Ngăn ngừa tái phát sau phẫu thuật ở bệnh Crohn

Olaison G, Smedh K, Sjödahl R: Natural course of Crohn's disease after ileocolic resection: endoscopically visualized ileal ulcers preceding symptoms. Gut 1992, 33:331–335. Kyle J: Prognosis after ileal resection for Crohn's disease. Br J Surg 1971, 58:735–737. Lennard-Jones JE, Stalder GA: Prognosis after resection of chronic regional enteritis. Gut 1967, 8:332–336. Greenstein AJ, Sachar DB, Pasternack BS, Janowitz HD: Reoperation and recurrence in Crohn's colitis and ileocolitis. N Engl J Med 1975, 293:685–690. Whelan G, Farmer RG, Fazio VW, Goormastic M: Recurrence after surgery in Crohn's disease. Gastroenterology 1985, 88:1826–1833. Rutgeerts P, Geboes K, Vantrappen G, et al.: Predictability of the postoperative course of Crohn's disease. Gastroenterology 1990, 99:956–963. McLeod RS, Wolff B, Steinhart H, et al.: Risk and significance of endoscopic/radiological evidence of recurrent Crohn's disease.Gastroenterology 1997, 113:1823–1827. Hellers G: Crohn's disease in Stockholm County 1955–1974: a study of epidemiology, results of surgical treatment and long-term prognosis. Acta Chir Scand 1979, 490 (suppl):5–81. Baker WNW. The results of ileorectal anastomosis at St. Mark's Hospital from 1953 to 1968. Gut 1970, 11:235–239. Sutherland LR, Ramcharan S, Bryant H, et al:Effect of cigarette smoking on recurrence of Crohn's disease. Gastroenterology 1990, 98:1123–1128. Cottone M, Rosselli M, Orlando A, et al.: Smoking habits and recurrence in Crohn's disease. Gastroenterology 1994, 106:643–648. Griffiths AM, Wesson DE, Shandling B, et al.: Factors influencing postoperative recurrence of Crohn's disease in childhood. Gut 1991, 32:491–495. Caprilli R, Corroa G, Taddei G, et al.: Prognostic factors for postoperative recurrence of Crohn's disease. Dis Col Rect 1996, 39:335–341. Aeberhard P, Berchtold W, Riedtmann HJ, et al.: Surgical recurrence of perforating and nonperforating Crohn's disease. Dis Col Rect 1996, 39:80–87. Desreumaux P, Brandt E, Gambiez L, et al.: Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease. Gastroenterology 1997, 113:118–126. This paper illustrates that the pathophysiology of Crohn's disease inflammation, as reflected by mucosal cytokine production, may be different in early versus established disease. Hellers G, Cortot A, Jewell D, et al.: Oral budesonide for prevention of postsurgical recurrence in Crohn's disease. Gastroenterology 1999, 116:294–300. Report from a well-designed clinical trial showing that corticosteroids do not prevent recurrence, except in patients operated upon for inflammatory rather than for fibrostenotic or penetrating disease. Colombel JF, Rutgeerts P, Malchow H, et al.: Safety and tolerance of subcutaneous recombinant human interleukin-10 in subjects with Crohn's disease after first ileal or ileocolonic resection [abstract]. Gastroenterology 1999, 116:A689. D'Haens G, Rutgeerts P: Maintenance and prophylactic therapy for Crohn's disease. Curr Opinion Gastroenterol 1997, 13:312–316. Sutherland LR, Martin F, Bailey RJ, et al. and the Canadian Mesalamine for Remission Study Group: A randomized, placebo-controlled, double-blind trial of mesalamine in the maintenance of remission of Crohn's disease. Gastroenterology 1997, 112:1069–1077. Results from this large controlled trial with many participating centers all over Canada demonstrate the limited impact of mesalamine therapy on the development of postoperative recurrence and on the maintenance of Crohn's disease overall. Camma C, Giunta M, Roselli M, Cottone M: Mesalamine in the maintenance treatment of Crohn's disease: a meta-analysis adjusted for confounding variables. Gastroenterology 1997, 113:1465–1473. Ewe K, Herfarth C, Malchow H et al.: Postoperative recurrence of Crohn's disease in relation to radicality of operation and sulfasalazine prophylaxis: a multicenter trial. Digestion 1989, 42:224–232. Caprilli