Programmed cell death-1 inhibition in lymphoma

The Lancet Oncology - Tập 16 - Trang e234-e245 - 2015
Eliza A Hawkes1,2,3, Andrew Grigg1,4, Geoff Chong1,5,6
1Department of Medical Oncology and Clinical Haematology, Olivia Newton John Cancer and Wellness Centre, Austin Hospital, Melbourne, VIC, Australia
2Department of Medical Oncology, Eastern Health, Melbourne, VIC Australia
3Monash University, Melbourne, Vic, Australia
4University of Melbourne, Melbourne, VIC, Australia.
5Department of Oncology, Northern Hospital, Melbourne, VIC, Australia
6Department of Medical Oncology, Ballarat Health Services, Ballarat, VIC, Australia

Tài liệu tham khảo

Ferlay, 2015, Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012, Int J Cancer, 136, E359, 10.1002/ijc.29210 Jaffe, 2001 Coiffier, 2010, Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte, Blood, 116, 2040, 10.1182/blood-2010-03-276246 Batlevi, 2013, Novel therapy for Hodgkin lymphoma, Hematology, 2013, 394, 10.1182/asheducation-2013.1.394 Fowler, 2013, Targeting B-cell receptor signaling: changing the paradigm, 2013, 553 Hernandez-Ilizaliturri, 2011, Higher response to lenalidomide in relapsed/refractory diffuse large B-cell lymphoma in nongerminal center B-cell-like than in germinal center B-cell-like phenotype, Cancer, 117, 5058, 10.1002/cncr.26135 Dunleavy, 2009, Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma, Blood, 113, 6069, 10.1182/blood-2009-01-199679 Quezada, 2013, Exploiting CTLA-4, PD-1 and PD-L1 to reactivate the host immune response against cancer, Br J Cancer, 108, 1560, 10.1038/bjc.2013.117 Zou, 2008, Inhibitory B7-family molecules in the tumour microenvironment, Nat Rev Immunol, 8, 467, 10.1038/nri2326 Pardoll, 2012, The blockade of immune checkpoints in cancer immunotherapy, Nat Rev Cancer, 12, 252, 10.1038/nrc3239 Keir, 2008, PD-1 and its ligands in tolerance and immunity, Annu Rev Immunol, 26, 677, 10.1146/annurev.immunol.26.021607.090331 Latchman, 2001, PD-L2 is a second ligand for PD–1 and inhibits T cell activation, Nat Immunol, 2, 261, 10.1038/85330 Yamamoto, 2008, PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma, Blood, 111, 3220, 10.1182/blood-2007-05-085159 Blank, 2004, PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells, Cancer Res, 64, 1140, 10.1158/0008-5472.CAN-03-3259 Norris, 2012, PD-1 expression on natural killer cells and CD8(+) T cells during chronic HIV-1 infection, Vir Immunol, 25, 329, 10.1089/vim.2011.0096 Okazaki, 2001, PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine, Proc Natl Acad Sci USA, 98, 13866, 10.1073/pnas.231486598 Dong, 2002, Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion, Nat Med, 8, 793, 10.1038/nm0902-1039c Ghebeh, 2006, The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors, Neoplasia, 8, 190, 10.1593/neo.05733 Thompson, 2007, Implications of B7-H1 expression in clear cell carcinoma of the kidney for prognostication and therapy, Clin Cancer Res, 13, 709, 10.1158/1078-0432.CCR-06-1868 Nomi, 2007, Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer, Clin Cancer Res, 13, 2151, 10.1158/1078-0432.CCR-06-2746 Wu, 2006, Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance, Acta Histochem, 108, 19, 10.1016/j.acthis.2006.01.003 Hamanishi, 2007, Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer, Proc Natl Acad Sci USA, 104, 3360, 10.1073/pnas.0611533104 Hino, 2010, Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma, Cancer, 116, 1757, 10.1002/cncr.24899 Myklebust, 2013, High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells, Blood, 121, 1367, 10.1182/blood-2012-04-421826 Andorsky, 2011, Programmed death ligand 1 is expressed by non-hodgkin lymphomas and inhibits the activity of tumor-associated T cells, Clin Cancer Res, 17, 4232, 10.1158/1078-0432.CCR-10-2660 Rossille, 2014, High