Primary hepatic mucosa-associated lymphoid tissue lymphoma: a case report and literature review
Tóm tắt
Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is an extremely rare disease. We herein describe the findings in a 74-year-old man with elevated liver enzyme levels. Dynamic computed tomography showed focal biliary dilation and atrophy in the posterior segment, while dynamic magnetic resonance images revealed a small, highly enhanced small mass located at the root of posterior branch of the biliary ducts. As the mass was not detected on abdominal ultrasonography, a biopsy could not be performed. Cholangiocellular carcinoma was suspected, and surgery was performed. However, the surgically resected hepatic tumor was a nodule of aggregated lymphocytes that formed a lymphoepithelial lesion. Immunohistochemical analysis revealed that the lymphoma cells were positive for CD20 and CD79a, but negative for CD3. No other lymphoid lesions were found during additional postoperative examinations. Therefore, the patient was diagnosed with primary hepatic MALT lymphoma. He was also diagnosed with Helicobacter pylori infection, and thus, pylorus eradication was performed. At the time of this report, the patient was free of disease for 2 years without any additional treatment. The present case contributed to the diagnosis and management of this rare disease, as previously published case reports described varying imaging features; it also suggested that preoperative diagnosis was often difficult without biopsy.
Tài liệu tham khảo
Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. Cancer. 1983;52:1410–6.
Yang XW, Tan WF, Yu WL, Shi S, Wang Y, Zhang YL, et al. Diagnosis and surgical treatment of primary hepatic lymphomas. World J Gastroenterol. 2010;16:6016–9.
Thieblemont C, Bertoni F, Cople-Bergman C, Ferreri AJ, Ponzoni M. Chronic inflammation and extra-nodal marginal-zone lymphoma of MALT type. Semin Cancer Biol. 2014;24:33–42.
Prabhu RM, Medeiros LJ, Kumar D, Drachenberg CI, Papadimitriou JC, Appleman HD, et al. Primary hepatic low grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) associated with primary biliary cirrhosis. Mod Pathol. 1998;11:404–10.
Sato S, Masuda T, Oikawa H, Satoh T, Suzuki Y, Takikawa Y, et al. Primary hepatic lymphoma associated with primary biliary cirrhosis. Am J Gastroenterol. 1999;94:1669–73.
Ye MQ, Suriawinata A, Black C, Min AD, Strauchen J, Thung SN. Primary hepatic marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type in a patient with primary biliary cirrhosis. Arch Pathol Lab Med. 2000;124:604–8.
Nakayama S, Yokote T, Kobayashi K, Hirata Y, Akioka T, Miyoshi T, et al. Primary hepatic MALT lymphoma associated with primary biliary cirrhosis. Leuk Res. 2010;34:e17–20.
Tanaka M, Fukushima N, Yamasaki F, Ohshima K. Primary hepatic extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type is associated with chronic inflammatory process. Open J Hematol. 2010. www.rossscience.org/ojhmt/articles/2075-907X-1-5.pdf. Accessed 14 Feb 2015.
Ascoli V, Lo Coco F, Artini M, Lerero M, Martelli M, Negro F. Extranodal lymphomas associated with hepatitis C virus infection. Am J Clin Pathol. 1998;109:600–9.
Yago K, Shimada H, Itoh M, Ooba N, Itoh K, Suzuki M, et al. Primary low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT)-type of the liver in a patient with hepatitis C virus infection. Leuk Lymphoma. 2002;43:1497–500.
Mizuno S, Isaji S, Tabata M, Uemoto S, Imai H, Shiraki K. Hepatic mucosa-associated lymphoid tissue (MALT) lymphoma associated with hepatitis C. J Hepatol. 2002;37:872–3.
Orrego M, Guo L, Reeder C, De Petris G, Balan V, Douglas DD, et al. Hepatic B-cell non-hodgkin’s lymphoma of MALT type in the liver explant of a patient with chronic hepatitis C infection. Liver Transpl. 2006;12:560–5.
