Progestogen Sensitization: a Unique Female Presentation of Anaphylaxis

Jonathan A. Bernstein1
1Department of Internal Medicine, Division of Immunology/Allergy Section, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML #563, Cincinnati, OH, USA

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Shelley WB, Preucel RW, Spoont SS. Autoimmune progesterone dermatitis. Cure by Oophorectomy JAMA. 1964;190:35–8.

Asai J, Katoh N, Nakano M, Wada M, Kishimoto S. Case of autoimmune progesterone dermatitis presenting as fixed drug eruption. J Dermatol. 2009;36(12):643–5.

Baptist AP, Baldwin JL. Autoimmune progesterone dermatitis in a patient with endometriosis: case report and review of the literature. Clin Mol Allergy. 2004;2(1):10.

Bernstein IL, Bernstein DI, Lummus ZL, Bernstein JA. A case of progesterone-induced anaphylaxis, cyclic urticaria/angioedema, and autoimmune dermatitis. J Womens health (Larchmt). 2011;20(4):643-8. This is a classic case report of woman with PH which discusses work up that elaborates on mechanisms of action based on in vitro testing used to make a diagnosis.

Farah FS, Shbaklu Z. Autoimmune progesterone urticaria. J Allergy Clin Immunol. 1971;48(5):257–61.

Hart R. Autoimmune progesterone dermatitis. Arch Dermatol. 1977;113(4):426–30.

Herzberg AJ, Strohmeyer CR, Cirillo-Hyland VA. Autoimmune progesterone dermatitis. J Am Acad Dermatol. 1995;32(2 Pt 2):333–8.

Hill JL, Carr TF. Iatrogenic autoimmune progesterone dermatitis treated with a novel intramuscular progesterone desensitization protocol. J Allergy Clin Immunol Pract. 2013;1(5):537–8.

Honda T, Kabashima K, Fujii Y, Katoh M, Miyachi Y. Autoimmune progesterone dermatitis that changed its clinical manifestation from anaphylaxis to fixed drug eruption-like erythema. J Dermatol. 2014;41(5):447–8.

Jenkins J, Geng A, Robinson-Bostom L. Autoimmune progesterone dermatitis associated with infertility treatment. J Am Acad Dermatol. 2008;58(2):353–5.

Jones WN, Gordon VH. Auto-immune progesterone eczema. An endogenous progesterone hypersensitivity. Arch Dermatol. 1969;99(1):57–9.

Maguire T. Autoimmune progesterone dermatitis. Dermatol Nurs. 2009;21(4):190–2.

Poole JA, Rosenwasser LJ. Chronic idiopathic urticaria exacerbated with progesterone therapy treated with novel desensitization protocol. J Allergy Clin Immunol. 2004;114(2):456–7.

Prieto-Garcia A, Sloane DE, Gargiulo AR, Feldweg AM, Castells M. Autoimmune progesterone dermatitis: clinical presentation and management with progesterone desensitization for successful in vitro fertilization. Fertil Steril. 2011;95(3):1121 e9–13.

Vasconcelos C, Xavier P, Vieira AP, Martinho M, Rodrigues J, Bodas A, et al. Autoimmune progesterone urticaria. Gynecol Endocrinol. 2000;14(4):245–7.

Wintzen M, Goor-van Egmond MB, Noz KC. Autoimmune progesterone dermatitis presenting with purpura and petechiae. Clin Exp Dermatol. 2004;29(3):316.

Wojnarowska F, Greaves MW, Peachey RD, Drury PL, Besser GM. Progesterone-induced erythema multiforme. J R Soc Med. 1985;78(5):407–8.

Meggs WJ, Pescovitz OH, Metcalfe D, Loriaux DL, Cutler G Jr, Kaliner M. Progesterone sensitivity as a cause of recurrent anaphylaxis. N Engl J Med. 1984;311(19):1236–8.

Snyder JL, Krishnaswamy G. Autoimmune progesterone dermatitis and its manifestation as anaphylaxis: a case report and literature review. Ann Allergy Asthma Immunol. 2003;90(5):469–77; quiz 77, 571.

Foer D, Buchheit KM. Progestogen hypersensitivity: an evidence-based approach to diagnosis and management in clinical practice. Immunol Allergy Clin N Am. 2017;37(4):773–84.

Foer D, Buchheit KM, Gargiulo AR, Lynch DM, Castells M, Wickner PG. Progestogen hypersensitivity in 24 cases: diagnosis, management, and proposed renaming and classification. J Allergy Clin Immunol Pract. 2016;4(4):723–9.

Moghadam BK, Hersini S, Barker BF. Autoimmune progesterone dermatitis and stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(5):537–41.

