Prevalence of chlamydial antibody in pregnancy
Tóm tắt
In this matched-pair study 139 pregnant women were matched on the basis of age to an equal number of non-pregnant women with no signs of genital infection. The mean age was 28.7 years (range 20–41). The cut-offs used for detection of chlamydial antibody were 1:64 and 1:128 for IgG and 1:16 for IgA. IgG antibody at 64 was detected in 37.4% of pregnant women, compared to 46% of controls (p=0.145). There was, however, a statistically significant difference between the groups for IgG at 128 (gravidae=15.8%; controls=28%;p=0.014). IgA were detected in 8.6% and 16.5% of subjects, respectively (p=0.047). IgG levels did not vary with increasing age among the pregnant women, but rose significantly with age in non-pregnant controls (logistic regressionp-values=0.011 and 0.006, for IgG at 64 and 128, respectively). IgG-positive women in the control group tended to be older than pregnant IgG-positive women (p=0.06). These differences could not be explained by marital status, parity or use of oral contraceptives. In view of the lack of epidemiological differences, biological explanations might be invoked.
Tài liệu tham khảo
Francois OP, Rouhan D, Hirtz P, Beaudoing A.Chlamydia trachomatis en pediatrie. Pediatrie 1988; 43: 101–108.
Preece PM, Anderson JM, Thompson RG.Chlamydia trachomatis infection in infants: A prospective study. Arch Dis Child 1989; 64: 525–529.
Dannevig L, Schive B, Straume BK, Melby K. Perinatal transmission ofChlamydia trachomatis. The use of serological tests in detecting infective women. Infection 1991; 19: 135–137.
McGregor JA, French JL.Chlamydia trachomatis infection during pregnancy. Am J Obstet Gynecol 1991; 164: 1782–1789.
Schachter J, Grossman M.Chlamydia. In: Remington J, Klein J, eds. Infectious diseases of the fetus and newborn infants. Semin Perinatol 1983; 9: 29–37.
Ridgway GL. The laboratory diagnosis of chlamydial infection. In: Oriel D, Ridgway D, Schachter J, Taylor-Robinson D, Ward M, eds. Chlamydial infections. Cambridge: Cambridge University Press, 1988: 533–549.
Hammerschlag MR, Cummings C, Roblin PM, Williams TH, Delke I. Efficacy of neonatal ocular prophylaxis for the prevention of chlamydial and gonococcal conjunctivitis. N Engl J Med 1989; 320: 769–772.
Ripa T. Epidemiologic control of genitalChlamydia trachomatis infections. Scand J Infect Dis 1990; 69 (suppl): 157–167.
Nettleman MD, Jones RB, Roberts SD, Dittus RS. Cost-effectiveness of serology and cell culture forChlamydia trachomatis in low prevalence women. In: Oriel D, Ridgway D, Schachter J, Taylor-Robinson D, Ward M, eds. Chlamydial infections. Cambridge: Cambridge University Press, 1983: 204–208.
Schachter J, Grossman M, Sweet RL, Holt J, Jordan C, Bishop E. Prospective study of perinatal transmission ofChlamydia trachomatis. JAMA 1986; 255: 3374–3377.
Bollani L, Belloni C, Gorini G, Milano F, Gerola O. Infezioni neonatali daChlamydia trachomatis. 3rd National Congress Gruppo di Lavoro di Neonatologia della Società Italiana di Pediatria, Stresa, 20 May–2 June 1989.
Nettleman MD, Bell TA. Cost-effectiveness of prenatal testing forChlamydia trachomatis. Am J Obstet Gynecol 1991; 164: 1289–1294.
Preece PM, Ades A, Thompson RG, Brooks JH.Chlamydia trachomatis infection in late pregnancy: A prospective study. Paediatr Perinat Epidemiol 1989; 3: 268–277.
Legris M, Hainaut F, Crimail P, Catalan F. Resultats du depistage et traitement precocé des infections àChlamydia trachomatis au course de la grossesse. J Gynecol Obstet Biol Reprod 1989; 18: 581–585.
Trachtenberg Al, Washington AE, Halldorson S. A cost-based decision analysis forChlamydia screening in California family planning clinics. Obstet Gynecol 1988; 71: 101–108.
Humphreys JT, Henneberry JF, Rickard RS, Beebe JL. Cost-benefit analysis of selective screening criteria forChlamydia trachomatis infection in women attending Colorado family planning clinics. Sex Transm Dis 1992; 19: 47–53.
Brasfield DM, Stagno S, Whitley RJ, Cloud G, Cassell G, Tiller RE. Infant pneumonitis associated with cytomegalovirus,Chlamydia, Pneumocystis and Ureaplasma: follow-up. Pediatrics 1987; 79: 76–83.