Preoperative Characteristics of Ocular Biometry in Children with Unilateral Congenital Cataracts
Tóm tắt
The ocular biometry characteristics are clinically significant for children with unilateral congenital cataracts, but there is a lack of data analysis concerning the preoperative measurements. The axial length (AL), mean keratometry (Km), corneal astigmatism (CA), and the anterior chamber depth (ACD) from both eyes before cataract surgery were obtained from 205 patients (410 eyes, 3–15 years of age) with unilateral congenital cataracts. In the congenital cataract eyes, shorter AL (22.44 ± 1.52 mm vs. 22.57 ± 1.04 mm, p = 0.036) and higher CA (– 1.89 ± 0.91 D vs. – 1.24 ± 0.67 D, p < 0.001) were found, and no significant difference was found in the Km and the ACD measurements compared to the contralateral normal eyes. Females had shorter AL and shallower ACD compared to males. However, the Km and CA in the females were significantly larger than that in males. Shorter AL, larger Km, higher CA, and shallower ACD were also found in females who had a binocular axial difference (the value obtained by subtraction of the contralateral normal eye from the congenital cataract eye) that less than zero. The preoperative ocular biometry of shorter AL, larger Km, higher CA, and shallower ACD should be considered in females with unilateral congenital cataracts. The age and the binocular axial differences had a statistically significant correlation (r = –0.192, p = 0.006). Therefore, changes in the binocular axial differences associated with aging may enhance the guidelines for intraocular lens selection and the management of congenital cataracts.
Tài liệu tham khảo
Bar-Sela SM, Spierer A (2006) Astigmatism outcomes of scleral tunnel and clear corneal incisions for congenital cataract surgery. Eye (london) 20:1044–1048. https://doi.org/10.1038/sj.eye.6702082
Bar-Sela S, Glovinsky Y, Wygnanski-Jaffe T, Spierer A (2009) The relationship between patient age and astigmatism magnitude after congenital cataract surgery. Eur J Ophthalmol 19:376–379. https://doi.org/10.1177/112067210901900308
Berry V, Georgiou M, Fujinami K, Quinlan R, Moore A, Michaelides M (2020) Inherited cataracts: molecular genetics, clinical features, disease mechanisms and novel therapeutic approaches. Brit J Ophthalmol 104:1331–1337. https://doi.org/10.1136/bjophthalmol-2019-315282
Capozzi P, Morini C, Piga S, Cuttini M, Vadala P (2008) Corneal curvature and axial length values in children with congenital/infantile cataract in the first 42 months of life. Invest Ophthalmol vis Sci 49:4774–4778. https://doi.org/10.1167/iovs.07-1564
Haargaard B, Wohlfahrt J, Fledelius HC, Rosenberg T, Melbye M (2004) A nationwide Danish study of 1027 cases of congenital/infantile cataracts: etiological and clinical classifications. Ophthalmology 111:2292–2298. https://doi.org/10.1016/j.ophtha.2004.06.024
Khokhar S, Jose CP, Sihota R, Midha N (2018) Unilateral congenital cataract: clinical profile and presentation. J Pediatr Ophthalmol Strabismus 55:107–112. https://doi.org/10.3928/01913913-20170703-11
Kun L, Szigeti A, Bausz M, Nagy ZZ, Maka E (2018) Preoperative biometry data of eyes with unilateral congenital cataract. J Cataract Refract Surg 44:1198–1202. https://doi.org/10.1016/j.jcrs.2018.06.054
Lin D, Chen J, Liu Z et al (2016a) Prevalence of corneal astigmatism and anterior segmental biometry characteristics before surgery in chinese congenital cataract patients. Sci Rep 6:22092. https://doi.org/10.1038/srep22092
Lin H, Lin D, Liu Z et al (2016b) A novel congenital cataract category system based on lens opacity locations and relevant anterior segment characteristics. Invest Ophthalmol vis Sci 57:6389. https://doi.org/10.1167/iovs.16-20280
Liu YC, Wilkins M, Kim T, Malyugin B, Mehta JS (2017) Cataracts. Lancet 390:600–612. https://doi.org/10.1016/S0140-6736(17)30544-5
Ma LW, Xuan D, Li XY, Zhang JS (2011) Corneal astigmatism correction with scleral flaps in trans-scleral suture-fixed posterior chamber lens implantation: a preliminary clinical observation. Int J Ophthalmol 4:502–507. https://doi.org/10.3980/j.issn.2222-3959.2011.05.09
Morrison DG, Lynn MJ, Freedman SF, Orge FH, Lambert SR (2015) Corneal changes in children after unilateral cataract surgery in the infant Aphakia treatment study. Ophthalmology 122:2186–2192. https://doi.org/10.1016/j.ophtha.2015.07.011
Sahu S, Panjiyar P (2019) Biometry characteristics in congenital cataract patients before surgery in a tertiary eye care centre in Nepal. Saudi J Ophthalmol 33:342–346. https://doi.org/10.1016/j.sjopt.2019.07.004
Seven E, Tekin S, Batur M, Artuç T, Yaşar T (2019) Evaluation of changes in axial length after congenital cataract surgery. J Cataract Refract Surg 45:470–474. https://doi.org/10.1016/j.jcrs.2018.11.012
Sheeladevi S, Lawrenson JG, Fielder AR, Suttle CM (2016) Global prevalence of childhood cataract: a systematic review. Eye (london) 30:1160–1169. https://doi.org/10.1038/eye.2016.156
Simsek T, Soba DO, Tirhis MH, Yilmazbas P, Ozturk F (2016) Evaluation of corneal biomechanical properties using an ocular response analyser to examine aphakic and pseudophakic patients after congenital cataract surgery. Acta Ophthalmol 94:e198-203. https://doi.org/10.1111/aos.12900
Somer D, Budak K, Demirci S, Duman S (2002) Against-the-rule (ATR) astigmatism as a predicting factor for the outcome of amblyopia treatment. Am J Ophthalmol 133:741–745. https://doi.org/10.1016/s0002-9394(02)01345-4
Sukhija J, Kaur S (2017) Central corneal thickness and intraocular pressure changes after congenital cataract surgery with intraocular lens implantation in children younger than 2 years. J Cataract Refract Surg 43:662–666. https://doi.org/10.1016/j.jcrs.2017.02.025
Trivedi RH, Wilson ME (2007) Biometry data from caucasian and African-American cataractous pediatric eyes. Invest Ophthalmol vis Sci 48:4671. https://doi.org/10.1167/iovs.07-0267
Trivedi RH, Wilson ME (2008) Keratometry in pediatric eyes with cataract. Arch Ophthalmol 126:38–42. https://doi.org/10.1001/archophthalmol.2007.22
von Noorden GK, Lewis RA (1987) Ocular axial length in unilateral congenital cataracts and blepharoptosis. Invest Ophthalmol vis Sci 28:750–752.