Prevention by the MER tubercle bacillus fraction of immunosuppression induced by cancer chemotherapeutic agents
Tóm tắt
Primary and secondary anti-sheep red blood cell antibody formation by BALB/c mice was reduced by administration of cyclophosphamide shortly following primary and secondary immunization. Treatment with the MER tubercle bacillus fraction by several schedules potentiated markedly and significantly the recovery of ability to respond to the antigen, as indicated by the production of specific plaque-forming cells and free hemagglutinating antibody.
Tài liệu tham khảo
Ben-Efraim, S., Diamantstein, T.: Mitogenic and adjuvant activity of a methanol extraction residue (MER) of tubercle bacilli on mouse lymphoid cells in vitro. Immunological Communications (in press)
Ben-Efraim, S., Ophir, R., Teitelbaum, R., Weiss, D. W.: Effects of the MER tubercle bacillus fraction on the tolerance threshold of mice to T-independent polysaccharide antigens (Submitted for publication)
Ben-Efraim, S., Ulmer, A., Schmidt, M., Diamantstein, T.: Differences between lymphoid cell populations of guinea pigs and mice as determined by the response to mitogens in vitro. Int. Arch Allerg. Imm. (in press)
Berenbaum, M. C., Cope, W. A., Double, J. A.: The effect of microsomal enzyme inhibition on the immunosuppressive and toxic effects of cyclophosphamide. Clin. Exp. Immunol. 14, 257 (1973)
Cohen, D., Yron, I., Haber, M., Grover, N., Weiss, D. W.: Chemoimmunotherapy of syngeneic mouse mammary carcinomas employing MER. Ann. N.Y. Acad. Sci. (in press)
Cuttner, J., Holland, J. F., Bekesi, J. G., Ramachandar, K., Donovan, P.: Chemoimmunotherapy of acute myelocytic leukemia. Proc. Amer. Soc. Clin. Oncol. 16, 264 (1975)
Dewys, W. D., Goldin, A., Mantel, N.: Hematopoietic recovery after large doses of cyclophosphamide: Correlation of proliferative state with sensitivity. Cancer Res. 30, 1692 (1970)
Dumont, F.: Destruction and regeneration of lymphocyte populations in the mouse spleen after cyclophosphamide treatment. Int. Arch. Allergy 47, 110 (1974)
Kuperman, O., Feigis, M., Weiss, D. W.: Reversal by the MER tubercle bacillus fraction of the suppressive effects of heterologous antilymphocytic serum (ALS) on the allograft reactivity of mice. Cell. Immunol. 8, 484 (1973)
Laskov, R., Scharff, M. D.: Synthesis, assembly, and secretion of gamma globulin by mouse myeloma cells. I. Adaptation of the Merwin plasma cell tumor — 11 to culture, cloning, and characterization of gamma globulin subunits. J. Exp. Med. 131, 515 (1970)
Miller, R. G.: Simultaneous Statistical Inference, p. 143. New York: McGraw Hill 1966
Moertel, C. G., Ritts, R. E., Jr., Schutt, A. J., Hahn, R. G.: Clinical studies of methanol extraction residue fraction of Bacillus Calmette-Guerin as an immunostimulant in patients with advanced cancer. Cancer Res. 35, 3075 (1975)
Pass, E., Jacobs, D. M., Weiss, D. W.: Modulation of the immune response by the methanol insoluble fraction (MER) of attenuated tubercle bacilli. III. Stimulation of antibody synthesis to a soluble protein, BGG (Submitted for publication)
Poulter, L. W., Turk, J. L.: Proportional increase in the 0 carrying lymphocytes in peripheral lymphoid tissue following treatment with cyclophosphamide. Nature (New Biology) 238, 17 (1972)
Richman, S. P.: Phase I study of immunotherapy with methanol extraction residue of BCG (MER). Proc. Amer. Soc. Clin. Oncol. 16, 227 (1975)
Robinson, E., Bartal, A., Cohen, Y., Haasz, R.: A preliminary report of the effects of methanol extraction residue of BCG (MER) on cancer patients. Brit. J. Cancer 32, 1 (1975)
Stockman, G. D., Heim, L. R., South, M. A., Trentin, J. J.: Differential effects of cyclophosphamide on the B and T cell compartments of adult mice. J. Immunol. 110, 277 (1973)
Stupp, Y., Manny, N., Zajcek, G., Weiss, D. W., Izak, G.: The immune response in acute myelocytic leukemia. The effect of MER on T and B cell functions, and their relation to the course of the disease. Brit. J. Hematol. (in press)
Van Elteren, P.: On the combination of two sample tests of Wilcoxon. Bull. Instit. Int. Statist. 37, 351 (1960)
Weiss, D. W.: Nonspecific stimulation and modulation of the immune response and of states of resistance by the MER fraction of tubercle bacilli. Natl. Cancer Inst. Monogr. 35, 157 (1972)
Weiss, D. W.: MER and other mycobacterial fractions in the immunotherapy of cancer. In: Medical Clinics Symposium on Immunotherapy in Malignant Disease (W. D. Terry, ed.), Philadelphia: W. B. Saunders Co. (In press)
Weiss, D. W., Stupp, Y., Manny, N., Izak, G.: Treatment of acute myelocytic leukemia (AML) patients with the MER tubercle bacillus fraction. A preliminary report. Transpl. Proc. Vol. VII, No. 1, Suppl. 1 (M. Schlesinger, R. E. Billingham, eds.), p. 545. New York: Grune and Stratton 1975
Weiss, D. W., Yashphe, D. J.: Nonspecific stimulation of antimicrobial and antitumor resistance and of immunological responsiveness by the MER fraction of tubercle bacilli. In: Dynamic Aspects of Host-Parasite Relationships, (A. Zuckerman, D. W. Weiss, eds.), Vol. 1. p. 163. New York: Academic Press 1973
Wortis, H. H., Taylor, R. B., Dresser, D. W.: Antibody production studied by means of the localized haemolysis in gel (LHG) assay. I. The splenic response of CBA mice to sheep erythrocytes. Immunology 11, 603 (1966)
Yashphe, D. J., Weiss, D. W.: Modulation of the immune response by a methanol-insoluble fraction of attenuated tubercle bacilli (BCG). I. Primary and secondary responses to sheep red blood cells and T2 phage. Clin. Exp. Immunol. 7, 269 (1970)
Yron, I., Cohen, D., Robinson, E., Haber, M., Weiss, D. W.: Effects of methanol extraction residue and therapeutic irradiation against established isografts and simulated local recurrence of mammary carcinomas. Cancer Res. 35, 1779 (1975)
Yron, I., Weiss, D. W., Robinson, E., Cohen, D., Adelberg, M. G., Mekori, T., Haber, M.: Immunotherapeutic studies in mice with the Methanol Extraction Residue (MER) fraction of BCG: Solid tumors. Natl. Cancer Inst. Monogr. 39, 33 (1973)
