Primary intraocular lymphoma: a review of the clinical, histopathological and molecular biological features
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Abrey LE, DeAngelis LM, Yahalom J (1998) Long-term survival in primary CNS lymphoma. J Clin Oncol 16:859?863
Akpek EK, Ahmed I, Hochberg FH et al (1999) Intraocular-central nervous system lymphoma: clinical features, diagnosis, and outcomes. Ophthalmology 106:1805?1810
Anagnostopoulos I, Stein H (2000) Large B-cell lymphomas: variants and entities. Pathologe 21:178?189
Appen RE (1975) Posterior uveitis and primary cerebral reticulum cell sarcoma. Arch Ophthalmol 93:123?124
Barr CC, Green WR, Payne JW et al (1975) Intraocular reticulum-cell sarcoma: clinico-pathologic study of four cases and review of the literature. Surv Ophthalmol 19:224?239
Basso U, Brandes AA (2002) Diagnostic advances and new trends for the treatment of primary central nervous system lymphoma. Eur J Cancer 38:1298?1312
Batchelor TT, Kolak G, Ciordia R et al (2003) High-dose methotrexate for intraocular lymphoma. Clin Cancer Res 9:711?715
Baumann MA, Ritch PS, Hande KR et al (1986) Treatment of intraocular lymphoma with high-dose Ara-C. Cancer 57:1273?1275
Bechrakis NE, Foerster MH, Bornfeld N (2002) Biopsy in indeterminate intraocular tumors. Ophthalmology 109:235?242
Ben-Ezra D, Sahel JA, Harris NL et al (1989) Uveal lymphoid infiltrates: immunohistochemical evidence for a lymphoid neoplasia. Br J Ophthalmol 73:846?851
Brown SM, Jampol LM, Cantrill HL (1994) Intraocular lymphoma presenting as retinal vasculitis. Surv Ophthalmol 39:133?140
Buggage RR, Chan CC, Nussenblatt RB (2001) Ocular manifestations of central nervous system lymphoma. Curr Opin Oncol 13:137?142
Cassoux N, Merle-Beral H, Leblond V et al (2000) Ocular and central nervous system lymphoma: clinical features and diagnosis. Ocul Immunol Inflamm 8:243?250
Chan CC, Whitcup SM, Solomon D, Nussenblatt RB (1995) Interleukin-10 in the vitreous of patients with primary intraocular lymphoma. Am J Ophthalmol 120:671?673
Chang TS, Byrne SF, Gass JD et al (1996) Echographic findings in benign reactive lymphoid hyperplasia of the choroid. Arch Ophthalmol 114:669?675
Char DH, Ljung BM, Deschenes J, Miller TR (1988) Intraocular lymphoma: immunological and cytological analysis. Br J Ophthalmol 72:905?911
Char DH, Ljung BM, Miller T, Phillips T (1988) Primary intraocular lymphoma (ocular reticulum cell sarcoma) diagnosis and management. Ophthalmology 95:625?630
Cheung MK, Martin DF, Chan CC et al (1994) Diagnosis of reactive lymphoid hyperplasia by chorioretinal biopsy. Am J Ophthalmol 118:457?462
Ciricillo SF, Rosenblum ML (1990) Use of CT and MR imaging to distinguish intracranial lesions and to define the need for biopsy in AIDS patients. J Neurosurg 73:720?724
Ciulla TA, Bains RA, Jakobiec FA et al (1997) Uveal lymphoid neoplasia: a clinical-pathologic correlation and review of the early form. Surv Ophthalmol 41:467?476
Ciulla TA, Pesavento RD, Yoo S (1997) Subretinal aspiration biopsy of ocular lymphoma. Am J Ophthalmol 123:420?422
Cochereau I, Hannouche D, Geoffray C et al (1996) Ocular involvement in Epstein?Barr virus-associated T-cell lymphoma. Am J Ophthalmol 121:322?324
Cockerham GC, Hidayat AA, Bijwaard KE, Sheng ZM (2000) Re-evaluation of ?reactive lymphoid hyperplasia of the uvea?: an immunohistochemical and molecular analysis of 10 cases. Ophthalmology 107:151?158
