Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors

Oncotarget - Tập 7 Số 6 - Trang 6593-6608 - 2016
Miguel Sampedro‐Núñez1, Raúl M. Luque2, Ana M. Ramos‐Leví1, Manuel D. Gahete2, Ana Serrano-Somavilla1, Alicia Villa-Osaba2, Magdalena Adrados1, Alejandro Ibáñez‐Costa2, Elena Martín‐Pérez1, Michael D. Culler3, Mónica Marazuela1, Justo P. Castaño2
1Department of Endocrinology and Nutrition, Hospital Universitario de la Princesa, Instituto de Investigación Princesa, Universidad Autónoma de Madrid, Madrid 28006, Spain
2Department of Cell Biology, Physiology and Immunology, University of Cordoba, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofia, and CIBER Fisiopatología de la Obesidad y Nutrición, Córdoba 14014, Spain
3IPSEN Bioscience, Cambridge, Massachusetts 02142, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Rindi, 2008, Gastroenteropancreatic neuroendocrine tumours, Lancet Oncol, 9, 61, 10.1016/S1470-2045(07)70410-2

Evans, 2008, One hundred years after “carcinoid”: Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the united states, J Clin Oncol, 26, 3063, 10.1200/JCO.2007.15.4377

Oberg, 2011, Circulating biomarkers in gastroenteropancreatic neuroendocrine tumours, Endocr Relat Cancer, 18, S17, 10.1530/ERC-10-0280

Schally, 1988, Oncological applications of somatostatin analogues, Cancer Res, 48, 6977

Hofland, 1996, Octreotide, N Engl J Med, 334, 246, 10.1056/NEJM199601253340408

Gress, 2009, Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: A report from the PROMID study group, J Clin Oncol, 27, 4656, 10.1200/JCO.2009.22.8510

Martinez, 2014, Lanreotide in metastatic enteropancreatic neuroendocrine tumors, N Engl J Med, 371, 224, 10.1056/NEJMoa1316158

Scoazec, 2010, VEGF secretion by neuroendocrine tumor cells is inhibited by octreotide and by inhibitors of the PI3K/AKT/mtor pathway, Neuroendocrinology, 91, 268, 10.1159/000289569

Rinke, 2012, Antitumor effects of somatostatin analogs in neuroendocrine tumors, Oncologist, 17, 747, 10.1634/theoncologist.2011-0458

Caplin, 2013, Update on the role of somatostatin analogs for the treatment of patients with gastroenteropancreatic neuroendocrine tumors, Semin Oncol, 40, 56, 10.1053/j.seminoncol.2012.11.006

Yalcin, 2013, A review of the use of somatostatin analogs in oncology, Onco Targets Ther, 6, 471, 10.2147/OTT.S39987

Castaño, 2009, Identification and characterization of two novel truncated but functional isoforms of the somatostatin receptor subtype 5 differentially present in pituitary tumors, J Clin Endocrinol Metab, 94, 2634, 10.1210/jc.2008-2564

Castaño, 2010, Identification and characterization of new functional truncated variants of somatostatin receptor subtype 5 in rodents, Cell Mol Life Sci, 67, 1147, 10.1007/s00018-009-0240-y

Zatelli, 2009, Antiproliferative effects of somatostatin analogs in endocrine tumours, F1000 Med Rep, 1

Stalla, 2013, Somatostatin receptors: From signaling to clinical practice, Front Neuroendocrinol, 34, 228, 10.1016/j.yfrne.2013.07.005

Hofland, 2002, Somatostatin analogs in the diagnosis and treatment of cancer, Trends Endocrinol Metab, 13, 451, 10.1016/S1043-2760(02)00667-7

Pyronnet, 2012, Clinical review: Current scientific rationale for the use of somatostatin analogs and mtor inhibitors in neuroendocrine tumor therapy, J Clin Endocrinol Metab, 97, 727, 10.1210/jc.2011-2088

Castaño, 2012, The new truncated somatostatin receptor variant sst5tmd4 is associated to poor prognosis in breast cancer and increases malignancy in MCF-7 cells, Oncogene, 31, 2049, 10.1038/onc.2011.389

Castaño, 2010, A potential inhibitory role for the new truncated variant of somatostatin receptor 5, sst5tmd4, in pituitary adenomas poorly responsive to somatostatin analogs, J Clin Endocrinol Metab, 95, 2497, 10.1210/jc.2009-2247

Vidal, 2014, The truncated isoform of somatostatin receptor5 (sst5tmd4) is associated with poorly differentiated thyroid cancer, PLoS One, 9, e85527, 10.1371/journal.pone.0085527

Zatelli, 2015, The expression of the truncated isoform of somatostatin receptor subtype 5 associates with aggressiveness in medullary thyroid carcinoma cells, Endocrine, 50, 442, 10.1007/s12020-015-0594-x

Davis-Smyth, 1997, The biology of vascular endothelial growth factor, Endocr Rev, 18, 4, 10.1210/edrv.18.1.0287

Jones, 2003, Not just angiogenesis—wider roles for the angiopoietins, J Pathol, 201, 515, 10.1002/path.1452

Olsen, 2006, Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling, Exp Cell Res, 312, 630, 10.1016/j.yexcr.2005.09.002

