Procalcitonin (PCT)-guided antibiotic stewardship: an international experts consensus on optimized clinical use

Clinical Chemistry and Laboratory Medicine - Tập 57 Số 9 - Trang 1308-1318 - 2019
Philipp Schüetz1,2, Albertus Beishuizen3, M. Broyles4, Ricard Ferrer5, G. Gavazzi6, Eric H. Gluck7, Juan González del Castillo8, Jens‐Ulrik Stæhr Jensen9,10, Péter Kanizsai11, Andrea Lay‐Hoon Kwa12,13, Stefan Krueger14,15, Charles‐Édouard Luyt16, Michael Oppert17, Mario Plebani18, Sergey Shlyapnikov19,20, Giulio Toccafondi21, Jennifer Townsend22, Tobias Welte23,24, Kordo Saeed25,26
1Department of Internal Medicine, Kantonsspital Aarau, Aarau, Switzerland
2University of Basel , Basel , Switzerland , Phone: +41 (0) 79 365 10 06, Fax: 41 (0) 62 838 9524
3Medisch Spectrum Twente, Enschede, The Netherlands
4Five Rivers Medical Center , Pocahontas, AR , USA
5Department of Intensive Care. Shock, Organ Dysfunction and Resuscitation Research Group , Vall d’Hebron University Hospital , Barcelona , Spain
6University Clinics of Geriatrics, University Hospital of Grenoble-Alpes, GREPI EA7408 University of Grenoble Alpes , Grenoble , France
7Swedish Covenant Hospital , Chicago, IL , USA
8Emergency Department, Hospital Clinico San Carlos , Madrid , Spain
9CHIP & PERSIMUNE , Rigshospitalet and University of Copenhagen , Copenhagen , Denmark
10Respiratory Medicine Section, Department of Internal Medicine, Herlev-Gentofte Hospital , Hellerup , Denmark
11University of Pécs, Clinical Centre , Pécs , Hungary
12Singapore General Hospital, Singapore, Singapore
13Singapore General Hospital, Singapore, Singapore; Emerging Infectious Diseases Program , Duke-National University of Singapore Medical School , Singapore , Singapore
14Clinic for Cardiology, Pneumology and Angiology , University Hospital Düsseldorf , Düsseldorf , Germany
15Florence-Nightingale-Krankenhaus, Kaiserswerther Diakonie, Düsseldorf, Germany
16Service de Médecine Intensive Réanimation, Institut de Cardiologie , Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris , Paris , France
17Klinik für Notfall- und Internistische Intensivmedizin, Klinikum Ernst von Bergmann , Potsdam , Germany
18Azienda Ospedaliera-Universitata di Padova , Padua , Italy
19North-West University-Mechnikov , St. Petersburg , Russian Federation
20Severe Sepsis Center , Scientific Research Institute of Emergency , St. Petersburg , Russian Federation
21Department for Health of the Tuscany Region, Clinical Risk Management and Patient Safety Centre of Tuscany Region , Florence , Italy
22The Johns Hopkins University School of Medicine, Baltimore, MD USA
23University of Hannover, Hannover Medical School , Hannover , Germany ; and Member of the German Center of Lung Research
24University of Hannover, Hannover Medical School, Hannover, Germany
25Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester and Basingstoke, UK
26University of Southampton, School of Medicine, Southampton, UK

Tóm tắt

Abstract Background

Procalcitonin (PCT)-guided antibiotic stewardship (ABS) has been shown to reduce antibiotics (ABxs), with lower side-effects and an improvement in clinical outcomes. The aim of this experts workshop was to derive a PCT algorithm ABS for easier implementation into clinical routine across different clinical settings.

Methods

Clinical evidence and practical experience with PCT-guided ABS was analyzed and discussed, with a focus on optimal PCT use in the clinical context and increased adherence to PCT protocols. Using a Delphi process, the experts group reached consensus on different PCT algorithms based on clinical severity of the patient and probability of bacterial infection.

Results

The group agreed that there is strong evidence that PCT-guided ABS supports individual decisions on initiation and duration of ABx treatment in patients with acute respiratory infections and sepsis from any source, thereby reducing overall ABx exposure and associated side effects, and improving clinical outcomes. To simplify practical application, the expert group refined the established PCT algorithms by incorporating severity of illness and probability of bacterial infection and reducing the fixed cut-offs to only one for mild to moderate and one for severe disease (0.25 μg/L and 0.5 μg/L, respectively). Further, guidance on interpretation of PCT results to initiate, withhold or discontinue ABx treatment was included.

Conclusions

A combination of clinical patient assessment with PCT levels in well-defined ABS algorithms, in context with continuous education and regular feedback to all ABS stakeholders, has the potential to improve the diagnostic and therapeutic management of patients suspected of bacterial infection, thereby improving ABS effectiveness.

Từ khóa


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