Probabilistic sensitivity analysis in health economics

Statistical Methods in Medical Research - Tập 24 Số 6 - Trang 615-634 - 2015
Gianluca Baio1,2, A. P. Dawid3
11Department of Statistical Science, University College London, London, UK.
22Department of Statistics, University of Milano Bicocca, Milan, Italy.
3Statistical Laboratory, Department of Pure Mathematics and Mathematical Statistics, University of Cambridge, Cambridge, UK

Tóm tắt

Health economic evaluations have recently become an important part of the clinical and medical research process and have built upon more advanced statistical decision-theoretic foundations. In some contexts, it is officially required that uncertainty about both parameters and observable variables be properly taken into account, increasingly often by means of Bayesian methods. Among these, probabilistic sensitivity analysis has assumed a predominant role. The objective of this article is to review the problem of health economic assessment from the standpoint of Bayesian statistical decision theory with particular attention to the philosophy underlying the procedures for sensitivity analysis.

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