Prevalence and pattern of dyslipidemia in an Egyptian children and adolescents with type 1 diabetes

Springer Science and Business Media LLC - 2021
Hisham M. Soliman1, Amany Ibrahim1
1The Diabetes Endocrine and Metabolism Pediatric Unit (DEMPU), Pediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Tóm tắt

Abstract Background Hyperglycemia and dyslipidemia are commonly found metabolic abnormalities in diabetic children and adolescents and both increase the risk of cardiovascular disease. This study aimed to assess the prevalence and the pattern of dyslipidemia in Egyptian children and adolescents with type 1 diabetes (T1DM) and determine its relation with the glycemic control. Results This retrospective study included 806 children and adolescents with T1DM; 358 (44.42%) males and 448 (55.58%) females. Their mean age was 11.71 ± 3.6 years. Clinical and laboratory data were recruited from patients’ files. Laboratory data include the most recent fasting lipid profile (triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL)), and the mean glycosylated hemoglobin (HbA1c) levels over the preceding year presented in percentage were calculated. Dyslipidemia in children and adolescents with T1DM represented 70.47% (568 patients). No statistically significant differences were detected between patients with and without dyslipidemia. As regards the pattern of dyslipidemia, high LDL and low HDL were the most frequent abnormalities in the study group; 62.16%, 60.21%, respectively. Patients with poor glycemic control (HbA1c > 7.5%) represent 73.45% and they were significantly older, with longer diabetes duration and higher TC, TG, and LDL compared to patients with good glycemic control. Significant positive correlations were found between HbA1c, TG, TC, and LDL with the age and diabetes duration. Conclusion We detected high prevalence of dyslipidemia in children and adolescents with T1DM. Therefore, dyslipidemia should be screened for in earlier ages in Egyptian children and adolescents suffering from T1DM. Programs directed to the prevention of dyslipidemia should be conducted, particularly for this group, in order to prevent/delay cardiovascular complications related to dyslipidemia. Also, parents should receive proper education targeting the prevention, control, and care of their diabetic children with dyslipidemia.

Từ khóa


Tài liệu tham khảo

Yang CC, Lin CH, Wang NK, Lai CC, Lo FS et al (2018) Risk factors associated with the development of nephropathy 10 years after diagnosis in Taiwanese children with juvenile-onset type 1 diabetes – a cohort study from the CGJDES. Front Endocrinol (Lausanne) 9:429

Donaghue KC, Wadwa RP, Dimeglio LA, Wong TY, Chiarelli F, Marcovecchio ML et al (2014) ISPAD clinical practice consensus guidelines 2014. Microvascular and macrovascular complications in children and adolescents. Pediatr Diabetes 15:257–269

Bekele S, Yohannes T, Mohammed AE (2017) Dyslipidemia and associated factors among diabetic patients attending Durame General Hospital in Southern Nations, Nationalities, and People’s Region. Diabetes Metab Syndr Obes 10:265–271

Chiesa ST, Charakida M, McLoughlin E, Nguyen HC, Georgiopoulos G, Motran L et al (2019) Elevated high-density lipoprotein in adolescents with Type 1 diabetes is associated with endothelial dysfunction in the presence of systemic inflammation. Eur Heart J 40:3559–3566

O’Neill F, Riwanto M, Charakida M, Colin S, Manz J, McLoughlin E et al (2015) Structural and functional changes in HDL with low grade and chronic inflammation. Int J Cardiol 188:111–116

Shroff R, Speer T, Colin S, Charakida M, Zewinger S, Staels B et al (2014) HDL in children with CKD promotes endothelial dysfunction and an abnormal vascular phenotype. J Am Soc Nephrol 25:2658–2668

Zewinger S, Drechsler C, Kleber ME, Dressel A, Riffel J, Triem S et al (2015) Serum amyloid A: high-density lipoproteins interaction and cardiovascular risk. Eur Heart J 36:3007–3016

Verges B (2015) Pathophysiology of diabetic dyslipidaemia: where are we? Diabetologia 58:886–899

Taskinen MR (2003) Diabetic dyslipidaemia: from basic research to clinical practice. Diabetologia 46:733–749

Zabeen B, Balsa AM, Islam N, Parveen M, Nahar J, Azad K (2018) Lipid profile in relation to glycemic control in type 1 diabetes children and adolescents in Bangladesh. Indian J Endocrinol Metab 22(1):89–92

Bulut T, Demirel F, Metin A (2017) The prevalence of dyslipidemia and associated factors in children and adolescents with type 1 diabetes. J Pediatr Endocrinol Metab 30(2):181–187

Rahbar A, Hajian A (2017) Dyslipidemia frequency and related factors to blood in children suffering from type 1 diabetes. Biomed Res 28 (19):8402-8405.