Corn BW, Donahue BR, Rosenstock JG et al (1997) Performance status and age as independent predictors of survival among AIDS patients with primary CNS lymphoma: a multivariate analysis of a multi-institutional experience. Cancer J Sci Am 3:52?56
Corriveau C, Easterbrook M, Payne D (1986) Lymphoma simulating uveitis (masquerade syndrome). Can J Ophthalmol 21:144?149
Coupland SE, Anastassiou G, Hummel M, Stein H Primary intraocular lymphoma of T-cell type: report of a case and review of the literature. Graefe?s Arch Clin Exp Ophthalm DOI 10.1007/s00417-004-0890-2 (in press)
Coupland SE, Bechrakis NE, Anastassiou G et al (2003) Evaluation of vitrectomy specimens and chorioretinal biopsies in the diagnosis of primary intraocular lymphoma in patients with Masquerade syndrome. Graefes Arch Clin Exp Ophthalmol 10:860?870
Coupland SE, Foss HD, Assaf C et al (1999) T-cell and T/natural killer-cell lymphomas involving ocular and ocular adnexal tissues: a clinicopathologic, immunohistochemical, and molecular study of seven cases. Ophthalmology 106:2109?2120
Coupland SE, Foss HD, Bechrakis NE et al (2001) Secondary ocular involvement in systemic ?memory? B-cell lymphocytic leukemia. Ophthalmology 108:1289?1295
Coupland SE, Foss HD, Hidayat AA et al (2002) Extranodal marginal zone B cell lymphomas of the uvea: an analysis of 13 cases. J Pathol 197:333?340
Coupland SE, Willerding G, Jahnke K, Stoltenburg-Didinger G, Hummel M, Stein H (2004) Demonstration of identical clonal derivation in a case of ?oculocerebral? lymphoma. Br J Ophthamol (in press)
Crookes GP, Mullaney J (1967) Lymphoid hyperplasia of the uveal tract simulating malignant lymphoma. Am J Ophthalmol 63:962?967
Davis JL, Solomon D, Nussenblatt RB et al (1992) Immunocytochemical staining of vitreous cells. Indications, techniques, and results. Ophthalmology 99:250?256
Davis JL, Viciana AL, Ruiz P (1997) Diagnosis of intraocular lymphoma by flow cytometry. Am J Ophthalmol 124:362?372
Dean JM, Novak MA, Chan CC, Green WR (1996) Tumor detachments of the retinal pigment epithelium in ocular/ central nervous system lymphoma. Retina 16:47?56
DeAngelis LM, Seiferheld W, Schold SC et al (2002) Combination chemotherapy and radiotherapy for primary central nervous system lymphoma: Radiation Therapy Oncology Group Study 93-10. J Clin Oncol 20:4643?4648
DeAngelis LM, Yahalom J, Thaler HT, Kher U (1992) Combined modality therapy for primary CNS lymphoma. J Clin Oncol 10:635?643
Desroches G, Abrams GW, Gass JD (1983) Reactive lymphoid hyperplasia of the uvea. A case with ultrasonographic and computed tomographic studies. Arch Ophthalmol 101:725?728
van Dongen JJ, Langerak AW, Bruggemann M et al (2003) Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 17:2257?2317
Duker JS, Shields JA, Ross M (1987) Intraocular large cell lymphoma presenting as massive thickening of the uveal tract. Retina 7:41?455
Eby NL, Grufferman S, Flannelly CM et al (1988) Increasing incidence of primary brain lymphoma in the US. Cancer 62:2461?2465
Erny BC, Egbert PR, Peat IM et al (1991) Intraocular involvement with subretinal pigment epithelium infiltrates by mycosis fungoides. Br J Ophthalmol 75:698?701 (Erratum 76(2):128)
Escoffery RF, Bobrow JC, Smith ME (1985) Exudative retinal detachment secondary to orbital and intraocular benign lymphoid hyperplasia. Retina 5:91?93
Falini B, Fizzotti M, Pucciarini A et al (2000) A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood 95:2084?2092
Faulborn J, Daicker B, Bowald S (1983) Clinical signs and histopathology of so-called reticulum cell sarcoma of the eye. Klin Monatsbl Augenheilkd 183:120?121
