Sta Iglesia, 2000, Disruption of the basement membrane after corneal débridement, Invest. Ophthalmol. Vis. Sci., 41, 1045 Stepp, 2014, Wounding the cornea to learn how it heals, Exp. Eye Res., 121, 178, 10.1016/j.exer.2014.02.007 Stapleton, 2008, Topical interleukin-1 receptor antagonist inhibits inflammatory cell infiltration into the cornea, Exp. Eye Res., 86, 753, 10.1016/j.exer.2008.02.001 Stern, 1995, Effect of platelet-derived growth factor on rabbit corneal wound healing, Wound Repair Regen., 3, 59, 10.1046/j.1524-475X.1995.30111.x Stramer, 2003, Molecular mechanisms controlling the fibrotic repair phenotype in cornea: implications for surgical outcomes, Invest. Ophthalmol. Vis. Sci., 44, 4237, 10.1167/iovs.02-1188 Sugaya, 2011, Regulation of soluble interleukin-6 (IL-6) receptor release from corneal epithelial cells and its role in the ocular surface, Jpn. J. Ophthalmol., 55, 277, 10.1007/s10384-011-0002-x Sumioka, 2008, Inhibitory effect of blocking TGF-β/Smad signal on injury-induced fibrosis of corneal endothelium, Mol. Vis., 14, 2272 Sumioka, 2013, Impaired cornea wound healing in a tenascin C-deficient mouse model, Lab. Invest., 93, 207, 10.1038/labinvest.2012.157 Sun, 2004, Corneal epithelial stem cells: past, present, and future, J. Invest. Dermatol. Symp. Proc., 9, 202, 10.1111/j.1087-0024.2004.09311.x SundarRaj, 1998, A Rho-associated protein kinase: differentially distributed in limbal and corneal epithelia, Invest. Ophthalmol. Vis. Sci., 39, 1266 Suzuki, 2000, Coordinated reassembly of the basement membrane and junctional proteins during corneal epithelial wound healing, Invest. Ophthalmol. Vis. Sci., 41, 2495 Suzuki, 2003, Cell-matrix and cell-cell interactions during corneal epithelial wound healing, Prog. Retin. Eye Res., 22, 113, 10.1016/S1350-9462(02)00042-3 Szerenyi, 1994, Keratocyte loss and repopulation of anterior corneal stroma after de-epithelialization, Arch. Ophthalmol., 112, 973, 10.1001/archopht.1994.01090190121031 Takamura, 2013, Aldose reductase inhibitor counteracts the enhanced expression of matrix metalloproteinase-10 and improves corneal wound healing in galactose-fed rats, Mol. Vis., 19, 2477 Tandon, 2013, BMP7 gene transfer via gold nanoparticles into stroma inhibits corneal fibrosis in vivo, PLoS One, 8, e66434, 10.1371/journal.pone.0066434 Teng, 2015, Signature microRNAs in human cornea limbal epithelium, Funct. Integr. Genomics, 15, 277, 10.1007/s10142-014-0417-9 Terai, 2011, Crosstalk between TGF-β and MAPK signaling during corneal wound healing, Invest. Ophthalmol. Vis. Sci., 52, 8208, 10.1167/iovs.11-8017 Teranishi, 2008, Protection of human corneal epithelial cells from hypoxia-induced disruption of barrier function by keratinocyte growth factor, Invest. Ophthalmol. Vis. Sci., 49, 2432, 10.1167/iovs.07-1464 Tervo, 1991, Expression of tenascin and cellular fibronectin in the rabbit cornea after anterior keratectomy. Immunohistochemical study of wound healing dynamics, Invest. Ophthalmol. Vis. Sci., 32, 2912 Thalmann-Goetsch, 1997, Comparative study on the effects of different growth factors on migration of bovine corneal endothelial cells during wound healing, Acta. Ophthalmol. Scand., 75, 490, 10.1111/j.1600-0420.1997.tb00134.x Thill, 2007, A novel population of repair cells identified in the stroma of the human cornea, Stem Cells Dev., 16, 733, 10.1089/scd.2006.0084 Tolino, 2011, Brief treatment with heparin-binding EGF-like growth factor, but not with EGF, is sufficient to accelerate epithelial wound healing, Biochim. Biophys. Acta, 1810, 875, 10.1016/j.bbagen.2011.05.011 