Pro- and anti-apoptotic roles of c-Jun N-terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes

Aroor, 2004, MAP kinase signaling in diverse effects of ethanol, Life Sci., 74, 2339, 10.1016/j.lfs.2003.11.001

Auer, 1998, The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes, Mol. Biol. Cell, 9, 561, 10.1091/mbc.9.3.561

Bass, 1983, Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation, J. Immunol., 130, 1910, 10.4049/jimmunol.130.4.1910

Brecher, 1997, A perspective on acetaldehyde concentrations and toxicity in man and animals, Alcohol, 14, 493, 10.1016/S0741-8329(96)00217-0

Brondello, 1997, The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/44MAPK cascade, J. Biol. Chem., 272, 1368, 10.1074/jbc.272.2.1368

Cardin, 2002, Hepatocyte proliferation and apoptosis in relation to oxidative damage in alcohol-related liver disease, Alcohol Alcohol., 37, 43, 10.1093/alcalc/37.1.43

Carter, 1988, Ethanol induced inhibition of liver cell function: I. Effect of ethanol on hormone stimulated hepatocyte DNA synthesis and the role of ethanol metabolism, Alcohol., Clin. Exp. Res., 12, 555, 10.1111/j.1530-0277.1988.tb00241.x

Cathcart, 1983, Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay, Anal. Biochem., 134, 111, 10.1016/0003-2697(83)90270-1

Chang, 2001, Mammalian MAP kinase signaling cascades, Nature, 410, 37, 10.1038/35065000

Chen, 1996, The role of c-Jun N-terminal Kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation. Duration of JNK activation may determine cell death and proliferation, J. Biol. Chem., 271, 31929, 10.1074/jbc.271.50.31929

Chen, 1998, Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver, Biochem. J., 334, 669, 10.1042/bj3340669

Chen, 2001, Ethanol inhibits the JAK-STAT signaling pathway in freshly isolated rat hepatocytes but not in cultured hepatocytes or HepG2 cells: evidence for a lack of involvement of ethanol metabolism, Clin. Biochem., 34, 203, 10.1016/S0009-9120(01)00216-8

Chung, 2002, Retinoic acid inhibits hepatic Jun N-terminal kinase-dependent signaling pathway in ethanol-fed rats, Oncogene, 21, 1539, 10.1038/sj.onc.1205023

Crenesse, 2000, Protein kinase activation by warm and cold hypoxia-reoxygenation in primary-cultured rat hepatocytes-JNK1/SAPK1 involvement in apoptosis, Hepatology, 32, 1029, 10.1053/jhep.2000.19065

Czaja, 2003, The future of GI and liver research: editorial perspectives: III. JNK/AP-1 regulation of hepatocyte death, Am. J. Physiol., 284, G875

Dai, 1993, Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates, Biochemistry, 32, 6928, 10.1021/bi00078a017

Davies, 2000, Specificity and mechanism of action of some commonly used protein kinase inhibitors, Biochem. J., 351, 95, 10.1042/0264-6021:3510095

DeSilva, 1998, Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy, J. Immunol., 160, 4175, 10.4049/jimmunol.160.9.4175

Duranteau, 1998, Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes, J. Biol. Chem., 273, 11619, 10.1074/jbc.273.19.11619

Graf, 2002, Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner, Gastroenterology, 122, 1411, 10.1053/gast.2002.32976

Hibi, 1993, Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain, Genes Dev., 7, 2135, 10.1101/gad.7.11.2135

Hirsch, 1997, Mitogen-activated protein kinase phosphatases inactivate stress-activated protein kinase pathways in vivo, J. Biol. Chem., 272, 4568, 10.1074/jbc.272.7.4568

Ho, 2000, High glucose-induced apoptosis in human endothelial cells is mediated by sequential activation of c-Jun NH2-terminal kinase and caspase-3, Circulation, 101, 2618, 10.1161/01.CIR.101.22.2618

Hoek, 2002, Ethanol, oxidative stress, and cytokine-induced liver cell injury, Alcohol, 27, 63, 10.1016/S0741-8329(02)00215-X

Holownia, 1999, Acetaldehyde cytotoxicity in cultured rat astrocytes, Brain Res., 833, 202, 10.1016/S0006-8993(99)01529-2

Ikeyama, 2001, A non-toxic heat shock protein 70 inducer, geranylgeranylacetone, suppresses apoptosis of cultured rat hepatocytes caused by hydrogen peroxide and ethanol, J. Hepatol., 35, 53, 10.1016/S0168-8278(01)00053-8

Keyse, 2000, Protein phosphatases and the regulation of mitogen-activated protein kinase signalling, Curr. Opin. Cell Biol., 12, 186, 10.1016/S0955-0674(99)00075-7

Koivisto, 1997, Effects of acetaldehyde on brush border enzyme activities in human colon adenocarcinoma cell line caco-2, Alcohol., Clin. Exp. Res., 21, 1599, 10.1111/j.1530-0277.1997.tb04495.x

Lee, 2002, Inhibition of PTPs by H(2)O(2) regulates the activation of distinct MAPK pathways, Free Radic. Biol. Med., 33, 1121, 10.1016/S0891-5849(02)01000-6

Lee, 2002, Temporal activation of p42/44 mitogen-activated protein kinase and c-Jun N-terminal kinase by acetaldehyde in rat hepatocytes and its loss after chronic ethanol exposure, J. Pharmacol. Exp. Ther., 301, 908, 10.1124/jpet.301.3.908