level of soluble programmed cell death ligand 1 in blood impacts overall survival in aggressive diffuse large B-Cell lymphoma: results from a French multicenter clinical trial, Leukemia, 28, 2367, 10.1038/leu.2014.137 Xerri, 2008, Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia, Hum Pathol, 39, 1050, 10.1016/j.humpath.2007.11.012 Chen, 2013, PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies, Clin Cancer Res, 19, 3462, 10.1158/1078-0432.CCR-13-0855 Hirano, 2005, Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity, Cancer Res, 65, 1089, 10.1158/0008-5472.1089.65.3 Iwai, 2005, PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells, Int Immunol, 17, 133, 10.1093/intimm/dxh194 Curiel, 2003, Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity, Nat Med, 9, 562, 10.1038/nm863 Hardy, 1994, A monoclonal antibody against a human B lymphoblastoid cell line induces tumor regression in mice, Cancer Res, 54, 5793 Gettinger, 2014, First-line nivolumab (anti-PD-1; BMS-936558, ONO-4538) monotherapy in advanced NSCLC: Safety, efficacy, and correlation of outcomes with PD-L1 status, Proc Am Soc Clin Oncol, 32 Motzer, 2014, Nivolumab for metastatic renal cell carcinoma: results of a randomized phase ii trial, J Clin Oncol, 10.1200/jco.2014.32.15_suppl.5009 Hamid, 2013, Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma, N Engl J Med, 369, 134, 10.1056/NEJMoa1305133 Aerts, 2013, Tumor-specific cytotoxic T cells are crucial for efficacy of immunomodulatory antibodies in patients with lung cancer, Cancer research, 73, 2381, 10.1158/0008-5472.CAN-12-3932 Mahoney, 2014, Prognostic and predictive markers for the new immunotherapies, Oncology, 28, 39 Dorfman, 2006, Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma, Am J Surg Pathol, 30, 802, 10.1097/01.pas.0000209855.28282.ce Green, 2010, Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma, Blood, 116, 3268, 10.1182/blood-2010-05-282780 Ansell, 2014, PD-1 is expressed on B-cells in Waldenstrom macroglobulinemia and promotes malignant cell viability and proliferation, Blood, 124, 10.1182/blood.V124.21.3015.3015 Wang, 2013, Immune evasion of mantle cell lymphoma: expression of B7-H1 leads to inhibited T-cell response to and killing of tumor cells, Haematologica, 98, 1458, 10.3324/haematol.2012.071340 Muenst, 2010, Diagnostic and prognostic utility of PD-1 in B cell lymphomas, Dis Markers, 29, 47, 10.1155/2010/404069 Chetaille, 2009, Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome, Blood, 113, 2765, 10.1182/blood-2008-07-168096 Shimauchi, 2007, Augmented expression of programmed death-1 in both neoplastic and non-neoplastic CD4+ T-cells in adult T-cell leukemia/lymphoma, Int J Cancer, 121, 2585, 10.1002/ijc.23042 Wilcox, 2009, B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders, Blood, 114, 2149, 10.1182/blood-2009-04-216671 Han, 2014, Role of programmed death ligands in effective T-cell interactions in extranodal natural killer/T-cell lymphoma, Oncol Lett, 8, 1461, 10.3892/ol.2014.2356 Chemnitz, 2007, RNA fingerprints provide direct evidence for the inhibitory role of TGFbeta and PD-1 on CD4+ T cells in Hodgkin lymphoma, Blood, 110, 3226, 10.1182/blood-2006-12-064360 Green, 2012, Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapy, Clin Cancer Res, 18, 1611, 10.1158/1078-0432.CCR-11-1942 Brown, 2003, Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production, J Immunol, 170, 1257, 10.4049/jimmunol.170.3.1257 Yang, 2006, Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma, Blood, 107, 3639, 10.1182/blood-2005-08-3376 Dave, 2004, Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells, N Engl J Med, 351, 2159, 10.1056/NEJMoa041869 Carreras, 2009, High numbers of tumor-infiltrating programmed cell death 1-positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma, J