Tomás-Juan, 2015, Corneal regeneration after photorefractive keratectomy: a review, J. Optom., 8, 149 Tomomatsu, 2009, Aldose reductase inhibitor counteracts the attenuated adhesion of human corneal epithelial cells induced by high glucose through modulation of MMP-10 expression, Diabetes Res. Clin. Pract., 86, 16, 10.1016/j.diabres.2009.07.007 Torricelli, 2014, Cellular and extracellular matrix modulation of corneal stromal opacity, Exp. Eye Res., 129, 151, 10.1016/j.exer.2014.09.013 Toriseva, 2009, Proteinases in cutaneous wound healing, Cell Mol. Life Sci., 66, 203, 10.1007/s00018-008-8388-4 Trosan, 2012, The key role of insulin-like growth factor I in limbal stem cell differentiation and the corneal wound-healing process, Stem Cells Dev., 21, 3341, 10.1089/scd.2012.0180 Tsai, 1990, Comparison of limbal and conjunctival autograft transplantation in corneal surface reconstruction in rabbits, Ophthalmology, 97, 446, 10.1016/S0161-6420(90)32575-7 Tsai, 2000, Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells, N. Engl. J. Med., 343, 86, 10.1056/NEJM200007133430202 Tseng, 1996, Regulation and clinical implications of corneal epithelial stem cells, Mol. Biol. Rep., 23, 47, 10.1007/BF00357072 Tseng, 2010, Critical appraisal of ex vivo expansion of human limbal epithelial stem cells, Curr. Mol. Med., 10, 841, 10.2174/156652410793937796 Tuft, 1993, Photorefractive keratectomy: implications of corneal wound healing, Br. J. Ophthalmol., 77, 243, 10.1136/bjo.77.4.243 Tuominen, 2001, Human tear fluid PDGF-BB, TNF-α and TGF-β1 vs corneal haze and regeneration of corneal epithelium and subbasal nerve plexus after PRK, Exp. Eye Res., 72, 631, 10.1006/exer.2001.0999 Tuori, 1996, The immunohistochemical composition of the human corneal basement membrane, Cornea, 15, 286, 10.1097/00003226-199605000-00010 van Gelderen, 2000, Cytokines in aqueous humour and serum before and after corneal transplantation and during rejection, Ophthalmic Res., 32, 157, 10.1159/000055607 Vazirani, 2014, Unilateral partial limbal stem cell deficiency: contralateral versus ipsilateral autologous cultivated limbal epithelial transplantation, Am. J. Ophthalmol., 157, 584, 10.1016/j.ajo.2013.11.011 Vu, 2000, Matrix metalloproteinases: effectors of development and normal physiology, Genes Dev., 14, 2123, 10.1101/gad.815400 Wachtlin, 1999, Immunohistology of corneal wound healing after photorefractive keratectomy and laser in situ keratomileusis, J. Refract Surg., 15, 451 Wang, 2012, Role of CTCF in EGF-induced migration of immortalized human corneal epithelial cells, Invest. Ophthalmol. Vis. Sci., 53, 946, 10.1167/iovs.11-8747 Wang, 2014, Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles, J. Mater. Chem. B. Mater. Biol. Med., 2, 8131, 10.1039/C4TB00979G Wang, 2010, Effect of EGF-induced HDAC6 activation on corneal epithelial wound healing, Invest. Ophthalmol. Vis. Sci., 51, 2943, 10.1167/iovs.09-4639 Wang, 2005, Plasminogen activator inhibitor-1 (PAI-1) stimulates human corneal epithelial cell adhesion and migration in vitro, Exp. Eye Res., 80, 1, 10.1016/j.exer.2004.06.006 Wang, 2012, Up-regulation of BMP-2 antagonizes TGF-β1/ROCK-enhanced cardiac fibrotic signalling through activation of Smurf1/Smad6 complex, J. Cell Mol. Med., 16, 2301, 10.1111/j.1582-4934.2012.01538.x Wang, 2013, Epidermal growth factor (EGF)-induced corneal epithelial wound healing through nuclear factor κB subtype-regulated CCCTC binding factor (CTCF) activation, J. Biol. Chem., 288, 24363, 10.1074/jbc.M113.458141 Wang, 2010, Effects of keratinocyte growth