R, Andreoli A, Capurso L, et al.: Oral mesalazine (Asacol) for the prevention of postoperative recurrence of Crohn's disease. Eur J Gastroenterol Hepatol 1994, 8:35–43. McLeod RS, Wolff BG, Steinhart AH, et al.: Prophylactic mesalamine treatment decreases postoperative recurrence of Crohn's disease. Gastroenterology 1995, 109:404–413. Brignola C, Cottone M, Pera A, et al.: Mesalamine in the prevention of endoscopic recurrence after intestinal resection for Crohn's disease. Gastroenterology 1995, 108:345–349. Lochs H, Mayer M, Fleig WE, et al.: Prophylaxis of postoperative relapse in Crohn's disease with mesalazine (Pentasa) in comparison to placebo [abstract]. Gastroenterology 1997, 112: A1027. This trial shows that Pentasa therapy reduces the clinical relapse rate in patients operated upon for small bowel disease alone. Clinical criteria (CDAI) were used instead of more objective endoscopic or radiologic end points. Florent C, Cortot A, Quandale P, et al.: Placebo-controlled clinical trial of mesalazine in the prevention of early endoscopic recurrences after resection for Crohn's disease. Eur J Gastroenterol Hepatol 1996, 8: 29–233. Fiasse R, Fontaine F, Vanheuverzwyn R: Prevention of Crohn's disease recurrences after intestinal resection with Eudragit-Lcoated 5-ASA [abstract]. Gastroenterology 1991, 100:A208. Ursing B, Kamme G: Metronidazole for Crohn's disease. Lancet 1975, 1:775–777. Blichfeldt P, Blomhoff JP, Myhre E, Gjone E: Metronidazole in Crohn's disease. Scand J Gastroenterol 1978, 13:123–127. Rath HC, Herfarth HH, Ikeda JS, et al.: Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis and arthritis in HLA-B27/b2 microglobulin transgenic rats J Clin Invest 1996, 98:945–953. Gorbach SL, Tabaqchali S: Bacteria, bile and the small bowel. Gut 1969, 10:963–971. Rutgeerts P, Peeters M, Hiele M, et al.: A placebo controlled trial of metronidazole for recurrence prevention of Crohn's disease after resection of the terminal ileum. Gastroenterology 1995, 108:1617–1621. Rutgeerts P, D'Haens G, Baert F, et al.: Nitroimidazol antibiotics are efficacious for prophylaxis of postoperative recurrence of Crohn's disease: a placebo controlled trial [abstract]. Gastroenterology 1999, 116: A808. Willoughby J.M., Beckett J, Kumar P.J., Dawson AM: Controlled trial of azathioprine in Crohn's disease. Lancet 1971, 2:944–947. Present D.H., Korelitz B.I., Wisch N, et al.: Treatment of Crohn's disease with 6-mercaptopurine: a long-term randomized double-blind study. N Engl J Med 1980, 302:981–987. Korelitz B, Hanauer S, Rutgeerts P, et al.: Postoperative prophylaxis with 6-MP, 5-ASA or placebo in Crohn's disease: a two year multicenter trial [abstract]. Gastroenterology 1998, 114:A1011. D'Haens G, Geboes K, Ponette E, et al.: Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn's disease. Gastroenterology 1997, 112:1475–1481. This study demonstrates in a retrospective cohort of patients that mucosal lesions in recurrent ileitis can heal under azathioprine therapy. Healing had never been shown with any other maintenance treatment. Raedler A, Peters I, Screiber S: Treatment with azathioprine and budesonide prevents reoccurence of ileocolonic stenosis after endoscopic dilatation in Crohn's disease [abstract]. Gastroenterology 1997, 112:A1067. McLeod RS: Is it possible to prevent recurrent Crohn's disease with medical or surgical interventions? Neth J Med 1996, 48:68–70. Cameron JL, Hamilton SR, Coleman J, et al.: Patterns of ileal recurrence in Crohn's disease. Ann Surg 1992, 215:546–551. Hshemi M, Novell JR, Lewis AAM: Side-to-side stapled anastomosis may delay recurrence in Crohn's disease. Dis Colon Rectum 1998; 41:1293–1296. Kotanagi HH, Kramer K, Fazio VW, Petras RE: Do microscopic abnormalities at resection margins correlate with increased anastomotic recurrence in Crohn's disease? Retrospective analysis of 100 cases. Dis Colon Rectum 1991, 34:909–916.