Doi H, Horiike N, Hiraoka A, Koizumi Y, Yamamoto Y, Hasebe A, et al. Primary hepatic marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type: case report and review of the literature. Int J Hematol. 2008;88:418–23.
Takeshima F, Kunisaki M, Aritomi T, Osabe M, Akama F, Nakasone T, et al. Hepatic mucosa-associated lymphoid tissue and hepatocellular carcinoma in a patient with hepatitis B virus infection. J Clin Gastroenterol. 2004;38:823–6.
Nart D, Ertan Y, Yilmaz F, Yüce G, Zeytunlu M, Kilic M. Primary hepatic marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type in a liver transplant patient with hepatitis B cirrhosis. Transplant Proc. 2005;37:4408–12.
Gockel HR, Heidemann J, Lugering A, Mesters RM, Parwaresch R, Domschke W, et al. Stable remission after administration of rituximab in a patient with primary hepatic marginal zone B-cell lymphoma. Eur J Haematol. 2005;74:445–7.
Yamabe H, Haga H, Kashu I, Watanabe C, Kobashi Y. Malignant lymphoma of mucosa-associated lymphoid tissue (MALT) type associated with ascariasis in the liver. Med Kagoshima Univ. 1995. http://ir.kagoshima-u.ac.jp/bitstream/10232/18332/1/AN00040104_v47s2_p137-139.pdf. Accessed 14 Feb 2015.
Chen F, Ike O, Wada H, Hitomi S. Pulmonary mucosa-associated lymphoid tissue lymphoma 8 years after resection of the same type of lymphoma of the liver. Jpn J Thorac Cardiovasc Surg. 2000;48:233–5.
Iida T, Iwahashi M, Nakamura M, Nakamori M, Yokoyama S, Tani M, et al. Primary hepatic low-grade B-cell lymphoma of MALT-type associated with helicobacter pylori infection. Hepatogastroenterology. 2007;54:1898–901.
Isaacson PG, Banks PM, Best PV, McLure SP, Muller-Hermelink HK, Wyatt JI. Primary low-grade hepatic B-cell lymphoma of mucosa-associated lymphoid tissue(MALT)-type. Am J Surg Pathol. 1995;19:571–5.
Ueda G, Oka K, Matsumoto T, Yatabe Y, Yamanaka K, Suyama M, et al. Primary hepatic marginal zone B-cell lymphoma with mantle cell lymphoma phenotype. Virchows Arch. 1996;428:311–4.
Maes M, Depardieu C, Dargent JL, Hermans M, Verhaeghe JL, Delabie J, et al. Primary low-grade B-cell lymphoma of MALT-type occurring in the liver: a study of two cases. J Hepatol. 1997;27:922–7.
Kirk CM, Lewin D, Lazarchick J. Primary hepatic B-cell lymphoma of mucosa-associated lymphoid tissue. Arch Pathol Lab Med. 1999;123:716–9.
Bouron D, Léger-Ravet MB, Gaulard P, Franco D, Capron F. Unusual hepatic tumor. Ann Pathol. 1999;19:547–8.
Raderer M, Traub T, Formanek M, Virgolini I, Osterreicher C, Fiebiger W, et al. Somatostatin-receptor scintigraphy for staging and follow-up of patients with extraintestinal marginal zone B-cell lymphoma of the mucosa associated lymphoid tissue (MALT)-type. Br J Cancer. 2001;85:1462–6.
Murakami J, Fukushima N, Ueno H, Saito T, Watanabe T, Tanosaki R, et al. Primary hepatic low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue type: a case report and review of the literature. Int J Hematol. 2002;75:85–90.
Arai O, Wani Y, Kaneyoshi T, Ikeda H, Kono Y, Tsukayama C. A case of primary hepatic low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT). Liver Cancer. 2003;9:144–9.
Streubel B, Lamprecht A, Dierlamm J, Cerroni L, Stolte M, Ott G, et al. T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma. Blood. 2003;101:2335–9.