factor-2 on corneal epithelial wound healing in a rabbit model of carbon dioxide laser injury, Biol. Pharm. Bull., 33, 971, 10.1248/bpb.33.971 Watanabe, 2003, Up-regulation of urokinase-type plasminogen activator in corneal epithelial cells induced by wounding, Invest. Ophthalmol. Vis. Sci., 44, 3332, 10.1167/iovs.02-1280 Weinger, 2005, Tri-nucleotide receptors play a critical role in epithelial cell wound repair, Purinerg. Signal, 1, 281, 10.1007/s11302-005-8132-6 West, 2015, Evaluating alternative stem cell hypotheses for adult corneal epithelial maintenance, World J. Stem Cells, 7, 281, 10.4252/wjsc.v7.i2.281 West-Mays, 2006, The keratocyte: corneal stromal cell with variable repair phenotypes, Int. J. Biochem. Cell Biol., 38, 1625, 10.1016/j.biocel.2006.03.010 Whikehart, 2005, Evidence suggesting the existence of stem cells for the human corneal endothelium, Mol. Vis., 11, 816 Williams, 2012, Gene therapy for corneal dystrophies and disease, where are we?, Curr. Opin. Ophthalmol., 23, 276, 10.1097/ICU.0b013e3283541eb6 Wilson, 2007, Apoptosis in the initiation, modulation and termination of the corneal wound healing response, Exp. Eye Res., 85, 305, 10.1016/j.exer.2007.06.009 Wilson, 2012, Control of scar tissue formation in the cornea: strategies in clinical and corneal tissue engineering, J. Funct. Biomater., 3, 642, 10.3390/jfb3030642 Wilson, 1996, Epithelial injury induces keratocyte apoptosis: hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization and wound healing, Exp. Eye Res., 62, 325, 10.1006/exer.1996.0038 Wilson, 1994, Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility and differentiation of human corneal epithelial cells, Exp. Eye Res., 59, 665, 10.1006/exer.1994.1152 Wilson, 1998, Lacrimal gland growth factors and receptors: lacrimal fibroblastic cells are a source of tear HGF, Adv. Exp. Med. Biol., 438, 625, 10.1007/978-1-4615-5359-5_88 Wilson, 1999, Stromal-epithelial interactions in the cornea, Prog. Retin. Eye Res., 18, 293, 10.1016/S1350-9462(98)00017-2 Wilson, 2001, The corneal wound healing response: cytokine mediated interaction of the epithelium, stroma, and inflammatory cells, Prog. Retin. Eye Res., 20, 625, 10.1016/S1350-9462(01)00008-8 Wilson, 2004, RANK, RANKL, OPG, and M-CSF expression in stromal cells during corneal wound healing, Invest. Ophthalmol. Vis. Sci., 45, 2201, 10.1167/iovs.03-1162 Wilson, 1993, Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea, Invest. Ophthalmol. Vis. Sci., 34, 2544 Winkler, 2014, Targeting miR-146a to treat delayed wound healing in human diabetic organ-cultured corneas, PLoS One, 9, e114692, 10.1371/journal.pone.0114692 Wirostko, 2015, Novel therapy to treat corneal epithelial defects: a hypothesis with growth hormone, Ocul. Surf., 13, 204, 10.1016/j.jtos.2014.12.005 Worm, 2009, Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of C/EBP β and down-regulation of G-CSF, Nucleic Acids Res., 37, 5784, 10.1093/nar/gkp577 Wu, 2014, Corneal stromal stem cells versus corneal fibroblasts in generating structurally appropriate corneal stromal tissue, Exp. Eye Res., 120, 71, 10.1016/j.exer.2014.01.005 Wu, 2014, Reconstruction of auto-tissue-engineered lamellar cornea by dynamic culture for transplantation: a rabbit model, PLoS One, 9, e93012, 10.1371/journal.pone.0093012 Xu, 2009, MicroRNA expression in the eyes and their significance in relation to functions, Prog. Retin. Eye Res., 28, 87, 10.1016/j.preteyeres.2008.11.003 Xu, 2004, Wound-induced HB-EGF ectodomain shedding and EGFR activation in corneal epithelial cells, Invest. Ophthalmol. Vis. Sci., 