Ferreri AJ, Blay JY, Reni M (2002) Relevance of intraocular involvement in the management of primary central nervous system lymphomas. Ann Oncol 13:531?538
Feugier P, Virion JM, Tilly H et al (2004) Incidence and risk factors for central nervous system occurrence in elderly patients with diffuse large-B-cell lymphoma: influence of rituximab. Ann Oncol 15:129?133
Fishburne BC, Wilson DJ, Rosenbaum JT, Neuwelt EA (1997) Intravitreal methotrexate as an adjunctive treatment of intraocular lymphoma. Arch Ophthalmol 115:1152?1156
Foerster H (1960) Mycosis fungoides with intraocular involvement. Trans Am Acad Ophthalmol Otolaryngol 64:308?314
Fredrick DR, Char DH, Ljung BM, Brinton DA (1989) Solitary intraocular lymphoma as an initial presentation of widespread disease. Arch Ophthalmol 107:395?397
Freeman LN, Schachat AP, Knox DL et al (1987) Clinical features, laboratory investigations, and survival in ocular reticulum cell sarcoma. Ophthalmology 94:1631?1639
Freilich RJ, Delattre JY, Monjour A, DeAngelis LM (1996) Chemotherapy without radiation therapy as initial treatment for primary CNS lymphoma in older patients. Neurology 46:435?439
Gärtner J (1989) Mycosis fungoides mit Beteiligung der Aderhaut. Klin Monatsbl Augenheilkd 131:61?69
Gass JD (1967) Retinal detachment and narrow-angle glaucoma secondary to inflammatory pseudotumor of the uveal tract. Am J Ophthalmol 64(Suppl):612?621
Gass JD, Sever RJ, Grizzard WS et al (1984) Multifocal pigment epithelial detachments by reticulum cell sarcoma. A characteristic funduscopic picture. Retina 4:135?143
Gass JD, Trattler HL (1991) Retinal artery obstruction and atheromas associated with non-Hodgkin?s large cell lymphoma (reticulum cell sarcoma). Arch Ophthalmol 109:1134?1139
Gill MK, Jampol LM (2001) Variations in the presentation of primary intraocular lymphoma: case reports and a review. Surv Ophthalmol 45:463?471
Goeminne JC, Brouillard A, Jaumain P et al (1999) Bilateral granulomatous panuveitis as initial presentation of diffuse systemic T cell lymphoma. Ophthalmologica 213:323?326
Goldey SH, Stern GA, Oblon DJ et al (1989) Immunophenotypic characterization of an unusual T-cell lymphoma presenting as anterior uveitis. A clinicopathologic case report. Arch Ophthalmol 107:1349?1353
Gorochov G, Parizot C, Bodaghi B et al (2003) Characterization of vitreous B-cell infiltrates in patients with primary ocular lymphoma, using CDR3 size polymorphism analysis of antibody transcripts. Invest Ophthalmol Vis Sci 44:5235?5241
Grossniklaus HE, Martin DF, Avery R et al (1998) Uveal lymphoid infiltration. Report of four cases and clinicopathologic review. Ophthalmology 105:1265?1273
Helbig H, Cerny T, De Smet MD (2003) Intravitreal chemotherapy for intraocular lymphoma. Ophthalmologe 100:145?149
Henry JM, Heffner RR Jr, Dillard SH et al (1974) Primary malignant lymphomas of the central nervous system. Cancer 34:1293?1302
Herrlinger U, Schabet M, Bitzer M et al (1999) Primary central nervous system lymphoma: from clinical presentation to diagnosis. J Neurooncol 43:219?226
Hoffman PM, McKelvie P, Hall AJ et al (2003) Intraocular lymphoma: a series of 14 patients with clinicopathological features and treatment outcomes. Eye 17:513?521
Holz FG, Boehmer HV, Mechtersheimer G et al (1999) Uveal non-Hodgkin?s lymphoma with epibulbar extension simulating choroidal effusion syndrome. Retina 19:343?346
