Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

Cribbs, 1996, Widespread neuronal expression of the presenilin-1 early onset Alzheimer's disease gene in the murine brain, Am. J. Pathol., 148, 1797

Doan, 1996, Protein topology of presenilin 1, Neuron, 17, 1023, 10.1016/S0896-6273(00)80232-9

Goate, 1991, Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease, Nature, 349, 704, 10.1038/349704a0

Haass, 1992, Amyloid β-peptide is produced by cultured cells during normal metabolism, Nature, 359, 322, 10.1038/359322a0

Harlow, 1988

Hartley, 1993, Glutamate receptor-induced 45Ca2+, J. Neurosci., 13, 1993, 10.1523/JNEUROSCI.13-05-01993.1993

Iwatsubo, 1995, Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in Down syndrome, Ann. Neurol., 37, 294, 10.1002/ana.410370305

Iwatsubo, 1995, Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43), Neuron, 13, 45, 10.1016/0896-6273(94)90458-8

Kovacs, 1996, Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells, Nature Med., 2, 224, 10.1038/nm0296-224

Lemere, 1996, Sequence of deposition of heterogeneous amyloid β-peptides and Apo E in Down syndrome: Implications for initial events in amyloid plaque formation, Neurobiol. Disease, 3, 16, 10.1006/nbdi.1996.0003

Lemere, 1996, The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology, Nature Med., 2, 1146, 10.1038/nm1096-1146

Levy-Lahad, 1995, Candidate gene for the chromosome 1 familial Alzheimer's disease locus, Science, 269, 973, 10.1126/science.7638622

Mercken, 1996, Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing, FEBS Lett., 389, 297, 10.1016/0014-5793(96)00608-4

Podlisny, 1995, Aggregation of secreted amyloid β-protein into SDS-stable oligomers in cell culture, J. Biol. Chem., 270, 9564, 10.1074/jbc.270.16.9564

Podlisny, 1991, Homology of the amyloid β-protein precursor in monkey and human supports a primate model for β-amyloidosis in Alzheimer's disease, Am. J. Pathol., 138, 1423

Rogaev, 1995, Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene, Nature, 376, 775, 10.1038/376775a0

Scheuner, 1996, Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increasedin vivo, Nature Med., 2, 864, 10.1038/nm0896-864

Selkoe, 1988, β-amyloid precursor protein of Alzheimer disease occurs as 110–135 kilodalton membrane-associated proteins in neural and nonneural tissues, Proc. Natl. Acad. Sci. USA, 85, 7341, 10.1073/pnas.85.19.7341

Sherrington, 1995, Cloning of a novel gene bearing missense mutations in early onset familial Alzheimer disease, Nature, 375, 754, 10.1038/375754a0

Strittmatter, 1993, Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease, Proc. Natl. Acad. Sci. USA, 90, 1977, 10.1073/pnas.90.5.1977

Suzuki, 1996, Regional and cellular presenilin 1 gene expression in human and rat tissues, Biochem. Biophys. Res. Commun., 219, 708, 10.1006/bbrc.1996.0299

Tanzi, 1996, The gene defects responsible for familial Alzheimer's disease, Neurobiol. Dis., 3, 159, 10.1006/nbdi.1996.0016

Thinakaran, 1996, Endoprotreolysis of presenilin 1 and accumulation of processed derivatives in vivo, Neuron, 17, 181, 10.1016/S0896-6273(00)80291-3

Thinakaran, 1996, Endoproteolytic processing and protein topology of presenilin 1, Neurosci. Abstr., 22, 728

Walter, 1996, The Alzheimer's disease associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum, Mol. Med., 10.1007/BF03401652

Xia, 1997, Enhanced production and oligomerization of the 42-residue amyloid β-protein by Chinese hamster ovary cells stably expressing mutant presenilins, J. Biol. Chem., 10.1074/jbc.272.12.7977