Production of abnormal prothrombin (des-γ-carboxy prothrombin) by hepatocellular carcinoma

Foli, 1969, α1-Fetoprotein in patients with liver disease, Lancet, ii, 1267, 10.1016/S0140-6736(69)90806-X Okuda, 1975, Clinical observations during a relatively early stage of hepatocellular carcinoma, with special reference to serum α-fetoprotein levels, Gastroenterology, 69, 226, 10.1016/S0016-5085(19)32658-7 Ebara, 1986, Natural history of minute hepatocellular carcinoma smaller than three centimeters complicating cirrhosis. A study in 22 patients, Gastroenterology, 90, 289, 10.1016/0016-5085(86)90923-6 Shinagawa, 1984, Diagnosis and clinical features of small hepatocellular carcinoma with emphasis on the utility of real-time ultrasonography. A study in 51 patients, Gastroenterology, 86, 495, 10.1016/S0016-5085(84)80020-7 Okabe, 1985, Production of erythropoietin-like activity by human renal and hepatic carcinomas in cell culture, Cancer, 55, 1918, 10.1002/1097-0142(19850501)55:9<1918::AID-CNCR2820550915>3.0.CO;2-9 Miatto, 1985, Diagnosis and prognostic value of serum copper and plasma fibrinogen in hepatic carcinoma, Cancer, 55, 774, 10.1002/1097-0142(19850215)55:4<774::AID-CNCR2820550415>3.0.CO;2-9 Warnock, 1969, Variant alkaline phosphatase in human hepatocellular carcinoma, Clin Chim Acta, 24, 5, 10.1016/0009-8981(69)90134-X Hemker, 1968, Kinetic aspects of the interaction of blood clotting enzymes. III. Demonstration of an inhibitor of prothrombin conversion in vitamin K deficiency, Thromb Diath Haemorrh, 19, 346, 10.1055/s-0038-1651213 Vermeer, 1978, The role of blood clotting factor V in the conversion of prothrombin and decarboxy prothrombin into thrombin, Biochim Biophys Acta, 538, 521, 10.1016/0304-4165(78)90413-0 1978, Vitamin K and the newborns, Lancet, ii, 755 Corrigan, 1981, Vitamin K dependent proteins, Adv Pediatr, 28, 57 Olson, 1984, The function and metabolism of vitamin K, Annu Rev Nutr, 4, 281, 10.1146/annurev.nu.04.070184.001433 Motohara, 1985, Effects of vitamin K administration on acarboxy prothrombin (PIVKA-II) levels in newborns, Lancet, ii, 242, 10.1016/S0140-6736(85)90291-0 Liebman, 1984, Des-γ-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma, N Engl J Med, 310, 1427, 10.1056/NEJM198405313102204 Motohara, 1985, Detection of vitamin K deficiency by use of an enzyme-linked immunosorbent assay for circulating abnormal prothrombin, Pediatr Res, 19, 354, 10.1203/00006450-198519040-00008 Huh, 1981, Production of HBs-antigen by two new human hepatoma cell lines and its enhancement by dexamethasone, Gann, 72, 178 Laurell, 1966, Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies, Anal Biochem, 15, 45, 10.1016/0003-2697(66)90246-6 Katsuta, 1976, Improved synthetic media suitable for tissue culture of various mammalian cells, Vol. 14, 145 Matsuda, 1982, Vitamin K-dependent blood coagulation factors in surgical patients, Acta Haematol Jpn, 45, 840 Blanchard, 1981, Acquired vitamin K-dependent carboxylation deficiency in liver disease, N Engl J Med, 305, 242, 10.1056/NEJM198107303050502 Blanchard, 1983, Immunoassays of human prothrombin species which correlate with functional coagulant activities, J Lab Clin Med, 101, 242 Fair, 1984, Human hepatoma cells secrete single chain factor X, prothrombin, and antithrombin III, Blood, 64, 194, 10.1182/blood.V64.1.194.194 Whitlon, 1978, Mechanism of coumarin action: Significance of vitamin K epoxide reductase inhibition, Biochemistry, 17, 1371, 10.1021/bi00601a003 Larson, 1978, Vitamin K-dependent carboxylase: Evidence for a hydroperoxide intermediate in the reaction, 75, 5413