Clin Oncol, 27, 1470, 10.1200/JCO.2008.18.0513 Wahlin, 2010, A unifying microenvironment model in follicular lymphoma: outcome is predicted by programmed death-1—positive, regulatory, cytotoxic, and helper T cells and macrophages, Clin Cancer Res, 16, 637, 10.1158/1078-0432.CCR-09-2487 Richendollar, 2011, Follicular programmed death 1-positive lymphocytes in the tumor microenvironment are an independent prognostic factor in follicular lymphoma, Hum Pathol, 42, 552, 10.1016/j.humpath.2010.08.015 Takahashi, 2013, Prognostic significance of programmed cell death-1-positive cells in follicular lymphoma patients may alter in the rituximab era, Eur J Haematol, 90, 286, 10.1111/ejh.12075 de Jong, 2011, The microenvironment in follicular lymphoma, Best Pract Res Clin Haematol, 24, 135, 10.1016/j.beha.2011.02.007 Delabie, 1993, The B7/BB1 antigen is expressed by Reed-Sternberg cells of Hodgkin's disease and contributes to the stimulating capacity of Hodgkin's disease-derived cell lines, Blood, 82, 2845, 10.1182/blood.V82.9.2845.2845 Nam-Cha, 2008, PD-1, a follicular T-cell marker useful for recognizing nodular lymphocyte-predominant Hodgkin lymphoma, Am J Surg Pathol, 32, 1252, 10.1097/PAS.0b013e318165b0d6 Muenst, 2009, Increased programmed death-1+ tumor-infiltrating lymphocytes in classical Hodgkin lymphoma substantiate reduced overall survival, Hum Pathol, 40, 1715, 10.1016/j.humpath.2009.03.025 Greaves, 2013, Defining characteristics of classical Hodgkin lymphoma microenvironment T-helper cells, Blood, 122, 2856, 10.1182/blood-2013-06-508044 Berger, 2008, Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies, Clin Cancer Res, 14, 3044, 10.1158/1078-0432.CCR-07-4079 Westin, 2014, Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial, Lancet Oncol, 15, 69, 10.1016/S1470-2045(13)70551-5 Armand, 2013, Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial, J Clin Oncol, 31, 4199, 10.1200/JCO.2012.48.3685 Lesokhin, 2014, Preliminary results of a phase I study of nivolumab (BMS-936558) in patients with relapsed or refractory lymphoid malignancies, Blood, 124, 10.1182/blood.V124.21.291.291 Ansell, 2015, PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma, N Engl J Med, 372, 311, 10.1056/NEJMoa1411087 Moskowitz, 2014, PD-1 blockade with the monoclonal antibody pembrolizumab (MK-3475) in patients with classical Hodgkin lymphoma after brentuximab vedotin failure: preliminary results from a phase 1b study (KEYNOTE-013), Blood, 124, 10.1182/blood.V124.21.290.290 Topalian, 2012, Safety, activity, and immune correlates of anti-PD-1 antibody in cancer, N Engl J Med, 366, 2443, 10.1056/NEJMoa1200690 Ribas, 2014, Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma (MEL), Proc Am Soc Clin Oncol, 32 Wolchok, 2009, Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria, Clin Cancer Res, 15, 7412, 10.1158/1078-0432.CCR-09-1624 Lipson, 2013, Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody, Clin Cancer Res, 19, 462, 10.1158/1078-0432.CCR-12-2625 Wolchok, 2013, Nivolumab plus ipilimumab in advanced melanoma, N Engl J Med, 369, 122, 10.1056/NEJMoa1302369 Amin, 2014, Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC), Proc Am Soc Clin Oncol, 32 Rizvi, 2013, A phase I study of nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus platinum-based doublet chemotherapy (PT-doublet) in chemotherapy-naive non-small cell lung cancer (NSCLC) patients (pts), Proc Am Soc Clin Oncol, 31 Blazar, 2003, Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism, J Immunol, 171, 1272, 10.4049/jimmunol.171.3.1272 Koestner, 2011, PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells, Blood, 117, 1030, 10.1182/blood-2010-04-283119 Bashey, 2009, CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation, Blood, 113, 1581, 10.1182/blood-2008-07-168468