Lieber, 1998, Hepatic and other medical disorders of alcoholism: from pathogenesis to treatment, J. Stud. Alcohol, 59, 9, 10.15288/jsa.1998.59.9

Liedtke, 2002, Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells, Hepatology, 36, 315, 10.1053/jhep.2002.34615

Liu, 2002, NFkB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun, Hepatology, 35, 772, 10.1053/jhep.2002.32534

Liu, 2003, Increased cytochrome P-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-alpha, Am. J. Physiol.: Gastrointest. Liver Physiol., 282, G257, 10.1152/ajpgi.00304.2001

Matsumaru, 2003, Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes, Hepatology, 37, 1425, 10.1053/jhep.2003.50230

Matysiak-Budnik, 1996, Hepatotoxicity and absorption of extrahepatic acetaldehyde in rats, J. Pathol., 178, 469, 10.1002/(SICI)1096-9896(199604)178:4<469::AID-PATH510>3.0.CO;2-9

Meriin, 1999, Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72, Mol. Cell. Biol., 19, 2547, 10.1128/MCB.19.4.2547

Nanji, 1996, Alcoholic liver disease, 891

Natori, 2001, Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis, J. Hepatol., 34, 248, 10.1016/S0168-8278(00)00089-1

Niemelä, 1995, Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease, Hepatology, 22, 1208, 10.1016/0270-9139(95)90630-4

Nuutinen, 1984, Blood acetaldehyde concentration gradient between hepatic and antecubital venous blood in ethanol intoxicated alcoholics and control, Eur. J. Clin. Invest., 14, 306, 10.1111/j.1365-2362.1984.tb01186.x

Paumelle, 2000, Sequential activation of ERK and repression of JNK by scatter factor/hepatocyte growth factor in Madin-Darby canine kidney epithelial cells, Mol. Biol. Cell, 11, 3751, 10.1091/mbc.11.11.3751

Peristeris, 1992, N-Acetylcysteine and glutathione as inhibitors of tumor necrosis factor production, Cell. Immunol., 140, 390, 10.1016/0008-8749(92)90205-4

Peters, 1988, Role of acetaldehyde in the pathogenesis of alcoholic liver disease, Mol. Aspects Med., 10, 179, 10.1016/0098-2997(88)90022-2

Rauen, 1999, Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: mediation by reactive oxygen species, FASEB J., 13, 155, 10.1096/fasebj.13.1.155

Reddy, 1996, Potentiation of mitogen-activated protein kinase by ethanol in embryonic liver cells, Biochem. Pharmacol., 51, 661, 10.1016/S0006-2952(95)02239-2

Roman, 1999, Differential role of ethanol and acetaldehyde in the induction of oxidative stress in HEP G2 cells: effect on transcription factors AP-1 and NF-kappaB, Hepatology, 30, 1473, 10.1002/hep.510300623

Salaspuro, 1991, Epidemiological aspects of alcohol and alcoholic liver disease, ethanol metabolism, and pathogenesis of alcoholic liver injury, 791

Sawada, 2000, Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons, FASEB J., 14, 1202, 10.1096/fasebj.14.9.1202

Schwabe, 2003, c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration, Hepatology, 37, 824, 10.1053/jhep.2003.50135

Shen, 2003, Cross-talk between JNK/SAPK and ERK/MAPK pathways: sustained activation of JNK blocks ERK activation by mitogenic factors, J. Biol. Chem., 278, 26715, 10.1074/jbc.M303264200

Shimamatsu, 1997, Role of ischemia in causing apoptosis, atrophy, and nodular hyperplasia in human liver, Hepatology, 26, 343, 10.1002/hep.510260214

Surapisitchat, 2001, Fluid shear stress inhibits TNF-α activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: inhibitory crosstalk among MAPK family members, Proc. Natl. Acad. Sci. U. S. A., 98, 6476, 10.1073/pnas.101134098

Tombes, 1998, The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic, Biochem. J., 330, 1451, 10.1042/bj3301451

Traber, 1992, In vivo modulation of total and mitochondrial glutathione in rat liver. Depletion by phorone and rescue by N-acetylcysteine, Biochem. Pharmacol., 43, 961, 10.1016/0006-2952(92)90599-E

Vanden Hoek, 1997, Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion, J. Mol. Cell. Cardiol., 29, 2571, 10.1006/jmcc.1997.0497

Webster, 1998, Cyclic adenosine monophosphate-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes, Hepatology, 27, 1324, 10.1002/hep.510270519

Wei, 2001, Differential MAP kinase activation and Na(+)/H(+) exchanger phosphorylation by H(2)O(2) in rat cardiac myocytes, Am. J. Physiol., Cell. Physiol., 281, C1542, 10.1152/ajpcell.2001.281.5.C1542

Weng, 2000, Ethanol alters angiotensin II stimulated mitogen activated protein kinase in hepatocytes: agonist selectivity and ethanol metabolic independence, Eur. J. Pharmacol., 398, 323, 10.1016/S0014-2999(00)00313-7

Yoshizumi, 2000, Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species, J. Biol. Chem., 275, 11706, 10.1074/jbc.275.16.11706

Zhou, 2003, A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production, Am. J. Pathol., 163, 1137, 10.1016/S0002-9440(10)63473-6

Zimmerman, 1995, Mechanisms of acetaldehyde mediated growth inhibition: delayed cell cycle progression and induction of apoptosis, Alcohol., Clin. Exp. Res., 19, 434, 10.1111/j.1530-0277.1995.tb01527.x