Jaffe ES, Harris NL, Stein H, Vardiman JW (2001) World Health Organization classification of tumours. Tumours of haematopoietic and lymphoid tissues. Pathology and genetics. IARC, Lyon
Jahnke K, Bechrakis NE, Coupland SE, et al (2004) Trofosfamide for relapsed intraocular lymphoma: case report and review of the literature. Graefes Arch Clin Exp Ophthalmol 242:771?776
Jakobiec FA, Sacks E, Kronish JW et al (1987) Multifocal static creamy choroidal infiltrates. An early sign of lymphoid neoplasia. Ophthalmology 94:397?406
Jensen OA, Johansen S, Kiss K (1994) Intraocular T-cell lymphoma mimicking a ring melanoma. First manifestation of systemic disease. Report of a case and survey of the literature. Graefes Arch Clin Exp Ophthalmol 232:148?152
Kaplan HJ, Meredith TA, Aaberg TM, Keller RH (1980) Reclassification of intraocular reticulum cell sarcoma (histiocytic lymphoma). Immunologic characterization of vitreous cells. Arch Ophthalmol 98:707?710
Katai N, Kuroiwa S, Fujimori K, Yoshimura N (1997) Diagnosis of intraocular lymphoma by polymerase chain reaction. Graefes Arch Clin Exp Ophthalmol 235:431?436
Kawai Y, Kawai R, Nakayama T et al (1999) Successful treatment of cytomegalovirus retinitis in a patient with malignant lymphoma: a case report and review of the literature. Int J Hematol 69:256?259
Keltner JL, Fritsch E, Cykiert RC, Albert DM (1977) Mycosis fungoides. Intraocular and central nervous system involvement. Arch Ophthalmol 95:645?650
Kirmani MH, Thomas EL, Rao NA, Laborde RP (1987) Intraocular reticulum cell sarcoma: diagnosis by choroidal biopsy. Br J Ophthalmol 71:748?752
Kohno T, Uchida H, Inomata H et al (1993) Ocular manifestations of adult T-cell leukemia/lymphoma. A clinicopathologic study. Ophthalmology 100:1794?1799
Kuker W, Herrlinger U, Gronewaller E et al (2002) Ocular manifestation of primary nervous system lymphoma: what can be expected from imaging? J Neurol 249:1713?1716
Kumar SR, Gill PS, Wagner DG et al (1994) Human T-cell lymphotropic virus type I-associated retinal lymphoma. A clinicopathologic report. Arch Ophthalmol 112:954?959
Lafaut BA, Hanssens M, Verbraeken H, De Laey JJ (1994) Chorioretinal biopsy in the diagnosis of intraocular lymphoma: a case report. Bull Soc Belge Ophtalmol 252:67?73
Leitch RJ, Rennie IG, Parsons MA (1993) Ocular involvement in mycosis fungoides. Br J Ophthalmol 77:126?127
Levy-Clarke GA, Byrnes GA, Buggage RR et al (2001) Primary intraocular lymphoma diagnosed by fine needle aspiration biopsy of a subretinal lesion. Retina 21:281?284
Ljung BM, Char D, Miller TR, Deschenes J (1988) Intraocular lymphoma. Cytologic diagnosis and the role of immunologic markers. Acta Cytol 32:840?847
Lobo A, Larkin G, Clark BJ et al (2003) Pseudo-hypopyon as the presenting feature in B-cell and T-cell intraocular lymphoma. Clin Exp Ophthalmol 31:155?158
Lobo A, Lightman S (2003) Vitreous aspiration needle tap in the diagnosis of intraocular inflammation. Ophthalmology 110:595?599
Lois N, Hiscott PS, Nash J, Wong D (2000) Immunophenotypic shift in a case of mycosis fungoides with vitreous invasion. Arch Ophthalmol 118:1692?1694
Margolis L, Fraser R, Lichter A, Char DH (1980) The role of radiation therapy in the management of ocular reticulum cell sarcoma. Cancer 45:688?692
Martin DF, Chan CC, de Smet MD et al (1993) The role of chorioretinal biopsy in the management of posterior uveitis. Ophthalmology 100:705?714
Mason JO, Fischer DH (2003) Intrathecal chemotherapy for recurrent central nervous system intraocular lymphoma. Ophthalmology 110:1241?1244