45, 813, 10.1167/iovs.03-0851 Xu, 2009, High glucose suppresses epidermal growth factor receptor/phosphatidylinositol 3-kinase/Akt signaling pathway and attenuates corneal epithelial wound healing, Diabetes, 58, 1077, 10.2337/db08-0997 Xu, 2004, Role of ErbB2 in corneal epithelial wound healing, Invest. Ophthalmol. Vis. Sci., 45, 4277, 10.1167/iovs.04-0119 Xu, 2012, MiR-146a suppresses tumor growth and progression by targeting EGFR pathway and in a p-ERK-dependent manner in castration-resistant prostate cancer, Prostate, 72, 1171, 10.1002/pros.22466 Xu, 2012, The role of microRNA-146a in the pathogenesis of the diabetic wound-healing impairment: correction with mesenchymal stem cell treatment, Diabetes, 61, 2906, 10.2337/db12-0145 Xu, 2011, Impaired epithelial wound healing and EGFR signaling pathways in the corneas of diabetic rats, Invest. Ophthalmol. Vis. Sci., 52, 3301, 10.1167/iovs.10-5670 Yamada, 2004, Role of the C domain of IGFs in synergistic promotion, with a substance P-derived peptide, of rabbit corneal epithelial wound healing, Invest. Ophthalmol. Vis. Sci., 45, 1125, 10.1167/iovs.03-0626 Yamagami, 2005, CCR5 chemokine receptor mediates recruitment of MHC class II-positive Langerhans cells in the mouse corneal epithelium, Invest. Ophthalmol. Vis. Sci., 46, 1201, 10.1167/iovs.04-0658 Yamanaka, 2012, Induced pluripotent stem cells: past, present, and future, Cell Stem Cell, 10, 678, 10.1016/j.stem.2012.05.005 Yan, 2014, Limbal stem cells and corneal epithelial regeneration: current status and prospectives, J. Ocul. Biol., 2, 10 Yanai, 2006, Correlation of proliferative and anti-apoptotic effects of HGF, insulin, IGF-1, IGF-2, and EGF in SV40-transformed human corneal epithelial cells, Exp. Eye Res., 83, 76, 10.1016/j.exer.2005.10.033 Yang, 2008, Reconstruction of damaged cornea by autologous transplantation of epidermal adult stem cells, Mol. Vis., 14, 1064 Yang, 2010, Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 (TRPV1) induces differential responses in corneal epithelial cells, Exp. Eye Res., 91, 462, 10.1016/j.exer.2010.06.022 Yang, 2014, Substance P promotes diabetic corneal epithelial wound healing through molecular mechanisms mediated via the neurokinin-1 receptor, Diabetes, 63, 4262, 10.2337/db14-0163 Yang, 2014, Generation of induced pluripotent stem cells from conjunctiva, Graefes Arch. Clin. Exp. Ophthalmol., 252, 423, 10.1007/s00417-014-2575-9 Yin, 2007, Wound-induced ATP release and EGF receptor activation in epithelial cells, J. Cell Sci., 120, 815, 10.1242/jcs.03389 Yin, 2008, Role of small GTPase Rho in regulating corneal epithelial wound healing, Invest. Ophthalmol. Vis. Sci., 49, 900, 10.1167/iovs.07-1122 Yin, 2008, Rho kinases regulate corneal epithelial wound healing, Am. J. Physiol. Cell Physiol., 295, C378, 10.1152/ajpcell.90624.2007 Yoon, 2014, Limbal stem cells: central concepts of corneal epithelial homeostasis, World J. Stem Cells, 6, 391, 10.4252/wjsc.v6.i4.391 Yoshida, 2011, Generation of stratified squamous epithelial progenitor cells from mouse induced pluripotent stem cells, PLoS One, 6, e28856, 10.1371/journal.pone.0028856 Yoshioka, 2010, Corneal epithelial wound healing impaired in keratinocyte-specific HB-EGF-deficient mice in vivo and in vitro, Invest. Ophthalmol. Vis. Sci., 51, 5630, 10.1167/iovs.10-5158 You, 2000, Neurotrophic factors in the human cornea, Invest. Ophthalmol. Vis. Sci., 41, 692 Yu, 2010, MicroRNA-205 promotes keratinocyte migration via the lipid phosphatase SHIP2, FASEB J., 24, 3950, 10.1096/fj.10-157404 Yu, 2010, Growth factors