Profiling the kinome for drug discovery
Tài liệu tham khảo
Bimbo, 2005, Systematic deletion analysis of fission yeast protein kinases, Eukaryot. Cell, 4, 799, 10.1128/EC.4.4.799-813.2005
Manning, 2002, The protein kinase complement of the human genome, Science, 298, 1912, 10.1126/science.1075762
Hopkins, 2002, The druggable genome, Nat. Rev. Drug Discov., 1, 727, 10.1038/nrd892
Stoughton, 2005, How molecular profiling could revolutionize drug discovery, Nat. Rev. Drug Discov., 4, 345, 10.1038/nrd1696
Ley, 2003, A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes, Proc. Natl. Acad. Sci. U S A, 100, 14275, 10.1073/pnas.2335924100
Schnittger, 2006, D324N single-nucleotide polymorphism in the FLT3 gene is associated with higher risk of myeloid leukemias, Genes Chromosomes Cancer, 45, 332, 10.1002/gcc.20294
Lynch, 2004, Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib, N. Engl. J. Med., 350, 2129, 10.1056/NEJMoa040938
Bardelli, 2003, Mutational analysis of the tyrosine kinome in colorectal cancers, Science, 300, 949, 10.1126/science.1082596
Kling, 2005, The search for a sequencing thoroughbred, Nat. Biotechnol., 23, 1333, 10.1038/nbt1105-1333
Carr, 2005, Mapping posttranslational modifications of proteins by MS-based selective detection: application to phosphoproteomics, Methods Enzymol., 405, 82, 10.1016/S0076-6879(05)05005-6
Corthals, 2005, Identification of phosphorylation sites using microimmobilized metal affinity chromatography, Methods Enzymol., 405, 66, 10.1016/S0076-6879(05)05004-4
Bose, 2006, Phosphoproteomic analysis of Her2/neu signaling and inhibition, Proc. Natl. Acad. Sci. U S A, 103, 9773, 10.1073/pnas.0603948103
Echeverri, 2006, High-throughput RNAi screening in cultured cells: a user's guide, Nat. Rev. Genet., 7, 373, 10.1038/nrg1836
Moffat, 2006, Building mammalian signalling pathways with RNAi screens, Nat. Rev. Mol. Cell. Biol., 7, 177, 10.1038/nrm1860
Fitzgerald, 2005, RNAi versus small molecules: different mechanisms and specificities can lead to different outcomes, Curr. Opin. Drug Discov. Devel., 8, 557
Yan, S.F. et al. Learning from the data: mining of large high-throughput screening databases. J. Chem. Inf. Model., doi:10.1021/ci060102u
Fabian, 2005, A small molecule-kinase interaction map for clinical kinase inhibitors, Nat. Biotechnol., 23, 329, 10.1038/nbt1068
Vieth, 2005, Kinomics: characterizing the therapeutically validated kinase space, Drug Discov. Today, 10, 839, 10.1016/S1359-6446(05)03477-X
Melnick, 2006, An efficient rapid system for profiling the cellular activities of molecular libraries, Proc. Natl. Acad. Sci. U S A, 103, 3153, 10.1073/pnas.0511292103
Vieth, 2004, Kinomics-structural biology and chemogenomics of kinase inhibitors and targets, Biochim. Biophys. Acta, 1697, 243, 10.1016/j.bbapap.2003.11.028
Chuaqui, 2005, Interaction profiles of protein kinase-inhibitor complexes and their application to virtual screening, J. Med. Chem., 48, 121, 10.1021/jm049312t
Steinert, 2005, Imatinib mesylate in the treatment of gastrointestinal stromal tumour, Expert Opin. Pharmacother., 6, 105, 10.1517/14656566.6.1.105
Yan, 2005, Novel statistical approach for primary high-throughput screening hit selection, J. Chem. Inf. Model., 45, 1784, 10.1021/ci0502808
Buijsman, 2004, Structural aspects of kinases and their inhibitors, 191
Weinstein, 1997, An information-intensive approach to the molecular pharmacology of cancer, Science, 275, 343, 10.1126/science.275.5298.343
Covell, 2005, Linking tumor cell cytotoxicity to mechanism of drug action: an integrated analysis of gene expression, small-molecule screening and structural databases, Proteins, 59, 403, 10.1002/prot.20392
Zhou, 1998, Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation, Nat. Genet., 20, 189, 10.1038/2496
Gilbertson, 2003, PDGFRB is overexpressed in metastatic medulloblastoma, Nat. Genet., 35, 197, 10.1038/ng1103-197
Daley, 1990, Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome, Science, 247, 824, 10.1126/science.2406902
Golub, 1994, Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation, Cell, 77, 307, 10.1016/0092-8674(94)90322-0
Davies, 2002, Mutations of the BRAF gene in human cancer, Nature, 417, 949, 10.1038/nature00766
Cappellen, 1999, Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas, Nat. Genet., 23, 18, 10.1038/12615
Baxter, 2005, Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders, Lancet, 365, 1054, 10.1016/S0140-6736(05)74230-6
Yamazaki, 1988, Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors, Mol. Cell. Biol., 8, 1816, 10.1128/MCB.8.4.1816
Hirota, 1998, Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors, Science, 279, 577, 10.1126/science.279.5350.577
Kiyoi, 1997, Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia, Leukemia, 11, 1447, 10.1038/sj.leu.2400756
Hermanson, 1992, Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops, Cancer Res., 52, 3213
Li, 1997, PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer, Science, 275, 1943, 10.1126/science.275.5308.1943