Buchheit KM, Bernstein JA. Progestogen hypersensitivity: heterogeneous manifestations with a common trigger. J allergy Clin Immunol Pract. 2017;5(3):566-74. This is a thorough review of PH.

Lavery WJ, Bernstein JA. Cyclical hypersensitivity, anaphylaxis, and related hormonal reaction. Ann allergy asthma Immunol. 2019;122(2):140-7. This is a very thorough review on cyclical hypersensitivity.

Nguyen T, Razzaque AA. Autoimmune progesterone dermatitis: update and insights. Autoimmun Rev. 2016;15(2):191–7.

Meltzer L. Hypersensitivity to gonadal hormones. South Med J. 1963;56:538–42.

Ghosh D, Bernstein JA. Development of a progesterone-specific IgE assay for diagnosing patients with suspected progestogen hypersensitivity. Ann Allergy Asthma Immunol. 2019;122(6):616–22.This manuscripts describes the development of a specific progesterone assay.

Blois SM, Joachim R, Kandil J, Margni R, Tometten M, Klapp BF, et al. Depletion of CD8+ cells abolishes the pregnancy protective effect of progesterone substitution with dydrogesterone in mice by altering the Th1/Th2 cytokine profile. J Immunol. 2004;172(10):5893–9.

Dosiou C, Hamilton AE, Pang Y, Overgaard MT, Tulac S, Dong J, et al. Expression of membrane progesterone receptors on human T lymphocytes and Jurkat cells and activation of G-proteins by progesterone. J Endocrinol. 2008;196(1):67–77.

Cheesman KL, Gaynor LV, Chatterton RT Jr, Radvany RM. Identification of a 17-hydroxyprogesterone-binding immunoglobulin in the serum of a woman with periodic rashes. J Clin Endocrinol Metab. 1982;55(3):597–9.

Schoenmakers A, Vermorken A, Degreef H, Dooms-Goossens A. Corticosteroid or steroid allergy? Contact Dermatitis. 1992;26(3):159–62.

Stranahan D, Rausch D, Deng A, Gaspari A. The role of intradermal skin testing and patch testing in the diagnosis of autoimmune progesterone dermatitis. Dermatitis. 2006;17(1):39–42.

Halevy S, Cohen AD, Lunenfeld E, Grossman N. Autoimmune progesterone dermatitis manifested as erythema annulare centrifugum: confirmation of progesterone sensitivity by in vitro interferon-gamma release. J Am Acad Dermatol. 2002;47(2):311–3.

Slater JE, Raphael G, Cutler GB Jr, Loriaux DL, Meggs WJ, Kaliner M. Recurrent anaphylaxis in menstruating women: treatment with a luteinizing hormone-releasing hormone agonist--a preliminary report. Obstet Gynecol. 1987;70(4):542–6.

Toms-Whittle LM, John LH, Griffiths DJ, Buckley DA. Autoimmune progesterone dermatitis: a diagnosis easily missed. Clin Exp Dermatol. 2011;36(4):378–80.

Yee KC, Cunliffe WJ. Progesterone-induced urticaria: response to buserelin. Br J Dermatol. 1994;130(1):121–3.

Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B, et al. The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73(7):1393–414.

Zuberbier T, Bernstein JA. A comparison of the United States and international perspective on chronic urticaria guidelines. J Allergy Clin Immunol Pract. 2018;6(4):1144–51.

Bernstein JA, Lang DM, Khan DA, Craig T, Dreyfus D, Hsieh F, et al. The diagnosis and management of acute and chronic urticaria: 2014 update. J Allergy Clin Immunol. 2014;133(5):1270–7.

Shahar E, Bergman R, Pollack S. Autoimmune progesterone dermatitis: effective prophylactic treatment with danazol. Int J Dermatol. 1997;36(9):708–11.

Cocuroccia B, Gisondi P, Gubinelli E, Girolomoni G. Autoimmune progesterone dermatitis. Gynecol Endocrinol. 2006;22(1):54–6.

Brestel EP, Thrush LB. The treatment of glucocorticosteroid-dependent chronic urticaria with stanozolol. J Allergy Clin Immunol. 1988;82(2):265–9.

Rodenas JM, Herranz MT, Tercedor J. Autoimmune progesterone dermatitis: treatment with oophorectomy. Br J Dermatol. 1998;139(3):508–11.

Heffler E, Fichera S, Nicolosi G, Crimi N. Anaphylaxis due to progesterone hypersensitivity successfully treated with omalizumab. J allergy Clin Immunol Pract. 2017;5(3):852-4. This is an index case describing successful treatment of PH with omalizumab.