Primary gliosarcoma with widespread extracranial metastases—spatiotemporal morphological variation

Chinese Neurosurgical Journal
Ming Luo1, Jun Yang2, Jianjun Sun2, Fengyun Wang3, Xiaodong Chai4
1Medical Imaging Department, Third Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China
2Department of Neurosurgery, Peking University Third hospital, Beijing, China
3Department of Oncology, First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China
4Department of Pathology, Peking University Third Hospital, Beijing, China

Tóm tắt

Abstract Background We summarize 5 cases of primary gliosarcoma with widespread extracranial metastases including our case. The glial components are eliminated due to the needs of the living environment in the process of parasitism and survival of brain glioma-sarcoma cells in lung metastasis. Methods A PubMed search using the keywords “gliosarcoma” and “extracranial metastases” was performed followed by a review of cited literature. Our case was a 50-year-old female presented with headache and dizziness. MRI examination showed that there was a cystic solid tumor in the right temporal lobe. The tumor was removed totally. Seven months after the operation, the patient suffered recurrent intermittent headache. The resection for the recurrent tumor was performed. Postoperative pathology confirmed the recurrent gliosarcoma. A needle biopsy was performed for the nodular on the right lung. The lung tumor pathology suggested a sarcoma structure. Results There was a female patient in five cases. The age range is 47 to 69 years old. The tumor recurred within a year. A combination of treatment modalities may extend survival; however, the prognosis remains poor. Conclusion Primary gliosarcoma with extracranial metastases is extremely rare. Some findings uncovered an unexpected spatiotemporal morphological variation in the different foci of the same malignancy.

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Tài liệu tham khảo

Choi MG, Lee JH, Lee MS, et al. Primary gliosarcoma with extracranial metastasis. Brain Tumor Res Treat. 2020;8(1):53–6.

Ben Nsir A, Thai QA, Kassar AZ, et al. Primary cerebellar gliosarcoma with extracranial metastases: an orphan differential diagnosis. World Neurosurg. 2015;84(6):2076.e13–7.

Rapp M, Felsberg J, Sorg RV, et al. Case report: extracranial metastasis from gliosarcoma–the influence of immune system. Br J Neurosurg. 2011;25(2):286–8.

Beaumont TL, Kupsky WJ, Barger GR, Sloan AE. Gliosarcoma with multiple extracranial metastases: case report and review of the literature. J Neuro-Oncol. 2007;83:39–46.

Guney Y, Hiçsönmez A, Yilmaz S, et al. Gliosarcoma: a study of four cases. Rare Tumors. 2010;2:e37.

Biswas A, Kumar N, Kumar P, et al. Primary gliosarcoma-clinical experience from a Regional Cancer Centre in North India. Br J Neurosurg. 2011;25:723–9.

Han SJ, Yang I, Tihan T, et al. Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity. J Neurooncol. 2010;96:313–20.

Moiyadi A, Sridhar E, Jalali R. Intraventricular gliosarcoma: unusual location of anuncommon tumor. J Neurooncol. 2010;96:291–4.

Pakos EE, Goussia AC, Zina VP, et al. Multi-focal gliosarcoma: a case report and review of the literature. J Neurooncol. 2005;74:301–4.

Dawar R, Fabiano AJ, Qiu J, et al. Secondary gliosarcoma with extra-cranial metastases: a report and review of the literature. Clin Neurol Neurosurg. 2013;115:375–80.

Demirci S, Akalin T, Islekel S, et al. Multiple spinal metastases of cranial gliosarcoma: a case report and review of the literature. J Neurooncol. 2008;88:199–204.

Beaumont TL, Kupsky WJ, Barger GR, et al. Gliosarcoma with multiple extracranial metastases: case report and review of the literature. J Neurooncol. 2007;83(1):39–46.

Lun M, Lok E, Gautam S, Wu E, Wong ET. The natural history of extracranial metastasis from glioblastoma multiforme. J Neuro-Oncol. 2011;105:261–73.

Reis RM, Konu-Lebleblicioglu D, Lopes JM, Kleihues P, Ohgaki H. Genetic profile of gliosarcomas. Am J Pathol. 2000;156:425–32.

Georgescu MM, Olar A. Genetic and histologic spatiotemporal evolution of recurrent, multifocal, multicentric and metastatic glioblastoma. Georgescu and Olar Acta Neuropathol Commun. 2020;8(1):10.

Park CC, Hartmann C, Folkerth R, Loeffler JS, Wen PY, Fine HA, et al. Systemic metastasis in glioblastoma may represent the emergence of neoplastic subclones. J Neuropathol Exp Neurol. 2000;59:1044–50.

Cho SY, Park C, Na D, et al. High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients. Exp Mole Med. 2017;49(4):e317.

Owusu BY, Galemmo R, Janetka J, Klampfer L. Hepatocyte growthfactor, a key tumor-promoting factor in the tumor microenvironment. Cancers (Basel). 2017;9:35.

Eckerich C, Zapf S, Fillbrandt R, Loges S, Westphal M, Lamszus K. Hypoxia can induce c-Met expression in glioma cells and enhance SF/HGFinduced cell migration. Int J Cancer. 2007;121:276–83.

Pennacchietti S, Michieli P, Galluzzo M, Mazzone M, Giordano S, Comoglio PM. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell. 2003;3:347–61.

Kozac KR, Mahadevan A, Moody JS. Adult gliosarcoma: epidemiology, natural history and factors associated with outcome. Neuro Oncol. 2009;11:183–91.

Frank S, Kuhn SA, Brodhun M, Mueller U, Romeike B, Kosmehl H, et al. Metastatic glioblastoma cells use common pathways via blood and lymphatic vessels. Neurol Neurochir Pol. 2009;43:183–90.

Ueda S, Mineta T, Suzuyama K, Furuta M, Shiraishi T, Tabuchi K. Biologic characterization of a secondary glioblastoma with extracranial progression and systemic metastasis. Neuro Oncol. 2003;5(1):14–8.

Kim JE, Kim CY, Kim DG, Jung HW. Implantation metastasis along the stereotactic biopsy tract in anaplastic astrocytoma: a case report. J Neuro-Oncol. 2003;61:215–8.

Narayan A, Jallo G, Huisman TA. Extracranial, peritoneal seeding of primary malignant brain tumors through ventriculo-peritoneal shunts in children: case report and review of the literature. Neuroradiol J. 2015;28:536–9.

Barajas RF Jr, Phelps A, Foster HC, Courtier J, Buelow BD, Gupta N, et al. Metastatic diffuse intrinsic pontine glioma to the peritoneal cavity viaventriculoperitoneal shunt: case report and literature review. J Neurol Surg Rep. 2015;76:91–6.

Steinmetz MP, Barnett GH, Kim BS, Chidel MA, Suh JH. Metastatic seeding of the stereotactic biopsy tract in glioblastoma multiforme: case report and review of the literature. J Neuro-Oncol. 2001;55:167–71.

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Chinese Neurosurgical Journal

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