Augustin, 2006, Angiopoietins: A link between angiogenesis and inflammation, Trends Immunol, 27, 552, 10.1016/j.it.2006.10.004

Lang, 2002, Angiopoietin-2 displays vegf-dependent modulation of capillary structure and endothelial cell survival, Proc Natl Acad Sci U S A, 99, 11205, 10.1073/pnas.172161899

Marazuela, 2010, The association of the angiopoietin/tie-2 system with the development of metastasis and leukocyte migration in neuroendocrine tumors, Endocr Relat Cancer, 17, 897, 10.1677/ERC-10-0020

Schettini, 1999, Somatostatin controls kaposi's sarcoma tumor growth through inhibition of angiogenesis, FASEB J, 13, 647, 10.1096/fasebj.13.6.647

Albini, 2003, Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities, Endocrinology, 144, 1574, 10.1210/en.2002-220949

Florio, 2005, Somatostatin receptor subtype-dependent regulation of nitric oxide release: Involvement of different intracellular pathways, Mol Endocrinol, 19, 255, 10.1210/me.2004-0280

Tacca, 1997, Inhibition of experimental angiogenesis by the somatostatin analogue octreotide acetate (SMS 201-995), Clin Cancer Res, 3, 265

Buchan, 2000, Somatostatin receptor subtype expression and function in human vascular tissue, Am J Physiol Heart Circ Physiol, 278, H1815, 10.1152/ajpheart.2000.278.6.H1815

Thanos, 2011, VEGF, ang-2 and SRIF associated abnormal postnatal development of the retinal capillary network in the royal college of surgeons rat, Exp Eye Res, 92, 128, 10.1016/j.exer.2010.12.002

McNicol, 2006, TNM staging of foregut (neuro)endocrine tumors: A consensus proposal including a grading system, Virchows Arch, 449, 395, 10.1007/s00428-006-0250-1

Wiedenmann, 2007, TNM staging of midgut and hindgut (neuro) endocrine tumors: A consensus proposal including a grading system, Virchows Arch, 451, 757, 10.1007/s00428-007-0452-1

Solcia, 2010, Nomenclature and classification of neuroendocrine neoplasms of the digestive system, WHO Classification of Tumours of the Digestive System, 4, 13

Halperin, 2007, Manual GETNE de Diagnóstico y tratamiento de los Tumores Neuroendocrinos, 1

Thompson, 1991, Establishment and characterization of a human carcinoid in nude mice and effect of various agents on tumor growth, Gastroenterology, 101, 303, 10.1016/0016-5085(91)90004-5

Kono, 1990, A somatostatin-secreting cell line established from a human pancreatic islet cell carcinoma (somatostatinoma): Release experiment and immunohistochemical study, Cancer Res, 50, 3691

Gadelha, 2007, Quantitative analysis of somatostatin receptor subtype (SSTR1-5) gene expression levels in somatotropinomas and non-functioning pituitary adenomas, Eur J Endocrinol, 156, 65, 10.1530/eje.1.02313

Tan, 2013, Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations, Br J Cancer, 108, 429, 10.1038/bjc.2012.538

Rougier, 2001, Antitumour activity of somatostatin analogues in progressive metastatic neuroendocrine tumours, Eur J Cancer, 37, 1014, 10.1016/S0959-8049(01)00073-9

Lupp, 2015, Inverse expression of somatostatin and CXCR4 chemokine receptors in gastroenteropancreatic neuroendocrine neoplasms of different malignancy, Oncotarget, 6, 27566, 10.18632/oncotarget.4491

Condeelis, 2005, Tumor cells caught in the act of invading: Their strategy for enhanced cell motility, Trends Cell Biol, 15, 138, 10.1016/j.tcb.2005.01.003

Grabowski, 2014, PI3K-AKT-mTOR-signaling and beyond: The complex network in gastroenteropancreatic neuroendocrine neoplasms, Theranostics, 4, 336, 10.7150/thno.7851

Bruns, 2003, Opportunities in somatostatin research: Biological, chemical and therapeutic aspects, Nat Rev Drug Discov, 2, 999, 10.1038/nrd1255

Holst, 2003, Somatostatin receptors, Biochim Biophys Acta, 1616, 1, 10.1016/S0005-2736(03)00235-9

Florio, 2008, Somatostatin/somatostatin receptor signalling: Phosphotyrosine phosphatases, Mol Cell Endocrinol, 286, 40, 10.1016/j.mce.2007.08.012

Ferrara, 2008, Role of bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression, Proc Natl Acad Sci U S A, 105, 2640, 10.1073/pnas.0712185105

Del Tacca, 2007, antiangiogenic activity of selective somatostatin subtype-1 receptor agonists, Eur J Clin Invest, 37, 700, 10.1111/j.1365-2362.2007.01848.x

Bagnoli, 2007, Antiangiogenic role of somatostatin receptor 2 in a model of hypoxia-induced neovascularization in the retina: Results from transgenic mice, Invest Ophthalmol Vis Sci, 48, 3480, 10.1167/iovs.06-1469

Held-Feindt, 2001, Somatostatin inhibits the production of vascular endothelial growth factor in human glioma cells, Int J Cancer, 92, 545, 10.1002/ijc.1223