Shin SY, Kim JS, Lim JK, Hahn JS, Yang WI, Suh CO. Long-lasting remission of primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma achieved by radiotherapy alone. Korean J Intern Med. 2006;21:127–31.
Hamada M, Tanaka Y, Kobayashi Y, Takeshita E, Joko K. A case of MALT lymphoma of the liver treated by RFA and Rituximab. Nippon Shokakibyo Gakkai Zasshi. 2006;103:655–60.
Yasui T, Okino H, Onitsuka K, Shono M, Watanabe J, Takeda S. A case of primary hepatic lymphoma. Nippon Rinsho Geka Gakkai Zasshi. 2006. www.ci.nii.ac.jp/naid/130003605234. Accessed 14 Feb 2015.
Chung YW, Sohn JH, Paik CH, Jeong JY, Han DS, Jeon YC, et al. High-grade hepatic mucosa-associated lymphoid tissue (MALT) lymphoma probably transformed from the low-grade gastric MALT lymphoma. Korean J Intern Med. 2006;21:194–8.
Chatelain D, Maes C, Yzet T, Brevet M, Bounicaud D, Plachot JP, et al. Primary hepatic lymphoma of MALT-type: a tumor that can simulate a liver metastasis. Ann Chir. 2006;131:121–4.
Ito T, Hiramatsu K, Machiki Y, Akagawa T, Miyata T, Hirata A, Hara T, Yoshida K, Kato K. A case of resected mucosa-associated lymphoid tissue lymphoma of the liver. Jpn J Gastroenterol Surg. 2008. www.journal.jsgs.or.jp/pdf/041091686.pdf. Accessed 14 Feb 2015.
Shito M, Kakefuda T, Omori T, Ishii S, Sugiura H. Primary non-Hodgkin’s lymphoma of the main hepatic duct junction. J Hepatobiliary Pancreat Surg. 2008;15:440–3.
Koubaa Mahjoub W, Chaumette-Planckaert MT, Murga Penas EM, Dierlamm J, Leroy K, Delfau MH, et al. Primary hepatic lymphoma of mucosa-associated lymphoid tissue type: a case report with cytogenetic study. Int J Surg Pathol. 2008;16:301–7.
Murata T, Uetsuka H, Uda M, Kawamata O, Nakai H, Ohta T. A case of mucosa-associated lymphoid tissue lymphoma of the liver mimicking a metastatic liver tumor of gastric cancer. Nippon Rinsho Geka Gakkai Zasshi. 2009. https://www.jstage.jst.go.jp/article/jjsa/70/6/70_6_1799/_pdf. Accessed 14 Feb 2015.
Yoshida M, Sekikawa S, Takanashi S, Kashiyama M, Ishigooka M, Kawashima H, et al. A resected primary hepatic mucosa-associated lymphoid tissue lymphoma with colon cancer. Nippon Rinsho Geka Gakkai Zasshi. 2010. www.ci.nii.ac.jp/naid/10026341055. Accessed 14 Feb 2015.
Hayashi M, Yonetani N, Hirokawa F, Asakuma M, Miyaji K, Takeshita A, et al. An operative case of hepatic pseudolymphoma difficult to differentiate from primary hepatic marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. World J Surg Oncol. 2011;9:3.
Miwa T, Yamamura Y, Fukuoka T, Mashita N, Inaoka K, Sawaki K, et al. A case of primary hepatic MALT lymphoma, in which hepatocellular carcinoma was diagnosed in preoperative images. Kanzo. 2011. www.ci.nii.ac.jp/naid/10029526600. Accessed 14 Feb 2015.
Sakaguchi T, Kaibori M, Matsui K, Ishizaki M, Matsushima H, Kwon AH. A case of hepatic MALT lymphoma. Nippon Rinsho Geka Gakkai Zasshi. 2012. www.ci.nii.ac.jp/naid/130004518360. Accessed 14 Feb 2015.