McGavic JS (1943) Lymphomatoid diseases involving the eye and its adnexa. Arch Ophthalmol 30:179?193
Merle-Beral H, Davi F, Cassoux N et al (2004) Biological diagnosis of primary intraocular lymphoma. Br J Haematol 124:469?473
Michels RG, Knox DL, Erozan YS, Green WR (1975) Intraocular reticulum cell sarcoma. Diagnosis by pars plana vitrectomy. Arch Ophthalmol 93:1331?1335
Nathwani BN, Kim H, Rappaport H et al (1978) Non-Hodgkin?s lymphomas: a clinicopathologic study comparing two classifications. Cancer 41:303?325
Nelson DF, Martz KL, Bonner H et al (1992) Non-Hodgkin?s lymphoma of the brain: can high dose, large volume radiation therapy improve survival? Report on a prospective trial by the Radiation Therapy Oncology Group (RTOG): RTOG 8315. Int J Radiat Oncol Biol Phys 23:9?17
Palexas GN, Green WR, Goldberg MF, Ding Y (1995) Diagnostic pars plana vitrectomy report of a 21-year retrospective study. Trans Am Ophthalmol Soc 93:281?308 (Discussion 308?314)
Parver LM, Font RL (1979) Malignant lymphoma of the retina and brain. Initial diagnosis by cytologic examination of vitreous aspirate. Arch Ophthalmol 97:1505?1507
Pavan PR, Oteiza EE, Margo CE (1995) Ocular lymphoma diagnosed by internal subretinal pigment epithelium biopsy. Arch Ophthalmol 113:1233?1234
Pels H, Schmidt-Wolf IG, Glasmacher A et al (2003) Primary central nervous system lymphoma: results of a pilot and phase II study of systemic and intraventricular chemotherapy with deferred radiotherapy. J Clin Oncol 21:4489?4495 (e-pub 3 Nov 2003)
Peterson K, Gordon KB, Heinemann MH, DeAngelis LM (1993) The clinical spectrum of ocular lymphoma. Cancer 72:843?849
Plowman PN, Montefiore DS, Lightman S (1993) Multiagent chemotherapy in the salvage cure of ocular lymphoma relapsing after radiotherapy. Clin Oncol R Coll Radiol 5:315?316
Qualman SJ, Mendelsohn G, Mann RB, Green WR (1983) Intraocular lymphomas. Natural history based on a clinicopathologic study of eight cases and review of the literature. Cancer 52:878?886
Reim H, Dieler R, Wessing A (1990) Non-Hodgkin?s lymphoma simulating chorioretinitis. Fortschr Ophthalmol 87:557?559
Ridley ME, McDonald HR, Sternberg P Jr et al (1992) Retinal manifestations of ocular lymphoma (reticulum cell sarcoma). Ophthalmology 99:1153?1160 (Discussion 1160?1161)
Rothova A, Ooijman F, Kerkhoff F et al (2001) Uveitis masquerade syndromes. Ophthalmology 108:386?399
Rubenstein JL, Combs D, Rosenberg J et al (2003) Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment. Blood 101:466?468 (e-pub 5 Sep 2002)
Ryan SJ Jr, Frank RN, Green WR (1971) Bilateral inflammatory pseudotumors of the ciliary body. Am J Ophthalmol 72:586?591
Ryan SJ, Zimmerman LE, King FM (1972) Reactive lymphoid hyperplasia. An unusual form of intraocular pseudotumor. Trans Am Acad Ophthalmol Otolaryngol 76:652?671
Saga T, Ohno S, Matsuda H et al (1984) Ocular involvement by a peripheral T-cell lymphoma. Arch Ophthalmol 102:399?402
Schachat AP, Markowitz JA, Guyer DR et al (1989) Ophthalmic manifestations of leukemia. Arch Ophthalmol 107:697?700
Scroggs MW, Johnston WW, Klintworth GK (1990) Intraocular tumors. A cytopathologic study. Acta Cytol 34:401?408
Shen DF, Zhuang Z, LeHoang P et al (1998) Utility of microdissection and polymerase chain reaction for the detection of immunoglobulin gene rearrangement and translocation in primary intraocular lymphoma. Ophthalmology 105:1664?1669
