Prevention of doxorubicin-induced experimental cardiotoxicity by Nigella sativa in rats

Balis, 2002, General principles of chemotherapy, 237 Menna, 2008, Cardiotoxicity of antitumor drugs, Chem Res Toxicol, 21, 978, 10.1021/tx800002r Forouzanfar, 2014, Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects, Iran J Basic Med Sci, 17, 929 Butt, 2010, Nigella sativa: reduces the risk of various maladies, Crit Rev Food Sci Nutr, 50, 654, 10.1080/10408390902768797 Ashraf, 2011, Nigella sativa extract as a potent antioxidant for petrochemical-induced oxidative stress, J Chromatogr Sci, 49, 321, 10.1093/chrsci/49.4.321 Ali, 2003, Pharmacological and toxicological properties of Nigella sativa, Phyther Res, 17, 299, 10.1002/ptr.1309 El-Tahir, 2006, The black seed Nigella sativa Linnaeus – a mine for multi cure: a plea for urgent clinical evaluation of its volatile oil, J Taibah University Med Sci, 1, 1, 10.1016/S1658-3612(06)70003-8 Badary, 2003, Thymoquinone is a potent superoxide anion scavenger, Drug Chem Toxicol, 26, 87, 10.1081/DCT-120020404 Abdel-Wahab, 2014, Thymoquinone attenuates toxicity and oxidative stress induced by bisphenol A in liver of male rats, Pak J Biol Sci, 17, 1152, 10.3923/pjbs.2014.1152.1160 Periasamy, 2016, Anticancer activity of an ultrasonic nanoemulsion formulation of Nigella sativa L. essential oil on human breast cancer cells, Ultrason Sonochem, 31, 449, 10.1016/j.ultsonch.2016.01.035 Saad, 2001, The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats, Pharmacol Res, 43, 211, 10.1006/phrs.2000.0769 Nagi, 2009, Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and toxicity, Phytother Res, 23, 1295, 10.1002/ptr.2766 Abukhader, 2012, The effect of route of administration in thymoquinone toxicity in male and female rats, Indian J Pharm Sci, 74, 195, 10.4103/0250-474X.106060 Esterbauer, 1990, Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal, Methods Enzymol, 186, 407, 10.1016/0076-6879(90)86134-H Erel, 2005, A new automated colorimetric method for measuring total oxidant status, Clin Biochem, 38, 1103, 10.1016/j.clinbiochem.2005.08.008 Erel, 2004, A novel automated method to measure total antioxidant response against potent free radical reactions, Clin Biochem, 37, 112, 10.1016/j.clinbiochem.2003.10.014 Gokcimen, 2007, Protective effect of N-acetylcysteine cafeic acid and vitamin E on doxorubicin hepatotoxicity, Hum Exp Toxicol, 26, 519, 10.1177/0960327107076885 Takemura, 2007, Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to management, Prog Cardiovasc Dis, 49, 330352, 10.1016/j.pcad.2006.10.002 Chatterjee, 2010, Doxorubicin cardiomyopathy, Cardiology, 115, 155, 10.1159/000265166 Tokarska-Schlattner, 2006, Alterations in myocardial energy metabolism induced by the anti-cancer drug doxorubicin, C R Biol, 329, 657, 10.1016/j.crvi.2005.08.007 Abdel-Raheem, 2013, Cardioprotective effects of nicorandil, a mitochondrial potassium channel opener against doxorubicin-induced cardiotoxicity in rats, Basic Clin Pharmacol Toxicol, 113, 158, 10.1111/bcpt.12078 Andreadou, 2007, Acute doxorubicin cardiotoxicity is successfully treated with the phytochemical oleuropein through suppression of oxidative and nitrosative stress, J Mol Cell Cardiol, 42, 549, 10.1016/j.yjmcc.2006.11.016 Zhang, 2005, Amelioration of doxorubicin-induced myocardial oxidative stress and immunosuppression by grape seed proanthocyanidins in tumour-bearing mice, J Pharm Pharmacol, 57, 1043, 10.1211/0022357056523 Du, 2008, Catechin and proanthocyanidin B4 from grape seeds prevent doxorubicininduced toxicity in cardiomyocytes, Eur J Pharmacol, 591, 96, 10.1016/j.ejphar.2008.06.068 Ghosheh, 1999, High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.), J Pharm Biomed Anal, 19, 757, 10.1016/S0731-7085(98)00300-8 Randhawa, 2013, The effect of thymoquinone, an active component of Nigella sativa, on isoproterenol induced myocardial injury, Pak J Pharm Sci, 26, 1215 Burıts, 2000, Antioxidant activity of Nigella sativa essential oil, Phytother Res, 14, 323, 10.1002/1099-1573(200008)14:5<323::AID-PTR621>3.0.CO;2-Q Ojha, 2015, Thymoquinone protects against myocardial ischemic injury by mitigating oxidative stress and inflammation, Evid Based Complement Alternat Med, 1, 10.1155/2015/143629 Nagi, 2011, Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats, J Biochem Mol Toxicol, 25, 135, 10.1002/jbt.20369 Islam, 2004, Immunosuppressive and cytotoxic properties of Nigella sativa, Phytother Res, 18, 395, 10.1002/ptr.1449 Ali, 2003, Pharmacological and toxicological properties of Nigella sativa, Phytother Res, 17, 299, 10.1002/ptr.1309 Darakhshan, 2015, Thymoquinone and its therapeutic potentials, Pharmacol Res, 95–96, 138, 10.1016/j.phrs.2015.03.011