and corneal epithelial wound healing, Brain Res. Bull., 81, 229, 10.1016/j.brainresbull.2009.08.024 Yu, 2013, Differentiation of mouse induced pluripotent stem cells into corneal epithelial-like cells, Cell Biol. Int., 37, 87, 10.1002/cbin.10007 Yuan, 2013, The experimental treatment of corneal graft rejection with the interleukin-1 receptor antagonist (IL-1ra) gene, PLoS One, 8, e60714, 10.1371/journal.pone.0060714 Zagon, 1995, Opioid growth factor modulates corneal epithelial outgrowth in tissue culture, Am. J. Physiol., 268, R942 Zagon, 1997, Homeostasis of ocular surface epithelium in the rat is regulated by opioid growth factor, Brain Res., 759, 92, 10.1016/S0006-8993(97)00238-2 Zagon, 1998, Reepithelialization of the rat cornea is accelerated by blockade of opioid receptors, Brain Res., 798, 254, 10.1016/S0006-8993(98)00427-2 Zagon, 1998, Reepithelialization of the rabbit cornea is regulated by opioid growth factor, Brain Res., 803, 61, 10.1016/S0006-8993(98)00610-6 Zagon, 2000, Reepithelialization of the human cornea is regulated by endogenous opioids, Invest. Ophthalmol. Vis. Sci., 41, 73 Zagon, 2009, Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus, Arch. Ophthalmol., 127, 1468, 10.1001/archophthalmol.2009.270 Zeppieri, 2013, Human adipose-derived stem cells for the treatment of chemically burned rat cornea: preliminary results, Curr. Eye Res., 38, 451, 10.3109/02713683.2012.763100 Zhang, 1997, Epidermal growth factor stimulation of phosphatidylinositol 3-kinase during wound closure in rabbit corneal epithelial cells, Invest. Ophthalmol. Vis. Sci., 38, 1139 Zhang, 2006, Keratan sulfate and chondroitin/dermatan sulfate in maximally recovered hypocellular stromal interface scars of postmortem human LASIK corneas, Invest. Ophthalmol. Vis. Sci., 47, 2390, 10.1167/iovs.05-1559 Zhang, 2010, Dependence of resolvin-induced increases in corneal epithelial cell migration on EGF receptor transactivation, Invest. Ophthalmol. Vis. Sci., 51, 5601, 10.1167/iovs.09-4468 Zhao, 2009, An investigation into corneal alkali burns using an organ culture model, Cornea, 28, 541, 10.1097/ICO.0b013e3181901e08 Zhou, 2015, Ciliary neurotrophic factor promotes the activation of corneal epithelial stem/progenitor cells and accelerates corneal epithelial wound healing, Stem Cells, 33, 1566, 10.1002/stem.1942 Zhou, 2006, Transcriptional profiling of enriched populations of stem cells versus transient amplifying cells. A comparison of limbal and corneal epithelial basal cells, J. Biol. Chem., 281, 19600, 10.1074/jbc.M600777200 Zhou, 2014, Assessing the impact of engineered nanoparticles on wound healing using a novel in vitro bioassay, Nanomedicine (Lond.), 9, 2803, 10.2217/nnm.14.40 Zhou, 2010, Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus encoding human vasohibin-1, Mol. Vis., 16, 1389 Zhu, 2014, Activation of RhoA-ROCK-BMP signaling reprograms adult human corneal endothelial cells, J. Cell Biol., 206, 799, 10.1083/jcb.201404032 Zieske, 2001, Extracellular matrix and wound healing, Curr. Opin. Ophthalmol., 12, 237, 10.1097/00055735-200108000-00001 Zieske, 2001, Kinetics of keratocyte proliferation in response to epithelial debridement, Exp. Eye Res., 72, 33, 10.1006/exer.2000.0926 Zieske, 1994, Basement membrane assembly and differentiation of cultured corneal cells: importance of culture environment and endothelial cell interaction, Exp. Cell Res., 214, 621, 10.1006/excr.1994.1300 Zieske, 2000, Activation of epidermal growth factor receptor during corneal epithelial migration, Invest. Ophthalmol. Vis. Sci., 41, 1346