Các yếu tố dự đoán tỷ lệ tử vong do ung thư tụy trong một nhóm lớn người trưởng thành ở Hoa Kỳ

Cancer Causes & Control - Tập 11 Số 10 - Trang 915-923 - 2000
Coughlin, Steven S.1, Calle, Eugenia E.2, Patel, Alpa V.2, Thun, Michael J.2
1Epidemiology and Health Services Research Branch, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA
2Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, USA

Tóm tắt

Mục tiêu: Hút thuốc lá được coi là một yếu tố rủi ro quan trọng gây ung thư tụy, nhưng những yếu tố rủi ro khác vẫn chưa được xác định rõ. Để tìm hiểu thêm về dịch tễ học của nguyên nhân tử vong quan trọng này, chúng tôi đã nghiên cứu mối liên hệ với nhiều yếu tố rủi ro tiềm năng khác đối với tử vong do ung thư tụy trong một nghiên cứu tiềm năng lớn trên người lớn ở Hoa Kỳ. Phương pháp: Chúng tôi đã sử dụng mô hình tỷ lệ nguy cơ tỷ lệ (hazard ratios) để có được các ước lượng đã điều chỉnh về nguy cơ tương đối. Trong 14 năm theo dõi, 3751 người đã tử vong do ung thư tụy trong một nhóm gồm 483.109 nam giới và 619.199 nữ giới không có tiền sử ung thư khi ghi danh vào năm 1982. Kết quả: Hút thuốc lá tại thời điểm đầu nghiên cứu có liên quan đến ung thư tụy gây tử vong ở nam giới (tỷ lệ nguy cơ đa biến [RR] = 2.1, khoảng tin cậy [CI] 95% 1.9–2.4) và ở nữ giới (RR = 2.0, CI 95% 1.8–2.3). Một xu hướng rủi ro đã được quan sát thấy với số lượng thuốc lá hút mỗi ngày tăng lên ở những người hút thuốc hiện tại tại thời điểm đầu nghiên cứu. Với một số biến được đưa vào các mô hình riêng biệt cho nam và nữ, chúng tôi đã tìm thấy một số yếu tố khác có thể dự đoán tỷ lệ tử vong do ung thư tụy, bao gồm lịch sử gia đình có ung thư tụy, chủng tộc da đen, tiểu đường và chỉ số khối cơ thể tăng. Lịch sử sỏi mật là một yếu tố dự đoán ung thư tụy ở nam giới. Một mối liên hệ nghịch với việc tiêu thụ rau đã được quan sát thấy ở nam giới, nhưng không có ý nghĩa thống kê. Kết luận: Các phát hiện của chúng tôi xác nhận rằng hút thuốc lá là một yếu tố dự đoán quan trọng đối với tỷ lệ tử vong do ung thư tụy, và xác định một số yếu tố khác có thể góp phần vào tăng nguy cơ.

Từ khóa

#hút thuốc lá #ung thư tụy #tỷ lệ tử vong #yếu tố rủi ro #nghiên cứu tiềm năng

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