Preparation of minor ginsenosides C-Mc, C-Y, F2, and C-K from American ginseng PPD-ginsenoside using special ginsenosidase type-I from Aspergillus niger g.848

Journal of Ginseng Research - Tập 39 - Trang 221-229 - 2015
Chun-Ying Liu1,2, Rui-Xin Zhou1, Chang-Kai Sun3, Ying-Hua Jin2, Hong-Shan Yu1, Tian-Yang Zhang1, Long-Quan Xu1, Feng-Xie Jin1
1College of Biotechnology, Dalian Polytechnic University, Dalian, People’s Republic of China
2Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, College of Life Science, Jilin University, Changchun, People's Republic of China
3Institute for Brain Disorders, Dalian Medical University, Dalian, People's Republic of China

Tài liệu tham khảo

Jin, 2009, 74 Attele, 1999, Ginseng pharmacology: multiple constituents and multiple actions, Biochem Pharmacol, 58, 1685, 10.1016/S0006-2952(99)00212-9 Christensen, 2009, Ginsenosides chemistry, biosynthesis, analysis, and potential health effects, Adv Food Nutr Res, 55, 1, 10.1016/S1043-4526(08)00401-4 Liu, 2011, Ginsenoside contents in three different ginseng, J Dalian Polytechnic Univ, 30, 79 Kobashi, 1998, Glycosides are natural prodrugs—evidence using germ-free and gnotobiotic rats associated with a human intestinal bacterium, J Trad Med, 15, 1 Bae, 2005, Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect, Bio Pharm Bull, 28, 1903, 10.1248/bpb.28.1903 Tawab, 2003, Degradatin of ginsenosides in humans after administration, Drug Metab Dispos, 31, 1065, 10.1124/dmd.31.8.1065 Cui, 2013, Characterization of the ginsenoside transforming recombinant β-glucosidase from Actinosynnema mirum and bioconversion of major ginsenosides into minor ginsenosides, Appl Microbiol Biotech, 97, 649, 10.1007/s00253-012-4324-5 Hasegawa, 1996, Main ginseng saponin metabolites formed by intestinal bacteria, Planta Med, 62, 453, 10.1055/s-2006-957938 Park, 2010, Biotransformation of ginsenosides by hydrolyzing sugar moieties of ginsenosides using microbial glycosidases, Appl Microbiol Biotechnol, 87, 9, 10.1007/s00253-010-2567-6 Leung, 2010, Pharmacology of ginsenosides: a literature review, Chin Med, 5, 20, 10.1186/1749-8546-5-20 Choi, 2009, Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases, Pharm Res, 26, 2280, 10.1007/s11095-009-9944-9 Choi, 2011, Differential effects of ginsenoside metabolites on HERG k channel currents, J Ginseng Res, 35, 191, 10.5142/jgr.2011.35.2.191 Kim, 2013, Efficient thermal deglycosylation of ginsenoside Rd and its contribution to the improved anticancer activity of ginseng, J Agric Food Chem, 61, 9185, 10.1021/jf402774d Kim, 2004, Compound K induces expression of hyaluronan synthase 2 gene in transformed human keratinocytes and increases hyaluronan in hairless mouse skin, Biochem Biophys Res Commun, 316, 348, 10.1016/j.bbrc.2004.02.046 Kim, 2009, The ginsenoside Rg3 has a stimulatory effect on insulin signaling in L6 myotubes, Biochem Biophys Res Commun, 389, 70, 10.1016/j.bbrc.2009.08.088 Lee, 2011, Effects of minor ginsenosides, ginsenoside metabolites, and ginsenoside epimers on the growth of Caenorhabditis elegans, J Ginseng Res, 35, 375, 10.5142/jgr.2011.35.3.375 Sala, 2002, Effects of ginsenoside Rg2 on human neuronal nicotinic acetylcholine receptors, J Pharmacol Exp Ther, 301, 1052, 10.1124/jpet.301.3.1052 Hasegawa, 2004, Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid, J Pharmacol Sci, 95, 153, 10.1254/jphs.FMJ04001X4 Popovich, 2002, Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line, Arch Biochem Biophys, 406, 1, 10.1016/S0003-9861(02)00398-3 Cui, 2013, Identification and characterization of Mucilaginibacter sp. QM49 β-glucosidase and its use in producing the pharmaceutically active minor ginsenosides, Rh1(S) and Rg2(S), Appl Environ Microbiol, 79, 5788, 10.1128/AEM.01150-13 Jin, 2012, Kinetics of a cloned special ginsenosidase hydrolyzing 3-O-glucoside of multi-protopanaxadiol-type ginsenosides, named ginsenosidase type III, J Microbiol Biotechnol, 22, 343, 10.4014/jmb.1107.07066 Yu, 2007, Purification and characterization of new special ginsenosidase hydrolyzing multi-glycisides of protopanaxadiol ginsenosides, ginsenosidase type I, Chem Pharm Bull, 55, 231, 10.1248/cpb.55.231 Liu, 2014, Biotransformation pathway and kinetics of ginsenosidase type I hydrolyzing 3-O- and 20-O-multi- glucosides of PPD type ginsenosides, Process Biochem, 49, 813, 10.1016/j.procbio.2014.02.011 Yu, 2009, A new ginsenosidase from Aspergillus strain hydrolyzing 20-O-multi-glycoside of PPD ginsenoside, Process Biochem, 44, 772, 10.1016/j.procbio.2009.02.005 Wang, 2012, Enzyme kinetics of ginsenosidase type IV hydrolyzing 6-O-multi-glycosides of protopanaxatriol type ginsenosides, Process Biochem, 47, 133, 10.1016/j.procbio.2011.10.026 Li, 1997, 189 Wang, 2002, 356 Lowry, 1951, Protein measurement with the Folin phenol reagent, J Biol Chem, 193, 265, 10.1016/S0021-9258(19)52451-6 Lineweaver, 1934, The determination of enzyme dissociation constants, J Am Chem Soc, 56, 658, 10.1021/ja01318a036 Tanaka, 1984, Saponins of ginseng and related plants, vol. 46, 1