American Diabetes Association (2019) Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2019. Diabetes Care 42(1):S13–S28

Ghali I, Salah N, Hussien F, Erfan M, El-ruby M, Mazen I et al (2008) Egyptian growth curves for infants, children and adolescents. In: Satorio A, JMH B, Marazzi N (eds) Crecere nel mondo. Ferring Publisher, Chemin de la Vergognausaz, Switzerland.

American Diabetes Association (2018) Cardiovascular disease and risk management: standards of medical care in diabetes-2018. Diabetes Care 41(1):S86–S104

Stamler J, Vaccaro O, Neaton JD, Wentworth D, Group MRFITR (1993) Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 16:434–444

Homma TK, Endo CM, Saruhashi T, Mori AP, Noronha RM, Monte O et al (2015) Dyslipidemia in young patients with type 1 diabetes mellitus. Arch Endocrinol Metab. 59:215–219

Giuliano ICB, Caramelli B (2008) Dislipidemias na infância e na adolescência. Pediatria 29(4):275–285

Boni A, Pugliese C, Chiantelli-Cláudio C, Patin RV, Oliveira FLC (2010) Vitaminas antioxidantes e prevenção da arteriosclerose na infância. Rev Paul Pediatr. 28(4):373–380

Guy J, Ogden L, Wadwa RP, Hamman RF, Mayer-Davis EJ, Liese AD et al (2009) Lipid and lipoprotein profiles in youth with and without type 1 diabetes: the SEARCH for Diabetes in Youth case-control study. Diabetes Care 32(3):416–420

Mona HM, Sahar SA, Hend SM, Nanees AA (2015) Dyslipidemia in type 1 diabetes mellitus: Relation to diabetes duration, glycemic control, body habitus, dietary intake and other epidemiological risk factors. Gaz Egypt Paediatr Assoc. 63(2):63–68

Kim SH, Jung IA, Jeon YJ, Cho WK, Cho KS, Park SH et al (2014) Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus. Ann Pediatr Endocrinol Metab 19:191–196

Moayeri H, Oloomi Z (2006) Prevalence of dyslipidemia in children and adolescents with diabetes mellitus type I. Iran J Pediatr 16:171–176

Taha HS, Badran HM, Kandil H, Farag N, Oraby A, El-Sharkawy M et al (2021) Egyptian practical guidance in lipid management 2020. Egypt Heart J 73:17

Rahma S, Rashid JA, Farage AH (2006) The significance of lipid abnormalities in children with insulin dependent diabetes mellitus. Iraqi Postgrad Med J 5:289–294

Al-Naama LM, Kadhim M, Al-Aboud MS (2002) Lipid profile in children with insulin dependent diabetes mellitus. J Pak Med Assoc 52:29–34

Alrabaty AA, Alnakshabandi AA, Yahya NB (2009) The lipid profile in children with type 1 diabetes mellitus in Erbil governorate. Iraqi Postgrad Med J 8:344–349

Giuffrida FM, Guedes AD, Rocco ER, Mory DB, Dualib P, Matos OS et al (2012) Brazilian Type 1 Diabetes Study Group (BrazDiab1SG). Heterogeneous behavior of lipids according to HbA1c levels undermines the plausibility of metabolic syndrome in type 1 diabetes: data from a nationwide multicenter survey. Cardiovasc Diabetol 11:156

Verma M, Paneri S, Badi P, Raman P (2006) Effect of increasing duration of diabetes mellitus type 2 on glycated hemoglobin and insulin sensitivity. Indian J Clin Biochem 21:142–146

Thông tin
Thông tin xuất bản

Springer Science and Business Media LLC

Thông tin tác giả