Prognostic role of tumor infiltrating lymphocytes in EBV positive and EBV negative nasopharyngeal carcinoma

Chang, 2006, The enigmatic epidemiology of nasopharyngeal carcinoma, Cancer Epidemiol Biomarkers Prev, 15, 1765, 10.1158/1055-9965.EPI-06-0353 Ali, 1965, Histology of the human nasopharyngeal mucosa, J Anat, 99, 657 Wei, 2005, Nasopharyngeal carcinoma, Lancet, 365, 2041, 10.1016/S0140-6736(05)66698-6 Petersson, 2015, Nasopharyngeal carcinoma: a review, Semin Diagn Pathol, 32, 54, 10.1053/j.semdp.2015.02.021 Gooden, 2011, The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis, Br J Cancer, 105, 93, 10.1038/bjc.2011.189 van Kempen, 2016, Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors, Cancer Immunol Immunother, 65, 575, 10.1007/s00262-016-1819-4 Radvanyi, 2015, Tumor-infiltrating lymphocyte therapy: addressing prevailing questions, Cancer J, 21, 450, 10.1097/PPO.0000000000000162 Zhang, 2015, Co-expression of PD-1 and PD-L1 predicts poor outcome in nasopharyngeal carcinoma, Med Oncol, 32, 86, 10.1007/s12032-015-0501-6 Don, 2014, Promoter hypermethylation patterns of P16, DAPK and MGMT in oral squamous cell carcinoma: a systematic review and meta-analysis, Indian J Dental Res: Official Publication Indian Soc Dental Res, 25, 797, 10.4103/0970-9290.152208 Nguyen, 2016, Tumor infiltrating lymphocytes and survival in patients with head and neck squamous cell carcinoma, Head Neck, 10.1002/hed.24406 Boon, 1997, Cancer tumor antigens, Curr Opin Immunol, 9, 681, 10.1016/S0952-7915(97)80049-0 Zhang, 2003, Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer, N Engl J Med, 348, 203, 10.1056/NEJMoa020177 Galon, 2006, Type, density, and location of immune cells within human colorectal tumors predict clinical outcome, Science, 313, 1960, 10.1126/science.1129139 Rosenberg, 2005, Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanoma, J Immunol, 175, 6169, 10.4049/jimmunol.175.9.6169 Morrissey, 2016, Immunotherapy and novel combinations in oncology- current landscape, challenges and opportunities, Clin Transl Sci, 10.1111/cts.12391 van Diest, 2002, No consent should be needed for using leftover body material for scientific purposes, For BMJ, 325, 648, 10.1136/bmj.325.7365.648 Noorlag, 2015, Nodal metastasis and survival in oral cancer: Association with protein expression of SLPI, not with LCN2, TACSTD2, or THBS2, Head Neck, 37, 1130, 10.1002/hed.23716 Rosenberg, 1984, Adoptive immunotherapy of cancer: accomplishments and prospects, Cancer Treat Rep, 68, 233 Jarrett, 2005, Impact of tumor Epstein-Barr virus status on presenting features and outcome in age-defined subgroups of patients with classic Hodgkin lymphoma: a population-based study, Blood, 106, 2444, 10.1182/blood-2004-09-3759 Basso, 2011, T cell therapy for nasopharyngeal carcinoma, J Cancer, 2, 341, 10.7150/jca.2.341 Rosenberg, 1985, Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer, N Engl J Med, 313, 1485, 10.1056/NEJM198512053132327 Punt, 2016, A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17(+) cell frequency, Cancer Immunol Immunother, 65, 393, 10.1007/s00262-016-1805-x Mao, 2016, The prognostic value of tumor-infiltrating lymphocytes in breast cancer: A systematic review and meta-analysis, PLoS One, 11, e0152500, 10.1371/journal.pone.0152500 Zarour, 2016, Reversing T-cell dysfunction and exhaustion in cancer, Clin Cancer Res, 22, 1856, 10.1158/1078-0432.CCR-15-1849 Ferradini, 1991, Cytotoxic potential despite impaired activation pathways in T lymphocytes infiltrating nasopharyngeal carcinoma, Int J Cancer, 47, 362, 10.1002/ijc.2910470309 Keir, 2008, PD-1 and its ligands in tolerance and immunity, Annu Rev Immunol, 26, 677, 10.1146/annurev.immunol.26.021607.090331 Fife, 2011, The role of the PD-1 pathway in autoimmunity and peripheral tolerance, Ann N Y Acad Sci, 1217, 45, 10.1111/j.1749-6632.2010.05919.x Francisco, 2010, The PD-1 pathway in tolerance and autoimmunity, Immunol Rev, 236, 219, 10.1111/j.1600-065X.2010.00923.x Topalian, 2012, Safety, activity, and immune correlates of anti-PD-1 antibody in cancer, N Engl J Med, 366, 2443, 10.1056/NEJMoa1200690 Freeman, 2000, Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation, J Exp Med, 192, 1027, 10.1084/jem.192.7.1027 Okazaki, 2006, The PD-1-PD-L pathway in immunological tolerance, Trends Immunol, 27, 195, 10.1016/j.it.2006.02.001 Farhat, 2008, Interleukin-10 and interferon-gamma gene polymorphisms in patients with nasopharyngeal carcinoma, Int J Immunogenet, 35, 197, 10.1111/j.1744-313X.2008.00752.x Liu, 2015, Sequence analysis of EBV immune evasion gene BNLF2a in EBV associated tumors and healthy individuals from nasopharyngeal carcinoma endemic and non-endemic regions of China, J Med Virol, 87, 1946, 10.1002/jmv.24254 Yoshizaki, 2011, A novel immune evasion mechanism of LMP-1, an EBV-primary oncogene, in nasopharyngeal carcinoma, Adv Otorhinolaryngol, 72, 157 Hsu, 2010, Increase of programmed death-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma, Mod Pathol, 23, 1393, 10.1038/modpathol.2010.130 Badoual, 2013, PD-1-expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-associated head and neck cancer, Cancer Res, 73, 128, 10.1158/0008-5472.CAN-12-2606 Gros, 2014, PD-1 identifies the patient-specific CD8(+) tumor-reactive repertoire infiltrating human tumors, J Clin Invest, 124, 2246, 10.1172/JCI73639 Kim, 2014, Prospects for targeting PD-1 and PD-L1 in various tumor types, Oncology (Williston Park), 28, 15 Hamanishi, 2007, Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer, Proc Natl Acad Sci U S A, 104, 3360, 10.1073/pnas.0611533104 Mani, 2016, Quantitative assessment of the spatial heterogeneity of tumor-infiltrating lymphocytes in breast cancer, Breast Cancer Res: BCR, 18, 78, 10.1186/s13058-016-0737-x Richards, 2014, The clinical utility of the local inflammatory response in colorectal cancer, Eur J Cancer, 50, 309, 10.1016/j.ejca.2013.09.008 Nielsen, 1999, Independent prognostic value of eosinophil and mast cell infiltration in colorectal cancer tissue, J Pathol, 189, 487, 10.1002/(SICI)1096-9896(199912)189:4<487::AID-PATH484>3.0.CO;2-I Roxburgh, 2012, The role of the in situ local inflammatory response in predicting recurrence and survival in patients with primary operable colorectal cancer, Cancer Treat Rev, 38, 451, 10.1016/j.ctrv.2011.09.001