Prognostic significance of p27KIP1 expression in resected non–small cell lung cancers: Analysis in combination with expressions of p16INK4A, pRB, and p53

Journal of Surgical Oncology - Tập 81 Số 4 - Trang 177-184 - 2002
Hirohisa Hirabayashi1, Mitsunori Ohta, H. Tanaka, Masahiro Sakaguchi, Yoshitaka Fujii, Shinichiro Miyoshi, Hikaru Matsuda
1Department of Surgery, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan. [email protected]

Tóm tắt

AbstractBackground and ObjectivesWhether a prognostic role for expression of the tumor suppressor gene (TSG) products exists in resected non–small call lung cancers (NSCLCs) remains controversial. Our study was performed to determine the value of TSGs expressions for patients survival in NSCLCs.MethodsWe examined 108 resected NSCLCs for the expression of TSG products, p27KIP1, p16INK4A, pRB, and p53 that govern cell cycle transition by immunohistochemistry and compared them with patient clinical characteristics and prognoses.ResultsAbnormal expressions of p27KIP1, p16INK4A, pRB, and p53 were found in 61 (57%), 53 (49%), 42 (39%), and 48 (44%), respectively, of the 108 NSCLCs. Univariate analysis showed abnormal expression of p27KIP1 to be a strong indicator for poor patient survival, not only in the total cohort (P = 0.0024), but also in subgroups with T1–T2 (P = 0.016), N0 (P = 0.047), and squamous cell carcinomas (P = 0.026), but not according to the expression of p16INK4A, pRB, or p53. In the Cox regression analysis, p27KIP1 expression was found to be an independent prognostic factor (P = 0.0148) and associated with pathological stage (P = 0.0278).ConclusionsOur results suggest that abnormal p27KIP1 expression may be a useful indicator to predict postoperative prognosis, especially in patients with early stage NSCLCs, as compared to other TSG products examined. J. Surg. Oncol. 2002;81:177–184. © 2002 Wiley‐Liss, Inc.

Từ khóa


Tài liệu tham khảo

10.1016/0092-8674(91)90641-B

10.1126/science.274.5293.1672

10.1016/0092-8674(94)90573-8

10.1002/(SICI)1097-0215(19960208)65:4<442::AID-IJC8>3.0.CO;2-X

Kratzke RA, 1996, Rb and p16INK4A expression in resected non‐small cell lung tumors, Cancer Res, 56, 3415

10.1016/0140-6736(90)90801-B

Quinlan DC, 1992, Accumulation of p53 protein correlates with a poor prognosis in human lung cancer, Cancer Res, 52, 4828

Esposito V, 1997, Prognostic role of the cyclin‐dependent kinase inhibitor p27 in non‐small cell lung cancer, Cancer Res, 57, 3381

10.1002/(SICI)1097-0142(19970801)80:3<389::AID-CNCR6>3.0.CO;2-N

10.1002/(SICI)1097-0215(19990219)84:1<49::AID-IJC10>3.0.CO;2-Y

Kinoshita I, 1996, Altered p16INK4 and retinoblastoma protein status in non‐small cell lung cancer: Potential synergistic effect with altered p53 protein proliferative activity, Cancer Res, 56, 5557

10.1016/S0169-5002(00)00191-4

10.1093/jnci/86.9.695

Geradts J, 1999, Correlation of abnormal RB, p16, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities, and clinical features in 103 primary non‐small cell lung cancers, Clin Cancer Res, 5, 791

10.1200/JCO.1995.13.8.1893

10.1016/S0169-5002(99)00085-9

Catzavelos C, 1999, Reduced expression of the cell cycle inhibitor p27Kip1 in non‐small cell lung carcinoma: A prognostic factor independent of Ras, Cancer Res, 59, 684

10.1002/(SICI)1097-0215(19980417)79:2<111::AID-IJC2>3.0.CO;2-W

10.1038/nm0297-227

10.1038/nm0297-231

10.1016/S0169-5002(01)00225-2

10.1126/science.2554494

10.1200/JCO.1996.14.2.497

Brambilla E, 1997, p53 and lung cancer, Pathol Biol, 45, 852

10.1016/S0169-5002(01)00345-2

Mitsudomi T, 2000, Prognostic significance of p53 alterations in patients with non‐small cell lung cancer: A meta‐analysis, Clin Cancer Res, 6, 4055

10.1002/1096-9098(200005)74:1<53::AID-JSO13>3.0.CO;2-D

10.1126/science.7624798

Ponce‐Castaneda MV, 1995, p27: Chromosomal mapping to 12p12–12p13.1 and absence of mutations in human tumors, Cancer Res, 55, 1211

10.1016/S0169-5002(01)00216-1

10.1159/000012092

Hommura F, 2000, Prognostic significance of p27 Kip1 protein and Ki‐67 growth fraction in non‐small cell cancers, Clin Cancer Res, 6, 4073

10.1016/S0169-5002(01)00211-2

Thông tin
Thông tin xuất bản

Journal of Surgical Oncology

Tập 81 Số 4

177-184

Thông tin tác giả