Progesterone Resistance, Aromatase, and Inflammation: The Important Relationships Between Hormones and Inflammation

Current Obstetrics and Gynecology Reports - Tập 1 - Trang 146-152 - 2012
Paola Vigano1, Elisa Rabellotti1, Luca Pagliardini1, Edgardo Somigliana2, Massimo Candiani1, Paolo Vercellini3
1Obstetrics and Gynecology Unit, San Raffaele Scientific Institute, Milano, Italy
2Department of Obstetrics, Gynecology and Neonatology, Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milano, Italy
3Istituto Ostetrico e Ginecologico “L. Mangiagalli,” University of Milano, Milano, Italy

Tóm tắt

Endometriosis is a complex gynecologic disorder in which alterations of specific biological processes involving both the endocrine and the immune systems have been identified. Recently, a reduced endometrial responsiveness to progesterone has been suggested as a crucial element in the pathophysiology of the disease but it is unclear whether this reduced sensitivity to the steroid is involved in the disease induction or is simply a consequence of the disease condition. Indeed, endometriosis is associated with a local and systemic inflammatory process that is strongly inter-related to the steroid activity, and both the systems mutually interact in a complex loop that strongly influences the disease development and maintenance. The link between prostaglandin E2 (PGE2), aromatase activity, and local estrogen synthesis represents a paradigm of this loop. A better understanding of the pathophysiology of this interaction should enable researchers to develop targeted therapeutics that may limit this self-supporting pathologic loop.

Tài liệu tham khảo

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