Shields JA, Augsburger JJ, Gonder JR, MacLeod D (1981) Localized benign lymphoid tumor of the iris. Arch Ophthalmol 99:2147?2148
Shields JA, McDonald PR (1974) Improvements in the diagnosis of posterior uveal melanomas. Arch Ophthalmol 91:259?264
de Smet MD, Nussenblatt RB, Davis JL, Palestine AG (1990) Large cell lymphoma masquerading as a viral retinitis. Int Ophthalmol 14:413?417
Soussain C, Merle-Beral H, Reux I et al (1996) A single-center study of 11 patients with intraocular lymphoma treated with conventional chemotherapy followed by high-dose chemotherapy and autologous bone marrow transplantation in 5 cases. Leuk Lymphoma 23:339?345
Soussain C, Suzan F, Hoang-Xuan K et al (2001) Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or intraocular lymphoma. J Clin Oncol 19:742?749
Strauchen JA, Dalton J, Friedman AH (1989) Chemotherapy in the management of intraocular lymphoma. Cancer 63:1918?1921
Triebenstein O (1920) Ein Beitrag zur Frage der aleukämischen Augenveränderungen. Klin Monatsbl Augenheilkd 64:825?836
Umland O, Ulmer AJ, Vollmer E, Goldmann T (2003) HOPE fixation of cytospin preparations of human cells for in situ hybridization and immunocytochemistry. J Histochem Cytochem 51:977?980
Ursea R, Heinemann MH, Silverman RH et al (1997) Ophthalmic, ultrasonographic findings in primary central nervous system lymphoma with ocular involvement. Retina 17:118?123
Valluri S, Moorthy RS, Khan A, Rao NA (1995) Combination treatment of intraocular lymphoma. Retina 15:125?129
Velez G, Chan CC, Csaky KG (2002) Fluorescein angiographic findings in primary intraocular lymphoma. Retina 22:37?43
Velez G, de Smet MD, Whitcup SM et al (2000) Iris involvement in primary intraocular lymphoma: report of two cases and review of the literature. Surv Ophthalmol 44:518?526
Verbraeken HE, Hanssens M, Priem H et al (1997) Ocular non-Hodgkin?s lymphoma: a clinical study of nine cases. Br J Ophthalmol 81:31?36
Wender A, Adar A, Maor E, Yassur Y (1994) Primary B-cell lymphoma of the eyes and brain in a 3-year-old boy. Arch Ophthalmol 112:450?451
Whitcup SM, de Smet MD, Rubin BI et al (1993) Intraocular lymphoma. Clinical and histopathologic diagnosis. Ophthalmology 100:1399?1406
Whitcup SM, Stark-Vancs V, Wittes RE et al (1997) Association of interleukin 10 in the vitreous and cerebrospinal fluid and primary central nervous system lymphoma. Arch Ophthalmol 115:1157?1160
White VA, Gascoyne RD, Paton KE (1999) Use of the polymerase chain reaction to detect B- and T-cell gene rearrangements in vitreous specimens from patients with intraocular lymphoma. Arch Ophthalmol 117:761?765
Williams GC, Holz E, Lee AG, Font RL (2000) T-cell lymphoproliferative disorder of vitreous associated with mycosis fungoides. Arch Ophthalmol 118:278?280
Wolter J, Leenhouts T, Hendrix R (1963) Corneal involvement in mycosis fungoides. Am J Ophthalmol 55:315?322
Wylen EL, Williams RB, Nanda A (1998) Cutaneous T-cell lymphoma with intracerebral and bilateral intraocular spread. Neurol Res 20:307?312
Yahalom C, Cohen Y, Averbukh E et al (2002) Bilateral iridociliary T-cell lymphoma. Arch Ophthalmol 120:204?207
Yamada K, Hirata A, Kimura A, Tanihara H (2003) A case of primary B-cell type non-Hodgkin lymphoma originating in the iris. Am J Ophthalmol 136:380?382
Young TL, Himelstein BP, Rebsamen SL et al (1996) Intraocular Ki-1 lymphoma in a 2-year-old boy. J Pediatr Ophthalmol Strabismus 33:268?270
Yunis JJ, Oken MM, Kaplan ME et al (1982) Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin?s lymphoma. N Engl J Med 307:1231?1236